Hypoxia pathway proteins and their impact on the blood vasculature

Mechanisms of angiogenesis

Risau, W. (1997) · Nature · doi:10.1038/386671a0 · Cited by 5,727 · see citing works

Mechanisms of angiogenesis and arteriogenesis

Carmeliet, P. (2000) · Nature Medicine · doi:10.1038/74651 · Cited by 4,146 · see citing works

VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia

Gerhardt, H., Golding, M., Fruttiger, M., Ruhrberg, C., Lundkvist, A., Abramsson, A., Jeltsch, M., Mitchell, C., Alitalo, K., Shima, D., et al. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302047 · Cited by 2,894 · see citing works

Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis

Suri, C., Jones, P. F., Patan, S., Bartunkova, S., Maisonpierre, P. C., Davis, S. H., Sato, T. N., & Yancopoulos, G. D. (1996) · Cell · doi:10.1016/s0092-8674(00)81813-9 · Cited by 2,831 · see citing works

Basic and Therapeutic Aspects of Angiogenesis

Potente, M., Gerhardt, H., & Carmeliet, P. (2011) · Cell · doi:10.1016/j.cell.2011.08.039 · Cited by 2,771 · see citing works

Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1

Ceradini, D. J., Kulkarni, A. R., Callaghan, M. J., Tepper, O. M., Bastidas, N., Kleinman, M. E., Capla, J. M., Galiano, R. D., Levine, J. P., & Gurtner, G. C. (2004) · Nature Medicine · doi:10.1038/nm1075 · Cited by 2,600 · see citing works

Regulation of angiogenesis by hypoxia: role of the HIF system

Pugh, C. W., & Ratcliffe, P. J. (2003) · Nature Medicine · doi:10.1038/nm0603-677 · Cited by 2,520 · see citing works

Molecular regulation of vessel maturation

Jain, R. K. (2003) · Nature Medicine · doi:10.1038/nm0603-685 · Cited by 2,515 · see citing works

Cellular and developmental control of O ₂ homeostasis by hypoxia-inducible factor 1α

Iyer, N. V., Kotch, L. E., Agani, F., Leung, S. W., Laughner, E., Wenger, R. H., Gassmann, M., Gearhart, J. D., Lawler, A. M., Yu, A. Y., et al. (1998) · Genes & Development · doi:10.1101/gad.12.2.149 · Cited by 2,476 · see citing works

Hypoxia and inflammation

Eltzschig, H. K., & Carmeliet, P. (2011) · New England Journal of Medicine · doi:10.1056/nejmra0910283 · Cited by 2,061 · see citing works

Microenvironmental regulation of tumour angiogenesis

De Palma, M., Biziato, D., & Petrova, T. V. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.51 · Cited by 1,847 · cited 1× · see citing works

Neutrophils in cancer: Neutral no more

Coffelt, S. B., Wellenstein, M. D., & de Visser, K. E. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.52 · Cited by 1,830 · see citing works

HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

Keith, B., Johnson, R. S., & Simon, M. C. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3183 · Cited by 1,693 · see citing works

Endothelial Cell Migration During Angiogenesis

Lamalice, L., Bœuf, F. L., & Huot, J. (2007) · Circulation Research · doi:10.1161/01.res.0000259593.07661.1e · Cited by 1,486 · see citing works

Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system

Augustin, H. G., Koh, G. Y., Thurston, G., & Alitalo, K. K. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2639 · Cited by 1,460 · see citing works

The integrins

Takada, Y., Ye, X., & Simon, S. I. (2007) · Genome biology · doi:10.1186/gb-2007-8-5-215 · Cited by 1,204 · see citing works

Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1

Manalo, D. J., Rowan, A., Lavoie, T., Natarajan, L., Kelly, B. D., Ye, S. Q., Garcia, J. G. N., & Semenza, G. L. (2005) · Blood · doi:10.1182/blood-2004-07-2958 · Cited by 1,154 · see citing works

Vascular Extracellular Matrix and Arterial Mechanics

Wagenseil, J. E., & Mecham, R. P. (2009) · Physiological Reviews · doi:10.1152/physrev.00041.2008 · Cited by 1,061 · see citing works

The hypoxic tumour microenvironment

Petrova, V., Annicchiarico‐Petruzzelli, M., Melino, G., & Amelio, I. (2018) · Oncogenesis · doi:10.1038/s41389-017-0011-9 · Cited by 1,035 · see citing works

Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation

Tammela, T., Zarkada, G., Wallgard, E., Murtomäki, A., Suchting, S., Wirzenius, M., Waltari, M., Hellström, M., Schomber, T., Peltonen, R., et al. (2008) · Nature · doi:10.1038/nature07083 · Cited by 814 · see citing works

Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

Mazzone, M., Dettori, D., de Oliveira, R. L., Loges, S., Schmidt, T., Jonckx, B., Tian, Y.-M., Lanahan, A. A., Pollard, P. J., de Almodóvar, C. R., et al. (2009) · Cell · doi:10.1016/j.cell.2009.01.020 · Cited by 812 · see citing works

Differential Transcriptional Regulation of the Two Vascular Endothelial Growth Factor Receptor Genes

Gerber, H.-P., Condorelli, F., Park, J., & Ferrara, N. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.38.23659 · Cited by 794 · see citing works

2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF

Mabjeesh, N. J., Escuin, D., LaVallee, T. M., Pribluda, V. S., Swartz, G. M., Johnson, M. S., Willard, M. T., Zhong, H., Simons, J. W., & Giannakakou, P. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00077-1 · Cited by 730 · see citing works

A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter.

Melillo, G., Musso, T., Sica, A., Taylor, L. S., Cox, G. W., & Varesio, L. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.182.6.1683 · Cited by 626 · see citing works

Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1

Kelly, B. D., Hackett, S. F., Hirota, K., Oshima, Y., Cai, Z., Berg-Dixon, S., Rowan, A., Yan, Z., Campochiaro, P. A., & Semenza, G. L. (2003) · Circulation Research · doi:10.1161/01.res.0000102937.50486.1b · Cited by 611 · see citing works

Impeding macrophage entry into hypoxic tumor areas by Sema3A/Nrp1 signaling blockade inhibits angiogenesis and restores antitumor immunity.

Casazza, A., Laoui, D., Wenes, M., Rizzolio, S., Bassani, N., Mambretti, M., Deschoemaeker, S., Ginderachter, J. V. V., Tamagnone, L., & Mazzone, M. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.11.007 · Cited by 601 · see citing works

Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo

Rankin, E. B., Biju, M. P., Liu, Q., Unger, T. L., Rha, J., Johnson, R. S., Simon, M. C., Keith, B., & Haase, V. H. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30117 · Cited by 596 · see citing works

HIF ‐1 at the crossroads of hypoxia, inflammation, and cancer

Balamurugan, K. (2015) · International Journal of Cancer · doi:10.1002/ijc.29519 · Cited by 572 · see citing works

Loss of HIF-1α in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis

Tang, N., Wang, L., Esko, J. D., Giordano, F. J., Huang, Y., Gerber, H., Ferrara, N., & Johnson, R. S. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.09.026 · Cited by 540 · see citing works

A Lactate-Induced Response to Hypoxia

Lee, D. C., Sohn, H. A., Park, Z., Oh, S. H., Kang, Y. K., Lee, K.-M., Kang, M., Jang, Y. J., Yang, S., Hong, Y. K., et al. (2015) · Cell · doi:10.1016/j.cell.2015.03.011 · Cited by 523 · see citing works

HIF-1-induced erythropoietin in the hypoxic retina protects against light-induced retinal degeneration

Grimm, C., Wenzel, A., Groszer, M., Mayser, H., Seeliger, M. W., Samardzija, M., Bauer, C., Gassmann, M., & Remé, C. E. (2002) · Nature Medicine · doi:10.1038/nm723 · Cited by 517 · see citing works

Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity.

Kong, D., Park, E. J., Stephen, A. G., Calvani, M., Cardellina, J. H., Monks, A., Fisher, R. J., Shoemaker, R. H., & Melillo, G. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1235 · Cited by 508 · see citing works

Targeting the HIF2–VEGF axis in renal cell carcinoma

Choueiri, T. K., & Kaelin, W. G. (2020) · Nature Medicine · doi:10.1038/s41591-020-1093-z · Cited by 477 · see citing works

An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia

Benita, Y., Kikuchi, H., Smith, A. D., Zhang, M. Q., Chung, D. C., & Xavier, R. J. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp425 · Cited by 469 · see citing works

Comparison of VEGF, VEGF-B, VEGF-C and Ang-1 mRNA regulation by serum, growth factors, oncoproteins and hypoxia

Enholm, B., Paavonen, K., Ristimäki, A., Kumar, V., Gunji, Y., Klefström, J. T., Kivinen, L., Laiho, M., Olofsson, B., Joukov, V., et al. (1997) · Oncogene · doi:10.1038/sj.onc.1201090 · Cited by 456 · see citing works

Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases

Koivunen, P., Hirsilä, M., Günzler, V., Kivirikko, K. I., & Myllyharju, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312254200 · Cited by 447 · see citing works

Vascular Endothelial Growth Factor Signaling in Hypoxia and Inflammation

Ramakrishnan, S., Anand, V., & Roy, S. (2014) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-014-9531-7 · Cited by 445 · see citing works

Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell–cell and cell–matrix contacts

Saharinen, P., Eklund, L., Miettinen, J., Wirkkala, R., Anisimov, A., Winderlich, M., Nottebaum, A., Vestweber, D., Deutsch, U., Koh, G. Y., et al. (2008) · Nature Cell Biology · doi:10.1038/ncb1715 · Cited by 415 · see citing works

Hypoxia-inducible factor–dependent induction of netrin-1 dampens inflammation caused by hypoxia

Rosenberger, P., Schwab, J. M., Mirakaj, V., Masekowsky, E., Mager, A., Morote–Garcia, J. C., Unertl, K. E., & Eltzschig, H. K. (2009) · Nature Immunology · doi:10.1038/ni.1683 · Cited by 406 · see citing works

YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation

Kim, J., Kim, Y. H., Kim, J., Park, D. Y., Bae, H., Lee, D. H., Kim, K. H., Hong, S. P., Jang, S. P., Kubota, Y., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci93825 · Cited by 402 · see citing works

Mechanisms of Vessel Branching

Smet, F. D., Segura, I., Bock, K. D., Hohensinner, P. J., & Carmeliet, P. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.185165 · Cited by 398 · see citing works

Hypoxia-Inducible Factors as Essential Regulators of Inflammation

Imtiyaz, H. Z., & Simon, M. C. (2010) · Current Topics in Microbiology and Immunology · doi:10.1007/82_2010_74 · Cited by 379 · see citing works

The Molecular Basis of Vascular Lumen Formation in the Developing Mouse Aorta

Strilić, B., Kučera, T., Eglinger, J., Hughes, M. R., McNagny, K. M., Tsukita, S., Dejana, E., Ferrara, N., & Lammert, E. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.08.011 · Cited by 374 · see citing works

Cellular and Molecular Mechanisms of Vascular Lumen Formation

Iruela‐Arispe, M. L., & Davis, G. E. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.01.013 · Cited by 373 · see citing works

AngiogenesisPreprint

Senger, D. R., & Davis, G. E. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005090 · Cited by 351 · see citing works

The Complex Role of Neutrophils in Tumor Angiogenesis and Metastasis

Liang, W. P., & Ferrara, N. (2016) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-15-0313 · Cited by 347 · see citing works

Transforming Growth Factor β1 Induces Hypoxia-inducible Factor-1 Stabilization through Selective Inhibition of PHD2 Expression

McMahon, S., Charbonneau, M., Grandmont, S., Richard, D. E., & Dubois, C. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604507200 · Cited by 329 · see citing works

Nitric Oxide Induces the Synthesis of Vascular Endothelial Growth Factor by Rat Vascular Smooth Muscle Cells

Dulak, J., Józkowicz, A., Dembinska-Kiec, A., Guevara, I., Zdzienicka, A., Zmudzinska-Grochot, D., Florek, I., Wójtowicz, A. K., Szuba, A., & Cooke, J. P. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.3.659 · Cited by 329 · see citing works

Endoglin Expression Is Regulated by Transcriptional Cooperation between the Hypoxia and Transforming Growth Factor-β Pathways

Sánchez-Elsner, T., Botella, L. M., Velasco, B., Langa, C., & Bernabéu, C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207160200 · Cited by 326 · see citing works

Vasohibin as an endothelium-derived negative feedback regulator of angiogenesis

Watanabe, K., Hasegawa, Y., Yamashita, H., Shimizu, K., Ding, Y., Abé, M., Ohta, H., Imagawa, K., Hojo, K., Maki, H., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200421152 · Cited by 316 · see citing works

HIF Inhibitors: Status of Current Clinical Development

Fallah, J., & Rini, B. I. (2019) · Current Oncology Reports · doi:10.1007/s11912-019-0752-z · Cited by 308 · see citing works

Direct transcriptional up-regulation of cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes colorectal tumor cell survival and enhances HIF-1 transcriptional activity during hypoxia

Kaidi, A., Qualtrough, D., Williams, A. C., & Paraskeva, C. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0425 · Cited by 300 · see citing works

Cellular signaling by neural cell adhesion molecules of the immunoglobulin superfamily

Crossin, K. L., & Krushel, L. A. (2000) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(200006)218:2 · Cited by 283 · see citing works

Endothelial cell metabolism in health and disease: impact of hypoxia

Wong, B. W., Marsch, E., Treps, L., Baes, M. I., & Carmeliet, P. (2017) · The EMBO Journal · doi:10.15252/embj.201696150 · Cited by 277 · see citing works

The EGLN-HIF O 2 -Sensing System: Multiple Inputs and Feedbacks

Ivan, M., & Kaelin, W. G. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.06.002 · Cited by 273 · see citing works

Cooperative Interaction of Hypoxia-inducible Factor-2α (HIF-2α) and Ets-1 in the Transcriptional Activation of Vascular Endothelial Growth Factor Receptor-2 (Flk-1)

Elvert, G., Kappel, A., Heidenreich, R., Englmeier, U., Lanz, S., Acker, T., Rauter, M., Plate, K. H., Sieweke, M. H., Breier, G., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211298200 · Cited by 272 · see citing works

Mast cells and tumor angiogenesis

Kessler, D. A., Langer, R., Pless, N. A., & Folkman, J. (1976) · International Journal of Cancer · doi:10.1002/ijc.2910180520 · Cited by 265 · see citing works

Vasohibin as an endothelium-derived negative feedback regulator of angiogenesis

Watanabe, K., Hasegawa, Y., Yamashita, H., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21152 · Cited by 264 · see citing works

Eosinophils and Cancer

Davis, B. P., & Rothenberg, M. E. (2014) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-13-0196 · Cited by 262 · see citing works

Regulation of hypoxia-inducible factor-1α by nitric oxide through mitochondria-dependent and -independent pathways

Mateo, J., García‐Lecea, M., Cadenas, S., HERNÁNDEZ, C., & Moncada, S. (2003) · Biochemical Journal · doi:10.1042/bj20031155 · Cited by 256 · see citing works

Endothelial deletion of hypoxia-inducible factor–2α (HIF-2α) alters vascular function and tumor angiogenesis

Skuli, N., Liu, L., Runge, A., Wang, T., Yuan, L., Patel, S., Iruela‐Arispe, M. L., Simon, M. C., & Keith, B. (2009) · Blood · doi:10.1182/blood-2008-12-193581 · Cited by 256 · see citing works

Global Expression Profiling of Fibroblast Responses to Transforming Growth Factor-β1 Reveals the Induction of Inhibitor of Differentiation-1 and Provides Evidence of Smooth Muscle Cell Phenotypic Switching

Chambers, R. C., Leoni, P., Kaminski, N., Laurent, G. J., & Heller, R. A. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63847-3 · Cited by 255 · see citing works

Neural guidance molecules regulate vascular remodeling and vessel navigationPreprint

Eichmann, A., Mäkinen, T., & Alitalo, K. K. (2005) · Genes & Development · doi:10.1101/gad.1305405 · Cited by 246 · see citing works

Inflammation and Hypoxia: HIF and PHD Isoform Selectivity

Watts, E., & Walmsley, S. R. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.10.006 · Cited by 236 · see citing works

The extracellular matrix and blood vessel formation: not just a scaffold

Rhodes, J., & Simons, M. (2007) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2007.00031.x · Cited by 232 · see citing works

Hypoxia-inducible Factor-1 Deficiency Results in Dysregulated Erythropoiesis Signaling and Iron Homeostasis in Mouse Development

Yoon, D., Pastore, Y. D., Divoký, V., Liu, E., Mlodnicka, A., Rainey, K., Poňka, P., Semenza, G. L., Schumacher, A., & Prchal, J. T. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602329200 · Cited by 230 · see citing works

Hypoxia-Inducible Factors 1α and 2α Regulate Trophoblast Differentiation

Dahl, K. D. C., Fryer, B. H., Mack, F. A., Compernolle, V., Maltepe, E., Adelman, D. M., Carmeliet, P., & Simon, M. C. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.23.10479-10491.2005 · Cited by 228 · see citing works

OS-9 Interacts with Hypoxia-Inducible Factor 1α and Prolyl Hydroxylases to Promote Oxygen-Dependent Degradation of HIF-1α

Baek, J. H., Mahon, P. C., Oh, J. C., Kelly, B., Krishnamachary, B., Pearson, M., Chan, D. A., Giaccia, A. J., & Semenza, G. L. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.01.011 · Cited by 218 · see citing works

Characterisation and trophic functions of murine embryonic macrophages based upon the use of a Csf1r–EGFP transgene reporter

Rae, F., Woods, K. J., Sasmono, R. T., Campanale, N., Taylor, D. F., Ovchinnikov, D. A., Grimmond, S. M., Hume, D. A., Ricardo, S. D., & Little, M. H. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.05.027 · Cited by 214 · see citing works

Branching morphogenesis and antiangiogenesis candidates: tip cells lead the way

Carmeliet, P., Smet, F. D., Loges, S., & Mazzone, M. (2009) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2009.64 · Cited by 213 · see citing works

HIF-1 in the inflammatory microenvironment

Dehne, N., & Brüne, B. (2009) · Experimental Cell Research · doi:10.1016/j.yexcr.2009.03.019 · Cited by 206 · see citing works

Hepatocellular Hypoxia-Induced Vascular Endothelial Growth Factor Expression and Angiogenesis in Experimental Biliary Cirrhosis

Rosmorduc, O., Wendum, D., Corpechot, C., Galy, B., Sebbagh, N., Raleigh, J. A., Housset, C., & Poupon, R. Y. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65209-1 · Cited by 205 · see citing works

The HIF family member EPAS1/HIF-2α is required for normal hematopoiesis in mice

Scortegagna, M., Morris, M. A., Oktay, Y., Bennett, M., & Garcia, J. A. (2003) · Blood · doi:10.1182/blood-2003-02-0448 · Cited by 203 · see citing works

Endothelial HIF-2α regulates murine pathological angiogenesis and revascularization processes

Skuli, N., Majmundar, A. J., Krock, B. L., Mesquita, R. C., Mathew, L. K., Quinn, Z. L., Runge, A., Liu, L., Kim, M. N., Liang, J., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci57322 · Cited by 201 · see citing works

Cellular and molecular mechanisms of inflammation‐induced angiogenesis

Szade, A., Grochot‐Przeczek, A., Florczyk, U., Józkowicz, A., & Dulak, J. (2015) · IUBMB Life · doi:10.1002/iub.1358 · Cited by 199 · see citing works

Notch3 Is Critical for Proper Angiogenesis and Mural Cell Investment

Liu, H., Zhang, W., Kennard, S., Caldwell, R. B., & Lilly, B. (2010) · Circulation Research · doi:10.1161/circresaha.110.218271 · Cited by 188 · see citing works

Lactate Engages Receptor Tyrosine Kinases Axl, Tie2, and Vascular Endothelial Growth Factor Receptor 2 to Activate Phosphoinositide 3-Kinase/Akt and Promote Angiogenesis

Ruan, G.-X., & Kazlauskas, A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.474619 · Cited by 182 · see citing works

FGF-dependent regulation of VEGF receptor 2 expression in mice

Murakami, M., Nguyen, L. T., Hatanaka, K., Schachterle, W., Chen, P., Zhuang, Z. W., Black, B. L., & Simons, M. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44762 · Cited by 182 · see citing works

The Role of Wnt Signalling in Angiogenesis.

Olsen, J. J., Pohl, S., Deshmukh, A. P., Visweswaran, M., Ward, N. C., Arfuso, F., Agostino, M., & Dharmarajan, A. (2017) · Europe PMC (PubMed Central) · Cited by 170 · see citing works

Wnt/Frizzled signaling in angiogenesis

Zerlin, M., Julius, M. A., & Kitajewski, J. (2008) · Angiogenesis · doi:10.1007/s10456-008-9095-3 · Cited by 168 · see citing works

Endothelial Cell HIF-1α and HIF-2α Differentially Regulate Metastatic Success

Branco-Price, C., Zhang, N., Schnelle, M., Evans, C., Katschinski, D. M., Liao, D., Ellies, L., & Johnson, R. S. (2012) · Cancer Cell · doi:10.1016/j.ccr.2011.11.017 · Cited by 168 · see citing works

Differential but complementary HIF1α and HIF2α transcriptional regulation

Downes, N. L., Laham-Karam, N., Kaikkonen, M. U., & Ylä-Herttuala, S. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.05.004 · Cited by 166 · see citing works

B Cells Promote Tumor Progression via STAT3 Regulated-Angiogenesis

Yang, C., Lee, H., Pal, S. K., Jové, V., Deng, J., Zhang, W., Hoon, D. S. �., Wakabayashi, M. T., Forman, S. J., & Yu, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064159 · Cited by 165 · see citing works

Hypoxia stimulates hepatocyte epithelial to mesenchymal transition by hypoxia-inducible factor and transforming growth factor-β-dependent mechanisms

Copple, B. L. (2010) · Liver International · doi:10.1111/j.1478-3231.2010.02205.x · Cited by 164 · see citing works

PDGF Promotes the Warburg Effect in Pulmonary Arterial Smooth Muscle Cells via Activation of the PI3K/AKT/mTOR/HIF-1α Signaling Pathway

Xiao, Y., Peng, H., Hong, C., Chen, Z., Deng, X., Wang, A., Yang, F., Yang, L., Chen, C., & Qin, X. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479401 · Cited by 164 · see citing works

Genetic augmentation of nitric oxide synthase increases the vascular generation of VEGF

Józkowicz, A. (2001) · Cardiovascular Research · doi:10.1016/s0008-6363(01)00344-3 · Cited by 152 · see citing works

Distinctive localization and opposed roles of vasohibin-1 and vasohibin-2 in the regulation of angiogenesis

Kimura, H., Miyashita, H., Suzuki, Y., Kobayashi, M., Watanabe, K., Sonoda, H., Ohta, H., Fujiwara, T., Shimosegawa, T., & Sato, Y. (2009) · Blood · doi:10.1182/blood-2008-07-170316 · Cited by 149 · see citing works

Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice

Rankin, E. B., Rha, J., Unger, T. L., Wu, C., Shutt, H. P., Johnson, R. S., Simon, M. C., Keith, B., & Haase, V. H. (2008) · Oncogene · doi:10.1038/onc.2008.160 · Cited by 145 · see citing works

Eph Receptor Tyrosine Kinases in Angiogenesis: From Development to Disease

Brantley‐Sieders, D. M., & Chen, J. (2004) · Angiogenesis · doi:10.1023/b:agen.0000037340.33788.87 · Cited by 145 · see citing works

Vascular endothelial growth factor acts as a pericyte mitogen under hypoxic conditions.

Yamagishi, S., Yonekura, H., Yamamoto, Y., Fujimori, H., Sakurai, S., Tanaka, N., & Yamamoto, H. (1999) · PubMed · Cited by 143 · see citing works

Salinomycin: A Novel Anti-Cancer Agent with Known Anti-Coccidial Activities

Zhou, S. Y., Wang, F., Wong, E. T., Fonkem, E., Hsieh, T., WU, J. M., & Wu, E. (2013) · Current Medicinal Chemistry · doi:10.2174/15672050113109990199 · Cited by 140 · see citing works

The hypoxia‐inducible miR‐429 regulates hypoxia‐inducible factor‐1α expression in human endothelial cells through a negative feedback loop

Bartoszewska, S., Rochan, K., Piotrowski, A., Kamysz, W., Ochocka, J. R., Collawn, J. F., & Bartoszewski, R. (2014) · The FASEB Journal · doi:10.1096/fj.14-267054 · Cited by 139 · see citing works

Hypoxia up‐regulates expression of Eph receptors and ephrins in mouse skin

Vihanto, M. M., Plock, J. A., Erni, D., Frey, B. M., Frey, F. J., & Huynh‐Do, U. (2005) · The FASEB Journal · doi:10.1096/fj.04-3647fje · Cited by 134 · see citing works

Hypoxia Selectively Disrupts Brain Microvascular Endothelial Tight Junction Complexes Through a Hypoxia‐Inducible Factor‐1 (HIF‐1) Dependent Mechanism

Engelhardt, S., Al-Ahmad, A. J., Gassmann, M., & Ogunshola, O. O. (2013) · Journal of Cellular Physiology · doi:10.1002/jcp.24544 · Cited by 131 · see citing works

Evidence that hypoxia-inducible factor-1 (HIF-1) mediates transcriptional activation of interleukin-1β (IL-1β) in astrocyte cultures

Zhang, W., Petrovic, J.-M., Callaghan, D., Jones, A., Cui, H., Howlett, C., & Stanimirovic, D. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.01.014 · Cited by 125 · see citing works

The new tumor-suppressor gene inhibitor of growth family member 4 (ING4) regulates the production of proangiogenic molecules by myeloma cells and suppresses hypoxia-inducible factor-1 α (HIF-1α) activity: involvement in myeloma-induced angiogenesis

Colla, S., Tagliaferri, S., Morandi, F., Lunghi, P., Donofrío, G., Martorana, D., Mancini, C., Lazzaretti, M., Mazzera, L., Ravanetti, L., et al. (2007) · Blood · doi:10.1182/blood-2007-02-074617 · Cited by 123 · see citing works

Reduction of Hypoxia-Induced Transcription through the Repression of Hypoxia-Inducible Factor-1α/Aryl Hydrocarbon Receptor Nuclear Translocator DNA Binding by the 90-kDa Heat-Shock Protein Inhibitor Radicicol

Hur, E., Kim, H.-H., Choi, S. M., Kim, J. H., Yim, S., Kwon, H. J., Choi, Y., Kim, D. K., Lee, M.-O., & Park, H. (2002) · Molecular Pharmacology · doi:10.1124/mol.62.5.975 · Cited by 120 · see citing works

Notch-1 Signaling Regulates Microglia Activation via NF-κB Pathway after Hypoxic Exposure In Vivo and In Vitro

Yao, L., Kan, E. M., Kaur, C., Dheen, S. T., Hao, A., Lu, J., & Ling, E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078439 · Cited by 116 · see citing works

Hypoxia-driven angiogenesis: role of tip cells and extracellular matrix scaffolding

Germain, S., Monnot, C., Muller, L., & Eichmann, A. (2010) · Current Opinion in Hematology · doi:10.1097/moh.0b013e32833865b9 · Cited by 114 · see citing works

HIF-Dependent Hematopoietic Factors Regulate the Development of the Embryonic Vasculature

Ramírez‐Bergeron, D. L., Runge, A., Adelman, D. M., Gohil, M., & Simon, M. C. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.04.018 · Cited by 113 · see citing works

Loss of Cited2 affects trophoblast formation and vascularization of the mouse placenta

Withington, S. L., Scott, A., Saunders, D. N., Floro, K. L., Preis, J. I., Michalicek, J., Maclean, K., Sparrow, D. B., Martı́nez-Barberá, J. P., & Dunwoodie, S. L. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.02.025 · Cited by 112 · see citing works

Erythrocytosis: the HIF pathway in control

Franke, K., Gassmann, M., & Wielockx, B. (2013) · Blood · doi:10.1182/blood-2013-01-478065 · Cited by 112 · see citing works

Hypoxia-Inducible Factor-1α Obstructs a Wnt Signaling Pathway by Inhibiting the hARD1-Mediated Activation of β-Catenin

Lim, J.-H., Chun, Y., & Park, J. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6234 · Cited by 112 · see citing works

Hypoxia Induces Netrin-1 and Unc5b in Atherosclerotic Plaques

Ramkhelawon, B., Yang, Y., van Gils, J. M., Hewing, B., Rayner, K. J., Parathath, S., Guo, L., Oldebeken, S. R., Feig, J. L., Fisher, E. A. A., et al. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.301008 · Cited by 109 · see citing works

Targeting VEGF pathway to normalize the vasculature: an emerging insight in cancer therapy

Wu, J., Tang, Y., & Liang, X. (2018) · OncoTargets and Therapy · doi:10.2147/ott.s172042 · Cited by 107 · see citing works

Hif-1α regulates macrophage-endothelial interactions during blood vessel development in zebrafish

Gerri, C., Marín‐Juez, R., Marass, M., Marks, A., Maischein, H., & Stainier, D. Y. R. (2017) · Nature Communications · doi:10.1038/ncomms15492 · Cited by 101 · see citing works

AKAP12 Regulates Human Blood–Retinal Barrier Formation by Downregulation of Hypoxia-Inducible Factor-1α

Choi, Y. K., Kim, J. H., Kim, W. J., Lee, H., Park, J. A., Lee, S., Yoon, D.-K., Kim, H. H., Chung, H., Yu, Y. S., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.5368-06.2007 · Cited by 99 · see citing works

The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity

Foxler, D. E., Bridge, K. S., James, V. H., Webb, T. M., Mee, M., Wong, S. C. K., Feng, Y., Constantin‐Teodosiu, D., Petursdottir, T. E., Björnsson, J., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2424 · Cited by 98 · see citing works

AT-533, a novel Hsp90 inhibitor, inhibits breast cancer growth and HIF-1α/VEGF/VEGFR-2-mediated angiogenesis in vitro and in vivo

Zhang, P., Liu, X., Li, M., Ma, Y., Sun, H., Tian, X., Wang, Y., Liu, M., Fu, L.-S., Wang, Y., et al. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.113771 · Cited by 97 · see citing works

Hypoxia and vascular endothelial growth factor acutely up-regulate angiopoietin-1 and Tie2 mRNA in bovine retinal pericytes

Park, Y. S., Kim, N. H., & Jo, I. (2003) · Microvascular Research · doi:10.1016/s0026-2862(02)00035-3 · Cited by 94 · see citing works

Hypoxia Inducible Factor 1-α Regulates of Platelet Derived Growth Factor-B in Human Glioblastoma Cells

Yoshida, D., Kim, K., Noha, M., & Teramoto, A. (2005) · Journal of Neuro-Oncology · doi:10.1007/s11060-005-3279-0 · Cited by 94 · see citing works

The novel hypoxia-inducible factor-1α inhibitor IDF-11774 regulates cancer metabolism, thereby suppressing tumor growth

Ban, H. S., Kim, B., Lee, H., Kim, H. M., Harmalkar, D. S., Nam, M., Park, S., Lee, K., Park, J.-T., Kim, I., et al. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.235 · Cited by 94 · see citing works

Hypoxia Enhances Proliferation of Human Adipose-Derived Stem Cells via HIF-1ɑ Activation

Kakudo, N., Morimoto, N., Ogawa, T., Taketani, S., & Kusumoto, K. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139890 · Cited by 93 · see citing works

HIF-1α- Targeting Acriflavine Provides Long Term Survival and Radiological Tumor Response in Brain Cancer Therapy

Mangraviti, A., Raghavan, T., Volpin, F., Skuli, N., Gullotti, D. M., Zhou, J., Asnaghi, L., Sankey, E. W., Liu, A., Wang, Y., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-14990-w · Cited by 93 · see citing works

Hypoxia. Regulation of NFκB signalling during inflammation: the role of hydroxylases

Oliver, K. M., Taylor, C. T., & Cummins, E. P. (2009) · Arthritis Research & Therapy · doi:10.1186/ar2575 · Cited by 91 · see citing works

Morphological and molecular aspects of physiological vascular morphogenesis

Ribatti, D., Nico, B., & Enrico Crivellato, B. (2009) · Angiogenesis · doi:10.1007/s10456-008-9125-1 · Cited by 89 · see citing works

FGF2 Translationally Induced by Hypoxia Is Involved in Negative and Positive Feedback Loops with HIF-1α

Conte, C., Riant, É., Toutain, C. E., Pujol, F., Arnal, J., Lenfant, F., & Prats, A. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003078 · Cited by 89 · see citing works

Hypoxia-Induced Alternative Splicing in Endothelial Cells

Weigand, J. E., Boeckel, J., Gellert, P., & Dimmeler, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042697 · Cited by 88 · see citing works

Macrophages and angiogenesis: a role for Wnt signaling

Newman, A. C., & Hughes, C. C. (2012) · Vascular Cell · doi:10.1186/2045-824x-4-13 · Cited by 87 · see citing works

A prospective phase II study of 2-methoxyestradiol administered in combination with bevacizumab in patients with metastatic carcinoid tumors

Kulke, M. H., Chan, J. A., Meyerhardt, J. A., Zhu, A. X., Abrams, T. A., Blaszkowsky, L. S., Regan, E. M., Sidor, C. F., & Fuchs, C. S. (2010) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-010-1478-7 · Cited by 86 · see citing works

Hemangioblast Commitment in the Avian Allantois: Cellular and Molecular Aspects

Caprioli, A., Minkó, K., Drevon, C., Eichmann, A., Dieterlen‐Lièvre, F., & Jaffredo, T. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0362 · Cited by 86 · see citing works

Hypoxia Pathway Proteins are Master Regulators of Erythropoiesis

Watts, D., Gaete, D., Rodriguez, D., Hoogewijs, D., Rauner, M., Sormendi, S., & Wielockx, B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218131 · Cited by 86 · see citing works

Tumor Hypoxia Blocks Wnt Processing and Secretion through the Induction of Endoplasmic Reticulum Stress

Verras, M., Papandreou, I., Lim, A. L., & Denko, N. C. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00947-08 · Cited by 84 · see citing works

Hypoxia activates the notch signaling pathway in cells of the intervertebral disc: Implications in degenerative disc disease

Hiyama, A., Skubutyte, R., Markova, D., Anderson, D. G., Yadla, S., Sakai, D., Mochida, J., Albert, T. J., Shapiro, I. M., & Risbud, M. V. (2011) · Arthritis & Rheumatism · doi:10.1002/art.30246 · Cited by 83 · see citing works

Pericytes on the Tumor Vasculature: Jekyll or Hyde?

Barlow, K. D., Sanders, A. M., Söker, S., Ergün, S., & Metheny‐Barlow, L. J. (2012) · Cancer Microenvironment · doi:10.1007/s12307-012-0102-2 · Cited by 83 · see citing works

HIF1α is a regulator of hematopoietic progenitor and stem cell development in hypoxic sites of the mouse embryo

Imanirad, P., Kartalaei, P. S., Crisan, M., Vink, C. S., Yamada-Inagawa, T., de Pater, E., Kurek, D., Kaimakis, P., van der Linden, R., Speck, N. A., et al. (2013) · Stem Cell Research · doi:10.1016/j.scr.2013.09.006 · Cited by 83 · see citing works

Activation of the Wnt/Planar Cell Polarity Pathway Is Required for Pericyte Recruitment during Pulmonary Angiogenesis

Yuan, K., Orcholski, M. E., Panaroni, C., Shuffle, E. M., Huang, N. F., Jiang, X., Tian, W., Vladar, E. K., Wang, L., Nicolls, M. R., et al. (2014) · American Journal Of Pathology · doi:10.1016/j.ajpath.2014.09.013 · Cited by 82 · see citing works

Hypoxia stimulates neural stem cell proliferation by increasing HIF"‘1α expression and activating Wnt/β-catenin signaling

Qi, C.-Y., Zhang, J., Chen, X., Wan, J., Wang, J., Zhang, P., & Liu, Y. (2017) · Cellular and Molecular Biology · doi:10.14715/cmb/2017.63.7.2 · Cited by 81 · see citing works

Hypoxia-inducible Factor-1-mediated Regulation of Semaphorin 4D Affects Tumor Growth and Vascularity

Sun, Q., Zhou, H., Binmadi, N. O., & Basile, J. R. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.057166 · Cited by 80 · see citing works

Early effects of hypoxia/reoxygenation on VEGF, Ang-1, Ang-2 and their receptors in the rat myocardium: Implications for myocardial angiogenesis

Ray, P. S., Estrada-Hernandez, T., Sasaki, H., Zhu, L., & Maulik, N. (2000) · Molecular and Cellular Biochemistry · doi:10.1023/a:1007180518474 · Cited by 71 · see citing works

Chronic hypoxia induces the activation of the Wnt/β-catenin signaling pathway and stimulates hippocampal neurogenesis in wild-type and APPswe-PS1ΔE9 transgenic mice in vivo

Varela-Nallar, L., Rojas-Ábalos, M., Abbott, A. C., Moya, E., Iturriaga, R., & Inestrosa, N. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00017 · Cited by 71 · see citing works

From Vessel Sprouting to Normalization

Coulon, C., Γεωργιάδου, Μ., Roncal, C., Bock, K. D., Langenberg, T., & Carmeliet, P. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.214106 · Cited by 70 · see citing works

PHD2: from hypoxia regulation to disease progression

Wielockx, B., & Meneses, A. (2016) · Hypoxia · doi:10.2147/hp.s53576 · Cited by 70 · see citing works

Salinomycin inhibits breast cancer progression via targeting HIF-1α/VEGF mediated tumor angiogenesis in vitro and in vivo

Dewangan, J., Srivastava, S., Mishra, S., Divakar, A., Kumar, S., & Rath, S. K. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.04.026 · Cited by 67 · see citing works

mAKAP Compartmentalizes Oxygen-Dependent Control of HIF-1α

Wong, W., Goehring, A. S., Kapiloff, M. S., Langeberg, L. K., & Scott, J. D. (2008) · Science Signaling · doi:10.1126/scisignal.2000026 · Cited by 63 · see citing works

Strengthening tight junctions of retinal microvascular endothelial cells by pericytes under normoxia and hypoxia involving angiopoietin-1 signal way

Wang, Y. L., Hui, Y.-N., Guo, B., & Ma, J. X. (2007) · Eye · doi:10.1038/sj.eye.6702716 · Cited by 61 · see citing works

Regulation of TGF-β ligand and receptor expression in neonatal rat lungs exposed to chronic hypoxia

Vicencio, A. G., Eickelberg, O., Stankewich, M. C., Kashgarian, M. J., & Haddad, G. G. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00031.2002 · Cited by 59 · see citing works

Prolyl Hydroxylase Domain Protein 2 (PHD2) Binds a Pro-Xaa-Leu-Glu Motif, Linking It to the Heat Shock Protein 90 Pathway

Song, D., Li, L.-S., Heaton-Johnson, K. J., Arsenault, P. R., Master, S. R., & Lee, F. S. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.440552 · Cited by 58 · see citing works

Hypoxia induces tumor and endothelial cell migration in a Semaphorin 3F- and VEGF-dependent manner via transcriptional repression of their common receptor Neuropilin 2

Coma, S., Shimizu, A., & Klagsbrun, M. (2011) · Cell Adhesion & Migration · doi:10.4161/cam.5.3.16294 · Cited by 57 · see citing works

iNOS Expression Inhibits Hypoxia-Inducible Factor-1 Activity

Yin, J., Yang, D., Ku, G., & Hsu, C. Y. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3896 · Cited by 57 · see citing works

Hypoxia and HIFs in regulating the development of the hematopoietic system

Imanirad, P., & Dzierzak, E. A. (2013) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2013.08.005 · Cited by 54 · see citing works

Signaling in and out: long-noncoding RNAs in tumor hypoxia

Kuo, T.-C., Kung, H.-J., & Shih, J.-W. (2020) · Journal of Biomedical Science · doi:10.1186/s12929-020-00654-x · Cited by 53 · see citing works

Human Placental Expression of SLIT/ROBO Signaling Cues: Effects of Preeclampsia and Hypoxia1

Liao, W.-X., Laurent, L. C., Agent, S., Hodges, J. K., & Chen, D. (2012) · Biology of Reproduction · doi:10.1095/biolreprod.110.088138 · Cited by 52 · see citing works

Identification of HIF-2α-regulated genes that play a role in human microvascular endothelial sprouting during prolonged hypoxia in vitro

Nauta, T. D., van den Broek, M., Gibbs, S., Kraan, T. C. T. M. V. D. P., Oudejans, C. B. M., van Hinsbergh, V. W. M., & Koolwijk, P. (2016) · Angiogenesis · doi:10.1007/s10456-016-9527-4 · Cited by 51 · see citing works

Endothelial cells are activated during hypoxia via endoglin/ALK-1/SMAD1/5 signaling in vivo and in vitro

Tian, F., Zhou, A., Smits, A. M., Larsson, E., Goumans, M., Heldin, C., Borén, J., & Akyürek, L. M. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.12.170 · Cited by 50 · see citing works

Vasculogenic Mimicry of HT1080 Tumour Cells In Vivo: Critical Role of HIF-1α-Neuropilin-1 Axis

Misra, R. M., Bajaj, M. S., & Kale, V. P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050153 · Cited by 48 · see citing works

RUNX3 inhibits hypoxia-inducible factor-1α protein stability by interacting with prolyl hydroxylases in gastric cancer cells

Lee, S. H., Bae, S., Kim, K. W., & Lee, Y. M. (2013) · Oncogene · doi:10.1038/onc.2013.76 · Cited by 45 · see citing works

Hypoxia Pathway Proteins in Normal and Malignant Hematopoiesis

Wielockx, B., Grinenko, T., Mirtschink, P., & Chavakis, T. (2019) · Cells · doi:10.3390/cells8020155 · Cited by 45 · see citing works

Nitric oxide: Its identity and role in blood pressure control

Das, S., & Kumar, K. N. (1995) · Life Sciences · doi:10.1016/0024-3205(95)02130-b · Cited by 43 · see citing works

Attenuation of TGFBR2 expression and tumour progression in prostate cancer involve diverse hypoxia-regulated pathways

Zhou, H., Wu, G., Ma, X., Xiao, J., Gan, Y., Yang, C., Xu, N. L., Zhang, B., Zhou, J., Ye, Z., et al. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0764-9 · Cited by 43 · see citing works

Bone Morphogenetic Protein Endothelial Cell Precursor–Derived Regulator Regulates Retinal Angiogenesis In Vivo in a Mouse Model of Oxygen-Induced Retinopathy

Moreno–Miralles, I., Ren, R., Moser, M., Hartnett, M. E., & Patterson, C. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.230235 · Cited by 40 · see citing works

Preserved placental oxygenation and development during severe systemic hypoxia

Schäffer, L., Vogel, J., Breymann, C., Gassmann, M., & Marti, H. H. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00237.2005 · Cited by 39 · see citing works

Sema4D expression and secretion are increased by HIF-1α and inhibit osteogenesis in bone metastases of lung cancer

Chen, W., Sun, J. F., Shen, W., Yang, S., Zhang, Y., Hu, X., Qiu, H., Xu, S.-C., & Chu, T. (2019) · Clinical & Experimental Metastasis · doi:10.1007/s10585-018-9951-5 · Cited by 39 · see citing works

Weibel-Palade Bodies Orchestrate Pericytes During Angiogenesis

Cossutta, M., Darche, M., Carpentier, G., Houppe, C., Ponzo, M., Raineri, F., Vallée, B., Gilles, M.-E., Villain, D., Picard, É., et al. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.313021 · Cited by 37 · see citing works

CITED2 controls the hypoxic signaling by snatching p300 from the two distinct activation domains of HIF-1α

Yoon, H., Lim, J.-H., Cho, C., Huang, E. L., & Park, J. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.08.018 · Cited by 35 · see citing works

VEGF-A121a binding to Neuropilins – A concept revisited

Sarabipour, S., & Gabhann, F. M. (2017) · Cell Adhesion & Migration · doi:10.1080/19336918.2017.1372878 · Cited by 34 · see citing works

HIF-Prolyl Hydroxylase Domain Proteins (PHDs) in Cancer—Potential Targets for Anti-Tumor Therapy?

Gaete, D., Rodriguez, D., Watts, D., Sormendi, S., Chavakis, T., & Wielockx, B. (2021) · Cancers · doi:10.3390/cancers13050988 · Cited by 34 · see citing works

Microvascular Endothelial Cells Differ in Basal and Hypoxia-Regulated Expression of Angiogenic Factors and Their Receptors

Tscheudschilsuren, G., Aust, G., Nieber, K., Schilling, N., & Spanel‐Borowski, K. (2002) · Microvascular Research · doi:10.1006/mvre.2001.2346 · Cited by 33 · see citing works

Oxygen Tension Regulates the Maturation of the Blood–Brain Barrier

Song, H. S., Son, M. J., Lee, Y. M., Kim, W. J., Lee, S., Kim, C. W., & Kim, K. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.6205 · Cited by 33 · see citing works

A HIF–LIMD1 negative feedback mechanism mitigates the pro‐tumorigenic effects of hypoxia

Foxler, D. E., Bridge, K. S., Foster, J. G., Grevitt, P., Curry, S., Shah, K., Davidson, K. M., Nagano, A., Gadaleta, E., Rhys, H. I., et al. (2018) · EMBO Molecular Medicine · doi:10.15252/emmm.201708304 · Cited by 33 · see citing works

Factor‐inhibiting HIF‐1 (FIH‐1) is required for human vascular endothelial cell survival

Kiriakidis, S., Henze, A., Kruszynska‐Ziaja, I., Skobridis, K., Theodorou, V., Paleolog, E. M., & Mazzone, M. (2015) · The FASEB Journal · doi:10.1096/fj.14-252379 · Cited by 31 · see citing works

Genome-wide analysis revealsNRP1as a direct HIF1α-E2F7 target in the regulation of motorneuron guidancein vivo

de Bruin, A., Cornelissen, P. W. A., Kirchmaier, B. C., Mokrý, M., Iich, E., Nirmala, E., Liang, K.-H., Végh, A. M. D., Scholman, K. T., Koerkamp, M. J. A. G., et al. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1471 · Cited by 31 · see citing works

SN-38 Acts as a Radiosensitizer for Colorectal Cancer by Inhibiting the Radiation-induced Up-regulation of HIF-1α

OKUNO, T., Kawai, K., Hata, K., Murono, K., Emoto, S., Kaneko, M., Sasaki, K., Nishikawa, T., Tanaka, T., & Nozawa, H. (2018) · Anticancer Research · doi:10.21873/anticanres.12598 · Cited by 30 · see citing works

PHD2: from hypoxia regulation to disease progression

Meneses, A., & Wielockx, B. (2016) · Dove Medical Press (Taylor and Francis Group) · Cited by 27 · see citing works

Sp1 mediate hypoxia induced ephrinB2 expression via a hypoxia-inducible factor independent mechanism

Sohl, M., Lanner, F., & Farnebo, F. A. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.10.146 · Cited by 25 · see citing works

Hypoxia impairs agonist-induced integrin αIIbβ3 activation and platelet aggregation

Kiouptsi, K., Gambaryan, S. P., Walter, E., Walter, U., Jurk, K., & Reinhardt, C. (2017) · Scientific Reports · doi:10.1038/s41598-017-07988-x · Cited by 25 · see citing works

HIF2α is a direct regulator of neutrophil motility

Sormendi, S., Deygas, M., Sinha, A. N., Krüger, A., Kourtzelis, I., Lay, G. L., Bernard, M., Sáez, P. J., Gerlach, M., Franke, K., et al. (2021) · Blood · doi:10.1182/blood.2020007505 · Cited by 24 · see citing works

Sema4A Responds to Hypoxia and Is Involved in Breast Cancer Progression

Liu, X., Sun, Y., Tian, W., Wang, F., Lv, X., Wang, M., Sun, T., Zhang, J., Wang, L., & Han, M. (2018) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b18-00423 · Cited by 22 · see citing works

Phospholipase D1 protein coordinates dynamic assembly of HIF-1α-PHD-VHL to regulate HIF-1α stability

Park, M. H., Choi, K., Jung, Y., & Min, D. S. (2014) · Oncotarget · doi:10.18632/oncotarget.2613 · Cited by 21 · see citing works

Hypoxia/Notch signaling in primary culture of rat lymphatic endothelial cells

Ota, H., Katsube, K., Ogawa, J., & Yanagishita, M. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.10.009 · Cited by 20 · see citing works

Hematopoietic hypoxia‐inducible factor 2α deficiency ameliorates pathological retinal neovascularization via modulation of endothelial cell apoptosis

Korovina, I., Neuwirth, A., Sprott, D., Weber, S., Pasha, S. P. B. S., Gercken, B., Breier, G., El‐Armouche, A., Deußen, A., Karl, M., et al. (2018) · The FASEB Journal · doi:10.1096/fj.201800430r · Cited by 17 · see citing works

Vasohibin induces prolyl hydroxylase‐mediated degradation of hypoxia‐inducible factor‐1α in human umbilical vein endothelial cells

Kozako, T., Matsumoto, N., Kuramoto, Y., Sakata, A., Motonagare, R., Aikawa, A., Imoto, M., Toda, A., Honda, S., Shimeno, H., et al. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.03.007 · Cited by 16 · see citing works

Hypoxia-inducible factors: cancer progression and clinical translation

Wicks, E. E., & Semenza, G. L. (2022) · Journal of Clinical Investigation · doi:10.1172/jci159839 · Cited by 600 · see citing works

Gas Therapy: Generating, Delivery, and Biomedical Applications

Ghaffari‐Bohlouli, P., Jafari, H., Okoro, O. V., Alimoradi, H., Nie, L., Jiang, G., Kakkar, A. K., & Shavandi, A. (2024) · Small Methods · doi:10.1002/smtd.202301349 · Cited by 111 · see citing works

Tumor hypoxia unveiled: insights into microenvironment, detection tools and emerging therapies

Ciepła, J., & Smolarczyk, R. (2024) · Clinical and Experimental Medicine · doi:10.1007/s10238-024-01501-1 · Cited by 79 · see citing works

Cancer-on-chip models for metastasis: importance of the tumor microenvironment

Jouybar, M., de Winde, C. M., Wolf, K., Friedl, P., Mebius, R. E., & den Toonder, J. M. J. (2024) · Trends in Biotechnology · doi:10.1016/j.tibtech.2023.10.001 · Cited by 66 · see citing works

Decoding Tumor Angiogenesis for Therapeutic Advancements: Mechanistic Insights

Kaur, G., & Roy, B. (2024) · Biomedicines · doi:10.3390/biomedicines12040827 · Cited by 53 · see citing works

The Interplay Between Inflammation and Stromal Components in Pancreatic Cancer

Li, Y., Wang, J., Wang, H., Zhang, S., Wei, Y., & Liu, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.850093 · Cited by 39 · see citing works

Hypoxia-associated autophagy flux dysregulation in human cancers

Fu, J., Lin, J., Dai, Z., Lin, B., & Zhang, J. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216823 · Cited by 37 · see citing works

Crosstalk between hypoxia-inducible factor-1α and short-chain fatty acids in inflammatory bowel disease: key clues toward unraveling the mystery

Xiao, J., Guo, X., & Wang, Z. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1385907 · Cited by 29 · see citing works

Challenges and Pitfalls of Research Designs Involving Magnesium-Based Biomaterials: An Overview

Hassan, N., Krieg, T. M., Kopp, A., Bach, A. D., & Kröger, N. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25116242 · Cited by 29 · see citing works

Hypoxia-Mimetic CoCl2 Agent Enhances Pro-Angiogenic Activities in Ovine Amniotic Epithelial Cells-Derived Conditioned Medium

Mattia, M. D., Mauro, A., Monache, S. D., Pulcini, F., Russo, V., Berardinelli, P., Citeroni, M. R., Turriani, M., Peserico, A., & Barboni, B. (2022) · Cells · doi:10.3390/cells11030461 · Cited by 27 · see citing works

L-Arginine and immune modulation: A pharmacological perspective on inflammation and autoimmune disorders

Dimeji, I. Y., Abass, K. S., Audu, N. M., & Adekola, S. A. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177615 · Cited by 23 · see citing works

Endothelial cells signaling and patterning under hypoxia: a mechanistic integrative computational model including the Notch-Dll4 pathway

Oliveira, R. H. D. M., Annex, B. H., & Popel, A. S. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1351753 · Cited by 17 · see citing works

Electrochemical sensor for vascular endothelial growth factor based on self-assembling DNA aptamer structure

Liustrovaitė, V., Ratautaitė, V., Ramanavičienė, A., Plikusienė, I., Malinovskis, U., Erts, D., Sarvutienė, J., & Ramanavičius, A. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.177151 · Cited by 16 · see citing works

The mechanistic immunosuppressive role of the tumour vasculature and potential nanoparticle-mediated therapeutic strategies

Ileiwat, Z. E., Tabish, T. A., Zinovkin, D. A., Yüzügülen, J., Arghiani, N., & Pranjol, M. Z. I. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.976677 · Cited by 14 · see citing works

From Vessels to Neurons—The Role of Hypoxia Pathway Proteins in Embryonic Neurogenesis

Stepien, B. K., & Wielockx, B. (2024) · Cells · doi:10.3390/cells13070621 · Cited by 13 · see citing works

Enhancing neovascularization post-myocardial infarction through injectable hydrogel functionalized with endothelial-derived EVs

Maiullari, F., Milan, M., Chirivì, M., Ceraolo, M. G., Bousselmi, S., Fratini, N., Galbiati, M., Fortunato, O., Costantini, M., Brambilla, F., et al. (2024) · Biofabrication · doi:10.1088/1758-5090/ad6190 · Cited by 13 · see citing works

Endothelial Cell–Derived Let-7c-Induced TLR7 Activation on Smooth Muscle Cell Mediate Vascular Wall Remodeling in Moyamoya Disease

Ma, X., Huang, Y., He, X., Zhang, X., Liu, Y., Yang, Y., Yue, P., Liu, Y., Gan, C., Shu, K., et al. (2022) · Translational Stroke Research · doi:10.1007/s12975-022-01088-3 · Cited by 12 · see citing works

Genomic Variation, Population History, and Long-Term Genetic Adaptation to High Altitudes in Tibetan Partridge (Perdix hodgsoniae)

Palacios, C., Wang, P., Wang, N., Brown, M. A., Capatosto, L., Du, J., Jiang, J., Zhang, Q., Dahal, N., & Lamichhaney, S. (2023) · Molecular Biology and Evolution · doi:10.1093/molbev/msad214 · Cited by 12 · see citing works

HIF2α regulates the synthesis and release of epinephrine in the adrenal medulla

Watts, D., Bechmann, N., Meneses, A., Poutakidou, I. K., Kaden, D., Conrad, C., Krüger, A., Stein, J., El‐Armouche, A., Chavakis, T., et al. (2021) · Journal of Molecular Medicine · doi:10.1007/s00109-021-02121-y · Cited by 12 · see citing works

In vivo real-time monitoring of the development of hypoxia and angiogenesis in cervical cancer

Chen, D., Wang, W., Zhu, Q., Wang, Q., Quan, D., Zeng, Y., Li, K., Zhou, Y., Liu, C., Zhan, W., et al. (2023) · Chemical Engineering Journal · doi:10.1016/j.cej.2023.145498 · Cited by 11 · see citing works

Generating human skeletal myoblast spheroids for vascular myogenic tissue engineering

Minne, M., Terrie, L., Wüst, R., Hasevoets, S., Kerchove, K. V., Nimako, K., Lambrichts, I., Thorrez, L., & Declercq, H. (2024) · Biofabrication · doi:10.1088/1758-5090/ad2fd5 · Cited by 11 · see citing works

Hypoxia-Induced Mitochondrial ROS and Function in Pulmonary Arterial Endothelial Cells

Wang, H., Song, T., Reyes-García, J., & Wang, Y.-X. (2024) · Cells · doi:10.3390/cells13211807 · Cited by 11 · see citing works

Blockage of αvβ3 integrin in 3D culture of triple-negative breast cancer and endothelial cells inhibits migration and discourages endothelial-to-mesenchymal plasticity

Casali, B. C., Baptista, M. P., Pachane, B. C., Cortez, A. A., Altei, W. F., & Selistre-de-Araújo, H. S. (2024) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2024.101686 · Cited by 10 · see citing works

Exploring Metabolic and Immunological Biomarkers for Oral Squamous Cell Carcinoma: Potential Targets for Precision Therapy

Rajneesh, Tiwari, R., Singh, V. K., Kumar, A., Mehrotra, S., Gautam, V., Neville, J. F., Bansal, V., Pathak, R., Singh, A. K., et al. (2025) · Biology · doi:10.3390/biology14091109 · Cited by 9 · see citing works

Harnessing retinal phagocytes to combat pathological neovascularization in ischemic retinopathies?

Ameln, A. K., & Sprott, D. (2022) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-022-02695-7 · Cited by 9 · see citing works

HIF‑1α overexpression improves the efficacy of human induced pluripotent stem cell‑derived cardiomyocytes for cardiac repair following myocardial infarction

Du, J., Wang, T., & Xu, L. (2024) · Molecular Medicine Reports · doi:10.3892/mmr.2024.13405 · Cited by 8 · see citing works

An edoplasmic reticulum-targeted NIR fluorescent probe with a large Stokes shift for hypoxia imaging

Lan, T., Ji, N., Tian, Q., Zhan, Y., & He, W. (2022) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2022.122201 · Cited by 8 · see citing works

Understanding human aging and the fundamental cell signaling link in age-related diseases: the middle-aging hypovascularity hypoxia hypothesis

Phua, T. J. (2023) · Frontiers in Aging · doi:10.3389/fragi.2023.1196648 · Cited by 7 · see citing works

Research Progress in the Construction and Application of In Vitro Vascular Models

He, Z., Cheng, P., Ying, G., & Ou, Z. (2024) · Applied Sciences · doi:10.3390/app14156780 · Cited by 7 · see citing works

Harnessing Macromolecular Chemistry to Design Hydrogel Micro‐ and Macro‐Environments

Soliman, B. G., Longoni, A., Major, G. S., Lindberg, G. C. J., Choi, Y. S., Zhang, Y. S., Woodfield, T. B. F., & Lim, K. S. (2023) · Macromolecular Bioscience · doi:10.1002/mabi.202300457 · Cited by 8 · see citing works

Intertwined regulators: hypoxia pathway proteins, microRNAs, and phosphodiesterases in the control of steroidogenesis

Ariyeloye, S., Kämmerer, S., Klapproth, E., Wielockx, B., & El‐Armouche, A. (2024) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-024-02921-4 · Cited by 7 · see citing works

Minibeam radiation therapy remodels tumor microenvironment and suppresses HIF-1α/VEGFR axis to overcome radioresistance in triple-negative breast cancer

Fang, Z., Zhou, X., Zou, P., Chen, J., Chen, X., Huang, N., Gong, C., Quan, L., Tang, J., Mi, Y., et al. (2025) · npj Precision Oncology · doi:10.1038/s41698-025-01178-z · Cited by 5 · see citing works

Serum angiopoietin-1 concentration does not distinguish patients with ischaemic stroke from those presenting to hospital with ischaemic stroke mimics

Moxon, J. V., Kraeuter, A.-K., Phie, J. K. P., Juliano, S., Anderson, G., Standley, G., Sealey, C., White, R. P., & Golledge, J. (2022) · BMC Cardiovascular Disorders · doi:10.1186/s12872-022-02918-w · Cited by 5 · see citing works

Dynamic equilibrium of cellular plasticity: The origin of diseases

Kwan, E., Flowers, J., & Ming, X. (2023) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2023.1077902 · Cited by 5 · see citing works

Hsa-miR-21-5p and Hsa-miR-145-5p Expression: From Normal Tissue to Malignant Changes—Context-Dependent Correlation with Estrogen- and Hypoxia–Vascularization-Related Pathways Genes: A Pilot Study

Górecki, M., Żbikowska, A., Tokłowicz, M., Sajdak, S., Englert-Golon, M., & Andrusiewicz, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26094461 · Cited by 5 · see citing works

Hypoxic injury triggers maladaptive repair in human kidney organoidsPreprint

Nunez-Nescolarde, A. B., Liao, Y., Perlaza-Jiménez, L., Piran, M., Cheng, Z., Barlow, C. K., Steele, J. R., Lucas, D. D., Lee, H.-C., Moreau, J. L. M., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.04.558359 · Cited by 5 · see citing works

Recent advancements in oxygen-releasing materials for tissue regenerative medicine and wound healing

Moghanian, A., Hosseini, S. H., Baino, F., Kızılkurtlu, A. A., Safaee, S., Vaseghi, M., Farmani, R., & Miri, A. K. (2025) · Materials Today Communications · doi:10.1016/j.mtcomm.2025.114582 · Cited by 4 · see citing works

Ex Vivo Preconditioning as a Useful Tool for Modification of the Extracellular Matrix of Multipotent Mesenchymal Stromal Cells

Andreeva, E. R., Zhidkova, O., Константиновна, М. Д., Gornostaeva, A. N., Lobanova, M. V., & Buravkova, L. B. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26136301 · Cited by 4 · see citing works

Epicatechin gallate promotes vascularization in co-culture of human osteoblasts and outgrowth endothelial cells

Zhang, L., Wang, M., Qiu, H., Wei, Y., Lu, Z., Nian, N., Shi, Z., Hu, D., & Ma, B. (2023) · Experimental Biology and Medicine · doi:10.1177/15353702231171894 · Cited by 3 · see citing works

The Role of miRNAs in Mechanotransduction Regulation and Cancer Development

Vela-Alcántara, A. M., HernáNdez-SáNchez, D. J., & Tamaríz, E. (2025) · Biocell · doi:10.32604/biocell.2025.066201 · Cited by 3 · see citing works

Medicinal gases for treating central nervous system injuries

Sienel, R. I., & Plesnila, N. (2026) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2026.115782 · Cited by 3 · see citing works

Effects of hypoxia on survival, apoptosis, and the transcriptome of the Chinese yellow pond turtle (Mauremys mutica)

Wei, L., Yu, C., Xiao, S., Liu, K., Lu, Y., Gan, B., Zhu, P., & Zhang, S. (2024) · Gene · doi:10.1016/j.gene.2024.149120 · Cited by 3 · see citing works

Role of Hypoxia-Inducible Factors in Respiratory Syncytial Virus Infection-Associated Lung Disease

Morris, D. R., Qu, Y., de Mello, A. H., Jones‐Hall, Y., Liu, T., Weglarz, M., Ivanciuc, T., Garofalo, R. P., & Casola, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26073182 · Cited by 3 · see citing works

Cetuximab and Paclitaxel Drug Response in Head and Neck Tumor Stem Cells

Serafim, V., Fernandes, G. M. D. M., Tedeschi, B. B. B., Cuzziol, C. I., Castanhole-Nunes, M. M. U., Ferreira, L. A. M., Rodrigues, G. H., de Oliveira-Cucolo, J. G., Pavarino, É. C., & Goloni‐Bertollo, E. M. (2025) · Biomolecules · doi:10.3390/biom15030352 · Cited by 2 · see citing works

Hypoxic stress is an early pathogenic event in human VCP-mutant ALS astrocytes

Franklin, H., Crerar, H., Parnandi, N., Lattke, M., Majewski, S., Clarke, B. E., Pallikonda, H. A., Howell, M., Boulton, S. J., & Patani, R. (2025) · Stem Cell Reports · doi:10.1016/j.stemcr.2025.102723 · Cited by 2 · see citing works

Coixol attenuates osteoclastogenesis and ovariectomy-induced bone loss via the HIF-1α-mediated suppression of NF-κB signaling

Shi, S., Fu, Y.-F., Wu, X., Wang, L. F., Zhang, Z.-Y., Luo, Z. X., Wu, J., Yuan, Z., Nie, H., Zhang, K.-Y., et al. (2026) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2026.178811 · Cited by 2 · see citing works

Hypoxia: A Potent Regulator of Angiogenesis Through Extracellular Matrix Remodelling

Karavasili, K., & Koolwijk, P. (2022) · Biology of extracellular matrix · doi:10.1007/978-3-031-19616-4_8 · Cited by 2 · see citing works

Hypoxic Signal Transduction and Compensatory Mechanisms in the Neurovascular Unit

Ma, X., Zou, Z., & Shi, Q. (2024) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2308149 · Cited by 2 · see citing works

Navigating the Intricacies of Tumor Heterogeneity: An Insight into Potential Prognostic Breast Cancer Biomarkers

Altriche, N., Gallant, S., Augustine, T. N., & Xulu, K. R. (2024) · Biomarker Insights · doi:10.1177/11772719241256798 · Cited by 2 · see citing works

Exploring shared hypoxic pathways in cancer and obstructive sleep apnea: A critical review of extracellular vesicles-non-coding RNA signaling and biological plausibility

Cammarata, G., Pinsino, A., Bue, A. L., Salvaggio, A., Afonso, J., Oliveira, L. V. F., Insalaco, G., & Taverna, S. (2026) · Sleep Medicine · doi:10.1016/j.sleep.2026.108865 · Cited by 1 · see citing works

Discovery of Casdatifan, Part II: A Potent and Orally Bioavailable Inhibitor of Hypoxia Inducible Factor-2α

Mailyan, A. K., Mata, G., Beatty, J. W., Drew, S. L., Fournier, J., Yu, K., Gál, B., Kalisiak, J., Yan, X., Tran, A., et al. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c03724 · Cited by 1 · see citing works

Modelling ischaemic AKI in human kidney organoids reveals injury-associated epithelial states and macrophage-epithelial crosstalk

Nunez-Nescolarde, A. B., Liao, Y., Perlaza-Jiménez, L., Piran, M., Cheng, Z., Barlow, C. K., Steele, J. R., Deveson, D., Moreau, J. L. M., Lee, H.-C., et al. (2026) · Genome Medicine · doi:10.1186/s13073-026-01712-z · Cited by 1 · see citing works

Hypoxia-inducible-factors differentially contribute to clinical disease and viral replication during RSV infectionPreprint

Morris, D. R., Qu, Y., de Mello, A. H., Jones‐Hall, Y., Liu, T., Weglarz, M., Ivanciuc, T., Garofalo, R., & Casola, A. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.15.553422 · Cited by 1 · see citing works

Bhlhe40 limits proliferation and prevents excessive angiogenesis in mouse embryoid bodies under hypoxiaPreprint

Acosta‐Iborra, B., Gil-Acero, A. I., Sanz‐Gómez, M., Berrouayel, Y., Puente-Santamaría, L., Alieva, M., del Peso, L., & Jiménez, B. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.03.597199 · Cited by 1 · see citing works

Hypoxic Vasoreactivity

Gao, Y. (2022) · Springer eBooks · doi:10.1007/978-981-19-7122-8_20

Endoglin regulates the integrity of the bone marrow vasculaturePreprint

Rodriguez, D., Jaykar, M. T., Watts, D., Sinha, A. N., Gaete, D., Krüger, A., Mirtschink, P., Rauner, M., Chavakis, T., Arthur, H. M., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.24.605039

Regulation of Angiogenesis by Cancer Hypoxia and Role of Hypoxia Inducible Factors with Therapeutic Paradigm

Ray, S. K., & Mukherjee, S. (2025) · Springer eBooks · doi:10.1007/978-981-96-1016-7_7

Angiogenesis and Microvascular Remodeling

Chappell, J. C. (2025) · Physiology in health and disease · doi:10.1007/978-3-031-99609-2_3

A Comparative Analysis of the Efficacy of CD117 and Special Stains as Indicators of Mechanical Asphyxial Deaths

Shekhawat, R. S., Panwar, R., Rao, M., Meshram, V., Kumar, M. S., Gnanasekaran, S., Rathore, M., & Kanchan, T. (2026) · Annals of African Medicine · doi:10.4103/aam.aam_377_25

HIF-1α coordinates adrenal steroidogenesis through direct transcriptional control and regulation of miRNA biogenesisPreprint

Stepien, B. K., Sinha, A., Ariyeloye, S., Krüger, A., Mirtschink, P., Bartoszewski, R., & Wielockx, B. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.24.707817

Preclinical Study of the Neuroprotective Effects of Pharmacological Agent-Modulators of HSP70 After Intrauterine Hypoxia

Belenichev, I. F., Aliyeva, O. G., Bukhtiyarova, N. V., Ryzhenko, V. P., Oliynyk, S., Lee, S., & Yi, K. (2026) · Journal of Integrative Neuroscience · doi:10.31083/jin51482

Ginsenoside compound K attenuates hypoxic pulmonary hypertension endothelial injury by suppressing POSTN-TrkB-mediated endothelial-mesenchymal transition

Ren, J., Wang, S., Ye, C., Fan, X., & He, R. (2026) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgag125

Oxygen sensors and angiogenesis

Maxwell, P. H., & Ratcliffe, P. J. (2002) · Seminars in Cell and Developmental Biology · doi:10.1006/scdb.2001.0287 · Cited by 328 · see citing works

Regulation of angiogenesis by oxygen sensing mechanisms

Fong, G. (2009) · Journal of Molecular Medicine · doi:10.1007/s00109-009-0458-z · Cited by 140 · see citing works

ATVB in Focus Oxygen Sensing From Vessel Sprouting to Normalization Role of the Prolyl Hydroxylase Domain Protein/Hypoxia-Inducible Factor Oxygen-Sensing Machinery

Coulon, C., Γεωργιάδου, Μ., Roncal, C., Bock, K. D., Langenberg, T., & Carmeliet, P. (2016)

Angiogenesis — a self-adapting principle in hypoxia

Marti, H. H. (2005) · Birkhäuser Basel eBooks · doi:10.1007/3-7643-7311-3_12 · Cited by 66 · see citing works

Hypoxia-inducible factors (HIFs) and biological responses, in hypoxia, inflammation and embryonic vascular development.

Hägg, M. (2008) · Gothenburg University Publications Electronic Archive (Gothenburg University)