Cited by 125Regulation of Appetite and ObesityHypothalamic control of reproductive hormonesNeuropeptides and Animal Physiology

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Ghrelin is an orexigenic and metabolic signaling peptide in the arcuate and paraventricular nuclei

Currie, Paul J., Mirza, Aaisha, Fuld, Rebecca, Park, Diana, Vasselli, Joseph R.·2005·American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

DOI 10.1152/ajpregu.00756.2004

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Abstract

Ghrelin is a 28-amino acid acylated peptide and is the endogenous ligand for the growth hormone secretagogue receptor (GHS-R). The GHS-R is expressed in hypothalamic nuclei, including the arcuate nucleus (Arc) where it is colocalized with neuropeptide Y (NPY) neurons. In the present study, we examined the effects of ghrelin on feeding and energy substrate utilization (respiratory quotient; RQ) following direct injections into either the arcuate or the paraventricular nucleus (PVN) of the hypothalamus. Ghrelin was administered at the beginning of the dark cycle at doses of 15-60 pmol to male and female rats. In feeding studies, food intake was measured 2 and 4 h postinjection. Separate groups of rats were injected with ghrelin, and the RQ (VCO(2)/VO(2)) was measured using an open circuit calorimeter over a 4-h period. Both Arc and PVN injections of ghrelin increased food intake in male and female rats. Ghrelin also increased RQ, reflecting a shift in energy substrate utilization in favor of carbohydrate oxidation. Because these effects are similar to those observed after PVN injection of NPY, we then assessed the impact of coinjecting ghrelin with NPY into the PVN. When rats were pretreated with very low doses of ghrelin (2.5-10 pmol), NPY's (50 pmol) effects on eating and RQ were potentiated. Overall, these data are in agreement with evidence suggesting that ghrelin functions as a gut-brain endocrine hormone implicated in the regulation of food intake and energy metabolism. Our findings are also consistent with a possible interactive role of hypothalamic ghrelin and NPY systems.

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Authors: Currie, P. J., Mirza, A., Fuld, R., Park, D., & Vasselli, J. R.
Affiliations: Columbia University (US)
ORCID: Currie, Paul J.
Vasselli, Joseph R.
Venue: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Publisher: American Physiological Society
Published: 2005-08
Volume: 289
Issue: 2
Pages: R353-R358
ISSN: 0363-6119 (ISSN-L)
1522-1490
DOI: 10.1152/ajpregu.00756.2004
OpenAlex: W2150628139
Cited by: 125
References: 71
Citations by year: 2024: 3 · 2023: 4 · 2022: 3 · 2021: 6 · 2020: 3 · 2019: 3 · 2018: 7 · 2017: 11 · 2016: 8 · 2015: 6 · 2014: 10 · 2013: 10 · 2012: 6
FWCI: 2.81
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (MH 070496-01A1, R03MH070496)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: ghrelin, growth hormone secretagogue receptor, arcuate nucleus, paraventricular nucleus, hypothalamus, neuropeptide Y, dietary intake, energy substrate utilization, respiratory quotient, carbohydrate oxidation, appetite regulation, energy metabolism
MeSH terms: Animals, Arcuate Nucleus of Hypothalamus, Drug Administration Schedule, Drug Combinations, Drug Synergism, Eating, Energy Metabolism, Female, Injections, Male, Neuropeptide Y, Oxidation-Reduction, Paraventricular Hypothalamic Nucleus, Rats, Sprague-Dawley, Photoperiod, Protein Sorting Signals, Peptide Hormones, Carbohydrate Metabolism, Rats, Ghrelin

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Ghrelin is an orexigenic and metabolic signaling peptide in the arcuate and paraventricular nuclei

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