Preserved placental oxygenation and development during severe systemic hypoxia
Open accessAbstract
Local tissue oxygenation profoundly influences placental development. To elucidate the impact of hypoxia on cellular and molecular adaptation in vivo, pregnant mice at embryonic days 7.5–11.5 were exposed to reduced environmental oxygen (6–7% O 2 ) for various periods of time. Hypoxia-inducible factor (HIF)-1α mRNA was highly expressed in the placenta, whereas HIF-2α was predominantly found in the decidua, indicating that HIF-1 is a relevant oxygen-dependent factor involved in placental development. During severe hypoxia, HIF-1α protein was strongly induced in the periphery but, however, not in the labyrinth layer of the placenta. Accordingly, no indication for tissue hypoxia in this central area was detected with 2-(2-nitro-1 H-imidazol-1-yl)- N-(2,2,3,3,3-pentafluoropropyl)acetamide staining and VEGF expression as hypoxic markers. The absence of significant tissue hypoxia was reflected by preserved placental architecture and trophoblast differentiation. In the search for mechanisms preventing local hypoxia, we found upregulation of endothelial nitric oxide synthase (NOS) expression in the labyrinth layer. Inhibition of NOS activity by N ω -nitro-l-arginine methyl ester application resulted in ubiquitous placental tissue hypoxia. Our results show that placental oxygenation is preserved even during severe systemic hypoxia and imply that NOS-mediated mechanisms are involved to protect the placenta from maternal hypoxia.
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Earlier in gestation, there appears to be little, if any, change in placental morphology during severe hypoxia of the mouse dam.
“Earlier in gestation, there appears to be little, if any, change in placental morphology during severe hypoxia of the mouse dam (483).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [483]
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- Authors
- Schäffer, L., Vogel, J., Breymann, C., Gassmann, M., & Marti, H. H.
- Affiliations
- University Hospital Zurich (CH)
- University of Zurich (CH)
- Heidelberg University (DE)
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2006-03
- Volume
- 290
- Issue
- 3
- Pages
- R844-R851
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W1981254978
- Cited by
- 39
- References
- 53
- Citations by year
- 2023: 1 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 2 · 2017: 2 · 2016: 3 · 2015: 4 · 2014: 2 · 2013: 3 · 2012: 3
- FWCI
- 2.42
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- Ministerul Cercetării, Inovării şi Digitalizării
- Foundation for Research in Science and the Humanities
- Abramson Family Cancer Research Institute
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Keywords
- placental oxygenation, systemic hypoxia, placental development, hypoxia-inducible factor-1α, HIF-2α, decidua, endothelial nitric oxide synthase, nitric oxide, trophoblast differentiation, vascular endothelial growth factor, nitric oxide synthase inhibition, L-NAME, maternal hypoxia, fetal development
- MeSH terms
- Animals, Hypoxia, Female, Oxygen, Placenta, Pregnancy, Tissue Distribution, Mice, Hypoxia-Inducible Factor 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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