The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Mechanotransduction in the renal tubule
Open accessAbstract
The role of mechanical forces in the regulation of glomerulotubular balance in the proximal tubule (PT) and Ca 2+signaling in the distal nephron was first recognized a decade ago, when it was proposed that the microvilli in the PT and the primary cilium in the cortical collecting duct (CCD) acted as sensors of local tubular flow. In this review, we present a summary of the theoretical models and experiments that have been conducted to elucidate the structure and function of these unique apical structures in the modulation of Na+, HCO 3−, and water reabsorption in the PT and Ca 2+signaling in the CCD. We also contrast the mechanotransduction mechanisms in renal epithelium with those in other cells in which fluid shear stresses have been recognized to play a key role in initiating intracellular signaling, most notably endothelial cells, hair cells in the inner ear, and bone cells. In each case, small hydrodynamic forces need to be greatly amplified before they can be sensed by the cell's intracellular cytoskeleton to enable the cell to regulate its membrane transporters or stretch-activated ion channels in maintaining homeostasis in response to changing flow conditions.
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Cites
Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells
Nauli, S. M., Alenghat, F. J., Luo, Y., Williams, E., Vassilev, P., Li, X., Elia, A. E. H., Lu, W., Brown, E. M., Quinn, S. J., et al. (2003) · Nature Genetics · doi:10.1038/ng1076 · Cited by 2,057
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Yoder, B. K., Hou, X., & Guay-Woodford, L. M. (2002) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000029587.47950.25 · Cited by 935
Primary cilia mediate mechanosensing in bone cells by a calcium-independent mechanism
Malone, A. M. D., Anderson, C. T., Tummala, P., Kwon, R. Y., Johnston, T. R., Stearns, T., & Jacobs, C. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700636104 · Cited by 477
Expression of primary cilia in mammalian cells
WHEATLEY, D. N., WANG, A. M., & STRUGNELL, G. E. (1996) · Cell Biology International · doi:10.1006/cbir.1996.0011 · Cited by 378
A model for the role of integrins in flow induced mechanotransduction in osteocytes
Wang, Y., McNamara, L. M., Schaffler, M. B., & Weinbaum, S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707246104 · Cited by 265
Self-citationXiao, Z., Zhang, S., Mahlios, J., Zhou, G., Magenheimer, B. S., Guo, D., Dallas, S. L., Maser, R., Calvet, J. P., Bonewald, L., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604772200 · Cited by 254
Cited by
Obesity-related glomerulopathy: clinical and pathologic characteristics and pathogenesis
D'Agati, V. D., Chagnac, A., de Vries, A. P. J., Levi, M., Porrini, E., Herman-Edelstein, M., & Praga, M. (2016) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.75 · Cited by 716
Wells, R. G. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.02.007 · Cited by 384
Modelling and targeting mechanical forces in organ fibrosis
Mascharak, S., L. Guo, J., Griffin, M., E. Berry, C., C. Wan, D., & T. Longaker, M. (2024) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00144-3 · Cited by 59
Profibrotic epithelial phenotype: a central role for MRTF and TAZ
Bialik, J. F., Ding, M., Speight, P., Dan, Q., Miranda, M. Z., Di Ciano-Oliveira, C., Kofler, M. M., Rotstein, O. D., Pedersen, S. F., Szászi, K., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-40764-7 · Cited by 41
Vormann, M. K., Tool, L. M., Ohbuchi, M., Gijzen, L., van Vught, R., Hankemeier, T., Kiyonaga, F., Kawabe, T., Goto, T., Fujimori, A., et al. (2022) · Kidney360 · doi:10.34067/kid.0003622021 · Cited by 39
Metadata
- Authors
- Weinbaum, S., Duan, Y., Satlin, L. M., Wang, T., & Weinstein, A. M.
- Venue
- American Journal of Physiology-Renal Physiology
- Publisher
- American Physiological Society
- Published
- 2010-12
- Volume
- 299
- Issue
- 6
- Pages
- F1220-F1236
- ISSN
- 1522-1466 (ISSN-L)
- 1931-857X
- OpenAlex
- W2018981570
- Cited by
- 158
- References
- 7
- FWCI
- 4.14
- Type
- journal article
- Language
- en
- Open access
- green
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- Weinbaum, S., Duan, Y., Satlin, L. M., Wang, T., & Weinstein, A. M. (2010). Mechanotransduction in the renal tubule. American Journal of Physiology-Renal Physiology. https://doi.org/10.1152/ajprenal.00453.2010
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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