The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.
Ghrelin is an orexigenic and metabolic signaling peptide in the arcuate and paraventricular nuclei
Abstract
Ghrelin is a 28-amino acid acylated peptide and is the endogenous ligand for the growth hormone secretagogue receptor (GHS-R). The GHS-R is expressed in hypothalamic nuclei, including the arcuate nucleus (Arc) where it is colocalized with neuropeptide Y (NPY) neurons. In the present study, we examined the effects of ghrelin on feeding and energy substrate utilization (respiratory quotient; RQ) following direct injections into either the arcuate or the paraventricular nucleus (PVN) of the hypothalamus. Ghrelin was administered at the beginning of the dark cycle at doses of 15-60 pmol to male and female rats. In feeding studies, food intake was measured 2 and 4 h postinjection. Separate groups of rats were injected with ghrelin, and the RQ (VCO(2)/VO(2)) was measured using an open circuit calorimeter over a 4-h period. Both Arc and PVN injections of ghrelin increased food intake in male and female rats. Ghrelin also increased RQ, reflecting a shift in energy substrate utilization in favor of carbohydrate oxidation. Because these effects are similar to those observed after PVN injection of NPY, we then assessed the impact of coinjecting ghrelin with NPY into the PVN. When rats were pretreated with very low doses of ghrelin (2.5-10 pmol), NPY's (50 pmol) effects on eating and RQ were potentiated. Overall, these data are in agreement with evidence suggesting that ghrelin functions as a gut-brain endocrine hormone implicated in the regulation of food intake and energy metabolism. Our findings are also consistent with a possible interactive role of hypothalamic ghrelin and NPY systems.
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“Glucocorticoids increase plasma leptin and ghrelin levels, while ghrelin which also increases with stress, appears to contribute to regulating anxiety and mood”
From Role of addiction and stress neurobiology on food intake and obesity (2018) · cites this paper as Currie et al., 2005
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Ghrelin - The Defender of Fat in the Face of Stress: Implications in Obesity Treatment
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Gut Hormones and Metabolic Syndrome
Bhat, S. Z., Park, H. K., & Ahima, R. S. (2023) · Springer eBooks · doi:10.1007/978-3-319-12125-3_25-2
Metadata
- Authors
- Currie, P. J., Mirza, A., Fuld, R., Park, D., & Vasselli, J. R.
- Affiliations
- Columbia University (US)
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2005-08
- Volume
- 289
- Issue
- 2
- Pages
- R353-R358
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2150628139
- Cited by
- 125
- References
- 71
- Citations by year
- 2024: 3 · 2023: 4 · 2022: 3 · 2021: 6 · 2020: 3 · 2019: 3 · 2018: 7 · 2017: 11 · 2016: 8 · 2015: 6 · 2014: 10 · 2013: 10 · 2012: 6
- FWCI
- 2.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH 070496-01A1, R03MH070496)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- ghrelin, growth hormone secretagogue receptor, arcuate nucleus, paraventricular nucleus, hypothalamus, neuropeptide Y, dietary intake, energy substrate utilization, respiratory quotient, carbohydrate oxidation, appetite regulation, energy metabolism
- MeSH terms
- Animals, Arcuate Nucleus of Hypothalamus, Drug Administration Schedule, Drug Combinations, Drug Synergism, Eating, Energy Metabolism, Female, Injections, Male, Neuropeptide Y, Oxidation-Reduction, Paraventricular Hypothalamic Nucleus, Rats, Sprague-Dawley, Photoperiod, Protein Sorting Signals, Peptide Hormones, Carbohydrate Metabolism, Rats, Ghrelin
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