Cited by 102Regulation of Appetite and ObesityNeuroendocrine regulation and behaviorNeuropeptides and Animal Physiology

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Oxytocin in the ventromedial hypothalamic nucleus reduces feeding and acutely increases energy expenditure

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Noble, Emily E., Billington, Charles J., Kotz, Catherine M., Wang, ChuanFeng·2014·American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

DOI 10.1152/ajpregu.00118.2014PMC PMC4166752

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Abstract

Central oxytocin reduces food intake and increases energy expenditure. The ventromedial hypothalamic nucleus (VMN) is associated with energy balance and contains a high density of oxytocin receptors. We hypothesized that oxytocin in the VMN is a negative regulator of energy balance acting to reduce feeding and increase energy expenditure. To test this idea, oxytocin or vehicle was injected directly into the VMN of Sprague-Dawley rats during fasted and nonfasted conditions. Energy expenditure (via indirect calorimetry) and spontaneous physical activity (SPA) were recorded simultaneously. Animals were also exposed to a conditioned taste aversion test, to determine whether oxytocin's effects on food intake were associated with malaise. When food was available during testing, oxytocin-induced elevations in energy expenditure lasted for 1 h, after which overall energy expenditure was reduced. In the absence of food during the testing period, oxytocin similarly increased energy expenditure during the first hour, but differences in 12-h energy expenditure were eliminated, implying that the differences may have been due to the thermic effects of feeding (digestion, absorption, and metabolic processing). Oxytocin acutely elevated SPA and reduced feeding at doses that did not cause a conditioned taste aversion during both the fed and fasted states. Together, these data suggest that oxytocin in the VMN promotes satiety and acutely elevates energy expenditure and SPA and implicates the VMN as a relevant site for the antiobesity effects of oxytocin.

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Additional file 1 of Angiostrongylus cantonensis induces energy imbalance and dyskinesia in mice by reducing the expression of melanin-concentrating hormone
Huang, H., Zhang, Z., Xing, M., Jin, Z., Hu, Y., Zhou, M., Wei, H., Liang, Y., & Lv, Z. (2024) · Figshare · doi:10.6084/m9.figshare.25678622
Additional file 4 of Angiostrongylus cantonensis induces energy imbalance and dyskinesia in mice by reducing the expression of melanin-concentrating hormone
Huang, H., Zhang, Z., Xing, M., Jin, Z., Hu, Y., Zhou, M., Wei, H., Liang, Y., & Lv, Z. (2024) · Figshare · doi:10.6084/m9.figshare.26710337
Additional file 2 of Angiostrongylus cantonensis induces energy imbalance and dyskinesia in mice by reducing the expression of melanin-concentrating hormone
Huang, H., Zhang, Z., Xing, M., Jin, Z., Hu, Y., Zhou, M., Wei, H., Liang, Y., & Lv, Z. (2024) · Figshare · doi:10.6084/m9.figshare.25678673
Additional file 3 of Angiostrongylus cantonensis induces energy imbalance and dyskinesia in mice by reducing the expression of melanin-concentrating hormone
Huang, H., Zhang, Z., Xing, M., Jin, Z., Hu, Y., Zhou, M., Wei, H., Liang, Y., & Lv, Z. (2024) · Figshare · doi:10.6084/m9.figshare.26710334
Additional file 5 of Angiostrongylus cantonensis induces energy imbalance and dyskinesia in mice by reducing the expression of melanin-concentrating hormone
Huang, H., Zhang, Z., Xing, M., Jin, Z., Hu, Y., Zhou, M., Wei, H., Liang, Y., & Lv, Z. (2024) · Figshare · doi:10.6084/m9.figshare.26710340
Bridging appetite and emotional dynamics: the oxytocinergic system as a therapeutic axis in feeding and eating disorders.
Eramo, B., Sepe, C., Friuli, M., Campagna, A., Romano, A., & Gaetani, S. (2026) · Pharmacological Research · doi:10.1016/j.phrs.2026.108279
Role of Oxytocin in Obesity
Williams, A. L., & Blevins, J. E. (2026) · Current Diabetes Reports · doi:10.1007/s11892-026-01640-7

Authors: Noble, E. E., Billington, C. J., Kotz, C. M., & Wang, C.
Affiliations: University of Minnesota (US)
Corresponding author: Wang, ChuanFeng
ORCID: Noble, Emily E.
Billington, Charles J.
Kotz, Catherine M.
Venue: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Publisher: American Physiological Society
Published: 2014-09-15
Volume: 307
Issue: 6
Pages: R737-R745
ISSN: 0363-6119 (ISSN-L)
1522-1490
DOI: 10.1152/ajpregu.00118.2014
PMC: PMC4166752
OpenAlex: W1972127276
Cited by: 102
References: 67
Citations by year: 2026: 8 · 2025: 8 · 2024: 12 · 2023: 8 · 2022: 4 · 2021: 13 · 2020: 6 · 2019: 7 · 2018: 8 · 2017: 11 · 2016: 6 · 2015: 8 · 2014: 3
FWCI: 4.55
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (T32DK083250)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: oxytocin, ventromedial hypothalamus, energy expenditure, dietary intake, energy balance, spontaneous physical activity, conditioned taste aversion, satiety, thermic effect of feeding, anti-obesity, fasting
MeSH terms: Animals, Dose-Response Relationship, Drug, Eating, Energy Metabolism, Fasting, Feeding Behavior, Injections, Intraventricular, Male, Motor Activity, Oxytocin, Satiety Response, Time Factors, Ventromedial Hypothalamic Nucleus, Rats, Sprague-Dawley, Anti-Obesity Agents, Rats

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Oxytocin in the ventromedial hypothalamic nucleus reduces feeding and acutely increases energy expenditure

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