Extrarenal potassium homeostasis
Abstract
Normal potassium homeostasis is regulated by both renal and extrarenal mechanisms. Although chronic potassium balance is primarily regulated by the kidneys, acute potassium tolerance is largely determined by extrarenal tissues. During the first 4-6 h following an acute potassium load, only about 50% of the potassium is excreted by the kidneys. Of the remaining 50% that is retained, over 80% is translocated into cells, and this provides the primary defense against hyperkalemia. Potassium uptake by both liver and muscle and intestinal secretion of potassium are the most important mechanisms of extrarenal potassium disposal. Several hormones, including insulin and epinephrine, have been shown to play an important role in the maintenance of normal extrarenal potassium metabolism. These hormones function by enhancing potassium uptake by liver and muscle. There is also evidence that aldosterone is necessary in the maintenance of normal extrarenal potassium tolerance. Although the major extrarenal site of action of aldosterone has not yet been clearly defined, gastrointestinal potassium secretion and muscle transport of potassium are both affected by the hormone. Evidence exists that glucocorticoids may also have an effect on extrarenal potassium homeostasis. In addition to this hormonal regulation, cellular shifts of potassium are influenced by changes in acid-base balance. Extrarenal potassium tolerance is impaired in chronic renal insufficiency. These uremia-related changes are discussed in the context of our present understanding of normal extrarenal potassium metabolism.
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After a K+ load, in the first 3-6 hours, only about 50% of the K+ load is excreted via urine; the remaining K+ load is excreted over the next 10 hours.
“After a K+ load, in the first 3–6 hours, only about 50% of the K+ load is excreted via urine; the remaining K+ load is excreted over the next 10 hours [1, 12].”
From A mathematical model of potassium homeostasis: Effect of feedforward and feedback controls (2022) · cites this paper as [12]
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Dynamics and consequences of potassium shifts in skeletal muscle and heart during exercise.
Sejersted, O., & Sjøgaard, G. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.4.1411 · Cited by 526 · see citing works
Ewart, H. S., & Klip, A. (1995) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1995.269.2.c295 · Cited by 460 · see citing works
Potassium Intake, Bioavailability, Hypertension, and Glucose Control
Stone, M. S., Martyn, L., & Weaver, C. M. (2016) · Nutrients · doi:10.3390/nu8070444 · Cited by 298 · see citing works
“, muscle) play an important role in K+ homeostasis as well [23,24].”
BackgroundPlasma potassium changes with high intensity exercise.
Medbø, J. I., & Sejersted, O. M. (1990) · The Journal of Physiology · doi:10.1113/jphysiol.1990.sp017935 · Cited by 275 · see citing works
Mechanisms for blood pressure lowering and metabolic effects of thiazide and thiazide-like diuretics
Duarte, J. D., & Cooper‐DeHoff, R. M. (2010) · Expert Review of Cardiovascular Therapy · doi:10.1586/erc.10.27 · Cited by 237 · see citing works
Regulation of the Na, K-pump in skeletal muscle
Clausen, T., & Everts, M. E. (1989) · Kidney International · doi:10.1038/ki.1989.1 · Cited by 237 · see citing works
Aronson, P. S., & Giebisch, G. (2011) · Journal of the American Society of Nephrology · doi:10.1681/asn.2011040414 · Cited by 235 · see citing works
Blumberg, A., Weidmann, P. U., Shaw, S., & Gnädinger, M. P. (1988) · The American Journal of Medicine · doi:10.1016/s0002-9343(88)80086-x · Cited by 226 · see citing works
Potassium homeostasis, oxidative stress, and human disease
Tchounwou, P., & Udensi, U. (2017) · International Journal of Clinical and Experimental Physiology · doi:10.4103/ijcep.ijcep_43_17 · Cited by 221 · see citing works
“The in and out of cell movement of potassium could be also affected by changes in acid–base balance.[11] This depends on the exchange of hydrogen ions for potassium across the cell membrane.”
BackgroundHyperkalemia in Dialysis Patients
Ahmed, J., & Weisberg, L. S. (2001) · Seminars in Dialysis · doi:10.1046/j.1525-139x.2001.00087.x · Cited by 179 · see citing works
Freestone, J. F., Wolfsheimer, K. J., Kamerling, S. G., CHURCH, G. E., Hamra, J., & Bagwell, C. A. (1991) · Equine Veterinary Journal · doi:10.1111/j.2042-3306.1991.tb02760.x · Cited by 167 · see citing works
Evans, K. J., & Greenberg, A. (2005) · Journal of Intensive Care Medicine · doi:10.1177/0885066605278969 · Cited by 160 · see citing works
Nebulized Albuterol for Acute Hyperkalemia in Patients on Hemodialysis
Allon, M., Dunlay, R., & Copkney, C. (1989) · Annals of Internal Medicine · doi:10.7326/0003-4819-110-6-426 · Cited by 157 · see citing works
Weiner, I. D., & Wingo, C. S. (1998) · Journal of the American Society of Nephrology · doi:10.1681/asn.v981535 · Cited by 153 · see citing works
Recent Advances in Understanding Integrative Control of Potassium Homeostasis
Youn, J. H., & McDonough, A. A. (2008) · Annual Review of Physiology · doi:10.1146/annurev.physiol.010908.163241 · Cited by 152 · see citing works
Treatment of hyperkalemia: something old, something new
Sterns, R. H., Grieff, M., & Bernstein, P. L. (2016) · Kidney International · doi:10.1016/j.kint.2015.11.018 · Cited by 141 · see citing works
“The serum potassium rises with exercise and falls after.(16) Because contractions of forearm muscles release intracellular potassium, fist clenching during phlebotomy raises both serum and plasma potassium by as much as 1 mmol/l.”
BackgroundBlumberg, A., Roser, H. W., Zehnder, C., & Müller‐Brand, J. (1997) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/12.8.1629 · Cited by 133 · see citing works
Rengarajan, S., Lee, D. H., Oh, Y. T., Delpire, E. J., Youn, J. H., & McDonough, A. A. (2014) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00015.2014 · Cited by 132 · see citing works
“ECF [K ] is a determinant of the membrane potential and critical for normal excitability of nerves and muscles (1, 19).”
BackgroundControversies in Management of Hyperkalemia
Long, B., Warix, J. R., & Koyfman, A. (2018) · Journal of Emergency Medicine · doi:10.1016/j.jemermed.2018.04.004 · Cited by 127 · see citing works
Hyperkalemia: An adaptive response in chronic renal insufficiency
Gennari, F. J., & Segal, A. S. (2002) · Kidney International · doi:10.1046/j.1523-1755.2002.00350.x · Cited by 123 · see citing works
Impaired Regulation of Renal K+ Elimination in the sgk1-Knockout Mouse
Huang, D. Y., Wulff, P., Völkl, H., Loffing, J., Richter, K., Kuhl, D., Lang, F. J. W., & Vallon, V. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000120368.59693.a8 · Cited by 124 · see citing works
Hyperkalemia in end-stage renal disease
Allon, M. (1995) · Journal of the American Society of Nephrology · doi:10.1681/asn.v641134 · Cited by 125 · see citing works
Potassium Regulation during Exercise and Recovery
Lindinger, M. I., & Sjøgaard, G. (1991) · Sports Medicine · doi:10.2165/00007256-199111060-00004 · Cited by 114 · see citing works
Perazella, M. A., & Mahnensmith, R. L. (1997) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.1997.07128.x · Cited by 112 · see citing works
Effect of prolonged bicarbonate administration on plasma potassium in terminal renal failure
Blumberg, A., Weidmann, P. U., & Ferrari, P. (1992) · Kidney International · doi:10.1038/ki.1992.51 · Cited by 112 · see citing works
Carter, B. L., Einhorn, P. T., Brands, M. W., He, J., Cutler, J. A., Whelton, P. K., Bakris, G. L., Brancati, F. L., Cushman, W. C., Oparil, S., et al. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.114389 · Cited by 109 · see citing works
Potassium homeostasis and clinical implications
Brown, R. S. (1984) · The American Journal of Medicine · doi:10.1016/s0002-9343(84)80002-9 · Cited by 108 · see citing works
“It appears that the basal level of insulin is essential to normal potassium homeostasis [12], although large potassium loads are capable of stimulating increased insulin secretion to help prevent hyperkalemia [13].”
BackgroundExtracellular Potassium Homeostasis: Insights from Hypokalemic Periodic Paralysis
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Regulation of Potassium Excretion
Malnic, G., Muto, S., & Giebisch, G. (2008) · Elsevier eBooks · doi:10.1016/b978-012088488-9.50050-4 · Cited by 105 · see citing works
Quach, K., Lvtvyn, L., Baigent, C., Bueti, J., Garg, A. X., Hawley, C. M., Haynes, R., Manns, B., Perkovic, V., Rabbat, C. G., et al. (2016) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2016.04.011 · Cited by 101 · see citing works
“Aldosterone may also affect extrarenal potassium excretion (eg, gastrointestinal, salivary, and perspiration), and the degree to which this is important in the absence of kidney function is uncertain.(29) Therefore, MRA-mediated hyperkalemia in dialysis patients may arise from reduced extrarenal excretion.”
BackgroundExtrarenal potassium homeostasis
Brown, R. S. (1986) · Kidney International · doi:10.1038/ki.1986.160 · Cited by 87 · see citing works
Regulation of Renal K Transport by Dietary K Intake
Wang, W. (2004) · Annual Review of Physiology · doi:10.1146/annurev.physiol.66.032102.112025 · Cited by 86 · see citing works
EFFECTS OF ACEPROMAZINE ON CAPTURE STRESS IN ROE DEER (CAPREOLUS CAPREOLUS)
Montané, J., Marco, I., Lopez‐Olvera, J. R., et al. (2003) · Journal of Wildlife Diseases · doi:10.7589/0090-3558-39.2.375 · Cited by 83 · see citing works
“Following the completion of exercise potassium quickly declines, controlled by extrarenal factors including insulin, catecholamines, glucocorticoids, and acidbase balance (Bia and DeFronzo, 1981).”
BackgroundHaas, M., & McManus, T. J. (1985) · The Journal of General Physiology · doi:10.1085/jgp.85.5.649 · Cited by 83 · see citing works
“In this case, however, the effector organs appear to be skeletal muscle and liver (for reviews, see Bia and DeFronzo, 1981 ; Epstein and Rosa, 1983) .”
BackgroundRegulation of muscle potassium: exercise performance, fatigue and health implications
Lindinger, M. I., & Cairns, S. P. (2021) · European Journal of Applied Physiology · doi:10.1007/s00421-020-04546-8 · Cited by 78 · see citing works
Hh, L., Chiang, S.-S., Wu, S.-C., et al. (1994) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(12)80983-8 · Cited by 77 · see citing works
Bundgaard, H., Kjeldsen, K. P., Krabbe, K. S., van Hall, G., Simonsen, L., Qvist, J., Hansen, C. M., Møller, K., Fonsmark, L., Madsen, P. L., et al. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00639.2002 · Cited by 74 · see citing works
“Assuming a total body skeletal muscle weight of 40% of body weight, a skeletal muscle mass in one leg drained by the femoral vein of 10% of body weight (20) and a skeletal muscle K content of 75% of total body K content of 3,500 mmol (3) the accumulated difference in leg K content in each leg 6 h after endotoxin and p…”
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Zehnder, C., Gutzwiller, J., Huber, A., Schindler, C., & Schneditz, D. (2001) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/16.1.78 · Cited by 73 · see citing works
CO2 stunning may compromise swine welfare compared with electrical stunning
Becerril-Herrera, M., Alonso-Spilsbury, M., Flores, C. L., et al. (2008) · Meat Science · doi:10.1016/j.meatsci.2008.07.025 · Cited by 66 · see citing works
“This plays an important role in the development of fatigue due to exercise (Bia & DeFronzo, 1981); high levels of potassium serum have also been related to a stress response (Kock, Clark, Franti, Jessup, & Wehaunsen, 1987; Peinado, FernándezArias, Zabala, & Palomeque, 1993).”
BackgroundPROPRANOLOL, EXERCISE, AND ARTERIAL PLASMA POTASSIUM
Lim, M. J., Linton, R. A. F., Wolff, C. B., et al. (1981) · The Lancet · doi:10.1016/s0140-6736(81)90987-9 · Cited by 66 · see citing works
Gut sensing of potassium intake and its role in potassium homeostasis
Youn, J. H. (2013) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2013.04.005 · Cited by 63 · see citing works
“However, during the first 4–6 h after an acute K+ load, only half of the administered dose appears in the urine, suggesting that extrarenal tissues also play an important role in the disposal of an acute extracellular K+ load (10).”
BackgroundEvidence for gut factor in K + homeostasis
Lee, F. N., Oh, G., McDonough, A. A., & Youn, J. H. (2007) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00427.2006 · Cited by 63 · see citing works
“Since the adaptation of the kidneys to altered K balance is slow (5), the K buffering capacity of extrarenal tissues is critically important in the acute regulation of extracellular K (1, 12).”
BackgroundInfluentialPotassium homeostasis: sensors, mediators, and targets
McDonough, A. A., & Fenton, R. A. (2022) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-022-02718-3 · Cited by 61 · see citing works
“Nonetheless, Bia and DeFronzo’s classic 1981 review, Extrarenal Potassium Homeostasis [7], lays out the importance of the postprandial shift in K from ECF to ICF and highlights that during the first 3–6 h after a K load (whether a meal or intravenous, and across species), only about 1⁄2 of the K is excreted in the uri…”
BackgroundInfluentialChanges in blood constituents of swine transported for 8 or 16h to an Abattoir
Becerril-Herrera, M., Alonso-Spilsbury, M., Ortega, M. E. T., et al. (2010) · Meat Science · doi:10.1016/j.meatsci.2010.07.021 · Cited by 61 · see citing works
EFFECTS OF EXOGENOUS CATECHOLAMINES AND EXERCISE ON PLASMA MAGNESIUM CONCENTRATIONS
JOBORN, H., Åkerström, G., & Ljunghall, S. (1985) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1985.tb00217.x · Cited by 61 · see citing works
Mineral homeostasis in obesity: Effects of euglycemic hyperinsulinemia
Kerstetter, J. E., Caballero, B. H., O'Brien, K. O., Wurtman, R. J., & Allen, L. H. (1991) · Metabolism · doi:10.1016/0026-0495(91)90088-e · Cited by 57 · see citing works
Blunted kaliuresis after an acute potassium load in patients with chronic renal failure
Pérez, G. O., Pelleya, R., Oster, J. R., Kem, D. C., & Vaamonde, C. A. (1983) · Kidney International · doi:10.1038/ki.1983.208 · Cited by 58 · see citing works
Gut sensing of dietary K<sup>+</sup> intake increases renal K<sup>+</sup> excretion
Oh, K.-S., Oh, Y. T., Kim, S.-W., Kita, T., Kang, I., & Youn, J. H. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00095.2011 · Cited by 55 · see citing works
“In addition, extrarenal tissues, mainly skeletal muscle and liver, provide K buffering capacity by shifting K between intracellular and extracellular spaces, which is critically important in the acute regulation of extracellular K after a meal (2, 14, 18).”
BackgroundGosmanov, A. R., Wong, J. A., & Thomason, D. B. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00096.2002 · Cited by 54 · see citing works
“SKELETAL MUSCLE IS WELL RECOGNIZED for its contribution to the regulation of plasma K concentration via insulin-, catecholamine-, and contraction-regulated Na -K ATPase activity (4, 8, 20, 27).”
BackgroundAcute increase in plasma osmolality as a cause of hyperkalemia in patients with renal failure
Conte, G., Canton, A. D., Imperatore, P., Nicola, L. D., Gigliotti, G., Pisanti, N., Memoli, B., Fuíano, G., Esposito, C., & Andreucci, V. E. (1990) · Kidney International · doi:10.1038/ki.1990.200 · Cited by 53 · see citing works
Role of Aldosterone and Dietary Potassium in Potassium Adaptation in the Distal Colon of the Rat
Foster, E. S., Jones, W., Hayslett, J. P., et al. (1985) · Gastroenterology · doi:10.1016/s0016-5085(85)80130-x · Cited by 53 · see citing works
Short-term K+deprivation provokes insulin resistance of cellular K+uptake revealed with the K+clamp
Choi, C. S., Thompson, C. B., Leong, P. K. K., McDonough, A. A., & Youn, J. H. (2001) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.2001.280.1.f95 · Cited by 51 · see citing works
“However, the adaptation is slow; during the first 4–6 h after an acute K(1) load, only about one-half of the K(1) load appears in the urine (5, 10).”
BackgroundPoole-Wilson, P. A. (1984) · Clinics in Endocrinology and Metabolism · doi:10.1016/s0300-595x(84)80021-3 · Cited by 53 · see citing works
Glucocorticoid receptors in the mammalian inner ear: RU 28362 binding sites
Pitovski, D. Z., Drescher, M. J., & Drescher, D. G. (1994) · Hearing Research · doi:10.1016/0378-5955(94)90269-0 · Cited by 52 · see citing works
Stanton, B. A., & Giebisch, G. (1992) · Comprehensive physiology · doi:10.1002/cphy.cp080119 · Cited by 50 · see citing works
Hager, N., McAtee, C. K., Lesko, M. A., & O’Donnell, A. F. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.796136 · Cited by 48 · see citing works
“Specifically, K is essential for normal functioning of nerve and muscle cells due to its contribution to membrane potential (Bia and DeFronzo, 1981; Youn and McDonough, 2009).”
BackgroundAristolochic acid-induced Fanconi's syndrome and nephropathy presenting as hypokalemic paralysis
Yang, S.-S., Chu, P., Lin, Y., Chen, A., & Lin, S. (2002) · American Journal of Kidney Diseases · doi:10.1053/ajkd.2002.31425 · Cited by 45 · see citing works
Adrogué, H. J., Chap, Z., Ishida, T., et al. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111775 · Cited by 47 · see citing works
“Other factors, however, have been identified as modulators of the plasma potassium response (5); prominent among them is the nature of the anion escorting the protons responsible for acidemia (6-9).”
BackgroundPathogenesis and therapy of non-oliguric hyperkalaemia of the premature infant
Mildenberger, E., & VERSMOLD, H. T. (2002) · European Journal of Pediatrics · doi:10.1007/s00431-002-0986-9 · Cited by 47 · see citing works
“of the complex relationship between changes in acidbase balance and serum K [10], it should be a general”
BackgroundInfluentialJOBORN, H., Hjemdahl, P., Larsson, P. T., Lithell, H., Olsson, G., WIDE, L. E., Bergström, R., & Ljunghall, S. (1990) · Clinical Physiology · doi:10.1111/j.1475-097x.1990.tb00082.x · Cited by 44 · see citing works
Beyond Homeostasis: Potassium and Pathogenesis during Bacterial Infections
Do, E. A., & Gries, C. M. (2021) · Infection and Immunity · doi:10.1128/iai.00766-20 · Cited by 47 · see citing works
“potassium ions, resulting in metabolic acidosis or alkalosis (24).”
BackgroundLopez‐Olvera, J. R., Marco, I., Montané, J., et al. (2007) · PubMed · Cited by 45 · see citing works
Adrenergic modulation of potassium metabolism in uremia
Castellino, P., BIA, M. J., & DeFronzo, R. A. (1990) · Kidney International · doi:10.1038/ki.1990.47 · Cited by 45 · see citing works
Self-citationHyponatraemia in acute brain disease
KRÖLL, M., Juhler, M., & Lindholm, J. (1992) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1992.tb00588.x · Cited by 45 · see citing works
Insulin resistance in chronic kidney disease is ameliorated by spironolactone in rats and humans
Hosoya, K., Minakuchi, H., Wakino, S., Fujimura, K., Hasegawa, K., Komatsu, M., Yoshifuji, A., Futatsugi, K., Shinozuka, K., Washida, N., et al. (2014) · Kidney International · doi:10.1038/ki.2014.348 · Cited by 44 · see citing works
Nonselective Beta-Adrenergic Blockade Augments Fasting Hyperkalemia in Hemodialysis Patients
Nowicki, M., & Miszczak-Kuban, J. (2002) · The Nephron journals/Nephron journals · doi:10.1159/000058396 · Cited by 43 · see citing works
Analysis of Long-Term Potassium Regulation*
Young, D. B. (1985) · Endocrine Reviews · doi:10.1210/edrv-6-1-24 · Cited by 42 · see citing works
Enhanced insulin sensitivity in extrarenal potassium handling in uremic rats
Goecke, I. A., Bonilla, S., Marusic, E. T., et al. (1991) · Kidney International · doi:10.1038/ki.1991.5 · Cited by 43 · see citing works
Chen, P. C., Guzman, J. P., Leong, P. K. K., Yang, L. E., Perianayagam, A., Babilonia, E., Ho, J. S., Youn, J. H., Wang, W. H., & McDonough, A. A. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00501.2005 · Cited by 40 · see citing works
“Extrarenal tissues are primarily responsible for acute ECF [K ] regulation (4).”
BackgroundExtrarenal Effects of Aldosterone on Potassium Homeostasis
Palmer, B. F., & Clegg, D. J. (2022) · Kidney360 · doi:10.34067/kid.0006762021 · Cited by 40 · see citing works
“cell such as acid base disorder and changes in tonicity have been reviewed elsewhere and therefore will not be addressed (2,3).”
BackgroundA dual-fluorophore sensor approach for ratiometric fluorescence imaging of potassium in living cells
Wang, Z., Detomasi, T. C., & Chang, C. J. (2020) · Chemical Science · doi:10.1039/d0sc03844j · Cited by 40 · see citing works
Harmer, A. R., Ruell, P. A., McKenna, M. J., et al. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00240.2005 · Cited by 39 · see citing works
“betic subjects, insulin is secreted in response to increments in plasma K (3); conversely, acute reduction of basal insulin secretion, induced by somatostatin, increases [K ] (8).”
BackgroundInsulin for the treatment of hyperkalemia: a double-edged sword?
Li, T., & Vijayan, A. (2014) · Clinical Kidney Journal · doi:10.1093/ckj/sfu049 · Cited by 38 · see citing works
“Tolerance for a rapid potassium load is impaired in ESRD, not only because of lack of renal excretion, but also as a result of impaired cellular distribution of potassium [5].”
BackgroundElectrolyte and salt disturbances in older people: causes, management and implications
Soiza, R. L., Hoyle, G. E., & Chua, M. P. (2008) · Reviews in Clinical Gerontology · doi:10.1017/s0959259809002822 · Cited by 36 · see citing works
McKenna, M. J., Renaud, J., Ørtenblad, N., & Overgaard, K. (2024) · European Journal of Applied Physiology · doi:10.1007/s00421-023-05335-9 · Cited by 38 · see citing works
Obesity is associated with impaired insulin-mediated potassium uptake
DeFronzo, R. A. (1988) · Metabolism · doi:10.1016/s0026-0495(98)90001-4 · Cited by 37 · see citing works
Self-citationSaha, B., Shabbir, W., Takagi, E., Duan, X., Dellova, D. C. A. L., Demko, J. E., Manis, A. D., Loffing‐Cueni, D., Loffing, J., Sørensen, M. V., et al. (2023) · Journal of the American Society of Nephrology · doi:10.1681/asn.0000000000000109 · Cited by 37 · see citing works
Recent insights into the pathogenesis and early management of the crush syndrome.
Better, O. S., Rubinstein, I., & Winaver, J. M. (1992) · PubMed · Cited by 36 · see citing works
The Protein Tyrosine Kinase-Dependent Pathway Mediates the Effect of K Intake on Renal K Secretion
Lin, D., Sterling, H., & Wang, W. (2005) · Physiology · doi:10.1152/physiol.00044.2004 · Cited by 35 · see citing works
Severe Hyperkalemia as a Complication of Timolol, a Topically Applied ß-Adrenergic Antagonist
Swenson, E. R. (1986) · Archives of Internal Medicine · doi:10.1001/archinte.1986.00360180240037 · Cited by 35 · see citing works
Williams, M. E. (1991) · Critical Care Clinics · doi:10.1016/s0749-0704(18)30329-4 · Cited by 35 · see citing works
Bonilla, S., Goecke, I. A., Bozzo, S. R., Alvo, M., Michea, L., & Marusic, E. T. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115544 · Cited by 33 · see citing works
Dietary potassium influences kidney maintenance of serum phosphorus concentration
Sebastián, A., Hernandez, R. E., Portale, A. A., et al. (1990) · Kidney International · doi:10.1038/ki.1990.120 · Cited by 34 · see citing works
Potassium homeostasis during and following exhaustive submaximal static handgrip contractions
Byström, S., & Sjøgaard, G. (1991) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1991.tb09128.x · Cited by 34 · see citing works
Lindinger, M. I., Franklin, T. W., Lands, L. C., Pedersen, P. K., Welsh, D. G., & Heigenhauser, G. J. F. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.276.1.r32 · Cited by 28 · see citing works
“Another possibility is that increases in plasma insulin may have increased Na1-K1-ATPase activity (9) as a result of a plasma [K1]-induced release of pancreatic insulin (6).”
BackgroundInfluentialLanzi, R., Manzoni, M. F., Andreotti, A. C., Malighetti, M. E., Bianchi, E., Sereni, L. P., Caumo, A., Luzi, L., & Pontiroli, A. E. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.7.2239 · Cited by 33 · see citing works
“sium into the cells (41) via an activation of membrane (Na(1)K(1))-adenosine triphosphatase (ATPase) (42, 43), insulin”
BackgroundRenal tubular hyperkalaemia in childhood
Rodr�guez-Soriano, J., & Vallo, A. (1988) · Pediatric Nephrology · doi:10.1007/bf00853448 · Cited by 31 · see citing works
Metabolism and liver transplantation: Review of perioperative issues
Merritt, W. T. (2000) · Liver Transplantation · doi:10.1002/lt.500060515 · Cited by 30 · see citing works
Haemodynamic consequences of changing potassium concentrations in haemodialysis fluids
Gabutti, L., Salvadé, I., Lucchini, B., et al. (2011) · BMC Nephrology · doi:10.1186/1471-2369-12-14 · Cited by 30 · see citing works
View of K+ secretion through the apical K channel of cortical collecting duct
Wang, W. (1995) · Kidney International · doi:10.1038/ki.1995.385 · Cited by 30 · see citing works
Choi, C. S., Lee, F. N., McDonough, A. A., & Youn, J. H. (2002) · Diabetes · doi:10.2337/diabetes.51.4.915 · Cited by 30 · see citing works
“Extracellular K levels are tightly regulated in mammals (1,2).”
BackgroundK+supplementation increases muscle [Na+-K+-ATPase] and improves extrarenal K+homeostasis in rats
Bundgaard, H., Schmidt, T. A., Larsen, J. S., et al. (1997) · Journal of Applied Physiology · doi:10.1152/jappl.1997.82.4.1136 · Cited by 30 · see citing works
Staniszewski, K., Lygre, H., Berge, T. I., & Rosén, A. (2019) · Pain Research and Management · doi:10.1155/2019/1360725 · Cited by 31 · see citing works
“Potassium homeostasis is regulated by renal and extrarenal mechanisms, aected by acid-base balance and hormonal regulation by epinephrine, insulin, and aldosterone [42].”
BackgroundSeeliger, E., Wiegard, M., & Reinhardt, H. W. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00676.2005 · Cited by 29 · see citing works
“It is conceivable that this exchange does not occur (to the same extent) on all cells, but (preferentially) on cells of specific tissues, since intracellular Na and K concentrations differ considerably among tissues (26), and compartmental redistributions of K during primary TBPotassium changes occur preferentially in…”
BackgroundEffects of Aldosterone on Urinary Kallikrein and Sodium Excretion during Fetal Life
Robillard, J., Nakamura, K. T., Lawton, W. J., et al. (1985) · Pediatric Research · doi:10.1203/00006450-198510000-00021 · Cited by 29 · see citing works
Garg, L. C., & Narang, N. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112059 · Cited by 28 · see citing works
A Patient With Hyperkalemia and Metabolic Acidosis
Kurtzman, N. A., Gonzalez, J., DeFronzo, R. A., & Giebisch, G. (1990) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(12)80080-1 · Cited by 27 · see citing works
Self-citationSodium Zirconium Cyclosilicate ( ZS ‐9): A Novel Agent for the Treatment of Hyperkalemia
Linder, K. E., Krawczynski, M. A., & Laskey, D. (2016) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.1797 · Cited by 26 · see citing works
“14 In individuals with normal kidney function, 95% of daily potassium load is eliminated in the urine, and the remaining 5% is excreted in the gut.(3) Under normal conditions, renal potassium handling depends on glomerular filtration rate and potassium secretion, both of which rely on the effects *Address for correspo…”
BackgroundPotassium Homeostasis and Hyperkalemic Syndromes
Clark, B. A., & Brown, R. S. (1995) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(18)30032-x · Cited by 26 · see citing works
Early physiologic responses to hemorrhagic hypotension
Filho, I. P. T., Torres, L. N., & Pittman, R. N. (2009) · Translational research · doi:10.1016/j.trsl.2009.09.001 · Cited by 24 · see citing works
- Authors
- Bia, M. J., & DeFronzo, R. A.
- Venue
- American Journal of Physiology-Renal Physiology
- Publisher
- American Physiological Society
- Published
- 1981-04-01
- Volume
- 240
- Issue
- 4
- Pages
- F257-F268
- ISSN
- 1522-1466 (ISSN-L)
- 1931-857X
- OpenAlex
- W2216918211
- Cited by
- 249
- References
- 0
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 6 · 2023: 3 · 2022: 6 · 2021: 5 · 2020: 6 · 2019: 1 · 2018: 4 · 2017: 7 · 2016: 7 · 2015: 2 · 2014: 4 · 2013: 6 · 2012: 5
- FWCI
- 7.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Renal Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Potassium and Related Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Keywords
- hyperkalemia, aldosterone, insulin, epinephrine, glucocorticoids, acid-base balance, chronic renal insufficiency, uremia
- MeSH terms
- Aldosterone, Animals, Dogs, Epinephrine, Glomerular Filtration Rate, Glucagon, Homeostasis, Humans, Hydrocortisone, Insulin, Kidney, Kidney Failure, Chronic, Male, Norepinephrine, Potassium, Prednisone, Somatostatin, Rats
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