An obligate role of oxytocin neurons in diet induced energy expenditure
Open accessAbstract
Oxytocin neurons represent one of the major subsets of neurons in the paraventricular hypothalamus (PVH), a critical brain region for energy homeostasis. Despite substantial evidence supporting a role of oxytocin in body weight regulation, it remains controversial whether oxytocin neurons directly regulate body weight homeostasis, feeding or energy expenditure. Pharmacologic doses of oxytocin suppress feeding through a proposed melanocortin responsive projection from the PVH to the hindbrain. In contrast, deficiency in oxytocin or its receptor leads to reduced energy expenditure without feeding abnormalities. To test the physiological function of oxytocin neurons, we specifically ablated oxytocin neurons in adult mice. Our results show that oxytocin neuron ablation in adult animals has no effect on body weight, food intake or energy expenditure on a regular diet. Interestingly, male mice lacking oxytocin neurons are more sensitive to high fat diet-induced obesity due solely to reduced energy expenditure. In addition, despite a normal food intake, these mice exhibit a blunted food intake response to leptin administration. Thus, our study suggests that oxytocin neurons are required to resist the obesity associated with a high fat diet; but their role in feeding is permissive and can be compensated for by redundant pathways.
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In rodent studies, oxytocin acts as a strong inhibitor of food intake.
“evidence from rodent studies indicates that the neuropeptide acts as a strong inhibitor of food intake and affects energy expenditure and glucose homeostasis (6–9).”
From Oxytocin Reduces Reward-Driven Food Intake in Humans (2013) · cites this paper as [9]
In rodent studies, oxytocin affects energy expenditure.
“evidence from rodent studies indicates that the neuropeptide acts as a strong inhibitor of food intake and affects energy expenditure and glucose homeostasis (6–9).”
From Oxytocin Reduces Reward-Driven Food Intake in Humans (2013) · cites this paper as [9]
In rodent studies, oxytocin affects glucose homeostasis.
“evidence from rodent studies indicates that the neuropeptide acts as a strong inhibitor of food intake and affects energy expenditure and glucose homeostasis (6–9).”
From Oxytocin Reduces Reward-Driven Food Intake in Humans (2013) · cites this paper as [9]
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Self-citation
- Authors
- Wu, Z., Xu, Y., Zhu, Y., Sutton, A. K., Zhao, R., Lowell, B. B., Olson, D. P., & Tong, Q.
- Affiliations
- Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases (US)
- University of Michigan (US)
- Beth Israel Deaconess Medical Center (US)
- The University of Texas Health Science Center at Houston (US)
- Corresponding author
- Olson, David P.
- Tong, Qingchun
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-09-18
- Volume
- 7
- Issue
- 9
- Pages
- e45167
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3445456
- OpenAlex
- W2153274139
- Cited by
- 181
- References
- 41
- Citations by year
- 2026: 9 · 2025: 18 · 2024: 14 · 2023: 10 · 2022: 14 · 2021: 17 · 2020: 9 · 2019: 11 · 2018: 13 · 2017: 17 · 2016: 14 · 2015: 13 · 2014: 12 · 2013: 10
- FWCI
- 4.99
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- American Heart Association
- Boston Area Diabetes Endocrinology Research Center (DK057521, DK046200)
- Boston Nutrition Obesity Research Center, Boston University (DK046200)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK057521, R01DK075632, P30DK046200, K08DK071561, DK046200, DK-057521, R01DK092605)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- oxytocin neurons, paraventricular hypothalamus, energy expenditure, diet-induced obesity, high-fat diet, neuronal ablation, dietary intake, body weight homeostasis, energy homeostasis, melanocortin pathway
- MeSH terms
- Animals, Body Weight, Energy Intake, Dietary Fats, Eating, Energy Metabolism, Homeostasis, Injections, Intraperitoneal, Male, Mice, Transgenic, Neurons, Obesity, Oxytocin, Paraventricular Hypothalamic Nucleus, Leptin, Mice, Diet, High-Fat
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