The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Maternal obesity at conception programs obesity in the offspring
Abstract
Risk of obesity in adult life is subject to programming during gestation. To examine whether in utero exposure to maternal obesity increases the risk of obesity in offspring, we developed an overfeeding-based model of maternal obesity in rats utilizing intragastric feeding of diets via total enteral nutrition. Feeding liquid diets to adult female rats at 220 kcal/kg 3/4 per day (15% excess calories/day) compared with 187 kcal/kg 3/4 per day for 3 wk caused substantial increase in body weight gain, adiposity, serum insulin, leptin, and insulin resistance. Lean or obese female rats were mated with ad libitum AIN-93G-fed male rats. Exposure to obesity was ensured to be limited only to the maternal in utero environment by cross-fostering pups to lean dams having ad libitum access to AIN-93G diets throughout lactation. Numbers of pups, birth weight, and size were not affected by maternal obesity. Male offspring from each group were weaned at postnatal day (PND)21 to either AIN-93G diets or high-fat diets (45% fat calories). Body weights of offspring from obese dams did not differ from offspring of lean dams when fed AIN-93G diets through PND130. However, offspring from obese dams gained remarkably greater ( P < 0.005) body weight and higher %body fat when fed a high-fat diet. Body composition was assessed by NMR, X-ray computerized tomography, and weights of adipose tissues. Adipose histomorphometry, insulin sensitivity, and food intake were also assessed in the offspring. Our data suggest that maternal obesity at conception leads to fetal programming of offspring, which could result in obesity in later life.
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Cites
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Flegal, K., Carroll, M., Kuczmarski, R., & Johnson, C. (1998) · International Journal of Obesity · doi:10.1038/sj.ijo.0800541 · Cited by 3,045
Developmental Origins of the Metabolic Syndrome: Prediction, Plasticity, and Programming
Mcmillen, I. C., & Robinson, J. S. (2005) · Physiological Reviews · doi:10.1152/physrev.00053.2003 · Cited by 1,910
The Developmental Origins of Adult Disease
Barker, D. J. P. (2004) · Journal of the American College of Nutrition · doi:10.1080/07315724.2004.10719428 · Cited by 1,854
Gender-linked hypertension in offspring of lard-fed pregnant rats
Khan, I. Y., Taylor, P. D., Dekou, V., Seed, P. T., Lakasing, L., Graham, D., Dominiczak, A. F., Hanson, M. A., & Poston, L. (2003) · Hypertension · doi:10.1161/01.hyp.0000047511.97879.fc · Cited by 365
Khan, I. Y., Dekou, V., Douglas, G., Jensen, R., Hanson, M. A., Poston, L., & Taylor, P. D. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00354.2004 · Cited by 357
Taylor, P. D., McConnell, J., Khan, I. Y., Holemans, K., Lawrence, K. M., Asare-Anane, H., Persaud, S. J., Jones, P. M., Petrie, L., Hanson, M. A., et al. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00355.2004 · Cited by 297
Cited by
Association of Intrauterine Exposure to Maternal Diabetes and Obesity With Type 2 Diabetes in Youth
Dabelea, D., Mayer-Davis, E. J., Lamichhane, A. P., D'Agostino, R. B., Liese, A. D., Vehik, K. S., Narayan, K. M. V., Zeitler, P., & Hamman, R. F. (2008) · Diabetes Care · doi:10.2337/dc07-2417 · Cited by 415
Epigenetic germline inheritance of diet-induced obesity and insulin resistance
Huypens, P., Sass, S., Wu, M., Dyckhoff, D., Tschöp, M., Theis, F., Marschall, S., de Angelis, M. H., & Beckers, J. (2016) · Nature Genetics · doi:10.1038/ng.3527 · Cited by 366
Maternal High-Fat Diet Effects on Third-Generation Female Body Size via the Paternal Lineage
Dunn, G. A., & Bale, T. L. (2011) · Endocrinology · doi:10.1210/en.2010-1461 · Cited by 371
Anzman, S. L., Rollins, B. Y., & Birch, L. L. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.43 · Cited by 369
Effects of Maternal Surgical Weight Loss in Mothers on Intergenerational Transmission of Obesity
Smith, J., Cianflone, K., Biron, S., Hould, F. S., Lebel, S., Marceau, S., Lescelleur, O., Biertho, L., Simard, S., Kral, J. G., et al. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0709 · Cited by 354
Metadata
- Authors
- Shankar, K., Harrell, A., Liu, X., Gilchrist, J. M., Ronis, M. J. J., & Badger, T. M.
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2008-02
- Volume
- 294
- Issue
- 2
- Pages
- R528-R538
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2160101394
- Cited by
- 385
- References
- 6
- FWCI
- 19.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- Shankar, K., Harrell, A., Liu, X., Gilchrist, J. M., Ronis, M. J. J., & Badger, T. M. (2008). Maternal obesity at conception programs obesity in the offspring. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. https://doi.org/10.1152/ajpregu.00316.2007
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