Leptin induces elongation of cardiac myocytes and causes eccentric left ventricular dilatation with compensation
Abstract
One of the major manifestations of obesity is an increased production of the adipocyte-derived 16-kDa peptide leptin, which acts mainly on hypothalamic leptin receptors. Leptin receptors are widely distributed in various tissues, including the heart. Whereas increased plasma leptin levels have been reported in patients with congestive heart failure, systemic alterations induced by obesity can affect cardiac hypertrophy, and the direct effects of leptin on cardiac structure and function still remain to be determined. We first exposed primary cardiac myocytes from neonatal rats to leptin for 48 h. This resulted in a significant increase in myocyte long-axis length ( P < 0.05 at 50 ng/ml) but not in the short-axis width. Leptin induced the rapid phosphorylation of STAT3 and its DNA binding in cardiac myocytes. Administration of a JAK2 inhibitor, AG-490, completely inhibited all of these effects by leptin. Furthermore, we examined the effect of continuous infusion of leptin for 4 wk following myocardial infarction in mice. Echocardiography demonstrated that left ventricular fractional shortening in the leptin-infused group (28.4 ± 2.8%) was significantly higher than that in the PBS-infused group (18.4 ± 2.2%) following myocardial infarction. Interestingly, left ventricular diastolic dimension in the leptin-infused group (4.56 ± 0.12 mm) was also higher than that in the PBS-infused group (4.13 ± 0.09 mm). These results demonstrate that leptin induces the elongation of cardiac myocytes via a JAK/STAT pathway and chronic leptin infusion causes eccentric dilatation with augmented systolic function after myocardial infarction.
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Leptin administration has been shown to reduce infarct size and enhance myocardial functional recovery following coronary artery ligation in mice.
“Thus leptin administration has been shown to reduce infarct size and enhance myocardial functional recovery following coronary artery ligation in mice (4, 326).”
From Cardiac remodeling in obesity (2008) · cites this paper as [4]
Leptin administration in mice has been shown to reduce infarct size and enhance functional recovery following coronary artery ligation.
“Notably, leptin administration in mice has been shown to reduce infarct size and enhance functional recovery following coronary artery ligation (4, 326).”
From Cardiac remodeling in obesity (2008) · cites this paper as [4]
Cites
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419 · see citing works
Obesity and the risk of heart failure
Kenchaiah, S., Evans, J. C., Levy, D., Wilson, P. W. F., Benjamin, E. J., Larson, M. G., Kannel, W. B., & Vasan, R. S. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa020245 · Cited by 3,093 · see citing works
Wallace, A. M., McMahon, A. D., Packard, C. J., Kelly, A., Shepherd, J., Gaw, A., & Sattar, N. A. (2001) · Circulation · doi:10.1161/hc5001.101061 · Cited by 821 · see citing works
Obesity cardiomyopathy: pathophysiology and evolution of the clinical syndrome
Alpert, M. A. (2001) · The American Journal of the Medical Sciences · doi:10.1097/00000441-200104000-00003 · Cited by 795 · see citing works
Left Ventricular Hypertrophy by Electrocardiogram
Kannel, W. B., GORDON, T., & OFFUTT, D. (1969) · Annals of Internal Medicine · doi:10.7326/0003-4819-71-1-89 · Cited by 755 · see citing works
Chronic Leptin Infusion Increases Arterial Pressure
Shek, E. W., Brands, M. W., & Hall, J. E. (1998) · Hypertension · doi:10.1161/01.hyp.31.1.409 · Cited by 686 · see citing works
The Small GTPase Rho: Cellular Functions and Signal Transduction
Narumiya, S. (1996) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a021401 · Cited by 413 · see citing works
de Simone, G., Devereux, R. B., Roman, M. J., Alderman, M. H., & Laragh, J. H. (1994) · Hypertension · doi:10.1161/01.hyp.23.5.600 · Cited by 391 · see citing works
Cardiotrophin-1 Activates a Distinct Form of Cardiac Muscle Cell Hypertrophy
Wollert, K. C., Taga, T., Saito, M., Narazaki, M., Kishimoto, T., Glembotski, C. C., Vernallis, A. B., Heath, J. K., Pennica, D., Wood, W. I., et al. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.16.9535 · Cited by 373 · see citing works
Barouch, L. A., Berkowitz, D. E., Harrison, R. W., O’Donnell, C. P., & Hare, J. M. (2003) · Circulation · doi:10.1161/01.cir.0000083716.82622.fd · Cited by 341 · see citing works
IL-1β mediates leptin induction during inflammation.
Faggioni, R., Fantuzzi, G., Fuller, J., Dinarello, C., Feingold, K., & Grunfeld, C. (1998) · American Journal of Physiology. Regulatory Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.274.1.r204 · Cited by 290 · see citing works
Rho family GTPases: the cytoskeleton and beyond
Symons, M. H. (1996) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(96)10022-0 · Cited by 260 · see citing works
The Obesity-Associated Peptide Leptin Induces Hypertrophy in Neonatal Rat Ventricular Myocytes
Rajapurohitam, V., Gan, X. T., Kirshenbaum, L. A., & Karmazyn, M. (2003) · Circulation Research · doi:10.1161/01.res.0000089255.37804.72 · Cited by 248 · see citing works
Rho Family Proteins Modulate Rapid Apoptosis Induced by Cytotoxic T Lymphocytes and Fas
Subauste, M. C., von Herrath, M., Planat‐Benard, V., Chamberlain, C. E., Chuang, T., Chu, K., Bokoch, G., & Hahn, K. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.13.9725 · Cited by 241 · see citing works
Xu, F.-P., Chen, M.-S., Wang, Y.-Z., Yi, Q., Lin, S.-B., Chen, A. F., & Luo, J.-D. (2004) · Circulation · doi:10.1161/01.cir.0000140766.52771.6d · Cited by 234 · see citing works
Alpert, M. A., Terry, B. E., & Kelly, D. L. (1985) · The American Journal of Cardiology · doi:10.1016/0002-9149(85)90156-0 · Cited by 210 · see citing works
Schulze, P. C., Kratzsch, J., Linke, A., Schoene, N., Adams, V., Gielen, S., Erbs, S., Möbius‐Winkler, S., & Schuler, G. C. (2003) · European Journal of Heart Failure · doi:10.1016/s1388-9842(02)00177-0 · Cited by 193 · see citing works
Aikawa, R., Komuro, I., Yamazaki, T., Zou, Y., Kudoh, S., Zhu, W., Kadowaki, T., & Yazaki, Y. (1999) · Circulation Research · doi:10.1161/01.res.84.4.458 · Cited by 188 · see citing works
Leptin plasma concentrations are dependent on body fat distribution in obese patients
Minocci, A., Savia, G., Lucantoni, R., Berselli, M. E., Tagliaferri, M., Calò, G., Petroni, M. L., Medici, C. D., Viberti, G., & Liuzzi, A. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801385 · Cited by 176 · see citing works
Hasegawa, K., Lee, S., Jobe, S. M., Markham, B. E., & Kitsis, R. N. (1997) · Circulation · doi:10.1161/01.cir.96.11.3943 · Cited by 174 · see citing works
Self-citationPersistent Expression of Cytokine in the Chronic Stage of Viral Myocarditis in Mice
Shioi, T., Matsumori, A., & Sasayama, S. (1996) · Circulation · doi:10.1161/01.cir.94.11.2930 · Cited by 173 · see citing works
Rat heart is a site of leptin production and action
Purdham, D. M., Zou, M.-X., Rajapurohitam, V., & Karmazyn, M. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00499.2004 · Cited by 173 · see citing works
Paolisso, G., Tagliamonte, M. R., Galderisi, M., Zito, G. A., Petrocelli, A., Carella, C., DIVITIIS, O. D., & Varricchio, M. (1999) · Hypertension · doi:10.1161/01.hyp.34.5.1047 · Cited by 156 · see citing works
Leptin is an autocrine/paracrine regulator of wound healing
Murad, A. A. A., Nath, A. K., Cha, S.-T., Demir, E., Floras-Riveras, J., & Sierra-Honigmann, M. R. (2003) · The FASEB Journal · doi:10.1096/fj.03-0068fje · Cited by 155 · see citing works
Perego, L., Pizzocri, P., Corradi, D., Maisano, F., Paganelli, M., Fiorina, P., Barbieri, M., Morabito, A., Paolisso, G., Folli, F. B., et al. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1963 · Cited by 123 · see citing works
MADANI, S., DEGIROLAMO, S., MUNOZ, D., LI, R., & SWEENEY, G. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.11.022 · Cited by 122 · see citing works
Link of Nonhemodynamic Factors to Hemodynamic Determinants of Left Ventricular Hypertrophy
SIMONE, G. D., Pasanisi, F., & Contaldo, F. (2001) · Hypertension · doi:10.1161/01.hyp.38.1.13 · Cited by 118 · see citing works
Tajmir, P., Ceddia, R. B., Li, R., Coe, I. R., & Sweeney, G. (2004) · Endocrinology · doi:10.1210/en.2003-1128 · Cited by 96 · see citing works
Inada, T., Fujiwara, H., Hasegawa, K., Araki, M., Yamauchi‐Kohno, R., Yabana, H., Fujiwara, T., Tanaka, M., & Sasayama, S. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00564-6 · Cited by 29 · see citing works
Self-citationEchocardiographic findings in obesity.
Cueto-Garcia, L., Laredo, C., Arriaga, J. J., & González‐Barranco, J. (1982) · PubMed · Cited by 28 · see citing works
Zema, M. J., & Caccavano, M. H. (1982) · Journal of Clinical Ultrasound · doi:10.1002/jcu.1870100107 · Cited by 15 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Abel, E. D., Litwin, S. E., & Sweeney, G. (2008) · Physiological Reviews · doi:10.1152/physrev.00017.2007 · Cited by 736 · see citing works
The myocardial JAK/STAT pathway: from protection to failure.
Boengler, K., Hilfiker-Kleiner, D., Drexler, H., Heusch, G., & Schulz, R. (2008) · Pharmacology and Therapeutics · doi:10.1016/j.pharmthera.2008.08.002 · Cited by 379 · see citing works
Recinella, L., Orlando, G., Ferrante, C., Chiavaroli, A., Brunetti, L., & Leone, S. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.578966 · Cited by 261 · see citing works
Gualillo, O., González-Juanatey, J. R., & Lago, F. (2007) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2007.09.005 · Cited by 193 · see citing works
Cardiovascular effects of leptin
Sweeney, G. (2009) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2009.224 · Cited by 184 · see citing works
The Adipokine Hypothesis of Heart Failure With a Preserved Ejection Fraction
Packer, M. (2025) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2025.06.055 · Cited by 190 · see citing works
Habbout, A., Li, N., Rochette, L., & Vergely, C. (2013) · Journal of Nutrition · doi:10.3945/jn.112.172825 · Cited by 138 · see citing works
Association of serum omentin-1 levels with coronary artery disease
Zhong, X., Zhang, H.-Y., Tan, H. C., Zhou, Y., Liu, F.-L., Chen, F.-Q., & Shang, D. (2011) · Acta Pharmacologica Sinica · doi:10.1038/aps.2011.26 · Cited by 128 · see citing works
Determinants of left ventricular mass in obesity; a cardiovascular magnetic resonance study
Rider, O. J., Francis, J. M., Ali, M. K., Byrne, J. P., Clarke, K., Neubauer, S., & Petersen, S. E. (2009) · Journal of Cardiovascular Magnetic Resonance · doi:10.1186/1532-429x-11-9 · Cited by 110 · see citing works
Rayner, J. J., Banerjee, R., Holloway, C. J., Lewis, A., Peterzan, M. A., Francis, J. M., Neubauer, S., & Rider, O. J. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.239 · Cited by 77 · see citing works
Mechanisms linking adipose tissue inflammation to cardiac hypertrophy and fibrosis
Anthony, S., Guarnieri, A., Gozdiff, A., Helsley, R. N., Owens, A. P., & Tranter, M. (2019) · Clinical Science · doi:10.1042/cs20190578 · Cited by 81 · see citing works
Leptin and cardiovascular diseases
Hou, N., & Luo, J. (2011) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2011.05619.x · Cited by 79 · see citing works
JAK redux: a second look at the regulation and role of JAKs in the heart
Kurdi, M., & Booz, G. W. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00032.2009 · Cited by 77 · see citing works
Bobbert, P., Jenke, A., Bobbert, T., Kühl, U., Rauch, U., Laßner, D., Scheibenbogen, C., Poller, W. C., Schultheiß, H., & Skurk, C. (2012) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfs111 · Cited by 76 · see citing works
Hu, X., Wu, R., Jiang, Z., Wang, L., Chen, P., Zhang, L., Yang, L., Wu, Y. R., Chen, H., Chen, H., et al. (2014) · Stem Cells · doi:10.1002/stem.1784 · Cited by 73 · see citing works
Leptin as a Cardiac Hypertrophic Factor: A Potential Target for Therapeutics
Karmazyn, M., Purdham, D. M., Rajapurohitam, V., & Zeidan, A. (2007) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2007.06.001 · Cited by 71 · see citing works
Rider, O. J., Petersen, S. E., Francis, J. M., Ali, M. K., Hudsmith, L., Robinson, M. R., Clarke, K., & Neubauer, S. (2010) · Heart · doi:10.1136/hrt.2009.185009 · Cited by 70 · see citing works
Adipokines and the cardiovascular system: mechanisms mediating health and disease
Northcott, J. M., Yeganeh, A., Taylor, C. G., Zahradka, P. C., & Wigle, J. T. (2012) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y2012-053 · Cited by 70 · see citing works
Leptin’s regulation of obesity-induced cardiac extracellular matrix remodeling
Zibadi, S., Cordova-Marks, F. M., Slack, E. H., WATSON, R. R., & Larson, D. F. (2011) · Cardiovascular Toxicology · doi:10.1007/s12012-011-9124-0 · Cited by 66 · see citing works
Obesity and its cardiovascular effects
Ortega‐Loubon, C., Fernández‐Molina, M., Singh, G., & Correa, R. R. (2019) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3135 · Cited by 68 · see citing works
The Impact of Left Ventricular Systolic Dysfunction on Survival After Renal Transplantation
Siedlecki, A. M., Foushee, M. T., Curtis, J. J., Gaston, R. S., Perry, G. J., Iskandrian, A. E., & de Mattos, A. M. (2007) · Transplantation · doi:10.1097/01.tp.0000295748.42884.97 · Cited by 60 · see citing works
Leptin Signaling in the Failing and Mechanically Unloaded Human Heart
McGaffin, K. R., Moravec, C. S., & McTiernan, C. F. (2009) · Circulation Heart Failure · doi:10.1161/circheartfailure.109.869909 · Cited by 58 · see citing works
Lubkowska, A., Radecka, A., Bryczkowska, I., Rotter, I., Laszczyńska, M., & Dudzińska, W. (2015) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph120911528 · Cited by 57 · see citing works
Exercise-Induced Activation of STAT3 Signaling Is Increased with Age
Caldow, M. K., Carey, K. A., Ward, A. C., Farnfield, M. M., & Cameron‐Smith, D. (2008) · Rejuvenation Research · doi:10.1089/rej.2007.0643 · Cited by 55 · see citing works
Leptin as a Key between Obesity and Cardiovascular Disease
Kang, K., Ok, M., & Lee, S. (2020) · Journal of Obesity & Metabolic Syndrome · doi:10.7570/jomes20120 · Cited by 53 · see citing works
Habbout, A., Delemasure, S., Goirand, F., Guilland, J.-C., Chabod, F., Sediki, M., Rochette, L., & Vergely, C. (2011) · Biochimie · doi:10.1016/j.biochi.2011.09.023 · Cited by 50 · see citing works
Pro-inflammatory Cytokines in Acute Coronary Syndromes
Mourouzis, K., Oikonomou, E. K., Siasos, G., Tsalamadris, S., Vogiatzi, G., Antonopoulos, A. S., Fountoulakis, P. N., Goliopoulou, A., Papaioannou, S., & Tousoulis, D. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200413082353 · Cited by 50 · see citing works
Schram, K., Wong, M. M. K., Palanivel, R., No, E. K., Dixon, I., & Sweeney, G. (2008) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2008.03.005 · Cited by 49 · see citing works
Leifheit‐Nestler, M., Wagner, N., Gogiraju, R., Didié, M., Konstantinides, S., Hasenfuss, G. P., & Schäfer, K. (2013) · Journal of Translational Medicine · doi:10.1186/1479-5876-11-170 · Cited by 48 · see citing works
Merits of Non-Invasive Rat Models of Left Ventricular Heart Failure
Carll, A. P., Willis, M. S., Lust, R. M., Costa, D. L. D. C., & Farraj, A. K. (2011) · Cardiovascular Toxicology · doi:10.1007/s12012-011-9103-5 · Cited by 49 · see citing works
mTOR mediates RhoA-dependent leptin-induced cardiomyocyte hypertrophy
Zeidan, A., Hunter, J. C., Javadov, S. A., & Karmazyn, M. (2011) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-011-0744-2 · Cited by 45 · see citing works
Zhao, Y., Wang, D., Liu, Y., Shan, L., & Zhou, J. (2015) · The Journal of Physiological Sciences · doi:10.1007/s12576-015-0418-z · Cited by 44 · see citing works
Obesity Hypertension: The Regulatory Role of Leptin
Kshatriya, S., Liu, K., Salah, A., Szombathy, T., Freeman, R. H., Reams, G. P., Spear, R. M., & Villarreal, D. (2011) · International Journal of Hypertension · doi:10.4061/2011/270624 · Cited by 45 · see citing works
Habbout, A., Guénancia, C., Lorin, J., Rigal, E., Fassot, C., Rochette, L., & Vergely, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056981 · Cited by 42 · see citing works
Roberts, A. W., Clark, A. L., & Witte, K. K. (2009) · Diabetes and Vascular Disease Research · doi:10.1177/1479164109338774 · Cited by 41 · see citing works
Sinoatrial node dysfunction induces cardiac arrhythmias in diabetic mice
Soltysinska, E., Speerschneider, T., Winther, S. V., & Thomsen, M. B. (2014) · Cardiovascular Diabetology · doi:10.1186/s12933-014-0122-y · Cited by 35 · see citing works
Khan, M. F., & Movahed, M. R. (2012) · Heart Failure Reviews · doi:10.1007/s10741-012-9320-4 · Cited by 33 · see citing works
Understanding Obesity-Related High Output Heart Failure and Its Implications
Shen, Q., Hiebert, J. B., Rahman, F. K., Krueger, K. J., Gupta, B. P., & Pierce, J. D. (2021) · International Journal of Heart Failure · doi:10.36628/ijhf.2020.0047 · Cited by 33 · see citing works
Serum Concentrations of Leptin and Adiponectin in Dogs with Myxomatous Mitral Valve Disease
Kim, H. ‐., Kang, J., Jeung, E., & Yang, M. (2016) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.14570 · Cited by 32 · see citing works
Structural and Metabolic Effects of Obesity on the Myocardium and the Aorta
Rider, O. J., Lewis, A., & Neubauer, S. (2014) · Obesity Facts · doi:10.1159/000368429 · Cited by 31 · see citing works
TG-interacting factor is required for the differentiation of preadipocytes
Horie, T., Ono, K., Kinoshita, M., Nishi, H., Nagao, K., Kawamura, T., Abe, Y., Wada, H., Shimatsu, A., Kita, T., et al. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m700578-jlr200 · Cited by 31 · see citing works
Self-citationCardiometabolic comorbidities and rheumatic diseases: Focus on the role of fat mass and adipokines
Lago, F., Gómez, R., Conde, J., Scotece, M., Gómez-Reino, J. J., & Gualillo, O. (2011) · Arthritis Care & Research · doi:10.1002/acr.20488 · Cited by 29 · see citing works
Abundis, E. M., Rajapurohitam, V., Haist, J. V., Gan, X. T., & Karmazyn, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041612 · Cited by 28 · see citing works
Leptin, a mediator of cardiac damage associated with obesity
Martínez‐Martínez, E., Jurado-López, R., Cervantes-Escalera, P., Cachofeiro, V., & Miana, M. (2014) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2013-0060 · Cited by 27 · see citing works
Enhanced hypertrophy in ob/ob mice due to an impairment in expression of atrial natriuretic peptide
Mascareno, E. J., Beckles, D. L., Dhar-Mascareño, M., & Siddiqui, M. A. Q. (2009) · Vascular Pharmacology · doi:10.1016/j.vph.2009.06.005 · Cited by 24 · see citing works
Obesity hypertension: the emerging role of leptin in renal and cardiovascular dyshomeostasis
Kshatriya, S., Reams, G. P., Spear, R. M., Freeman, R. H., Dietz, J. R., & Villarreal, D. (2009) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0b013e328332fb49 · Cited by 24 · see citing works
Obesity Hypertension: Pathophysiological Role of Leptin in Neuroendocrine Dysregulation
Go, O., Liu, K., Villarreal, D., Spear, R. M., Freeman, R. H., Reams, G. P., & Weber, K. T. (2013) · The American Journal of the Medical Sciences · doi:10.1097/maj.0b013e31827ad5cf · Cited by 22 · see citing works
JAK/STAT pathway in myocardial infarction: Crossroads of immune signaling and cardiac remodeling
Yang, Q., Ji, H., & Chahardehi, A. M. (2025) · Molecular Immunology · doi:10.1016/j.molimm.2025.08.018 · Cited by 24 · see citing works
Polyakova, E. A., Mikhaylov, E. N., Galagudza, M. M., & Shlyakhto, E. V. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e08491 · Cited by 23 · see citing works
Moey, M., Rajapurohitam, V., Zeidan, A., & Karmazyn, M. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.111.182600 · Cited by 23 · see citing works
Newer Biomarkers in Heart Failure
Gupta, S. K., Drazner, M. H., & de Lemos, J. A. (2009) · Heart Failure Clinics · doi:10.1016/j.hfc.2009.04.004 · Cited by 23 · see citing works
Gómez‐Hurtado, N., Domínguez‐Rodríguez, A., Matéo, P., Fernández‐Velasco, M., Val‐Blasco, A., Aizpún, R., Sabourin, J., Gomez, A. M., Bénitah, J., & Delgado, C. (2017) · The Journal of Physiology · doi:10.1113/jp274030 · Cited by 23 · see citing works
Rajapurohitam, V., Kilić, A., Javadov, S. A., & Karmazyn, M. (2012) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-012-1307-x · Cited by 22 · see citing works
Sowa, N., Horie, T., Kuwabara, Y., Baba, O., Watanabe, S., Nishi, H., Kinoshita, M., Takanabe‐Mori, R., Wada, H., Shimatsu, A., et al. (2012) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24222 · Cited by 22 · see citing works
Self-citationModulation of the cardiovascular system by leptin
Abel, E. D., & Sweeney, G. (2012) · Biochimie · doi:10.1016/j.biochi.2012.03.019 · Cited by 22 · see citing works
Inhibition of cardiac leptin expression after infarction reduces subsequent dysfunction
Moro, C., Grauzam, S. E., Ormezzano, O., Toufektsian, M.-C., Tanguy, S., Calabrèse, P., Coll, J., Bak, I., Juhász, B., Tósaki, Á., et al. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01154.x · Cited by 21 · see citing works
The role of dietary fatty acids in predicting myocardial structure in fat-fed rats
Jeckel, K. M., Miller, K. E., Chicco, A. J., Chapman, P. L., Mulligan, C. M., Falcone, P. H., Miller, M. L., Pagliassotti, M. J., & Frye, M. A. (2011) · Lipids in Health and Disease · doi:10.1186/1476-511x-10-92 · Cited by 21 · see citing works
Chen, H., Li, M., Liu, L., Zhu, D., & Tian, G. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370220908215 · Cited by 20 · see citing works
Matsui, H., Yokoyama, T., Tanaka, C., Sunaga, H., Koitabashi, N., Takizawa, T., Arai, M., & Kurabayashi, M. (2012) · BMC Cell Biology · doi:10.1186/1471-2121-13-37 · Cited by 19 · see citing works
Huisamen, B., Hafver, T. L., Lumkwana, D., & Lochner, A. (2016) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-016-6665-2 · Cited by 18 · see citing works
Rubio, B., Mora, C., Pintado, C., Mazuecos, L., Fernández, A., López, V., Andrés, A., & Gallardo, N. (2020) · Metabolism · doi:10.1016/j.metabol.2020.154453 · Cited by 17 · see citing works
JAK-STAT signaling in cardiomyogenesis of cardiac stem cells
Mohri, T., Iwakura, T., Nakayama, H., & Fujio, Y. (2012) · JAK-STAT · doi:10.4161/jkst.20296 · Cited by 17 · see citing works
Karmazyn, M., Gan, X. T., & Rajapurohitam, V. (2013) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2013-0057 · Cited by 15 · see citing works
Karmazyn, M., & Gan, X. T. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021137 · Cited by 12 · see citing works
From Beats to Metabolism: the Heart at the Core of Interorgan Metabolic Cross Talk
Romero-Becerra, R., Santamans, A. M., Arcones, A. C., & Sabio, G. (2023) · Physiology · doi:10.1152/physiol.00018.2023 · Cited by 12 · see citing works
Gómez‐Hurtado, N., Fernández‐Velasco, M., Fernández‐Alfonso, M. S., Boscá, L., & Delgado, C. (2013) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-013-1348-3 · Cited by 12 · see citing works
Difficult-to-Treat or Resistant Hypertension: Etiology, Pathophysiology, and Innovative Therapies
Papademetriou, V., Tsioufis, C. P., Gradman, A. H., & Punzi, H. A. (2011) · International Journal of Hypertension · doi:10.4061/2011/438198 · Cited by 11 · see citing works
Gómez-Crisóstomo, N. P., la Cruz-Hernández, E. N. D., Méndez, E. R. M., Hernández-Landero, M. F., Liévano, J. U. C., & Abundis, E. M. (2018) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2018.1517181 · Cited by 10 · see citing works
van Waveren, A., Duncan, M. J., Coulson, F. R., & Fenning, A. S. (2014) · BMC Obesity · doi:10.1186/2052-9538-1-11 · Cited by 7 · see citing works
Radin, M. J., Holycross, B. J., McCune, S. A., & Altschuld, R. A. (2011) · Experimental Biology and Medicine · doi:10.1258/ebm.2011.011144 · Cited by 6 · see citing works
DeClercq, V., Defries, D. M., Hunt, R., Taylor, C. G., & Zahradka, P. C. (2011) · Wiley eBooks · doi:10.1002/9780470910016.ch4 · Cited by 5 · see citing works
Pemberton, C. J. (2007) · Cardiovascular Research · doi:10.1093/cvr/cvm053 · Cited by 5 · see citing works
Karmazyn, M., & Gan, X. T. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms27010003 · Cited by 5 · see citing works
Marketou, M. E., Kontaraki, J. E., Maragkoudakis, S., Danelatos, C., Papadaki, S., Zervakis, S., Plevritaki, A., Vardas, P. E., PARTHENAKIS, F. I., & KOCHIADAKIS, G. E. (2021) · Current Vascular Pharmacology · doi:10.2174/1570161120666211227125033 · Cited by 4 · see citing works
Correlation between Leptin with Diastolic Function in Young Adult Obesity
Nugraha, F. A., Akbar, M. R., Aprami, T. M., & Martha, J. W. (2019) · ACI (Acta Cardiologia Indonesiana) · doi:10.22146/aci.44552 · Cited by 3 · see citing works
The cellular specificity of leptin-mediated actions in the infarcted heart
Dobaczewski, M. P., & Frangogiannis, N. G. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq354 · Cited by 3 · see citing works
Zhang, R., Wang, M., Lang, Y., Zhang, J., Wang, Y., Han, Z., Zheng, Y., & Zhou, B. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1501397 · Cited by 2 · see citing works
Zhu, L., Zhou, J., Gu, Y., Xu, Y., & Guo, Y.-F. (2025) · Physiological Reports · doi:10.14814/phy2.70360 · Cited by 2 · see citing works
Compensation: A Contemporary Regulatory Machinery in Cardiovascular Diseases?
Fan, X.-J., & Ren, J. T. (2012) · Cardiovascular Toxicology · doi:10.1007/s12012-012-9167-x · Cited by 2 · see citing works
PLASMA LEPTIN LEVELS IN METABOLIC SYNDROME PATIENTS WITH ISCHEMIC HEART DISEASE
Drapkina, O. M., Шепель, Р. Н., & Deeva, Т. A. (2016) · CARDIOVASCULAR THERAPY AND PREVENTION · doi:10.15829/1728-8800-2016-3-43-48 · Cited by 2 · see citing works
Saidullah, S., Ahmad, B. A., Waqas, M., Fatima, A., Khan, M. H. U. H., Khiyam, U., & Malik, J. (2024) · International Journal of Arrhythmia · doi:10.1186/s42444-023-00108-z · Cited by 1 · see citing works
Drapkina, O. M., Шепель, Р. Н., & Deeva, Т. A. (2018) · Rational Pharmacotherapy in Cardiology · doi:10.20996/1819-6446-2018-14-1-27-33 · Cited by 1 · see citing works
Zabojska, K., Cygnarowicz, A., Wojtas, A. K., Korotko, U., Mandziuk, A., Witowska, K., Turemka, M., Biskupski, M., Hosseinnejad, N., & Sacher, K. (2024) · Quality in Sport · doi:10.12775/qs.2024.35.56489 · Cited by 1 · see citing works
Nożyński, J. K., Zakliczyńśki, M., Konecka-Mrówka, D., Żegleń, S., Przybylski, R., Zembala, M., Lange, D., Zembala‐Nożyńska, E., Męcik-Kronenberg, T., & Dąbrówka, K. (2009) · Transplantation Proceedings · doi:10.1016/j.transproceed.2009.07.067 · Cited by 1 · see citing works
Polyakova, E. A., Mikhaylov, E. N., Galagudza, M. M., & Shlyakhto, E. V. (2021) · Preprints.org · doi:10.20944/preprints202108.0019.v1 · Cited by 1 · see citing works
Obesity and Cardiac Dysfunction
Sweeney, G., Litwin, S. E., & Abel, E. D. (2010) · Springer eBooks · doi:10.1007/978-1-4419-1607-5_14
Carll, A. P. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/s2k3-rg49
Biochemii, K., & Medyczny, U. (2012)
Mineralocorticoid Receptor and Leptin: A Dangerous Liaison in the Obese Heart
Marín‐Royo, G., Luaces, M., Cachofeiro, V., & Martínez‐Martínez, E. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.87236
Leptin and Obesity: Role in Cardiac Structure and Dysfunction
Zibadi, S., Larson, D. F., & WATSON, R. R. (2010) · Humana Press eBooks · doi:10.1007/978-1-60327-571-2_12
Zhang, R., Wang, Y., Lang, Y., & Zheng, Y. (2024) · Research Square · doi:10.21203/rs.3.rs-4413337/v1
Luanpaisanon, P., Ryall, K. A., Tan, P. M., O'Hearn, J. J., Woo, L. A., Harris, B. N., Wissmann, B., Paap, A., Rhoads, M., Fallahi‐Sichani, M., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.01.679873
Obesity–Hypertension: Leptin as the Common Link to Cardiovascular and Renal Dysregulation
Kshatriya, S., Kozman, H., Siddiqui, D., Bhatta, L., Liu, K., Salah, A., Ford, T., Michiel, R. R., Carhart, R. L., & Villarreal, D. (2011) · Springer eBooks · doi:10.1007/978-1-4419-7130-2_25
Metabolic Syndrome-Induced Cardiac Fibrosis
Zibadi, S. (2009) · UA Campus Repository (The University of Arizona)
The intersection of disorders of sex development and cardiovascular diseases
Hashmi, S., & Aherrahrou, R. (2026) · Biology of Sex Differences · doi:10.1186/s13293-025-00814-4
Dong, Z., Wang, L., Lang, Y., Zhang, R., Wang, Y., Zhao, C., Chen, Q., & Zheng, Y. (2026) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2026.1759091
- Authors
- Abe, Y., Ono, K., Kawamura, T., Wada, H., Kita, T., Shimatsu, A., & Hasegawa, K.
- Affiliations
- Kyoto University (JP)
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 2007-05
- Volume
- 292
- Issue
- 5
- Pages
- H2387-H2396
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- OpenAlex
- W2165799170
- Cited by
- 97
- References
- 31
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 4 · 2023: 1 · 2021: 4 · 2020: 5 · 2019: 5 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 5 · 2013: 6 · 2012: 11
- FWCI
- 5.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Heart and Circulatory Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- leptin, cardiac compensation, STAT3 phosphorylation, JAK2 signaling, myocardial infarction, obesity, congestive heart failure, cardiac hypertrophy, leptin receptor
- MeSH terms
- Animals, Animals, Newborn, Cells, Cultured, Dose-Response Relationship, Drug, Rats, Sprague-Dawley, Hypertrophy, Left Ventricular, Leptin, Myocytes, Cardiac, Cell Size, Rats
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