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Cited by 455

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Sleep-promoting effects of endogenous pyrogen (interleukin-1)

Krueger, J. M., Walter, J., Dinarello, C. A., Wolff, S. M., Chedid, L.·1984·American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Abstract

When infused into the lateral cerebral ventricles of rabbits, human endogenous pyrogen (EP) preparations induced dose-dependent increases in slow-wave sleep concomitant with increasing body temperature. Heating EP to 70 degrees C destroyed its sleep-promoting and pyrogenic activity. Anisomycin (an antipyretic) prevented EP from increasing body temperature without affecting its sleep-promoting activity. Intravenous injection of EP induced fever and transient increases in slow-wave sleep but failed to induce prolonged increases in slow-wave sleep. We conclude that the somnogenic activity of EP is not secondary to its pyrogenic activity.

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Crossref · 10.1152/ajpregu.1984.246.6.r994

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Metadata

Authors
Krueger, J. M., Walter, J., Dinarello, C. A., Wolff, S. M., & Chedid, L.
Venue
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Published
1984-06-01
Volume
246
Issue
6
Pages
R994-R999
ISSN
  • 0363-6119 (ISSN-L)
  • 1522-1490
OpenAlex
W1961152089
Cited by
455
References
2
FWCI
6.48
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Sleep-promoting effects of endogenous pyrogen (interleukin-1). https://app.cochat.ai/papers/10.1152/ajpregu.1984.246.6.r994
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Krueger, J. M., Walter, J., Dinarello, C. A., Wolff, S. M., & Chedid, L. (1984). Sleep-promoting effects of endogenous pyrogen (interleukin-1). American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. https://doi.org/10.1152/ajpregu.1984.246.6.r994

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