The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Leptin deficiency enhances sensitivity to endotoxin-induced lethality
Abstract
Leptin is induced by lipopolysaccharide (LPS) and cytokines. We investigated the role of leptin in LPS-induced toxicity using leptin-deficient ( ob/ ob) and leptin receptor-deficient ( db/ db) mice. Sensitivity to LPS-induced mortality is significantly greater in ob/ obmice compared with their own lean littermates but not in db/ dbmice. LPS reduced serum glucose in both ob/ oband db/ dbmice but induced corticosterone only in db/ dbmice. Despite the very high basal levels of serum leptin in db/ dbmice, a twofold increase in serum leptin levels was observed after LPS in both db/ dbmice and their lean littermates. No differences were detected in LPS-induced serum levels of interleukin (IL)-1β, tumor necrosis factor, macrophage inflammatory protein-1α, and interferon-γ in ob/ obmice compared with their own littermates. In contrast, a blunted induction of IL-10 and IL-1 receptor antagonist (IL-1Ra) was observed in ob/ obmice compared with their littermates. In vitro, leptin induced IL-1Ra production and upregulated the IL-1Ra induction by LPS in macrophages. Moreover, treatment with leptin reversed the increased sensitivity to LPS-induced lethality found in ob/ obmice. These results suggest that leptin participates in the host response to inflammation by modulating the host immune and cytokine responses after LPS.
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Cites
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Cited by
Adipose tissue, adipokines, and inflammation
Fantuzzi, G. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.02.023 · Cited by 2,606
Self-citationNonalcoholic fatty liver disease
Adams, L. A. (2005) · Canadian Medical Association Journal · doi:10.1503/cmaj.045232 · Cited by 1,610
Leptin in the regulation of immunity, inflammation, and hematopoiesis
Fantuzzi, G., & Faggioni, R. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.68.4.437 · Cited by 980
Self-citationWisse, B. E. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000141966.69934.21 · Cited by 933
Mouse models in non‐alcoholic fatty liver disease and steatohepatitis research
Anstee, Q. M., & Goldin, R. D. (2006) · International Journal of Experimental Pathology · doi:10.1111/j.0959-9673.2006.00465.x · Cited by 714
Metadata
- Authors
- Faggioni, R., Fantuzzi, G., Gabay, C., Moser, A., Dinarello, C. A., Feingold, K. R., & Grunfeld, C.
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 1999-01-01
- Volume
- 276
- Issue
- 1
- Pages
- R136-R142
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2114538698
- Cited by
- 287
- References
- 33
- FWCI
- 13.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- Faggioni, R., Fantuzzi, G., Gabay, C., Moser, A., Dinarello, C. A., Feingold, K. R., & Grunfeld, C. (1999). Leptin deficiency enhances sensitivity to endotoxin-induced lethality. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. https://doi.org/10.1152/ajpregu.1999.276.1.r136
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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