The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Sympathetic and cardiovascular actions of orexins in conscious rats
Abstract
The novel hypothalamic peptides orexin-A and orexin-B are known to induce feeding behavior when administered intracerebroventricularly, but little is known about other physiological functions. The renal sympathetic nerves play important roles in the homeostasis of body fluids and the circulatory system. We examined the effects of intracerebroventricularly administered orexins on mean arterial pressure (MAP), heart rate (HR), renal sympathetic nerve activity (RSNA), and plasma catecholamine in conscious rats. Orexin-A (0.3, 3.0 nmol) provoked an increase in MAP (94.3 ± 0.7 to 101.9 ± 0.7 mmHg and 93.1 ± 1.1 to 108.3 ± 0.8 mmHg, respectively) and RSNA (28.0 ± 7.0 and 57.9 ± 12.3%, respectively). Similarly, orexin-B (0.3, 3.0 nmol) increased MAP (93.9 ± 0.9 to 97.9 ± 0.9 mmHg and 94.5 ± 1.1 to 105.3 ± 1.7 mmHg, respectively). Orexin-A and -B at 3.0 nmol also increased HR. In other conscious rats, a high dose of orexin-A and -B increased plasma norepinephrine. Plasma epinephrine only increased with a high dose of orexin-A. These results indicate that central orexins regulate sympathetic nerve activity and affect cardiovascular functions.
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Cites
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Cited by
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Hypothalamic Orexin Neurons Regulate Arousal According to Energy Balance in Mice
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Discharge of Identified Orexin/Hypocretin Neurons across the Sleep-Waking Cycle
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The hypothalamus and the control of energy homeostasis
Williams, G., Bing, C., Cai, X. J., Harrold, J. A., King, P. J., & Liu, X. H. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00612-6 · Cited by 578
Metadata
- Authors
- Shirasaka, T., Nakazato, M., Matsukura, S., Takasaki, M., & Kannan, H.
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 1999-12-01
- Volume
- 277
- Issue
- 6
- Pages
- R1780-R1785
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2101032752
- Cited by
- 440
- References
- 24
- FWCI
- 11.05
- Type
- journal article
- Language
- en
- Open access
- closed
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