Cited by 102Regulation of Appetite and ObesityNeuroendocrine regulation and behaviorNeuropeptides and Animal Physiology

The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.

Oxytocin in the ventromedial hypothalamic nucleus reduces feeding and acutely increases energy expenditure

Open access

Noble, Emily E., Billington, Charles J., Kotz, Catherine M., Wang, ChuanFeng·2014·American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

DOI 10.1152/ajpregu.00118.2014PMC PMC4166752

Open this paper in CoChat — free account

Abstract

Central oxytocin reduces food intake and increases energy expenditure. The ventromedial hypothalamic nucleus (VMN) is associated with energy balance and contains a high density of oxytocin receptors. We hypothesized that oxytocin in the VMN is a negative regulator of energy balance acting to reduce feeding and increase energy expenditure. To test this idea, oxytocin or vehicle was injected directly into the VMN of Sprague-Dawley rats during fasted and nonfasted conditions. Energy expenditure (via indirect calorimetry) and spontaneous physical activity (SPA) were recorded simultaneously. Animals were also exposed to a conditioned taste aversion test, to determine whether oxytocin's effects on food intake were associated with malaise. When food was available during testing, oxytocin-induced elevations in energy expenditure lasted for 1 h, after which overall energy expenditure was reduced. In the absence of food during the testing period, oxytocin similarly increased energy expenditure during the first hour, but differences in 12-h energy expenditure were eliminated, implying that the differences may have been due to the thermic effects of feeding (digestion, absorption, and metabolic processing). Oxytocin acutely elevated SPA and reduced feeding at doses that did not cause a conditioned taste aversion during both the fed and fasted states. Together, these data suggest that oxytocin in the VMN promotes satiety and acutely elevates energy expenditure and SPA and implicates the VMN as a relevant site for the antiobesity effects of oxytocin.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1152/ajpregu.00118.2014

Cites

67 of 67 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The rat brain in stereotaxic coordinates
Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,959
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
Brown Adipose Tissue: Function and Physiological Significance
CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433
The paraventricular nucleus of the hypothalamus: Cytoarchitectonic subdivisions and organization of projections to the pituitary, dorsal vagal complex, and spinal cord as demonstrated by retrograde fluorescence double‐labeling methods
Swanson, L. W., & Kuypers, H. G. J. M. (1980) · Journal of Comparative Neurology · doi:10.1002/cne.901940306 · Cited by 1,413
UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality
Feldmann, H. M., Golozoubova, V., Cannon, B., & Nedergaard, J. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.12.014 · Cited by 1,318
An anorexic lipid mediator regulated by feeding
de Fonseca, F. R., Navarro, M. A., de Heras, R. G., Escuredo, L., Nava, F. A., Fu, J., Murillo‐Rodríguez, E., Giuffrida, A., LoVerme, J., Gaetani, S., et al. (2001) · Nature · doi:10.1038/35102582 · Cited by 695
Oxytocin and Vasopressin Agonists and Antagonists as Research Tools and Potential Therapeutics
Manning, M., Misicka, A., Olma, A., Bankowski, K., Stoev, S., Chini, B., Durroux, T., Mouillac, B., Corbani, M., & Guillon, G. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02303.x · Cited by 423
Alterations in the hypothalamic paraventricular nucleus and its oxytocin neurons (putative satiety cells) in Prader-Willi syndrome: a study of five cases
Swaab, D. F., Purba, J. S., & Hofman, M. A. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.2.7852523 · Cited by 421
Diffusion from an injected volume of a substance in brain tissue with arbitrary volume fraction and tortuosity
Nicholson, C. (1985) · Brain Research · doi:10.1016/0006-8993(85)91586-0 · Cited by 364
Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brain stem nuclei controlling meal size
Blevins, J. E., Schwartz, M. W., & Baskin, D. G. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00604.2003 · Cited by 332
Nesfatin-1-Regulated Oxytocinergic Signaling in the Paraventricular Nucleus Causes Anorexia through a Leptin-Independent Melanocortin Pathway
Maejima, Y., Sedbazar, U., Suyama, S., Kohno, D., Onaka, T., Takano, E., Yoshida, N., Koike, M., Uchiyama, Y., Fujiwara, K., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.09.002 · Cited by 317
Oxytocin receptor-deficient mice developed late-onset obesity
Takayanagi, Y., Kasahara, Y., Onaka, T., Takahashi, N., Kawada, T., & Nishimori, K. (2008) · Neuroreport · doi:10.1097/wnr.0b013e3283021ca9 · Cited by 294
Oxytocin and an oxytocin agonist administered centrally decrease food intake in rats
Olson, B. R., Drutarosky, M. D., Chow, M.-S., Hruby, V. J., Stricker, E. M., & Verbalis, J. G. (1991) · Peptides · doi:10.1016/0196-9781(91)90176-p · Cited by 283
Prosocial effects of oxytocin and clinical evidence for its therapeutic potential
Striepens, N., Kendrick, K. M., Maier, W., & Hurlemann, R. (2011) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2011.07.001 · Cited by 283
Immunohistochemical localization of oxytocin receptors in human brain
Boccia, M. L., Petrusz, P., Suzuki, K., Marson, L., & Pedersen, C. A. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.08.048 · Cited by 276
Mediobasal Hypothalamic Leucine Sensing Regulates Food Intake through Activation of a Hypothalamus-Brainstem Circuit
Blouet, C., Jo, Y., Li, X., & Schwartz, G. J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1668-09.2009 · Cited by 256
Oxytocin inhibits food and fluid intake in rats
Arletti, R., Benelli, A., & Bertolini, A. (1990) · Physiology & Behavior · doi:10.1016/0031-9384(90)90234-u · Cited by 254
Mechanisms of the anti-obesity effects of oxytocin in diet-induced obese rats
Deblon, N., Veyrat-Durebex, C., Bourgoin, L., Caillon, A., Bussier, A.-L., Petrosino, S., Piscitelli, F., Legros, J.-J., Geenen, V., Foti, M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025565 · Cited by 254
Oxytocin Deficiency Mediates Hyperphagic Obesity of Sim1 Haploinsufficient Mice
Kublaoui, B. M., Gemelli, T., Tolson, K. P., Wang, Y., & Zinn, A. R. (2008) · Molecular Endocrinology · doi:10.1210/me.2008-0067 · Cited by 239
Low sympathetic tone and obese phenotype in oxytocin-deficient mice
Camerino, C. (2009) · Obesity · doi:10.1038/oby.2009.12 · Cited by 235
Oxytocin Reduces Reward-Driven Food Intake in Humans
Ott, V., Finlayson, G., Lehnert, H., Heitmann, B., Heinrichs, M., Born, J., & Hallschmid, M. (2013) · Diabetes · doi:10.2337/db13-0663 · Cited by 226
Treatment of obesity and diabetes using oxytocin or analogs in patients and mouse models
Zhang, H., Wu, C., Chen, Q., Chen, X., Xu, Z., Wu, J., & Cai, D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061477 · Cited by 224
Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass
Maejima, Y., Iwasaki, Y., Yamahara, Y., Kodaira, M., Sedbazar, U., & Yada, T. (2011) · Aging · doi:10.18632/aging.100408 · Cited by 220
Peripheral oxytocin suppresses food intake and causes weight loss in diet-induced obese rats
Morton, G. J., Thatcher, B. S., Reidelberger, R. D., Ogimoto, K., Wolden-Hanson, T., Baskin, D. G., Schwartz, M. W., & Blevins, J. E. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00296.2011 · Cited by 213
Neuropeptide exocytosis involving synaptotagmin-4 and oxytocin in hypothalamic programming of body weight and energy balance
Zhang, G., Bai, H., Zhang, H., Dean, C., Wu, Q., Li, J., Guariglia, S., Meng, Q., & Cai, D. (2011) · Neuron · doi:10.1016/j.neuron.2010.12.036 · Cited by 208
An obligate role of oxytocin neurons in diet induced energy expenditure
Wu, Z., Xu, Y., Zhu, Y., Sutton, A. K., Zhao, R., Lowell, B. B., Olson, D. P., & Tong, Q. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045167 · Cited by 181
Brain oxytocin receptor antagonism blunts the effects of anorexigenic treatments in rats: evidence for central oxytocin inhibition of food intake
OLSON, B. R., DRUTAROSKY, M. D., STRICKER, E. M., & VERBALIS, J. G. (1991) · Endocrinology · doi:10.1210/endo-129-2-785 · Cited by 180
Circadian intervention of obesity development via resting-stage feeding manipulation or oxytocin treatment
Zhang, G., & Cai, D. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00196.2011 · Cited by 171
Oxytocin innervation of caudal brainstem nuclei activated by cholecystokinin
Blevins, J. E., Eakin, T. J., Murphy, J. A., Schwartz, M. W., & Baskin, D. G. (2003) · Brain Research · doi:10.1016/j.brainres.2003.08.036 · Cited by 164
Modulation of Meal Pattern in the Rat by the Anorexic Lipid Mediator Oleoylethanolamide
Gaetani, S., Oveisi, F., & Piomelli, D. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300166 · Cited by 159
Oxytocin Receptors in the Central Nervous System: Distribution, Development, and Species Differencesa
TRIBOLLET, E., DUBOIS‐DAUPHIN, M., DREIFUSS, J. J., BARBERIS, C., & JARD, S. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb34343.x · Cited by 156
Oxytocin, feeding, and satiety
Sabatier, N., Leng, G., & Menzies, J. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00035 · Cited by 149
The Hypothalamic-Neurohypophysial System of the Rat: Localization and Quantitation of Neurophysin by Light Microscopic Immunocytochemistry in Normal Rats and in Brattleboro Rats Deficient in Vasopressin and a Neurophysin
Sokol, H. W., Zimmerman, E. A., Sawyer, W. H., & ROBINSON, A. G. (1976) · Endocrinology · doi:10.1210/endo-98-5-1176 · Cited by 140
Reduced sympathetic nervous system activity in rats with ventromedial hypothalamic lesions
Tuig, J. G. V., KNEHANS, A. W., & Romsos, D. R. (1982) · Life Sciences · doi:10.1016/0024-3205(82)90619-1 · Cited by 139
Oxytocin enhances cranial visceral afferent synaptic transmission to the solitary tract nucleus
Peters, J. H., McDougall, S. J., Kellett, D. O., Jordan, D., Llewellyn-Smith, I. J., & Andresen, M. C. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3419-08.2008 · Cited by 135
The Fat-Induced Satiety Factor Oleoylethanolamide Suppresses Feeding through Central Release of Oxytocin
Gaetani, S., Fu, J., Cassano, T., Dipasquale, P., Romano, A., Righetti, L., Cianci, S., Laconca, L., Giannini, E., Scaccianoce, S., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0036-10.2010 · Cited by 124
Oxytocin action in the ventral tegmental area affects sucrose intake
Mullis, K., Kay, K., & Williams, D. L. (2013) · Brain Research · doi:10.1016/j.brainres.2013.03.026 · Cited by 122
Enhanced initial and sustained intake of sucrose solution in mice with an oxytocin gene deletion
Amico, J. A., Vollmer, R. R., Cai, H.-M., Miedlar, J. A., & Rinaman, L. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00558.2005 · Cited by 120
Oxytocin and appetite
LENG, G., ONAKA, T., CAQUINEAU, C., SABATIER, N., TOBIN, V, & TAKAYANAGI, Y. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00413-5 · Cited by 112 · cited 2×
“On the basis of the proximity of oxytocin neurons to the third ventricle, it has been hypothesized that PVN oxytocin may act in a paracrine manner following dendritic release by entering the ventricular system prior to activating oxytocin receptor in more distal areas of the brain (21, 47).”
Background
Novel Leptin-Regulated Genes Revealed by Transcriptional Profiling of the Hypothalamic Paraventricular Nucleus
Tung, Y. L., Ma, M. K. L., Piper, S., Coll, A. P., O’Rahilly, S., & Yeo, G. S. H. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3412-08.2008 · Cited by 111
Role of oxytocin signaling in the regulation of body weight
Blevins, J. E., & Ho, J. M. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9260-x · Cited by 108
Elevated hypothalamic orexin signaling, sensitivity to orexin A, and spontaneous physical activity in obesity-resistant rats
Teske, J. A., Levine, A. S., Kuskowski, M. A., Levine, J. A., & Kotz, C. M. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00536.2005 · Cited by 106
Self-citation
Brain-derived neurotrophic factor in the hypothalamic paraventricular nucleus increases energy expenditure by elevating metabolic rate
Wang, C., Bomberg, E. M., Billington, C. J., Levine, A. S., & Kotz, C. M. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00516.2006 · Cited by 104
Self-citation
Distribution of oxytocin in the brain of a eusocial rodent
Rosen, G. J., de Vries, G. J., Goldman, S. L., Goldman, B. D., & Forger, N. G. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.05.039 · Cited by 102
Brain-derived neurotrophic factor in the ventromedial nucleus of the hypothalamus reduces energy intake
Wang, C., Bomberg, E. M., Levine, A. S., Billington, C. J., & Kotz, C. M. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00125.2007 · Cited by 99
Self-citation
Oxytocin Receptor in the Hypothalamus Is Sufficient to Rescue Normal Thermoregulatory Function in Male Oxytocin Receptor Knockout Mice
Kasahara, Y., Sato, K., Takayanagi, Y., Mizukami, H., Ozawa, K., Hidema, S., So, K.-H., Kawada, T., Inoue, N., Ikeda, I., et al. (2013) · Endocrinology · doi:10.1210/en.2012-2206 · Cited by 96
Oxytocin as feeding inhibitor: Maintaining homeostasis in consummatory behavior
Olszewski, P. K., Klockars, A., Schiöth, H. B., & Levine, A. S. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.05.026 · Cited by 92
Leptin Activates Oxytocin Neurons of the Hypothalamic Paraventricular Nucleus in Both Control and Diet-Induced Obese Rodents
Perelló, M., & Raingo, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059625 · Cited by 89
Impaired thermoregulatory ability of oxytocin-deficient mice during cold-exposure
KASAHARA, Y., TAKAYANAGI, Y., KAWADA, T., ITOI, K., & NISHIMORI, K. (2007) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.70498 · Cited by 89
Oxytocin, feeding and satiety
eSabatier, N., eLeng, G., & eMenzies, J. (2013) · Frontiers in Endocrinology · Cited by 83
Opposing effects of chronic stress and weight restriction on cardiovascular, neuroendocrine and metabolic function
Flak, J. N., Jankord, R., Solomon, M. B., Krause, E. G., & Herman, J. P. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.03.002 · Cited by 79
A New Oxytocin-Saporin Cytotoxin for Lesioning Oxytocin-Receptive Neurons in the Rat Hindbrain
Baskin, D. G., Kim, F., Gelling, R. W., Russell, B. J., Schwartz, M. W., Morton, G. J., Simhan, H. N., Moralejo, D. H., & Blevins, J. E. (2010) · Endocrinology · doi:10.1210/en.2010-0295 · Cited by 72
Urocortin in the lateral septal area modulates feeding induced by orexin A in the lateral hypothalamus
Wang, C., & Kotz, C. M. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00558.2001 · Cited by 68
Self-citation
Leanness and heightened nonresting energy expenditure: role of skeletal muscle activity thermogenesis
Gavini, C. K., Mukherjee, S., Shukla, C., Britton, S. L., Koch, L. G., Shi, H., & Novak, C. M. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00555.2013 · Cited by 64
Effects of Central Oxytocin Administration on Intraoral Intake of Glucose in Deprived and Nondeprived Rats
Lokrantz, C.-M., Uvnäs‐Moberg, K., & Kaplan, J. M. (1997) · Physiology & Behavior · doi:10.1016/s0031-9384(97)00021-8 · Cited by 57
Ovarian hormone-induced reorganization of oxytocin-labeled dendrites and synapses lateral to the hypothalamic ventromedial nucleus in female rats
Griffin, G. D., Ferri‐Kolwicz, S. L., Reyes, B. A. S., Van Bockstaele, E. J., & Flanagan‐Cato, L. M. (2010) · Journal of Comparative Neurology · doi:10.1002/cne.22470 · Cited by 56
Sympathetic activity and food intake of rats with ventromedial hypothalamic lesions.
Sakaguchi, T., Arase, K., & Ga, B. (1988) · PubMed · Cited by 56
Involvement of Prolactin‐Releasing Peptide in the Activation of Oxytocin Neurones in Response to Food Intake
Yamashita, M., Takayanagi, Y., Yoshida, M., Nishimori, K., Kusama, M., & Onaka, T. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12019 · Cited by 54
%β3adrenergicagonist%Satiety
Tsujii, S., & Bray, G. A. (1998) · Physiology & Behavior · doi:10.1016/s0031-9384(97)00518-0 · Cited by 45
The satiety signal oleoylethanolamide stimulates oxytocin neurosecretion from rat hypothalamic neurons
Romano, A., Cassano, T., Tempesta, B., Cianci, S., Dipasquale, P., Coccurello, R., Cuomo, V., & Gaetani, S. (2013) · Peptides · doi:10.1016/j.peptides.2013.08.006 · Cited by 43
High and low activity rats: Elevated intrinsic physical activity drives resistance to diet‐induced obesity in non‐bred rats
Perez‐Leighton, C. E., Boland, K., Billington, C. J., & Kotz, C. M. (2013) · Obesity · doi:10.1002/oby.20045 · Cited by 39
Self-citation
Effects of ventromedial hypothalamus stimulation on glycogenolysis in rat liver using in vivo microdialysis
Takahashi, A., Ishimaru, H., Ikarashi, Y., Kishi, E., & Maruyama, Y. (1997) · Metabolism · doi:10.1016/s0026-0495(97)90076-7 · Cited by 31
Possible involvement of uncoupling protein 1 in appetite control by leptin
Okamatsu‐Ogura, Y., Nio‐Kobayashi, J., Iwanaga, T., Terao, A., Kimura, K., & Saito, M. (2011) · Experimental Biology and Medicine · doi:10.1258/ebm.2011.011143 · Cited by 31
Differential distribution of acetylcholinesterase activity among vasopressin- and oxytocin-containing supraoptic magnocellular neurons
Pow, D. V., & Morris, J. F. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90236-4 · Cited by 21
Fto colocalizes with a satiety mediator oxytocin in the brain and upregulates oxytocin gene expression
Olszewski, P. K., Fredriksson, R., Eriksson, J., Mitra, A., Radomska, K. J., Gosnell, B. A., Solvang, M. N., Levine, A. S., & Schiöth, H. B. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.04.037 · Cited by 19
Oxytocin projections to the nucleus of the solitary tract contribute to the increased meal‐related satiety responses in primary adrenal insufficiency
Uchôa, E. T., Zahm, D. S., Borges, B. C., Rorato, R. C., Antunes‐Rodrigues, J., & Elias, L. L. K. (2013) · Experimental Physiology · doi:10.1113/expphysiol.2013.073726 · Cited by 18
Untitled work
Rinaman (1998) · doi:10.1002/(sici)1096-9861(19980914)399:1

Research works printed but not linked: 2

Sakaguchi T, 1988, Int J Obes, 12, 285
Swaab DF, 1995, J Clin Endocrinol Metab, 80, 573

Sorted by citations

Oxytocin reduces caloric intake in men
Lawson, E. A., Marengi, D. A., DeSanti, R. L., Holmes, T. M., Schoenfeld, D. A., & Tolley, C. J. (2015) · Obesity · doi:10.1002/oby.21069 · Cited by 208
Chronic oxytocin administration inhibits food intake, increases energy expenditure, and produces weight loss in fructose-fed obese rhesus monkeys
Blevins, J. E., Graham, J. L., Morton, G. J., Bales, K. L., Schwartz, M. W., Baskin, D. G., & Havel, P. J. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00441.2014 · Cited by 191
The physiological control of eating: signals, neurons, and networks
Watts, A. G., Kanoski, S. E., Sanchez-Watts, G., & Langhans, W. (2022) · Physiological Reviews · doi:10.1152/physrev.00028.2020 · Cited by 168
Central nervous system regulation of organismal energy and glucose homeostasis
Myers, M. G., Affinati, A. H., Richardson, N. E., & Schwartz, M. W. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00408-5 · Cited by 165
Metabolic Effects of Oxytocin
McCormack, S. E., Blevins, J. E., & Lawson, E. A. (2019) · Endocrine Reviews · doi:10.1210/endrev/bnz012 · Cited by 148

See all 102

Authors: Noble, E. E., Billington, C. J., Kotz, C. M., & Wang, C.
Affiliations: University of Minnesota (US)
Corresponding author: Wang, ChuanFeng
ORCID: Noble, Emily E.
Billington, Charles J.
Kotz, Catherine M.
Venue: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Publisher: American Physiological Society
Published: 2014-09-15
Volume: 307
Issue: 6
Pages: R737-R745
ISSN: 0363-6119 (ISSN-L)
1522-1490
DOI: 10.1152/ajpregu.00118.2014
PMC: PMC4166752
OpenAlex: W1972127276
Cited by: 102
References: 67
Citations by year: 2026: 8 · 2025: 8 · 2024: 12 · 2023: 8 · 2022: 4 · 2021: 13 · 2020: 6 · 2019: 7 · 2018: 8 · 2017: 11 · 2016: 6 · 2015: 8 · 2014: 3
FWCI: 4.55
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (T32DK083250)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: oxytocin, ventromedial hypothalamus, energy expenditure, dietary intake, energy balance, spontaneous physical activity, conditioned taste aversion, satiety, thermic effect of feeding, anti-obesity, fasting
MeSH terms: Animals, Dose-Response Relationship, Drug, Eating, Energy Metabolism, Fasting, Feeding Behavior, Injections, Intraventricular, Male, Motor Activity, Oxytocin, Satiety Response, Time Factors, Ventromedial Hypothalamic Nucleus, Rats, Sprague-Dawley, Anti-Obesity Agents, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Oxytocin in the ventromedial hypothalamic nucleus reduces feeding and acutely increases energy expenditure

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks