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Cited by 52Vestibular and auditory disordersNausea and vomiting managementSpaceflight effects on biology

Prolonged reduction of motion sickness sensitivity by visual-vestibular interaction

Open access
Dai, Mingjia, Raphan, Ted, Cohen, Bernard·2011·Experimental Brain Research
DOI 10.1007/s00221-011-2548-8PMC PMC3182575
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Abstract

The angular vestibulo-ocular reflex (aVOR) and optokinetic nystagmus (OKN) were elicited simultaneously at low frequencies to study effects of habituation of the velocity storage time constant in the vestibular system on motion sickness. Twenty-nine subjects, eleven of whom were susceptible to motion sickness from common transportation, were habituated by sinusoidal rotation at 0.017 Hz at peak velocities from 5 to 20°/s, while they watched a full-field OKN stimulus. The OKN stripes rotated in the same direction and at the same frequency as the subjects, but at a higher velocity. This produced an OKN opposite in direction to the aVOR response. Motion sickness sensitivity was evaluated with off-vertical axis rotation (OVAR) and by the response to transportation before and after 5 days of visual-vestibular habituation. Habituation did not induce motion sickness or change the aVOR gains, but it shortened the vestibular time constants in all subjects. This greatly reduced motion sickness produced by OVAR and sensitivity to common transport in the motion susceptible subjects, which persisted for up to 18 weeks. Two motion susceptible subjects who only had aVOR/OKN habituation without being tested with OVAR also became asymptomatic. Normal subjects who were not habituated had no reduction in either their aVOR time constants or motion sickness sensitivity. The opposing aVOR/OKN stimulation, which has not been studied before, was well tolerated, and for the first time was an effective technique for rapid and prolonged habituation of motion sickness without exposure to drugs or other nauseating habituation stimuli.

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  • Combined visual-vestibular habituation training is more effective than conventional ground-based training and can produce a long-term effect against travel-induced motion sickness for up to 18 weeks in susceptible subjects.

    “Compared with conventional ground-based training procedures using revolving chair, winding stair, idler wheel, and swing, combined visual-vestibular habituation training was more effective and can produce long-term effect against travel-induced MS for up to 18 weeks in susceptible subjects [143,144].”

    From Motion Sickness: Current Knowledge and Recent Advance. (2016) · cites this paper as [143]

    The Discussion reports that visual-vestibular habituation reduced travel-induced motion sickness in susceptible subjects for at least 18 weeks. The Introduction and Discussion contrast this approach with other habituation methods, but do not establish that it was more effective than the listed conventional ground-based procedures. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • Exposing subjects to visual-vestibular interactions reduces their sensitivity to motion sickness during travel in transports such as buses.

    “Exposing subjects to visual–vestibular interactions has been shown to reduce their sensitivity to motion sickness during travel in transports such as buses (Dai et al. 2011).”

    From Motion sickness: more than nausea and vomiting (2014) · cites this paper as Dai et al. 2011

    Experimental — accuracy not yet measured

  • Repeated real motion exposure and combined visual-vestibular interaction training accelerate the progress of habituation.

    “Repeated real motion exposure and combined visual-vestibular interaction training accelerate the progress of habituation.”

    From Motion Sickness: Current Knowledge and Recent Advance. (2016) · cites this paper as [143]

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Research works printed but not linked: 3

  1. Guedry FE Conflicting sesory orientation cues as a factor in motion sickness Fourth Symposium on the Role of the Vestibular Organs in Space Exploration, vol NASA Report SP-187 1970 Washington DC National Aeronautics and Space Administration 45 52
  2. Money KE Motion sickness Physiol Rev 1972 50 1 39 4904269
  3. Reason JT Brand JJ Motion sickness 1975 London Academic Press

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Authors
Dai, M., Raphan, T., & Cohen, B.
Affiliations
  • Icahn School of Medicine at Mount Sinai (US)
  • City University of New York (US)
Corresponding author
Dai, Mingjia
ORCID
Cohen, Bernard
Venue
Experimental Brain Research
Publisher
Springer Science and Business Media LLC
Published
2011-02-02
Volume
210
Issue
3-4
Pages
503-513
ISSN
  • 0014-4819 (ISSN-L)
  • 1432-1106
DOI
10.1007/s00221-011-2548-8
PMC
PMC3182575
OpenAlex
W2122267555
Cited by
52
References
61
Citations by year
2026: 3 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 3 · 2021: 6 · 2020: 2 · 2019: 5 · 2018: 3 · 2017: 5 · 2016: 3 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 1
FWCI
1.24
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Experimental Brain Research (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute on Deafness and Other Communication Disorders (R01DC007847)
Topics
  • Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
  • Health Sciences › Medicine › Surgery › Nausea and vomiting management
  • Health Sciences › Medicine › Physiology › Spaceflight effects on biology
Keywords
motion sickness, visual-vestibular interaction, vestibulo-ocular reflex, optokinetic nystagmus, habituation, off-vertical axis rotation, sinusoidal rotation, nausea
MeSH terms
Adult, Disease Susceptibility, Eye Movements, Female, Habituation, Psychophysiologic, Humans, Male, Middle Aged, Motion Sickness, Reflex, Vestibulo-Ocular, Rotation, Sensory Thresholds, Time Factors, Nystagmus, Optokinetic

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