Experimental Motion Sickness in Dogs: Importance of Labyrinth and Vestibular Cerebellum
Abstract
Motion sickness was experimentally induced in dogs by means of a standardized swinging exposure. Susceptible dogs were selected for surgical extirpation of the labyrinths or various parts of the cerebellum. It was found that animals showed no vomiting responses to long exposures of swinging motion after bilateral labyrinthectomy or ablation of the nodulus and uvula. Even with incomplete extirpation of these structures, animals would become partially or totally resistant to motion sickness. In general, these operated animals exhibited normal responses to intravenously administered apomorphine or orally administered copper sulfate. These results indicate that motion stimulates the labyrinthine receptors, and the vestibular impulses traverse the nodulus and uvula of the cerebellum, and the chemoceptive emetic trigger zone, and finally reach the medullary vomiting center.
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Dogs' susceptibility patterns and emetic responses are similar to those of humans.
“Dogs have long been used in animal studies of motion sickness because their susceptibility patterns and emetic responses are similar to those of humans (Wang and Chinn 1956).”
From Motion sickness: more than nausea and vomiting (2014) · cites this paper as Wang and Chinn 1956
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Motion sickness: more than nausea and vomiting
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“Many internal signals under normal circumstances are subject to sensory inhibition as so elegantly shown in von Bekesy’s classic experiments (cf von Bekesy 1967).”
BackgroundPhysiological basis and pharmacology of motion sickness: an update
Yates, B. J., Miller, A. D., & Lucot, J. B. (1998) · Brain Research Bulletin · doi:10.1016/s0361-9230(98)00092-6 · Cited by 230 · see citing works
Brainstem processing of vestibular sensory exafference: implications for motion sickness etiology
Oman, C. M., & Cullen, K. E. (2014) · Experimental Brain Research · doi:10.1007/s00221-014-3973-2 · Cited by 103 · see citing works
Yates, B. J., Catanzaro, M. F., Miller, D. J., & McCall, A. A. (2014) · Experimental Brain Research · doi:10.1007/s00221-014-3937-6 · Cited by 90 · see citing works
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Dai, M., Raphan, T., & Cohen, B. (2011) · Experimental Brain Research · doi:10.1007/s00221-011-2548-8 · Cited by 52 · see citing works
Gastrointestinal motor and myoelectric correlates of motion sickness
Lang, I. M., Sarna, S. K., & Shaker, R. (1999) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1999.277.3.g642 · Cited by 43 · see citing works
Arshian, M. S., Puterbaugh, S. R., Miller, D. J., Catanzaro, M. F., Hobson, C. E., McCall, A. A., & Yates, B. J. (2013) · Experimental Brain Research · doi:10.1007/s00221-013-3568-3 · Cited by 12 · see citing works
- Authors
- Wang, S. C., & Chinn, H. I.
- Affiliations
- United States Air Force (US)
- Venue
- American Journal of Physiology-Legacy Content
- Publisher
- American Physiological Society
- Published
- 1956-06-01
- Volume
- 185
- Issue
- 3
- Pages
- 617-623
- ISSN
- 0002-9513 (ISSN-L)
- OpenAlex
- W2415605516
- Cited by
- 78
- References
- 0
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 2 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 1 · 2014: 4 · 2013: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Legacy Content (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
- Health Sciences › Medicine › Surgery › Nausea and vomiting management
- Health Sciences › Medicine › Physiology › Spaceflight effects on biology
- Keywords
- motion sickness, vestibular system, labyrinthectomy, Nodulus, uvula, cerebellum, vomiting center, apomorphine, copper sulfate, dogs
- MeSH terms
- Animals, Cerebellum, Dogs, Ear, Inner, Motion Sickness, Vestibule, Labyrinth
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