Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brain stem nuclei controlling meal size
Abstract
Hindbrain projections of oxytocin neurons in the parvocellular paraventricular nucleus (pPVN) are hypothesized to transmit leptin signaling from the hypothalamus to the nucleus of the solitary tract (NTS), where satiety signals from the gastrointestinal tract are received. Using immunocytochemistry, we found that an anorectic dose of leptin administered into the third ventricle (3V) increased twofold the number of pPVN oxytocin neurons that expressed Fos. Injections of fluorescent cholera toxin B into the NTS labeled a subset of pPVN oxytocin neurons that expressed Fos in response to 3V leptin. Moreover, 3V administration of an oxytocin receptor antagonist, [d-(CH2)5,Tyr(Me)2,Orn8]-vasotocin (OVT), attenuated the effect of leptin on food intake over a 0.5- to 4-h period (P < 0.05). Furthermore, to determine whether oxytocin contributes to leptin's potentiation of Fos activation within NTS neurons in response to CCK, we counted the number of Fos-positive neurons in the medial NTS (mNTS) after 3V administration of OVT before 3V leptin and intraperitoneal CCK-8 administration. OVT resulted in a significant 37% decrease (P < 0.05) in the potentiating effect of leptin on CCK activation of mNTS neuronal Fos expression. Furthermore, 4V OVT stimulated 2-h food intake by 43% (P < 0.01), whereas 3V OVT at the same dose was ineffective. These findings suggest that release of oxytocin from a descending pPVN-to-NTS pathway contributes to leptin's attenuation of food intake by a mechanism that involves the activation of pPVN oxytocin neurons by leptin, resulting in increased sensitivity of NTS neurons to satiety signals.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Several food motivation pathways, including those involving leptin, alpha-MSH and AgRP, converge on oxytocin neurons.
“Several food motivation pathways, including those involving leptin, alpha-MSH and AgRP, converge on oxytocin neurons(20, 21, 22).”
From Oxytocin reduces caloric intake in men (2015) · cites this paper as [21]
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
Central nervous system control of food intake
Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451 · see citing works
Self-citationRole of leptin in the neuroendocrine response to fasting
Ahima, R. S., Prabakaran, D., Mantzoros, C., Qu, D., Lowell, B., Maratos-Flier, E., & Flier, J. S. (1996) · Nature · doi:10.1038/382250a0 · Cited by 3,117 · see citing works
Identification of targets of leptin action in rat hypothalamus.
Schwartz, M. W., Seeley, R. J., Campfield, L. A., Burn, P., & Baskin, D. G. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118891 · Cited by 1,475 · see citing works
Self-citationSawchenko, P. E., & Swanson, L. W. (1982) · Journal of Comparative Neurology · doi:10.1002/cne.902050306 · Cited by 1,150 · see citing works
Abdominal Vagotomy Blocks the Satiety Effect of Cholecystokinin in the Rat
Smith, G. P., Jerome, C., Cushin, B. J., Eterno, R., & Simansky, K. J. (1981) · Science · doi:10.1126/science.7268408 · Cited by 804 · see citing works
Leptin Activates Neurons in Ventrobasal Hypothalamus and Brainstem
Elmquist, J. K., Ahima, R. S., Maratos–Flier, E., Flier, J. S., & Saper, C. B. (1997) · Endocrinology · doi:10.1210/endo.138.2.5033 · Cited by 438 · see citing works
Vasopressin and oxytocin receptors in the central nervous system
Tribollet, E., & Barberis, C. (1996) · Critical Reviews™ in Neurobiology · doi:10.1615/critrevneurobiol.v10.i1.60 · Cited by 399 · see citing works
Evidence That the Caudal Brainstem Is a Target for the Inhibitory Effect of Leptin on Food Intake
Grill, H. J., Schwartz, M. W., Kaplan, J. M., Foxhall, J. S., Breininger, J., & Baskin, D. G. (2002) · Endocrinology · doi:10.1210/endo.143.1.8589 · Cited by 395 · cited 1× · see citing works
“Recent reports demonstrate that leptin may act directly within the dorsal vagal complex to reduce food intake (17, 19).”
Self-citationHypothalamic paraventricular nucleus lesions produce overeating and obesity in the rat
LEIBOWITZ, S. F., Hammer, N. J., & Chang, K. (1981) · Physiology & Behavior · doi:10.1016/0031-9384(81)90366-8 · Cited by 384 · see citing works
Afferent axons in abdominal vagus mediate satiety effect of cholecystokinin in rats
Smith, G. P., Jerome, C., & Norgren, R. (1985) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1985.249.5.r638 · Cited by 373 · see citing works
Harris, M., Aschkenasi, C., Elias, C. F., Chandrankunnel, A., Nillni, E. A., Bjørbæk, C., Elmquist, J. K., Flier, J. S., & Hollenberg, A. N. (2001) · Journal of Clinical Investigation · doi:10.1172/jci10741 · Cited by 341 · see citing works
Food Intake and the Regulation of Body Weight
Woods, S. C., Schwartz, M. W., Baskin, D. G., & Seeley, R. J. (2000) · Annual Review of Psychology · doi:10.1146/annurev.psych.51.1.255 · Cited by 332 · see citing works
Self-citationInfluence of oxytocin on feeding behavior in the rat
Arletti, R., Benelli, A., & Bertolini, A. (1989) · Peptides · doi:10.1016/0196-9781(89)90082-x · Cited by 328 · see citing works
Vaccari, C., Lolait, S. J., & Ostrowski, N. L. (1998) · Endocrinology · doi:10.1210/endo.139.12.6382 · Cited by 308 · see citing works
Oxytocin and an oxytocin agonist administered centrally decrease food intake in rats
Olson, B. R., Drutarosky, M. D., Chow, M.-S., Hruby, V. J., Stricker, E. M., & Verbalis, J. G. (1991) · Peptides · doi:10.1016/0196-9781(91)90176-p · Cited by 283 · see citing works
Intraventricular Leptin Reduces Food Intake and Body Weight of Lean Rats but Not Obese Zucker Rats
Seeley, R. J., van Dijk, G., Campfield, L. A., Smith, F., Burn, P., Nelligan, J., Bell, S. M., Baskin, D. S., Woods, S. C., & Schwartz, M. W. (1996) · Hormone and Metabolic Research · doi:10.1055/s-2007-979874 · Cited by 253 · see citing works
Self-citationOxytocin inhibits food and fluid intake in rats
Arletti, R., Benelli, A., & Bertolini, A. (1990) · Physiology & Behavior · doi:10.1016/0031-9384(90)90234-u · Cited by 246 · see citing works
Central leptin modulates behavioral and neural responsivity to CCK
Emond, M. H., Schwartz, G. J., Ladenheim, E. E., & Moran, T. H. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.276.5.r1545 · Cited by 225 · see citing works
Brain Stem Is a Direct Target for Leptin’s Action in the Central Nervous System
Hosoi, T., Kawagishi, T., Okuma, Y., Tanaka, J., & Nomura, Y. (2002) · Endocrinology · doi:10.1210/en.2002-220077 · Cited by 205 · see citing works
Capsaicin pretreatment attenuates suppression of food intake by cholecystokinin
Ritter, R. C., & Ladenheim, E. E. (1985) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1985.248.4.r501 · Cited by 186 · see citing works
Sawchenko, P. E. (1987) · Brain Research · doi:10.1016/0006-8993(87)91641-6 · Cited by 184 · see citing works
Hypothalamic corticotropin-releasing hormone is a mediator of the anorexigenic effect of leptin.
Uehara, Y., Shimizu, H., Ohtani, K., Sato, N., & Mori, M. (1998) · Diabetes · doi:10.2337/diabetes.47.6.890 · Cited by 183 · see citing works
OLSON, B. R., DRUTAROSKY, M. D., STRICKER, E. M., & VERBALIS, J. G. (1991) · Endocrinology · doi:10.1210/endo-129-2-785 · Cited by 180 · see citing works
Thiele, T. E., van Dijk, G., Yagaloff, K. A., Fisher, S. L., Schwartz, M. W., Burn, P., & Seeley, R. J. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.274.1.r248 · Cited by 176 · see citing works
Self-citationOxytocin innervation of caudal brainstem nuclei activated by cholecystokinin
Blevins, J. E., Eakin, T. J., Murphy, J. A., Schwartz, M. W., & Baskin, D. G. (2003) · Brain Research · doi:10.1016/j.brainres.2003.08.036 · Cited by 164 · see citing works
Self-citationTraub, R. J., Sengupta, J. N., & Gebhart, G. F. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00173-x · Cited by 163 · see citing works
Localization of oxytocin receptor messenger ribonucleic acid in the rat brain.
Yoshimura, R., Kiyama, H., Kimura, T., Araki, T., Maeno, H., Tanizawa, O., & Tohyama, M. (1993) · Endocrinology · doi:10.1210/endo.133.3.8396014 · Cited by 161 · see citing works
Hou-Yu, A., Lamme, A., Zimmerman, E. A., & Silverman, A. (2008) · Neuroendocrinology · doi:10.1159/000124651 · Cited by 160 · see citing works
Eckel, L. A., Langhans, W., Kahler, A., Campfield, L. A., Smith, F. J., & Geary, N. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.275.1.r186 · Cited by 159 · see citing works
Chemoarchitectonic Atlas of the Rat Brainstem
Paxinos, G. (1999) · Cited by 158 · see citing works
Olson, B. R., Freilino, M. L., Hoffman, G. E., Stricker, E. M., Sved, A. F., & Verbalis, J. G. (1993) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1993.1011 · Cited by 155 · see citing works
Multiple brain sites sensitive to feeding stimulation by opioid agonists: A cannula-mapping study
Stanley, B. G., Lanthier, D., & LEIBOWITZ, S. F. (1988) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(88)90391-7 · Cited by 136 · see citing works
Loup, F., Tribollet, E., Dubois-Dauphin, M., Pizzolato, G., & Dreifuss, J. J. (1989) · Brain Research · doi:10.1016/0006-8993(89)90317-x · Cited by 136 · see citing works
Leptin Deficiency Induced by Fasting Impairs the Satiety Response to Cholecystokinin
McMinn, J. E., Sindelar, D. K., Havel, P. J., & Schwartz, M. W. (2000) · Endocrinology · doi:10.1210/endo.141.12.7815 · Cited by 129 · see citing works
Self-citationMode of action of OB protein (leptin) on feeding
Flynn, M. C., Scott, T. R., Pritchard, T. C., & Plata‐Saláman, C. R. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.275.1.r174 · Cited by 119 · see citing works
Obese mice and the satiety effects of cholecystokinin, bombesin and pancreatic polypeptide
McLaughlin, C. L., & Baile, C. A. (1981) · Physiology & Behavior · doi:10.1016/0031-9384(81)90171-2 · Cited by 114 · see citing works
Aja, S. M., Sahandy, S., Ladenheim, E. E., Schwartz, G. J., & Moran, T. H. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.281.6.r1862 · Cited by 107 · see citing works
Crawley, J. N., & Kiss, J. Z. (1985) · Peptides · doi:10.1016/0196-9781(85)90324-9 · Cited by 104 · see citing works
Kahler, A., Geary, N., Eckel, L. A., Campfield, L. A., Smith, F. J., & Langhans, W. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.275.1.r180 · Cited by 82 · see citing works
Dunn-Meynell, A. A., Govek, E. K., & Levin, B. E. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01280-2 · Cited by 81 · see citing works
Emond, M. H., Ladenheim, E. E., Schwartz, G. J., & Moran, T. H. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(00)00393-0 · Cited by 81 · see citing works
CNS effects of circulating CCK8: involvement of brainstem neurones responding to gastric distension
Raybould, H. E., Gayton, R. J., & Dockray, G. J. (1985) · Brain Research · doi:10.1016/0006-8993(85)91373-3 · Cited by 78 · see citing works
Abdominal vagal mediation of the satiety effects of exogenous and endogenous cholecystokinin in rats
Reidelberger, R. D. (1992) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1992.263.6.r1354 · Cited by 73 · see citing works
Lokrantz, C.-M., Uvnäs‐Moberg, K., & Kaplan, J. M. (1997) · Physiology & Behavior · doi:10.1016/s0031-9384(97)00021-8 · Cited by 57 · see citing works
How the brain regulates food intake and body weight: the role of leptin.
Baskin, D. G., Blevins, J. E., & Schwartz, M. W. (2001) · PubMed · Cited by 56 · see citing works
Self-citationThe Brain Oxytocin Receptor(s?)
Verbalis, J. G. (1999) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1999.0178 · Cited by 45 · see citing works
Cholecystokinin and D-fenfluramine inhibit food intake in oxytocin-deficient mice
Mantella, R. C., Rinaman, L., Vollmer, R. R., & Amico, J. A. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00383.2002 · Cited by 44 · see citing works
Nucleus tractus solitarius lesions block the behavioral actions of cholecystokinin
Crawley, J. N., & Schwaber, J. S. (1983) · Peptides · doi:10.1016/0196-9781(83)90030-x · Cited by 38 · see citing works
Blevins, J. E., Dixon, K. D., Hernandez, E. J., Barrett, J. A., & Gietzen, D. W. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02734-7 · Cited by 18 · see citing works
Self-citationDantzler, W. H. (1992) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1992.263.1.r1 · Cited by 1 · see citing works
Rinaman (1998) · doi:10.1002/(sici)1096-9861(19980914)399:1
Flagged first, then by citations
1 of the 53 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Central nervous system control of food intake and body weight
Morton, G. J., Cummings, D. E., Baskin, D. G., Barsh, G. S., & Schwartz, M. W. (2006) · Nature · doi:10.1038/nature05026 · Cited by 2,503 · see citing works
Self-citationDivergence of Melanocortin Pathways in the Control of Food Intake and Energy Expenditure
Balthasar, N., Dalgaard, L. T., Lee, C. E., Yu, J. H., Funahashi, H., Williams, T. B., Ferreira, M. A. R., Tang, V., McGovern, R. A., Kenny, C. D., et al. (2005) · Cell · doi:10.1016/j.cell.2005.08.035 · Cited by 1,122 · see citing works
Neurobiology of food intake in health and disease
Morton, G. J., Meek, T. H., & Schwartz, M. W. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3745 · Cited by 748 · see citing works
Self-citationHindbrain Neurons as an Essential Hub in the Neuroanatomically Distributed Control of Energy Balance
Grill, H. J., & Hayes, M. R. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.06.015 · Cited by 483 · see citing works
Neuronal Regulation of Energy Homeostasis: Beyond the Hypothalamus and Feeding
Waterson, M. J., & Horváth, T. L. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.09.026 · Cited by 439 · see citing works
The expectant brain: adapting for motherhood
Brunton, P. J., & Russell, J. A. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2280 · Cited by 407 · see citing works
Leptin and the Central Nervous System Control of Glucose Metabolism
Morton, G. J., & Schwartz, M. W. (2011) · Physiological Reviews · doi:10.1152/physrev.00007.2010 · Cited by 338 · see citing works
“Beyond the hypothalamus, functional leptin receptors are expressed in the hippocampus, hindbrain [including the nucleus of the solitary tract (NTS)], pyriform cortex and other olfactory processing areas, and in mesolimbic areas involved in reward including the ventral tegmental area (VTA) and substantia nigra (SN) (61…”
BackgroundInfluentialSelf-citationInsulin Signaling in the Central Nervous System
Porte, D., Baskin, D. G., & Schwartz, M. W. (2005) · Diabetes · doi:10.2337/diabetes.54.5.1264 · Cited by 334 · see citing works
Self-citationHypothalamic nutrient sensing in the control of energy homeostasis
Blouet, C., & Schwartz, G. J. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.12.024 · Cited by 321 · see citing works
Maejima, Y., Sedbazar, U., Suyama, S., Kohno, D., Onaka, T., Takano, E., Yoshida, N., Koike, M., Uchiyama, Y., Fujiwara, K., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.09.002 · Cited by 317 · see citing works
Malcher‐Lopes, R., Di, S., Marcheselli, V., Weng, F., Stuart, C. T., Bazan, N. G., & Tasker, J. G. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5126-05.2006 · Cited by 268 · see citing works
Oxytocin is an anabolic bone hormone
Tamma, R., Colaianni, G., Zhu, L.-L., DiBenedetto, A., Greco, G., Montemurro, G., Patano, N., Strippoli, M., Vergari, R., Mancini, L., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901890106 · Cited by 267 · see citing works
Stengel, A., Goebel, M., Wang, L., Rivier, J., Kobelt, P., Mönnikes, H., Lambrecht, N. W. G., & Taché, Y. (2009) · Endocrinology · doi:10.1210/en.2009-0578 · Cited by 262 · see citing works
Kohno, D., Nakata, M., Maejima, Y., Shimizu, H., Sedbazar, U., Yoshida, N., Dezaki, K., Onaka, T., Mori, M., & Yada, T. (2007) · Endocrinology · doi:10.1210/en.2007-1276 · Cited by 258 · see citing works
Leptin action in the forebrain regulates the hindbrain response to satiety signals
Morton, G. J., Blevins, J. E., Williams, D. L., Niswender, K. D., Gelling, R. W., Rhodes, C. J., Baskin, D. G., & Schwartz, M. W. (2005) · Journal of Clinical Investigation · doi:10.1172/jci22081 · Cited by 253 · see citing works
Self-citationHayes, M. R., Skibicka, K. P., Leichner, T. M., Guarnieri, D. J., Dileone, R., Bence, K. K., & Grill, H. J. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2009.10.009 · Cited by 245 · see citing works
Shah, B. P., Vong, L., Olson, D. P., Koda, S., Krashes, M. J., Ye, C., Yang, Z., Fuller, P. M., Elmquist, J. K., & Lowell, B. B. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1407843111 · Cited by 240 · see citing works
Blouet, C., Jo, Y., Li, X., & Schwartz, G. J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1668-09.2009 · Cited by 240 · see citing works
Oxytocin Deficiency Mediates Hyperphagic Obesity of Sim1 Haploinsufficient Mice
Kublaoui, B. M., Gemelli, T., Tolson, K. P., Wang, Y., & Zinn, A. R. (2008) · Molecular Endocrinology · doi:10.1210/me.2008-0067 · Cited by 239 · see citing works
Low sympathetic tone and obese phenotype in oxytocin-deficient mice
Camerino, C. (2009) · Obesity · doi:10.1038/oby.2009.12 · Cited by 235 · see citing works
Hypothalamic neuropeptides and the regulation of appetite
Parker, J., & Bloom, S. R. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.02.004 · Cited by 233 · see citing works
Oxytocin Reduces Reward-Driven Food Intake in Humans
Ott, V., Finlayson, G., Lehnert, H., Heitmann, B., Heinrichs, M., Born, J., & Hallschmid, M. (2013) · Diabetes · doi:10.2337/db13-0663 · Cited by 226 · see citing works
Peripheral oxytocin suppresses food intake and causes weight loss in diet-induced obese rats
Morton, G. J., Thatcher, B. S., Reidelberger, R. D., Ogimoto, K., Wolden-Hanson, T., Baskin, D. G., Schwartz, M. W., & Blevins, J. E. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00296.2011 · Cited by 213 · see citing works
Self-citationOxytocin reduces caloric intake in men
Lawson, E. A., Marengi, D. A., DeSanti, R. L., Holmes, T. M., Schoenfeld, D. A., & Tolley, C. J. (2015) · Obesity · doi:10.1002/oby.21069 · Cited by 208 · see citing works
Blevins, J. E., Graham, J. L., Morton, G. J., Bales, K. L., Schwartz, M. W., Baskin, D. G., & Havel, P. J. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00441.2014 · Cited by 187 · see citing works
Self-citationFunctional identification of a neurocircuit regulating blood glucose
Meek, T. H., Nelson, J. T., Matsen, M. E., Dorfman, M. D., Guyenet, S. J., Damian, V. M., Allison, M. B., Scarlett, J. M., Hồng, N. T., Thaler, J. P., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1521160113 · Cited by 178 · see citing works
Self-citationAn obligate role of oxytocin neurons in diet induced energy expenditure
Wu, Z., Xu, Y., Zhu, Y., Sutton, A. K., Zhao, R., Lowell, B. B., Olson, D. P., & Tong, Q. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045167 · Cited by 181 · see citing works
Leptin Regulation of the Anorexic Response to Glucagon-Like Peptide-1 Receptor Stimulation
Williams, D. L., Baskin, D. G., & Schwartz, M. W. (2006) · Diabetes · doi:10.2337/db06-0558 · Cited by 178 · see citing works
Self-citationYosten, G. L. C., & Samson, W. K. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00804.2009 · Cited by 177 · see citing works
Brain regulation of energy balance and body weight
Rui, L. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9261-9 · Cited by 168 · see citing works
The physiological control of eating: signals, neurons, and networks
Watts, A. G., Kanoski, S. E., Sanchez-Watts, G., & Langhans, W. (2022) · Physiological Reviews · doi:10.1152/physrev.00028.2020 · Cited by 168 · see citing works
German, J., Kim, F., Schwartz, G. J., Havel, P. J., Rhodes, C. J., Schwartz, M. W., & Morton, G. J. (2009) · Endocrinology · doi:10.1210/en.2009-0445 · Cited by 164 · see citing works
Self-citationThe Paraventricular Nucleus of the Hypothalamus: Development, Function, and Human Diseases
Qin, C., Li, J., & Tang, K. (2018) · Endocrinology · doi:10.1210/en.2018-00453 · Cited by 164 · see citing works
Hormone Interactions Regulating Energy Balance During Pregnancy
Ladyman, S. R., Augustine, R. A., & Grattan, D. R. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02017.x · Cited by 161 · see citing works
Tupone, D., Madden, C. J., & Morrison, S. F. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1980-13.2013 · Cited by 156 · see citing works
Veening, J. G., & Barendregt, H. P. (2010) · Cerebrospinal Fluid Research · doi:10.1186/1743-8454-7-1 · Cited by 161 · see citing works
The role of oxytocin in male and female reproductive behavior
Veening, J. G., A, T. R. D. J., Waldinger, M. D., Korte, S. M., & Olivier, B. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.07.045 · Cited by 156 · see citing works
NTS Catecholamine Neurons Mediate Hypoglycemic Hunger via Medial Hypothalamic Feeding Pathways
Aklan, İ., Sayar, N., Yavuz, Y., Ateş, T., Çoban, İ., Alkan, F. K., Filiz, G., Topcu, I. C., Öncül, M., Dilsiz, P., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.11.016 · Cited by 152 · see citing works
Control of Food Intake and Energy Expenditure by Nos1 Neurons of the Paraventricular Hypothalamus
Sutton, A. K., Pei, H., Burnett, K. H., Myers, M. G., Rhodes, C. J., & Olson, D. P. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0226-14.2014 · Cited by 153 · see citing works
Welch, M. G., Margolis, K. G., Li, Z., & Gershon, M. D. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00176.2014 · Cited by 152 · see citing works
Hypothalamic control of energy metabolism via the autonomic nervous system
Kalsbeek, A., Bruinstroop, E., Yi, C., Klieverik, L. P., la Fleur, S. E., & Fliers, E. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05800.x · Cited by 148 · see citing works
Brainstem Nutrient Sensing in the Nucleus of the Solitary Tract Inhibits Feeding
Blouet, C., & Schwartz, G. J. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.10.003 · Cited by 145 · see citing works
Central Nervous System Regulation of Food Intake
Schwartz, M. W. (2006) · Obesity · doi:10.1038/oby.2006.275 · Cited by 146 · see citing works
Self-citationHuo, L., Maeng, L. Y., Bjørbæk, C., & Grill, H. J. (2007) · Endocrinology · doi:10.1210/en.2006-1572 · Cited by 142 · see citing works
Serotonin and energy balance: molecular mechanisms and implications for type 2 diabetes
Lam, D. D., & Heisler, L. K. (2007) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399407000245 · Cited by 142 · see citing works
Sutton, G. M., Duos, B., Patterson, L. M., & Berthoud, H. (2005) · Endocrinology · doi:10.1210/en.2005-0562 · Cited by 140 · see citing works
McCormack, S. E., Blevins, J. E., & Lawson, E. A. (2019) · Endocrine Reviews · doi:10.1210/endrev/bnz012 · Cited by 140 · see citing works
Self-citationDiversity of oxytocin neurones: Beyond magno‐ and parvocellular cell types?
Althammer, F., & Grinevich, V. (2018) · Journal of Neuroendocrinology · doi:10.1111/jne.12549 · Cited by 138 · see citing works
Oxytocin’s inhibitory effect on food intake is stronger in obese than normal-weight men
Thienel, M., Fritsche, A., Heinrichs, M., Peter, A., Ewers, M., Lehnert, H., Jan Born, A., & Hallschmid, M. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.149 · Cited by 139 · see citing works
Leptin and the systems neuroscience of meal size control
Grill, H. J. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.10.005 · Cited by 138 · see citing works
PostnatalSim1Deficiency Causes Hyperphagic Obesity and ReducedMc4randOxytocinExpression
Tolson, K. P., Gemelli, T., Gautron, L., Elmquist, J. K., Zinn, A. R., & Kublaoui, B. M. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5444-09.2010 · Cited by 137 · see citing works
Berthoud, H., Sutton, G. M., Townsend, R. L., Patterson, L. M., & Zheng, H. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.08.018 · Cited by 136 · see citing works
Blevins, J. E., & Baskin, D. G. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.05.023 · Cited by 132 · see citing works
Self-citationNesfatin-1, a unique regulatory neuropeptide of the brain
Pałasz, A., Krzystanek, M., Worthington, J. J., Czajkowska, B. I., Kostro, K., Wiaderkiewicz, R., & Bajor, G. (2012) · Neuropeptides · doi:10.1016/j.npep.2011.12.002 · Cited by 126 · see citing works
Lawson, E. A., Donoho, D. A., Blum, J. I., Meenaghan, E. M., Misra, M., Herzog, D. B., Sluss, P. M., Miller, K. K., & Klibanski, A. (2011) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.10m06617 · Cited by 124 · see citing works
Oxytocin-messages via the cerebrospinal fluid: Behavioral effects; a review
Veening, J. G., A, T. R. D. J., & Barendregt, H. P. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.05.004 · Cited by 126 · see citing works
Roles of Oxytocin Neurones in the Control of Stress, Energy Metabolism, and Social Behaviour
Onaka, T., Takayanagi, Y., & Yoshida, M. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02300.x · Cited by 123 · see citing works
Allopregnanolone in the brain: Protecting pregnancy and birth outcomes
Brunton, P. J., Russell, J. A., & Hirst, J. J. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.08.005 · Cited by 122 · see citing works
The Role of PVH Circuits in Leptin Action and Energy Balance
Sutton, A. K., Myers, M. G., & Olson, D. P. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105347 · Cited by 121 · see citing works
Oxytocin action in the ventral tegmental area affects sucrose intake
Mullis, K., Kay, K., & Williams, D. L. (2013) · Brain Research · doi:10.1016/j.brainres.2013.03.026 · Cited by 122 · see citing works
Lawson, E. A., Holsen, L. M., Santin, M., Meenaghan, E. M., Eddy, K. T., Becker, A. E., Herzog, D. B., Goldstein, J. M., & Klibanski, A. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1702 · Cited by 121 · see citing works
Starvation after AgRP neuron ablation is independent of melanocortin signaling
Wu, Q., Howell, M. P., Cowley, M. A., & Palmiter, R. D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712062105 · Cited by 121 · see citing works
Enhanced initial and sustained intake of sucrose solution in mice with an oxytocin gene deletion
Amico, J. A., Vollmer, R. R., Cai, H.-M., Miedlar, J. A., & Rinaman, L. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00558.2005 · Cited by 120 · see citing works
Multinodal regulation of the arcuate/paraventricular nucleus circuit by leptin
Ghamari‐Langroudi, M., Srisai, D., & Cone, R. D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016785108 · Cited by 113 · see citing works
OxytocinSynthesis, Secretion, and Reproductive Functions
BURBACH, J., YOUNG, L., & RUSSELL, J. (2006) · Knobil and Neill's Physiology of Reproduction · doi:10.1016/b978-012515400-0/50063-4 · Cited by 113 · see citing works
LENG, G., ONAKA, T., CAQUINEAU, C., SABATIER, N., TOBIN, V, & TAKAYANAGI, Y. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00413-5 · Cited by 112 · see citing works
Tung, Y. L., Ma, M. K. L., Piper, S., Coll, A. P., O’Rahilly, S., & Yeo, G. S. H. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3412-08.2008 · Cited by 111 · see citing works
Divergent Effects of Oxytocin Treatment of Obese Diabetic Mice on Adiposity and Diabetes
Altirriba, J., Poher, A.-L., Caillon, A., Arsenijevic, D., Veyrat‐Durebex, C., Lyautey, J., Dulloo, A. G., & Rohner‐Jeanrenaud, F. (2014) · Endocrinology · doi:10.1210/en.2014-1466 · Cited by 111 · see citing works
Douglas, A. J., Johnstone, L. E., & Leng, G. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.04.012 · Cited by 108 · see citing works
Role of oxytocin signaling in the regulation of body weight
Blevins, J. E., & Ho, J. M. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9260-x · Cited by 108 · see citing works
Self-citationOxytocin Treatment Prevents the Cardiomyopathy Observed in Obese Diabetic Male db/db Mice
Plante, É., Ménaouar, A., Danalache, B. A., Yip, D., Broderick, T. L., Chiasson, J., Jankowski, M., & Gutkowska, J. (2015) · Endocrinology · doi:10.1210/en.2014-1718 · Cited by 107 · see citing works
Blevins, J. E., Thompson, B. W., Anekonda, V. T., Ho, J. M., Graham, J. L., Roberts, Z. S., Hwang, B. H., Ogimoto, K., Wolden‐Hanson, T., Nelson, J. T., et al. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00220.2015 · Cited by 107 · see citing works
Self-citationOlszewski, P. K., Klockars, A., Olszewska, A. M., Fredriksson, R., Schiöth, H. B., & Levine, A. S. (2010) · Endocrinology · doi:10.1210/en.2010-0151 · Cited by 104 · see citing works
Noble, E. E., Billington, C. J., Kotz, C. M., & Wang, C. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00118.2014 · Cited by 102 · see citing works
Gastrointestinal dysfunction after spinal cord injury
Holmes, G. M., & Blanke, E. N. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.113009 · Cited by 106 · see citing works
Role of oxytocin in the control of stress and food intake
Onaka, T., & Takayanagi, Y. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12700 · Cited by 98 · see citing works
Integrative capacity of the caudal brainstem in the control of food intake
Schwartz, G. J. (2006) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2006.1862 · Cited by 100 · see citing works
The role of oxytocin in regulation of appetitive behaviour, body weight and glucose homeostasis
Lawson, E. A., Olszewski, P. K., Weller, A., & Blevins, J. E. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12805 · Cited by 97 · see citing works
Self-citationHypothalamic-Brainstem Circuits Controlling Eating
Blevins, J. E., & Baskin, D. G. (2009) · Forum of nutrition/Bibliotheca Nutritio et dieta · doi:10.1159/000264401 · Cited by 93 · see citing works
Self-citationOxytocin as feeding inhibitor: Maintaining homeostasis in consummatory behavior
Olszewski, P. K., Klockars, A., Schiöth, H. B., & Levine, A. S. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.05.026 · Cited by 92 · see citing works
Nesfatin‐1 Influences the Excitability of Paraventricular Nucleus Neurones
Price, C. J., Hoyda, T. D., Samson, W. K., & Ferguson, A. V. (2007) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2007.01641.x · Cited by 86 · see citing works
Zheng, H., Patterson, L. M., Rhodes, C. J., Louis, G. W., Skibicka, K. P., Grill, H. J., Myers, M. G., & Berthoud, H. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00619.2009 · Cited by 84 · see citing works
Perelló, M., & Raingo, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059625 · Cited by 84 · see citing works
Role of oxytocin in energy metabolism
Chaves, V. E., Tilelli, C. Q., Brito, N. A., & Brito, M. N. (2013) · Peptides · doi:10.1016/j.peptides.2013.04.010 · Cited by 90 · see citing works
Prolactin-Releasing Peptide Mediates Cholecystokinin-Induced Satiety in Mice
Bechtold, D. A., & Luckman, S. M. (2006) · Endocrinology · doi:10.1210/en.2006-0753 · Cited by 81 · see citing works
Skibicka, K. P., & Grill, H. J. (2008) · Endocrinology · doi:10.1210/en.2008-1316 · Cited by 77 · see citing works
Flak, J. N., Jankord, R., Solomon, M. B., Krause, E. G., & Herman, J. P. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.03.002 · Cited by 76 · see citing works
The multiple faces of the oxytocin and vasopressin systems in the brain
Grinevich, V., & Ludwig, M. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.13004 · Cited by 74 · see citing works
Ho, J. M., Anekonda, V. T., Thompson, B. W., Zhu, M., Curry, R. W., Hwang, B. H., Morton, G. J., Schwartz, M. W., Baskin, D. G., Appleyard, S. M., et al. (2014) · Endocrinology · doi:10.1210/en.2014-1148 · Cited by 74 · see citing works
Self-citationZiko, I., Luca, S. N. D., Dinan, T., Barwood, J. M., Sominsky, L., Cai, G., Kenny, R., Stokes, L., Jenkins, T. A., & Spencer, S. J. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.06.014 · Cited by 73 · see citing works
Forebrain melanocortin signaling enhances the hindbrain satiety response to CCK-8
Blevins, J. E., Morton, G. J., Williams, D. L., Caldwell, D. W., Bastian, L. S., Wisse, B. E., Schwartz, M. W., & Baskin, D. G. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90544.2008 · Cited by 73 · see citing works
Self-citationMack, S. O., Wu, M., Kc, P., & Haxhiu, M. A. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00522.2006 · Cited by 73 · see citing works
Role of Somatostatin in the Regulation of Central and Peripheral Factors of Satiety and Obesity
Kumar, U., & Singh, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072568 · Cited by 73 · see citing works
A New Oxytocin-Saporin Cytotoxin for Lesioning Oxytocin-Receptive Neurons in the Rat Hindbrain
Baskin, D. G., Kim, F., Gelling, R. W., Russell, B. J., Schwartz, M. W., Morton, G. J., Simhan, H. N., Moralejo, D. H., & Blevins, J. E. (2010) · Endocrinology · doi:10.1210/en.2010-0295 · Cited by 72 · see citing works
Self-citationSpetter, M. S., Feld, G. B., Thienel, M., Preissl, H. T., Hege, M. A., & Hallschmid, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-20963-4 · Cited by 70 · see citing works
Roberts, Z. S., Wolden‐Hanson, T., Matsen, M. E., Ryu, V., Vaughan, C. H., Graham, J. L., Havel, P. J., Chukri, D. W., Schwartz, M. W., Morton, G. J., et al. (2017) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00169.2017 · Cited by 68 · see citing works
Self-citationComing Full Circle: Contributions of Central and Peripheral Oxytocin Actions to Energy Balance
Ho, J. M., & Blevins, J. E. (2012) · Endocrinology · doi:10.1210/en.2012-1751 · Cited by 67 · see citing works
Self-citationZheng, H., Patterson, L. M., Morrison, C. D., Banfield, B. W., Randall, J. A., Browning, K. N., Travagli, R. A., & Berthoud, H. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.06.055 · Cited by 66 · see citing works
The Anorexigenic Neural Pathways of Oxytocin and Their Clinical Implication
Maejima, Y., Yokota, S., Nishimori, K., & Shimomura, K. (2018) · Neuroendocrinology · doi:10.1159/000489263 · Cited by 65 · see citing works
Oxytocin enhances cognitive control of food craving in women
Striepens, N., Schröter, F., Stoffel‐Wagner, B., Maier, W., Hurlemann, R., & Scheele, D. (2016) · Human Brain Mapping · doi:10.1002/hbm.23308 · Cited by 63 · see citing works
- Authors
- Blevins, J. E., Schwartz, M. W., & Baskin, D. G.
- Affiliations
- VA Puget Sound Health Care System (US)
- University of Washington (US)
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2004-07
- Volume
- 287
- Issue
- 1
- Pages
- R87-R96
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2111100731
- Cited by
- 332
- References
- 53
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 17 · 2023: 11 · 2022: 8 · 2021: 15 · 2020: 12 · 2019: 14 · 2018: 19 · 2017: 17 · 2016: 21 · 2015: 16 · 2014: 23 · 2013: 19 · 2012: 17
- FWCI
- 4.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (2r01dk012829-36)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 12829, R01DK052989, DK-52989, DK-17047, P30DK017047)
- National Institute of Neurological Disorders and Stroke (NS-32273)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, paraventricular nucleus, leptin, nucleus tractus solitarius, meal size, food intake regulation, satiety signals, cholecystokinin, Fos expression, arginine vasotocin, third ventricle
- MeSH terms
- Animals, Brain Stem, Cholecystokinin, Eating, Gene Expression Regulation, Immunohistochemistry, Injections, Intraventricular, Male, Neurons, Oxytocin, Paraventricular Hypothalamic Nucleus, Satiety Response, Stereotaxic Techniques, Signal Transduction, Genes, fos, Rats, Wistar, Solitary Nucleus, Receptors, Oxytocin, Leptin, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review