The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Fas pathway is a critical mediator of cardiac myocyte death and MI during ischemia-reperfusion in vivo
Abstract
Fas is a widely expressed cell surface receptor that can initiate apoptosis when activated by its ligand (FasL). Whereas Fas abundance on cardiac myocytes increases in response to multiple pathological stimuli, direct evidence supporting its role in the pathogenesis of heart disease is lacking. Moreover, controversy exists even as to whether Fas activation induces apoptosis in cardiac myocytes. In this study, we show that adenoviral overexpression of FasL, but not β-galactosidase, results in marked apoptosis both in cultures of primary neonatal cardiac myocytes and in the myocardium of intact adult rats. Myocyte killing by FasL is a specific event, because it does not occur in lpr (lymphoproliferative) mice that lack functional Fas. To assess the contribution of the Fas pathway to myocardial infarction (MI) in vivo, lpr mice were subjected to 30 min of ischemia followed by 24 h of reperfusion. Compared with wild-type mice, lpr mice exhibited infarcts that were 62.3% smaller with 63.8% less myocyte apoptosis. These data provide direct evidence that activation of Fas can induce apoptosis in cardiac myocytes and that Fas is a critical mediator of MI due to ischemia-reperfusion in vivo.
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Cites
Death Receptors: Signaling and Modulation
Ashkenazi, A., & Dixit, V. M. (1998) · Science · doi:10.1126/science.281.5381.1305 · Cited by 5,866
Lethal effect of the anti-Fas antibody in mice
Ogasawara, J., Watanabe-Fukunaga, R., Adachi, M., Matsuzawa, A., Kasugai, T., Kitamura, Y., Itoh, N., Suda, T., & Nagata, S. (1993) · Nature · doi:10.1038/364806a0 · Cited by 1,881
Apoptosis in the Failing Human Heart
Olivetti, G., Abbi, R., Quaini, F., Kajstura, J., Cheng, W., Nitahara, J. A., Quaini, E., Di Loreto, C., Beltrami, C. A., Krajewski, S., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704173361603 · Cited by 1,673
Apoptosis in human acute myocardial infarction.
Saraste, A., Pulkki, K., Kallajoki, M., Henriksen, K., Parvinen, M., & Voipio-Pulkki, L.-M. (1997) · Circulation · doi:10.1161/01.cir.95.2.320 · Cited by 825 · cited 1×
“CARDIAC MYOCYTES undergo apoptosis in a wide variety of pathophysiological situations, including ischemia (6, 14, 25, 44), ischemia-reperfusion (8, 14, 16), and hemodynamic overload and heart failure (33, 41, 51).”
BackgroundReperfusion injury is not affected by blockade of P-selectin in the diabetic mouse heart
Jones, S. P., Girod, W. G., Granger, D. N., Palazzo, A. J., & Lefer, D. J. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.277.2.h763 · Cited by 80
Self-citation
Cited by
Fundamental Mechanisms of Regulated Cell Death and Implications for Heart Disease
Del Re, D. P., Amgalan, D., Linkermann, A., Liu, Q., & Kitsis, R. N. (2019) · Physiological Reviews · doi:10.1152/physrev.00022.2018 · Cited by 961
Self-citationCell Death in the Pathogenesis of Heart Disease: Mechanisms and Significance
Whelan, R. S., Kaplinskiy, V., & Kitsis, R. N. (2010) · Annual Review of Physiology · doi:10.1146/annurev.physiol.010908.163111 · Cited by 759
Self-citationApoptosis: a basic biological phenomenon with wide‐ranging implications in human disease
FADEEL, B., & ORRENIUS, S. (2005) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2005.01570.x · Cited by 698
Molecular machinery and interplay of apoptosis and autophagy in coronary heart disease
Dong, Y., Chen, H., Gao, J., Liu, Y., Li, J., & Wang, J. (2019) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2019.09.001 · Cited by 438
Myocyte apoptosis in heart failure
VANEMPEL, V, BERTRAND, A., HOFSTRA, L., CRIJNS, H., DOEVENDANS, P., & DEWINDT, L. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.04.012 · Cited by 373
Metadata
- Authors
- Lee, P., Sata, M., Lefer, D. J., Factor, S. M., Walsh, K., & Kitsis, R. N.
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 2003-02-01
- Volume
- 284
- Issue
- 2
- Pages
- H456-H463
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- OpenAlex
- W2146150621
- Cited by
- 226
- References
- 5
- FWCI
- 8.73
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lee, P., Sata, M., Lefer, D. J., Factor, S. M., Walsh, K., & Kitsis, R. N. (2003). Fas pathway is a critical mediator of cardiac myocyte death and MI during ischemia-reperfusion in vivo. American Journal of Physiology-Heart and Circulatory Physiology. https://doi.org/10.1152/ajpheart.00777.2002
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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