Cited by 125Regulation of Appetite and ObesityHypothalamic control of reproductive hormonesNeuropeptides and Animal Physiology

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Ghrelin is an orexigenic and metabolic signaling peptide in the arcuate and paraventricular nuclei

Currie, Paul J., Mirza, Aaisha, Fuld, Rebecca, Park, Diana, Vasselli, Joseph R.·2005·American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

DOI 10.1152/ajpregu.00756.2004

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Abstract

Ghrelin is a 28-amino acid acylated peptide and is the endogenous ligand for the growth hormone secretagogue receptor (GHS-R). The GHS-R is expressed in hypothalamic nuclei, including the arcuate nucleus (Arc) where it is colocalized with neuropeptide Y (NPY) neurons. In the present study, we examined the effects of ghrelin on feeding and energy substrate utilization (respiratory quotient; RQ) following direct injections into either the arcuate or the paraventricular nucleus (PVN) of the hypothalamus. Ghrelin was administered at the beginning of the dark cycle at doses of 15-60 pmol to male and female rats. In feeding studies, food intake was measured 2 and 4 h postinjection. Separate groups of rats were injected with ghrelin, and the RQ (VCO(2)/VO(2)) was measured using an open circuit calorimeter over a 4-h period. Both Arc and PVN injections of ghrelin increased food intake in male and female rats. Ghrelin also increased RQ, reflecting a shift in energy substrate utilization in favor of carbohydrate oxidation. Because these effects are similar to those observed after PVN injection of NPY, we then assessed the impact of coinjecting ghrelin with NPY into the PVN. When rats were pretreated with very low doses of ghrelin (2.5-10 pmol), NPY's (50 pmol) effects on eating and RQ were potentiated. Overall, these data are in agreement with evidence suggesting that ghrelin functions as a gut-brain endocrine hormone implicated in the regulation of food intake and energy metabolism. Our findings are also consistent with a possible interactive role of hypothalamic ghrelin and NPY systems.

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The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
Ghrelin is a growth-hormone-releasing acylated peptide from stomach
Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., & Kangawa, K. (1999) · Nature · doi:10.1038/45230 · Cited by 8,479
Central nervous system control of food intake
Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451
Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80949-6 · Cited by 5,501
Ghrelin induces adiposity in rodents
Tschöp, M., Smiley, D. L., & Heiman, M. L. (2000) · Nature · doi:10.1038/35038090 · Cited by 3,949
The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity
de Lecea, L., Kilduff, T. S., Peyron, C., Gao, X.-B., Foye, P. E., Danielson, P. E., Fukuhara, C., Battenberg, E. L. F., Gautvik, V. T., Bartlett, F. S., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.322 · Cited by 3,878
The Fire of Life: An Introduction to Animal Energetics
Kleiber, M. (1975) · Medical Entomology and Zoology · Cited by 2,529
Obesity and the regulation of energy balance
Spiegelman, B. M., & Flier, J. S. (2001) · Cell · doi:10.1016/s0092-8674(01)00240-9 · Cited by 2,398
A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release
Howard, A., Feighner, S., Cully, D., Arena, J. P., Liberator, P., Rosenblum, C., Hamelin, M., Hreniuk, D. L., Palyha, O., Anderson, J., et al. (1996) · Science · doi:10.1126/science.273.5277.974 · Cited by 2,106
Circulating Ghrelin Levels Are Decreased in Human Obesity
Tschöp, M. H., Weyer, C., Tataranni, P. A., Devanarayan, V., Ravussin, É., & Heiman, M. L. (2001) · Diabetes · doi:10.2337/diabetes.50.4.707 · Cited by 2,031
Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
Fan, W., Boston, B. A., Kesterson, R. A., Hruby, V. J., & Cone, R. D. (1997) · Nature · doi:10.1038/385165a0 · Cited by 1,924
Ghrelin, a Novel Growth Hormone-Releasing Acylated Peptide, Is Synthesized in a Distinct Endocrine Cell Type in the Gastrointestinal Tracts of Rats and Humans
Date, Y., Kojima, M., Hosoda, H., Sawaguchi, A., Mondal, M. S., Suganuma, T., Matsukura, S., Kangawa, K., & Nakazato, M. (2000) · Endocrinology · doi:10.1210/endo.141.11.7757 · Cited by 1,916
Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein
Ollmann, M. M., Wilson, B. D., Yang, Y.-K., Kerns, J. A., Chen, Y., Gantz, I., & Barsh, G. S. (1997) · Science · doi:10.1126/science.278.5335.135 · Cited by 1,881
The Distribution and Mechanism of Action of Ghrelin in the CNS Demonstrates a Novel Hypothalamic Circuit Regulating Energy Homeostasis
Cowley, M. A., Smith, R. G., Diano, S., Tschöp, M., Pronchuk, N., Grove, K. L., Strasburger, C. J., Bidlingmaier, M., Esterman, M., Heiman, M. L., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00063-1 · Cited by 1,679
Interacting Appetite-Regulating Pathways in the Hypothalamic Regulation of Body Weight
Kalra, S. P., Dube, M. G., Pu, S., Xu, B., Horváth, T. L., & Kalra, P. S. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.1.0357 · Cited by 1,564
Interacting Appetite-Regulating Pathways in the Hypothalamic Regulation of Body Weight
Kalra, S. P. (1999) · Endocrine Reviews · doi:10.1210/er.20.1.68 · Cited by 1,554
A role for melanin-concentrating hormone in the central regulation of feeding behaviour
Qu, D., Ludwig, D. S., Gammeltoft, S., Piper, M., Pelleymounter, M. A., Cullen, M. J., Mathes, W. F., Przypek, J., Kanarek, R. B., & Maratos–Flier, E. (1996) · Nature · doi:10.1038/380243a0 · Cited by 1,320
Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues.
Guan, X.-M., Yu, H., Palyha, O., McKee, K., Feighner, S., Sirinathsinghji, D., Smith, R. G., van der Ploeg, L., & Howard, A. (1997) · Brain Research. Molecular Brain Research · doi:10.1016/s0169-328x(97)00071-5 · Cited by 1,185
Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin
Asakawa, A., Inui, A., Kaga, O., Yuzuriha, H., Nagata, T., Ueno, N., Makino, S., Fujimiya, M., Niijima, A., Fujino, M., et al. (2001) · Gastroenterology · doi:10.1053/gast.2001.22158 · Cited by 1,182
Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons
Hahn, T. M., Breininger, J. F., Baskin, D. G., & Schwartz, M. W. (1998) · Nature Neuroscience · doi:10.1038/1082 · Cited by 1,164
Ghrelin Causes Hyperphagia and Obesity in Rats
Wren, A., Small, C. J., Abbott, C. R., Dhillo, W. S., Seal, L., Cohen, M. A., Batterham, R. L., Taheri, S., Stanley, S. A., Ghatei, M. A., et al. (2001) · Diabetes · doi:10.2337/diabetes.50.11.2540 · Cited by 1,124
Transient increase in obese gene expression after food intake or insulin administration
Saladin, R., Vos, P. D., Guerre-Millo, M., Leturque, A., Girard, J. R., Staels, B., & Auwerx, J. H. (1995) · Nature · doi:10.1038/377527a0 · Cited by 1,093
The melanin‐concentrating hormone system of the rat brain: An immuno‐ and hybridization histochemical characterization
Bittencourt, J. C., Presse, F., Arias, C. M., Peto, C. A., Vaughan, J. M., Nahon, J., Vale, W., & Sawchenko, P. E. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903190204 · Cited by 1,075
Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor
Lu, D., Willard, D. H., Patel, I. R., Kadwell, S. H., Overton, L. K., Kost, T., Luther, M., Chen, W., Woychik, R. P., Wilkison, W. O., et al. (1994) · Nature · doi:10.1038/371799a0 · Cited by 1,075
Ghrelin and Des-acyl Ghrelin: Two Major Forms of Rat Ghrelin Peptide in Gastrointestinal Tissue
Hosoda, H., Kojima, M., Matsuo, H., & Kangawa, K. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.4039 · Cited by 943
Localization of leptin receptor mRNA and the long form splice variant (Ob‐Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization
Mercer, J. G., Hoggard, N., Williams, L. M., Lawrence, C. B., Hannah, L. T., & Trayhurn, P. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00473-5 · Cited by 881
Leptin Increases Hypothalamic Pro-opiomelanocortin mRNA Expression in the Rostral Arcuate Nucleus
Schwartz, M. W., Seeley, R. J., Woods, S. C., Weigle, D. S., Campfield, L. A., Burn, P., & Baskin, D. G. (1997) · Diabetes · doi:10.2337/diab.46.12.2119 · Cited by 879
Ghrelin, an Endogenous Growth Hormone Secretagogue, Is a Novel Orexigenic Peptide That Antagonizes Leptin Action Through the Activation of Hypothalamic Neuropeptide Y/Y1 Receptor Pathway
Shintani, M., Ogawa, Y., Ebihara, K., Aizawa‐Abe, M., Miyanaga, F., Takaya, K., Hayashi, T., Inoue, G., Hosoda, K., Kojima, M., et al. (2001) · Diabetes · doi:10.2337/diabetes.50.2.227 · Cited by 848
Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure
Banks, W. A., Tschöp, M., Robinson, S. M., & Heiman, M. L. (2002) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.034827 · Cited by 691
Chronic Central Infusion of Ghrelin Increases Hypothalamic Neuropeptide Y and Agouti-Related Protein mRNA Levels and Body Weight in Rats
Kamegai, J., Tamura, H., Shimizu, T., Ishii, S., Sugihara, H., & Wakabayashi, I. (2001) · Diabetes · doi:10.2337/diabetes.50.11.2438 · Cited by 624
Co-Localization of Growth Hormone Secretagogue Receptor and NPY mRNA in the Arcuate Nucleus of the Rat
Willesen, M. G., Kristensen, P., & Rømer, J. (1999) · Neuroendocrinology · doi:10.1159/000054491 · Cited by 605
Endocrine Activities of Ghrelin, a Natural Growth Hormone Secretagogue (GHS), in Humans: Comparison and Interactions with Hexarelin, a Nonnatural Peptidyl GHS, and GH-Releasing Hormone
Arvat, E., Maccario, M., Vito, L. D., Broglio, F., Benso, A. S., Gottero, C., Papotti, M. G., Muccioli, G., Diéguez, C., Casanueva, F. F., et al. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.3.7314 · Cited by 553
Food deprivation and ingestion induce reciprocal changes in neuropeptide Y concentrations in the paraventricular nucleus
Sahu, A., Kalra, P. S., & Kalra, S. P. (1988) · Peptides · doi:10.1016/0196-9781(88)90013-7 · Cited by 503
Antagonism of ghrelin receptor reduces food intake and body weight gain in mice
Asakawa, A., Inui, A., Kaga, T., Katsuura, G., Fujimiya, M., Fujino, M. A., & Kasuga, M. (2003) · Gut · doi:10.1136/gut.52.7.947 · Cited by 478
Acute Central Ghrelin and GH Secretagogues Induce Feeding and Activate Brain Appetite Centers
Lawrence, C. B., Snape, A. C., Baudoin, F., & Luckman, S. M. (2002) · Endocrinology · doi:10.1210/endo.143.1.8561 · Cited by 443
Neuroendocrine and peripheral activities of ghrelin: implications in metabolism and obesity
Muccioli, G., Tschöp, M. H., Papotti, M., Deghenghi, R., Heiman, M. L., & Ghigo, E. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01432-2 · Cited by 388
A-like cells in the rat stomach contain ghrelin and do not operate under gastrin control
de la Cour, C. D., Björkqvist, M., Sandvik, A. K., Bakke, I., Zhao, C., Chen, D., & Håkanson, R. (2001) · Regulatory Peptides · doi:10.1016/s0167-0115(01)00243-9 · Cited by 368
The Biology of Neuropeptide Y and Related Peptides
(1993) · Humana Press eBooks · doi:10.1007/978-1-59259-465-8 · Cited by 339
Ghrelin-producing cells exist as two types of cells, closed- and opened-type cells, in the rat gastrointestinal tract
Sakata, I., Nakamura, K., Yamazaki, M., Matsubara, M., Hayashi, Y., Kangawa, K., & Sakai, T. (2002) · Peptides · doi:10.1016/s0196-9781(01)00633-7 · Cited by 331
Hyperphagic Effects of Brainstem Ghrelin Administration
Faulconbridge, L. F., Cummings, D. E., Kaplan, J. M., & Grill, H. J. (2003) · Diabetes · doi:10.2337/diabetes.52.9.2260 · Cited by 307
Neuroendocrine Responses to Starvation and Weight Loss
Schwartz, M. W., & Seeley, R. J. (1997) · New England Journal of Medicine · doi:10.1056/nejm199706193362507 · Cited by 265
Evidence Suggesting That Galanin (GAL), Melanin-Concentrating Hormone (MCH), Neurotensin (NT), Proopiomelanocortin (POMC) and Neuropeptide Y (NPY) Are Targets of Leptin Signaling in the Hypothalamus
Sahu, A. (1998) · Endocrinology · doi:10.1210/endo.139.2.5909 · Cited by 235
Hypothalamic growth hormone secretagogue receptor regulates growth hormone secretion, feeding, and adiposity.
Shuto, Y., Shibasaki, T., Otagiri, A., Kuriyama, H., Ohata, H., Tamura, H., Kamegai, J., Sugihara, H., Oikawa, S., & Wakabayashi, I. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0213300 · Cited by 220
The cannabinoid CB1 receptor antagonist SR141716 blocks the orexigenic effects of intrahypothalamic ghrelin
Tucci, S. A., Rogers, E. K., Korbonits, M., & Kirkham, T. C. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705968 · Cited by 192
Expression of Growth Hormone Secretagogue-Receptors by Growth Hormone-Releasing Hormone Neurons in the Mediobasal Hypothalamus
Tannenbaum, G. S., Lapointe, M., Beaudet, A., & Howard, A. D. (1998) · Endocrinology · doi:10.1210/endo.139.10.6330 · Cited by 169
GH-Releasing Peptide-2 Increases Fat Mass in Mice Lacking NPY: Indication for a Crucial Mediating Role of Hypothalamic Agouti-Related Protein
Tschöp, M. H., Statnick, M. A., Suter, T. M., & Heiman, M. L. (2002) · Endocrinology · doi:10.1210/endo.143.2.8633 · Cited by 151
Growth Hormone Secretagogue Receptor Family Members and Ligands
Smith, R. G., Leonard, R. J., Bailey, A. R. T., Palyha, O. C., Feighner, S. D., Tan, C. P., McKee, K. K., Pong, S., Griffin, P. R., & Howard, A. (2001) · Endocrine · doi:10.1385/endo:14:1:009 · Cited by 136
Distribution of the pro-opiomelanocortin derived peptides, adrenocorticotrope hormone, α-melanocyte-stimulating hormone and β-endorphin (ACTH, α-MSH, β-END) in the rat hypothalamus
Mezey, É., Kiss, J. Z., Mueller, G. P., Eskay, R. L., O’Donohue, T. L., & Palkovits, M. (1985) · Brain Research · doi:10.1016/0006-8993(85)91046-7 · Cited by 130
The Rat Arcuate Nucleus Integrates Peripheral Signals Provided by Leptin, Insulin, and a Ghrelin Mimetic
Hewson, A. K., Tung, L. Y. C., Connell, D. W., Tookman, L. A., & Dickson, S. L. (2002) · Diabetes · doi:10.2337/diabetes.51.12.3412 · Cited by 125
Generation of polyclonal antiserum against the growth hormone secretagogue receptor (GHS-R)
Shuto, Y., Shibasaki, T., Wada, K., Parhar, I. S., Kamegai, J., Sugihara, H., Oikawa, S., & Wakabayashi, I. (2001) · Life Sciences · doi:10.1016/s0024-3205(00)01001-8 · Cited by 124
Neuropeptide Y in Multiple Hypothalamic Sites Controls Eating Behavior, Endocrine, and Autonomic Systems for Body Energy Balance
Stanley, B. G. (1993) · Humana Press eBooks · doi:10.1007/978-1-59259-465-8_11 · Cited by 107
Metabolic effects of neuropeptide Y injections into the paraventricular nucleus of the hypothalamus
Menéndez, J., McGregor, I. S., Healey, P. A., Atrens, D. M., & LEIBOWITZ, S. F. (1990) · Brain Research · doi:10.1016/0006-8993(90)90890-n · Cited by 94
Leptin Receptor Immunoreactivity is Associated with the Golgi Apparatus of Hypothalamic Neurones and Glial Cells
Diano, S., Kalra, S. P., & Horváth, T. L. (1998) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1998.00261.x · Cited by 93
Endocrine and Non-Endocrine Actions of Ghrelin
Broglio, F., Gottero, C., Arvat, E., & Ghigo, E. (2003) · Hormone Research in Paediatrics · doi:10.1159/000069065 · Cited by 92
Molecular regulation of eating behavior: new insights and prospects for therapeutic strategies
Ahima, R. S., & Osei, S. Y. (2001) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(01)01989-x · Cited by 85
Ghrelin as a Potential Anti-Obesity Target
Horváth, T. L., Castañeda, T. R., Tang‐Christensen, M., Pagotto, U., & Tschöp, M. H. (2003) · Current Pharmaceutical Design · doi:10.2174/1381612033454748 · Cited by 69
Hypothalamic neuropeptide Y gene expression in rats on scheduled feeding regimen
Sahu, A., White, J. D., Kalra, P. S., & Kalra, S. P. (1992) · Molecular Brain Research · doi:10.1016/0169-328x(92)90145-2 · Cited by 62
Hypothalamic paraventricular nucleus injections of urocortin alter food intake and respiratory quotient
Currie, P. J., Coscina, D. V., Bishop, C., Coiro, C. D., Koob, G. F., Rivier, J., & Vale, W. W. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02851-7 · Cited by 56
Localization of leptin receptor immunoreactivity in the lean and obese Zucker rat brain
Yarnell, D. O., Knight, D. S., Hamilton, K. A., Tulp, O. L., & Tso, P. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01388-7 · Cited by 53
Differential Orexigenic Effects of Hexarelin and Its Analogs in the Rat Hypothalamus: Indication for Multiple Growth Hormone Secretagogue Receptor Subtypes
Torsello, A., Locatelli, V., Melis, M. R., Succu, S., Spano, M. S., Deghenghi, R., Müller, E. E., & Argiolas, A. (2000) · Neuroendocrinology · doi:10.1159/000054601 · Cited by 51
Regional hypothalamic differences in neuropeptide Y-induced feeding and energy substrate utilization
Currie, P. J., & Coscina, D. V. (1996) · Brain Research · doi:10.1016/0006-8993(96)00738-x · Cited by 46
Hypothalamic paraventricular 5-hydroxytryptamine: Receptor-specific inhibition of NPY-stimulated eating and energy metabolism
Currie, P. J., Coiro, C. D., Niyomchai, T., Lira, A., & Farahmand, F. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00671-2 · Cited by 45
Ghrelin injected into the paraventricular nucleus of the hypothalamus of male rats induces feeding but not penile erection
Melis, M. R., Mascia, M. S., Succu, S., Torsello, A., Müller, E. E., Deghenghi, R., & Argiolas, A. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00673-0 · Cited by 40
Stimulation of 5–HT2A/2C receptors within specific hypothalamic nuclei differentially antagonizes NPY-induced feeding
Currie, P. J., & Coscina, D. V. (1997) · Neuroreport · doi:10.1097/00001756-199712010-00020 · Cited by 33
5-Hydroxytryptaminergic receptor agonists: effects on neuropeptide Y potentiation of feeding and respiratory quotient1Published on the world wide web on 10 July 1998.1
Currie, P. J., & Coscina, D. V. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00643-x · Cited by 33
Nutrient Balance and Obesity: An Approach to Control of Food Intake in Humans
Bray, G. A. (1989) · Medical Clinics of North America · doi:10.1016/s0025-7125(16)30690-3 · Cited by 31
5-HT2A/2C receptor antagonists in the paraventricular nucleus attenuate the action of DOI on NPY-stimulated eating
Currie, P. J., Saxena, N., & Tu, A. Y. (1999) · Neuroreport · doi:10.1097/00001756-199909290-00029 · Cited by 29
Integration of hypothalamic feeding and metabolic signals: focus on neuropeptide Y
Currie, P. J. (2003) · Appetite · doi:10.1016/j.appet.2003.08.011 · Cited by 26
The Regulation of Energy Balance
Seeley, R. J., & Schwartz, M. W. (1997) · Current Directions in Psychological Science · doi:10.1111/1467-8721.ep11512618 · Cited by 19
Lack of physiological suppression of circulating IGFBP-1 in puberty in patients with insulin-dependent diabetes mellitus
Riihimaa, P. H., Knip, M., Ruokonen, A., & Tapanainen, P. J. (2002) · European Journal of Endocrinology · doi:10.1530/eje.0.1470235 · Cited by 8
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Authors: Currie, P. J., Mirza, A., Fuld, R., Park, D., & Vasselli, J. R.
Affiliations: Columbia University (US)
ORCID: Currie, Paul J.
Vasselli, Joseph R.
Venue: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Publisher: American Physiological Society
Published: 2005-08
Volume: 289
Issue: 2
Pages: R353-R358
ISSN: 0363-6119 (ISSN-L)
1522-1490
DOI: 10.1152/ajpregu.00756.2004
OpenAlex: W2150628139
Cited by: 125
References: 71
Citations by year: 2024: 3 · 2023: 4 · 2022: 3 · 2021: 6 · 2020: 3 · 2019: 3 · 2018: 7 · 2017: 11 · 2016: 8 · 2015: 6 · 2014: 10 · 2013: 10 · 2012: 6
FWCI: 2.81
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (MH 070496-01A1, R03MH070496)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: ghrelin, growth hormone secretagogue receptor, arcuate nucleus, paraventricular nucleus, hypothalamus, neuropeptide Y, dietary intake, energy substrate utilization, respiratory quotient, carbohydrate oxidation, appetite regulation, energy metabolism
MeSH terms: Animals, Arcuate Nucleus of Hypothalamus, Drug Administration Schedule, Drug Combinations, Drug Synergism, Eating, Energy Metabolism, Female, Injections, Male, Neuropeptide Y, Oxidation-Reduction, Paraventricular Hypothalamic Nucleus, Rats, Sprague-Dawley, Photoperiod, Protein Sorting Signals, Peptide Hormones, Carbohydrate Metabolism, Rats, Ghrelin

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Ghrelin is an orexigenic and metabolic signaling peptide in the arcuate and paraventricular nuclei

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