Modelling and targeting mechanical forces in organ fibrosis
Open accessAbstract
Few efficacious therapies exist for the treatment of fibrotic diseases, such as skin scarring, liver cirrhosis and pulmonary fibrosis, which is related to our limited understanding of the fundamental causes and mechanisms of fibrosis. Mechanical forces from cell-matrix interactions, cell-cell contact, fluid flow and other physical stimuli may play a central role in the initiation and propagation of fibrosis. In this Review, we highlight the mechanotransduction mechanisms by which various sources of physical force drive fibrotic disease processes, with an emphasis on central pathways that may be therapeutically targeted to prevent and reverse fibrosis. We then discuss engineered models of mechanotransduction in fibrosis, as well as molecular and biomaterials-based therapeutic approaches for limiting fibrosis and promoting regenerative healing phenotypes in various organs. Finally, we discuss challenges within fibrosis research that remain to be addressed and that may greatly benefit from next-generation bioengineered model systems.
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Cadherin-11 facilitates adhesion between M2-like macrophages and myofibroblasts, creating a niche enriched with active TGF-b, and acts as a mechano-immune bridge in fibrosis.
“A seminal study demonstrated that Cadherin-11 facilitates robust adhesion between M2-like macrophages and myofibroblasts, creating a niche enriched with active TGF-b (3, 57, 63, 64).”
From The mechanotransduction-immune axis in organ fibrosis: dual regulatory mechanisms and translational therapeutic perspectives (2025) · cites this paper as [3]
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Gurtner, G. C., Werner, S., Barrandon, Y., & Longaker, M. T. (2008) · Nature · doi:10.1038/nature07039 · Cited by 6,542 · see citing works
Mechanisms of fibrosis: therapeutic translation for fibrotic disease
Wynn, T. A., & Ramalingam, T. R. (2012) · Nature Medicine · doi:10.1038/nm.2807 · Cited by 3,541 · see citing works
Single-molecule force spectroscopy: optical tweezers, magnetic tweezers and atomic force microscopy
Neuman, K. C., & Nagy, A. (2008) · Nature Methods · doi:10.1038/nmeth.1218 · Cited by 2,388 · see citing works
Munger, J. S., Huang, X., Kawakatsu, H., Griffiths, M. J. D., Dalton, S. L., Wu, J., Pittet, J.-F., Kaminski, N., Garat, C., Matthay, M. A., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80545-0 · Cited by 2,076 · see citing works
Histopathological Image Analysis: A Review
Gurcan, M. N., Boucheron, L. E., Can, A., Madabhushi, A., Rajpoot, N. M., & Yener, B. (2009) · IEEE Reviews in Biomedical Engineering · doi:10.1109/rbme.2009.2034865 · Cited by 2,052 · see citing works
Transition from inflammation to proliferation: a critical step during wound healing
Landén, N. X., Li, D., & Ståhle, M. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2268-0 · Cited by 1,980 · cited 1× · see citing works
“Within 2 to 10 days, wound repair enters a proliferative phase, characterized by angiogenesis, formation of granulation tissue, and reconstitution of the epithelial barrier by proliferation and migration of keratinocytes at the leading edge 252,253 .”
Fibrotic disease and the TH1/TH2 paradigm
Wynn, T. A. (2004) · Nature Reviews Immunology · doi:10.1038/nri1412 · Cited by 1,765 · see citing works
Formation and function of the myofibroblast during tissue repair
Hinz, B. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700613 · Cited by 1,658 · see citing works
Human organs-on-chips for disease modelling, drug development and personalized medicine
Ingber, D. E. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-022-00466-9 · Cited by 1,589 · see citing works
Deep profiling of mouse splenic architecture with CODEX multiplexed imaging
Goltsev, Y., Samusik, N., Kennedy-Darling, J., Bhate, S., Hale, M., Vazquez, G., Black, S., & Nolan, G. P. (2018) · Cell · doi:10.1016/j.cell.2018.07.010 · Cited by 1,501 · cited 1× · see citing works
“…can resolve the spatial heterogeneity of fibrosis by quantifying in situ gene and protein expression, which may help to identify cell–cell interactions involved in mechanotransduction signalling and elucidate how localized mechanobiological niches influence profibrotic transcription 185,186 .”
Force triggers YAP nuclear entry by regulating transport across nuclear pores
Elosegui-Artola, A., Andreu, I., Beedle, A. E. M., Lezamiz, A., Uroz, M., Kosmalska, A. J., Oria, R., Kechagia, J. Z., Rico-Lastres, P., Le Roux, A.-L., et al. (2017) · Cell · doi:10.1016/j.cell.2017.10.008 · Cited by 1,491 · see citing works
Type 2 immunity in tissue repair and fibrosis
Gieseck, R. L., Wilson, M. S., & Wynn, T. A. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.90 · Cited by 1,055 · cited 1× · see citing works
“Innate and adaptive immune responses, infectious organisms (such as viruses or helminths) and genetic factors (for example telomerase mutations in idiopathic pulmonary fibrosis) have been implicated as important drivers of fibrosis 6,7 .”
Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors
Morsut, L., Roybal, K. T., Xiong, X., Gordley, R. M., Coyle, S. M., Thomson, M., & Lim, W. A. (2016) · Cell · doi:10.1016/j.cell.2016.01.012 · Cited by 1,002 · see citing works
Hippo–YAP/TAZ signalling in organ regeneration and regenerative medicine
Moya, I. M., & Halder, G. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0086-y · Cited by 981 · see citing works
Cellular Mechanotransduction: From Tension to Function
Martino, F. D., Perestrelo, A. R., Vinarský, V., Pagliari, S., & Forte, G. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00824 · Cited by 958 · see citing works
Griffin, D., Weaver, W., Scumpia, P. O., Carlo, D. D., & Segura, T. (2015) · Nature Materials · doi:10.1038/nmat4294 · Cited by 881 · see citing works
Barry-Hamilton, V., Spangler, R., Marshall, D., McCauley, S., Rodriguez, H. M., Oyasu, M., Mikels, A., Vaysberg, M., Ghermazien, H., Wai, C., et al. (2010) · Nature Medicine · doi:10.1038/nm.2208 · Cited by 870 · see citing works
Mechanisms of sensory transduction in the skin
Lumpkin, E. A., & Caterina, M. J. (2007) · Nature · doi:10.1038/nature05662 · Cited by 860 · see citing works
High-throughput sequencing of the transcriptome and chromatin accessibility in the same cell
Chen, S., Lake, B. B., & Zhang, K. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0290-0 · Cited by 810 · see citing works
Seyhan, A. A. (2019) · Translational Medicine Communications · doi:10.1186/s41231-019-0050-7 · Cited by 731 · see citing works
Nuclear Shape, Mechanics, and Mechanotransduction
Dahl, K. N., Ribeiro, A. J. S., & Lammerding, J. (2008) · Circulation Research · doi:10.1161/circresaha.108.173989 · Cited by 714 · see citing works
Strunz, M., Simon, L. M., Ansari, M., Kathiriya, J. J., Angelidis, I., Mayr, C. H., Tsidiridis, G., Lange, M., Mattner, L. F., Yee, M., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17358-3 · Cited by 710 · see citing works
Organ-on-a-chip: recent breakthroughs and future prospects
Wu, Q., Liu, J., Wang, X., Feng, L., Wu, J., Zhu, X., Wen, W., & Gong, X. (2020) · BioMedical Engineering OnLine · doi:10.1186/s12938-020-0752-0 · Cited by 704 · see citing works
YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration
Yui, S., Azzolin, L., Maimets, M., Pedersen, M. T., Fordham, R. P., Hansen, S. L., Larsen, H. L., Guiu, J., Alves, M. R. P., Rundsten, C. F., et al. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.11.001 · Cited by 678 · see citing works
Therapy for Fibrotic Diseases: Nearing the Starting Line
Friedman, S. L., Sheppard, D., Duffield, J. S., & Violette, S. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3004700 · Cited by 655 · see citing works
Transcription upregulation via force-induced direct stretching of chromatin
Tajik, A., Zhang, Y., Wei, F., Sun, J., Jia, Q., Zhou, W., Singh, R., Khanna, N., Belmont, A. S., & Wang, N. (2016) · Nature Materials · doi:10.1038/nmat4729 · Cited by 633 · see citing works
Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis
Ding, B.-S., Cao, Z., Lis, R., Nolan, D. J., Guo, P., Simons, M., Penfold, M. E., Shido, K., Rabbany, S. Y., & Rafii, S. (2014) · Nature · doi:10.1038/nature12681 · Cited by 626 · see citing works
Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring
Mascharak, S., desJardins-Park, H. E., Davitt, M. F., Griffin, M., Borrelli, M. R., Moore, A. L., Chen, K., Duoto, B. A., Chinta, M. S., Foster, D. S., et al. (2021) · Science · doi:10.1126/science.aba2374 · Cited by 622 · see citing works
Self-citationIsolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus
Guilluy, C., Osborne, L. D., Landeghem, L. V., Sharek, L., Superfine, R., García‐Mata, R., & Burridge, K. (2014) · Nature Cell Biology · doi:10.1038/ncb2927 · Cited by 613 · see citing works
Bayat, A., McGrouther, D. A., & Ferguson, M. W. J. (2003) · BMJ · doi:10.1136/bmj.326.7380.88 · Cited by 608 · see citing works
Borghi, N., Sorokina, M., Shcherbakova, O. G., Weis, W. I., Pruitt, B. L., Nelson, W. J., & Dunn, A. R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1204390109 · Cited by 596 · see citing works
Increased stiffness of the rat liver precedes matrix deposition: implications for fibrosis
Georges, P. C., Hui, J.-J., Gombos, Z., McCormick, M. E., Wang, A. Y., Uemura, M., Mick, R., Janmey, P. A., Furth, E. E., & Wells, R. G. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00032.2007 · Cited by 577 · see citing works
The role of α-smooth muscle actin in fibroblast-mediated matrix contraction and remodeling
Shinde, A. V., Humeres, C. D., & Frangogiannis, N. G. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.11.006 · Cited by 575 · see citing works
Fibrotic extracellular matrix activates a profibrotic positive feedback loop
Parker, M. W., Rossi, D., Peterson, M., Smith, K. A., Sikström, K., White, E. S., Connett, J. E., Henke, C. A., Larsson, O. S., & Bitterman, P. B. (2014) · Journal of Clinical Investigation · doi:10.1172/jci71386 · Cited by 554 · see citing works
Sun, G., Zhang, X., Shen, Y.-I., Sebastian, R., Dickinson, L. E., Fox-Talbot, K., Reinblatt, M., Steenbergen, C., Harmon, J. W., & Gerecht, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1115973108 · Cited by 553 · see citing works
Diverse functions of matrix metalloproteinases during fibrosis
Giannandrea, M., & Parks, W. C. (2014) · Disease Models & Mechanisms · doi:10.1242/dmm.012062 · Cited by 543 · see citing works
Mechanisms, Management, and Treatment of Fibrosis in Patients With Inflammatory Bowel Diseases
Rieder, F., Fiocchi, C., & Rogler, G. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.09.047 · Cited by 534 · see citing works
Activating an adaptive immune response from a hydrogel scaffold imparts regenerative wound healing
Griffin, D. R., Archang, M. M., Kuan, C., Weaver, W. M., Weinstein, J. S., Feng, A., Ruccia, A., Sideris, E., Ragkousis, V., Koh, J., et al. (2020) · Nature Materials · doi:10.1038/s41563-020-00844-w · Cited by 521 · see citing works
Mechanical load initiates hypertrophic scar formation through decreased cellular apoptosis
Aarabi, S., Bhatt, K. A., Shi, Y., Paterno, J., Chang, E. I.-F., Loh, S. A., Holmes, J. W., Longaker, M. T., Yee, H. T., & Gurtner, G. C. (2007) · The FASEB Journal · doi:10.1096/fj.07-8218com · Cited by 516 · see citing works
Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling
Wong, V. W., Rustad, K. C., Akaishi, S., Sorkin, M., Glotzbach, J. P., Januszyk, M., Nelson, E. R., Levi, K., Paterno, J., Vial, I. N., et al. (2012) · Nature Medicine · doi:10.1038/nm.2574 · Cited by 515 · see citing works
Mechanotransduction: All Signals Point to Cytoskeleton, Matrix, and Integrins
Alenghat, F. J., & Ingber, D. E. (2002) · Science s STKE · doi:10.1126/stke.2002.119.pe6 · Cited by 498 · see citing works
Injectable and bioresponsive hydrogels for on-demand matrix metalloproteinase inhibition
Purcell, B. P., Lobb, D. C., Charati, M. B., Dorsey, S. M., Wade, R. J., Zellars, K. N., Doviak, H., Pettaway, S., Logdon, C. B., Shuman, J. A., et al. (2014) · Nature Materials · doi:10.1038/nmat3922 · Cited by 480 · see citing works
The Healing of Rat Skin Wounds
Levenson, S. Μ., Geever, E. F., CHOWLEY, L. V., OATES, J. F., Berard, C. W., & ROSEN, H. (1965) · Annals of Surgery · doi:10.1097/00000658-196502000-00019 · Cited by 478 · see citing works
Daly, A. C., Davidson, M. D., & Burdick, J. A. (2021) · Nature Communications · doi:10.1038/s41467-021-21029-2 · Cited by 470 · see citing works
Doyle, A. D., Carvajal, N., Jin, A. J., Matsumoto, K., & Yamada, K. M. (2015) · Nature Communications · doi:10.1038/ncomms9720 · Cited by 462 · see citing works
Tensile Forces and Mechanotransduction at Cell–Cell Junctions
Charras, G., & Yap, A. S. (2018) · Current Biology · doi:10.1016/j.cub.2018.02.003 · Cited by 460 · see citing works
Optogenetic protein clustering and signaling activation in mammalian cells
Bugaj, L. J., Choksi, A. T., Mesuda, C. K., Kane, R. S., & Schaffer, D. V. (2013) · Nature Methods · doi:10.1038/nmeth.2360 · Cited by 456 · see citing works
Charrier, E. E., Pogoda, K., Wells, R. G., & Janmey, P. A. (2018) · Nature Communications · doi:10.1038/s41467-018-02906-9 · Cited by 416 · see citing works
Fluid Shear Stress Activation of Focal Adhesion Kinase
Li, S., Kim, M. S., Hu, Y., Jalali, S., Schlaepfer, D. D., Hunter, T. R., Chien, S., & Shyy, J. Y.-J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.48.30455 · Cited by 414 · see citing works
Wells, R. G. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.02.007 · Cited by 384 · see citing works
<scp>FDA</scp> Modernization Act 2.0 allows for alternatives to animal testing
Han, J. J. (2023) · Artificial Organs · doi:10.1111/aor.14503 · Cited by 381 · cited 2× · see citing works
“The recent passage of the Food and Drug Administration (FDA) Modernization Act 2.0 has authorized the usage of certain alternatives to animal models, such as cellular assays and computational models, to establish the efficacy and/or safety of some preclinical drug candidates 85 .”
InfluentialMechanobiology of force transduction in dermal tissue
Silver, F. H., Siperko, L. M., & Seehra, G. P. (2003) · Skin Research and Technology · doi:10.1034/j.1600-0846.2003.00358.x · Cited by 380 · see citing works
Hypertrophic Scars and Keloids
Alster, T. S., & Tanzi, E. L. (2003) · American Journal of Clinical Dermatology · doi:10.2165/00128071-200304040-00003 · Cited by 379 · see citing works
Jain, N., Iyer, K. V., Kumar, A., & Shivashankar, G. V. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1300801110 · Cited by 362 · see citing works
Control of cellular responses to mechanical cues through YAP/TAZ regulation
Dasgupta, I., & McCollum, D. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.rev119.007963 · Cited by 360 · see citing works
Kanasaki, K., Shi, S., Kanasaki, M., He, J., Nagai, T., Nakamura, Y., Ishigaki, Y., Kitada, M., Srivastava, S. P., & Koya, D. (2014) · Diabetes · doi:10.2337/db13-1029 · Cited by 359 · see citing works
Mechanotransduction through growth-factor shedding into the extracellular space
Tschumperlin, D. J., Dai, G., Maly, I. V., Kikuchi, T., Laiho, L. H., McVittie, A. K., Haley, K. J., Lilly, C. M., So, P. T. C., Lauffenburger, D. A., et al. (2004) · Nature · doi:10.1038/nature02543 · Cited by 353 · see citing works
Tschumperlin, D. J., Ligresti, G., Hilscher, M. B., & Shah, V. H. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93561 · Cited by 343 · see citing works
Wilson, E., Sudhir, K., & Ives, H. E. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118293 · Cited by 313 · see citing works
The role of hyperosmotic stress in inflammation and disease
Brocker, C. N., Thompson, D. C., & Vasiliou, V. (2012) · BioMolecular Concepts · doi:10.1515/bmc-2012-0001 · Cited by 302 · see citing works
The cell biology of polycystic kidney disease
Chapin, H. C., & Caplan, M. J. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201006173 · Cited by 282 · see citing works
Forced unfolding of the fibronectin type III module reveals a tensile molecular recognition switch
Krammer, A., Lu, H. J., Isralewitz, B., Schulten, K. J., & Viola Vogel, B. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.4.1351 · Cited by 278 · see citing works
Hydrogels with Reversible Mechanics to Probe Dynamic Cell Microenvironments
Rosales, A. M., Vega, S. L., DelRio, F. W., Burdick, J. A., & Anseth, K. S. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201705684 · Cited by 275 · see citing works
Atiyeh, B. S. (2007) · Aesthetic Plastic Surgery · doi:10.1007/s00266-006-0253-y · Cited by 267 · see citing works
Nih, L. R., Sideris, E., Carmichael, S. T., & Segura, T. (2017) · Advanced Materials · doi:10.1002/adma.201606471 · Cited by 265 · see citing works
Mierke, C. T. (2019) · Reports on Progress in Physics · doi:10.1088/1361-6633/ab1628 · Cited by 262 · see citing works
Revisiting fibrosis in inflammatory bowel disease: the gut thickens
D’Alessio, S., Ungaro, F., Noviello, D., Lovisa, S., Peyrin‐Biroulet, L., & Danese, S. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00543-0 · Cited by 258 · see citing works
Multi-omic analysis reveals divergent molecular events in scarring and regenerative wound healing
Mascharak, S., desJardins-Park, H. E., Januszyk, M., Griffin, M., Chen, K., Davitt, M. F., Demeter, J., Henn, D., Bonham, C. A., Foster, D. S., et al. (2022) · Cell stem cell · doi:10.1016/j.stem.2021.12.011 · Cited by 247 · see citing works
Self-citationMasszi, A., Fan, L., Rosivall, L., McCulloch, C. A., Rotstein, O. D., Mucsi, I., & Kapùs, A. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63247-6 · Cited by 242 · see citing works
Knipe, R. S., Tager, A. M., & Liao, J. K. (2015) · Pharmacological Reviews · doi:10.1124/pr.114.009381 · Cited by 233 · see citing works
Mechanical communication in fibrosis progression
Long, Y., Niu, Y., Liang, K., & Du, Y. (2022) · Trends in Cell Biology · doi:10.1016/j.tcb.2021.10.002 · Cited by 233 · see citing works
Biophysical Principles of Ion-Channel-Mediated Mechanosensory Transduction
Cox, C. D., Bavi, N., & Martinac, B. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.08.075 · Cited by 232 · see citing works
Mechanotransduction: use the force(s)
Paluch, E. K., Nelson, C. M., Biais, N., Fabry, B., Moeller, J., Pruitt, B. L., Wollnik, C., Kudryasheva, G., Rehfeldt, F., & Federle, W. (2015) · BMC Biology · doi:10.1186/s12915-015-0150-4 · Cited by 227 · see citing works
Foster, D. S., Januszyk, M., Delitto, D., Yost, K. E., Griffin, M., Guo, J. L., Guardino, N. J., Delitto, A. E., Chinta, M. S., Burcham, A. R., et al. (2022) · Cancer Cell · doi:10.1016/j.ccell.2022.09.015 · Cited by 220 · see citing works
Self-citationSelective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis
Haak, A. J., Kostallari, E., Sicard, D., Ligresti, G., Choi, K. M., Caporarello, N., Jones, D. L., Tan, Q., Meridew, J. A., Espinosa, A. M. D., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aau6296 · Cited by 219 · see citing works
Caliari, S. R., Perepelyuk, M., Cosgrove, B. D., Tsai, S. J., Lee, G. Y., Mauck, R. L., Wells, R. G., & Burdick, J. A. (2016) · Scientific Reports · doi:10.1038/srep21387 · Cited by 218 · see citing works
β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis
Beyer, C., Schramm, A., Akhmetshina, A., Dees, C., Kireva, T., Gelse, K., Sonnylal, S., de Crombrugghe, B., Taketo, M. M., Distler, O., et al. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2011-200568 · Cited by 203 · see citing works
Targeting the renin-angiotensin-aldosterone system in fibrosis
Alqudah, M., Hale, T. M., & Czubryt, M. P. (2020) · Matrix Biology · doi:10.1016/j.matbio.2020.04.005 · Cited by 202 · see citing works
Mechanical regulation of cardiac fibroblast profibrotic phenotypes
Herum, K. M., Choppe, J., Kumar, A., Engler, A. J., & McCulloch, A. D. (2017) · Molecular Biology of the Cell · doi:10.1091/mbc.e17-01-0014 · Cited by 198 · see citing works
Integrated spatial multiomics reveals fibroblast fate during tissue repair
Foster, D. S., Januszyk, M., Yost, K. E., Chinta, M. S., Gulati, G. S., Nguyen, A. T., Burcham, A. R., Salhotra, A., Ransom, R. C., Henn, D., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2110025118 · Cited by 194 · see citing works
Self-citationInhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation
Lagares, D., Busnadiego, Ó., García-Fernández, R. A., Kapoor, M., Liu, S., Carter, D. E., Abraham, D., Shiwen, X., Carreira, P. E., Fontaine, B. A., et al. (2011) · Arthritis & Rheumatism · doi:10.1002/art.33482 · Cited by 192 · see citing works
Collagen microarchitecture mechanically controls myofibroblast differentiation
Seo, B. R., Chen, X., Lu, L., Song, Y. H., Shimpi, A. A., Choi, S., Gonzalez, J., Sapudom, J., Wang, K., Eguiluz, R. C. A., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1919394117 · Cited by 192 · see citing works
Mastikhina, O., Moon, B., Williams, K., Hatkar, R., Gustafson, D., Mourad, O., Sun, X., Koo, M., Lam, A. Y. L., Sun, Y., et al. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119741 · Cited by 190 · see citing works
Mechanical properties of normal skin and hypertrophic scars
Clark, J. A., Cheng, J. C. Y., & Leung, K. (1996) · Burns · doi:10.1016/0305-4179(96)00038-1 · Cited by 184 · see citing works
Cell–cell junctional mechanotransduction in endothelial remodeling
Dorland, Y. L., & Huveneers, S. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2325-8 · Cited by 181 · see citing works
Fibroblast inflammatory priming determines regenerative versus fibrotic skin repair in reindeer
Sinha, S., Sparks, H. D., Labit, E., Robbins, H. N., Gowing, K., Jaffer, A., Kutluberk, E., Arora, R., Raredon, M. S. B., Cao, L., et al. (2022) · Cell · doi:10.1016/j.cell.2022.11.004 · Cited by 178 · see citing works
Confalonieri, P., Volpe, M. C., Jacob, J., Maiocchi, S., Salton, F., Ruaro, B., Confalonieri, M., & Braga, L. (2022) · Cells · doi:10.3390/cells11132095 · Cited by 175 · see citing works
Peyronnet, R., Martins, J. R., Duprat, F., Demolombe, S., Arhatte, M., Jodar, M., Tauc, M., Duranton, C., Paulais, M., Teulon, J., et al. (2013) · EMBO Reports · doi:10.1038/embor.2013.170 · Cited by 169 · see citing works
Webb, K., Hitchcock, R. W., Smeal, R. M., Li, W., Gray, S. D., & Tresco, P. A. (2005) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2004.08.026 · Cited by 168 · see citing works
The LINC complex, mechanotransduction, and mesenchymal stem cell function and fate
Bouzid, T., Kim, E., Riehl, B. D., Esfahani, A. M., Rosenbohm, J., Yang, R., Duan, B., & Lim, J. Y. (2019) · Journal of Biological Engineering · doi:10.1186/s13036-019-0197-9 · Cited by 166 · see citing works
Peng, X. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24497 · Cited by 166 · see citing works
Zhou, M., Zhang, X., Wen, X., Wu, T., Wang, W., Yang, M., Wang, J., Fang, M., Lin, B., & Lin, H. (2016) · Scientific Reports · doi:10.1038/srep31771 · Cited by 162 · see citing works
Jones, M. G., Andriotis, O. G., Roberts, J., Lunn, K., Tear, V. J., Cao, L., Ask, K., Smart, D. E., Bonfanti, A., Johnson, P., et al. (2018) · eLife · doi:10.7554/elife.36354 · Cited by 162 · see citing works
Mechanotransduction in the renal tubule
Weinbaum, S., Duan, Y., Satlin, L. M., Wang, T., & Weinstein, A. M. (2010) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00453.2010 · Cited by 158 · see citing works
The mammalian LINC complex regulates genome transcriptional responses to substrate rigidity
Alam, S. G., Zhang, Q., Prasad, N., Li, Y., Chamala, S., Kuchibhotla, R. A., Birendra, K. C., Aggarwal, V., Shrestha, S., Jones, A., et al. (2016) · Scientific Reports · doi:10.1038/srep38063 · Cited by 154 · see citing works
Pakulska, M. M., Donaghue, I. E., Obermeyer, J. M., Tuladhar, A., McLaughlin, C. K., Shendruk, T. N., & Shoichet, M. S. (2016) · Science Advances · doi:10.1126/sciadv.1600519 · Cited by 153 · see citing works
Duan, J., Ruan, B., Yan, X., Liang, L., Song, P., Yang, Z., Liu, Y., Dou, K., Han, H., & Wang, L. (2018) · Hepatology · doi:10.1002/hep.29834 · Cited by 153 · see citing works
Kim, T., Zheng, S., Sun, J., Muhamed, I., Wu, J., Lei, L., Kong, X., Leckband, D. E., & Wang, Y. (2014) · Current Biology · doi:10.1016/j.cub.2014.11.017 · Cited by 150 · see citing works
Podocytes are sensitive to fluid shear stress in vitro
Friedrich, C., Endlich, N., Kriz, W., & Endlich, K. (2006) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00196.2005 · Cited by 150 · see citing works
The primary cilium functions as a mechanical and calcium signaling nexus
Lee, K. L., Guevarra, M. D., Nguyen, A. M., Chua, M., Wang, Y., & Jacobs, C. R. (2015) · Cilia · doi:10.1186/s13630-015-0016-y · Cited by 149 · see citing works
A review of fibroblast‐populated collagen lattices
Dallon, J. C., & Ehrlich, H. P. (2008) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2008.00392.x · Cited by 148 · see citing works
Schneider, D. J., Wu, M., Le, T. T., Cho, S., Brenner, M. B., Blackburn, M. R., & Agarwal, S. K. (2011) · The FASEB Journal · doi:10.1096/fj.11-186098 · Cited by 146 · see citing works
Norona, L. M., Nguyen, D. G., Gerber, D. A., Presnell, S. C., & LeCluyse, E. L. (2016) · Toxicological Sciences · doi:10.1093/toxsci/kfw169 · Cited by 145 · see citing works
Russo, I., Cavalera, M., Huang, S., Su, Y., Hanna, A., Chen, B., Shinde, A. V., Conway, S. J., Graff, J. M., & Frangogiannis, N. G. (2019) · Circulation Research · doi:10.1161/circresaha.118.314438 · Cited by 134 · see citing works
Fibroblast Primary Cilia Are Required for Cardiac Fibrosis
Villalobos, E., Criollo, A., Schiattarella, G. G., Altamirano, F. J., French, K. M., May, H. I., Jiang, N., Nguyen, N. U. N., Romero, D., Roa, J. C., et al. (2019) · Circulation · doi:10.1161/circulationaha.117.028752 · Cited by 134 · see citing works
Genetics in Idiopathic Pulmonary Fibrosis Pathogenesis, Prognosis, and Treatment
Kaur, A., Mathai, S. K., & Schwartz, D. A. (2017) · Frontiers in Medicine · doi:10.3389/fmed.2017.00154 · Cited by 130 · see citing works
Focal Adhesion Kinase Regulates Hepatic Stellate Cell Activation and Liver Fibrosis
Zhao, X., Yu, L., Cheng, M., Che, P., Lu, Y., Zhang, Q., Mu, M., Li, H., Zhu, L.-L., Zhu, J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-04317-0 · Cited by 128 · see citing works
Soare, A., Györfi, H. A., Matei, A., Dees, C., Rauber, S., Wohlfahrt, T., Chen, C., Ludolph, I., Horch, R. E., Bäuerle, T., et al. (2019) · Arthritis & Rheumatology · doi:10.1002/art.41058 · Cited by 124 · see citing works
Durotaxis: The Hard Path from In Vitro to In Vivo
Shellard, A., & Mayor, R. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.11.019 · Cited by 124 · see citing works
The extracellular matrix and mechanotransduction in pulmonary fibrosis
Deng, Z., Fear, M. W., Choi, Y. S., Wood, F. M., Allahham, A., Mutsaers, S. E., & Prêle, C. M. (2020) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2020.105802 · Cited by 122 · see citing works
HDAC inhibitors as antifibrotic drugs in cardiac and pulmonary fibrosis
Lyu, X., Hu, M., Peng, J., Zhang, X.-Y., & Sanders, Y. (2019) · Therapeutic Advances in Chronic Disease · doi:10.1177/2040622319862697 · Cited by 121 · see citing works
Cherry, C., Maestas, D. R., Han, J., Andorko, J. I., Cahan, P., Fertig, E. J., Garmire, L. X., & Elisseeff, J. H. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00770-5 · Cited by 120 · see citing works
Primary cilia: Cell and molecular mechanosensors directing whole tissue function
Spasić, M. R., & Jacobs, C. R. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.08.036 · Cited by 117 · see citing works
Extracellular fluid viscosity enhances liver cancer cell mechanosensing and migration
Gonzalez‐Molina, J., Zhang, X., Borghesan, M., da Silva, J. M., Awan, M., Fuller, B. J., Gavara, N., & Selden, C. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.05.058 · Cited by 115 · see citing works
Deep learning enables automated scoring of liver fibrosis stages
Yu, Y., Wang, J., Ng, C. W., Ma, Y., Mo, S., Fong, E. L. S., Xing, J., Song, Z., Xie, Y., Si, K., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-34300-2 · Cited by 114 · see citing works
Disrupting biological sensors of force promotes tissue regeneration in large organisms
Chen, K., Kwon, S. H., Henn, D., Kuehlmann, B. A., Tevlin, R., Bonham, C. A., Griffin, M., Trotsyuk, A. A., Borrelli, M. R., Noishiki, C., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25410-z · Cited by 110 · see citing works
Self-citationMatera, D. L., DiLillo, K. M., Smith, M. R., Davidson, C. D., Parikh, R., Said, M., Wilke, C., Lombaert, I. M. A., Arnold, K. B., Moore, B. B., et al. (2020) · Science Advances · doi:10.1126/sciadv.abb5069 · Cited by 106 · see citing works
Blackburn, N. J. R., Sofrenovic, T., Kuraitis, D., Ahmadi, A., McNeill, B., Deng, C., Rayner, K. J., Zhong, Z., Ruel, M., & Suuronen, E. J. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.11.004 · Cited by 103 · see citing works
Liu, L., Sun, Q., Davis, F. M., Mao, J., Zhao, H., & Ma, D. (2022) · Burns & Trauma · doi:10.1093/burnst/tkac011 · Cited by 100 · see citing works
Disrupting mechanotransduction decreases fibrosis and contracture in split-thickness skin grafting
Chen, K., Henn, D., Januszyk, M., Barrera, J. A., Noishiki, C., Bonham, C. A., Griffin, M., Tevlin, R., Carlomagno, T., Shannon, T., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abj9152 · Cited by 98 · see citing works
Self-citationChai, R. J., Werner, H., Li, P. Y., Lee, Y. L., Khaing, N. T., Solovei, I. V., Luu, T. D. A., Sharma, B., Navasankari, R., Maric, M., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24849-4 · Cited by 97 · see citing works
Fasudil, a Rho-Kinase Inhibitor, Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice
Jiang, C., Huang, H. F., Liu, J., Wang, Y., Lu, Z., & Xu, Z. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms13078293 · Cited by 96 · see citing works
Incorporating mechanical strain in organs-on-a-chip: Lung and skin
Guenat, O. T., & Francois Berthiaume, B. (2018) · Biomicrofluidics · doi:10.1063/1.5024895 · Cited by 95 · see citing works
Reduction of Cardiac Fibrosis by Interference With YAP-Dependent Transactivation
Garoffolo, G., Casaburo, M., Amadeo, F., Salvi, M., Bernava, G., Piacentini, L., Chimenti, I., Zaccagnini, G., Milcovich, G., Zuccolo, E., et al. (2022) · Circulation Research · doi:10.1161/circresaha.121.319373 · Cited by 94 · see citing works
Liu, L., Yu, H., Zhao, H., Wu, Z., Long, Y., Zhang, J., Yan, X., You, Z., Zhou, L., Xia, T., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1910650117 · Cited by 94 · see citing works
Sarkar, U., Rivera‐Burgos, D., Large, E. M., Hughes, D. J., Ravindra, K. C., Dyer, R. L., Ebrahimkhani, M. R., Wishnok, J. S., Griffith, L. G., & Tannenbaum, S. R. (2015) · Drug Metabolism and Disposition · doi:10.1124/dmd.115.063495 · Cited by 93 · see citing works
Spatial-omics: Novel approaches to probe cell heterogeneity and extracellular matrix biology
Bingham, G. C., Lee, F., Naba, A., & Barker, T. H. (2020) · Matrix Biology · doi:10.1016/j.matbio.2020.04.004 · Cited by 92 · see citing works
Ford, A. J., Jain, G., & Rajagopalan, P. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.06.028 · Cited by 91 · see citing works
Engineered Biomaterial Platforms to Study Fibrosis
Davidson, M. D., Burdick, J. A., & Wells, R. G. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.201901682 · Cited by 90 · see citing works
Mihalko, E. P., Huang, K., Sproul, E. P., Cheng, K., & Brown, A. C. (2018) · ACS Nano · doi:10.1021/acsnano.8b01977 · Cited by 89 · see citing works
Darling, N. J., Sideris, E., Hamada, N., Carmichael, S. T., & Segura, T. (2018) · Advanced Science · doi:10.1002/advs.201801046 · Cited by 88 · see citing works
The Psychology of Scars: A Mini-Review.
Ngaage, L. M., & Agius, M. A. (2018) · PubMed · Cited by 86 · see citing works
TRPC3-GEF-H1 axis mediates pressure overload-induced cardiac fibrosis
Numaga‐Tomita, T., Kitajima, N., Kuroda, T., Nishimura, A., Miyano, K., Yasuda, S., Kuwahara, K., Sato, Y., Ide, T., Birnbaumer, L., et al. (2016) · Scientific Reports · doi:10.1038/srep39383 · Cited by 85 · see citing works
A new strategy to measure intercellular adhesion forces in mature cell-cell contacts
Sancho, A., Vandersmissen, I., Craps, S., Luttun, A., & Gröll, J. (2017) · Scientific Reports · doi:10.1038/srep46152 · Cited by 84 · see citing works
Epithelial-to-Mesenchymal Transition in Fibrosis: Concepts and Targeting Strategies
Lovisa, S. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.737570 · Cited by 84 · see citing works
Vorstandlechner, V., Laggner, M., Copic, D., Klas, K., Direder, M., Chen, Y., Golabi, B., Haslik, W., Radtke, C., Tschachler, E., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26495-2 · Cited by 84 · see citing works
Lu, F. Z., Ogawa, R., Nguyen, D. T., Chen, B., Guo, D., Helm, D. L., Zhan, Q., Murphy, G. F., & Orgill, D. P. (2011) · Annals of Plastic Surgery · doi:10.1097/sap.0b013e3181ea1e9b · Cited by 83 · see citing works
Desmoglein 2 mutant mice develop cardiac fibrosis and dilation
Krusche, C. A., Holthöfer, B., Hofe, V., van de Sandt, A. M., Eshkind, L. G., Bockamp, E., Merx, M. W., Kant, S., Windoffer, R., & Leube, R. E. (2011) · Basic Research in Cardiology · doi:10.1007/s00395-011-0175-y · Cited by 83 · see citing works
Application of FRET Biosensors in Mechanobiology and Mechanopharmacological Screening
Liu, L., He, F., Yu, Y., & Wang, Y. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.595497 · Cited by 83 · see citing works
Mechanotransduction in the pathogenesis of non-alcoholic fatty liver disease
Mitten, E. K., & Baffy, G. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.08.028 · Cited by 81 · see citing works
Chen, K., Sivaraj, D., Davitt, M. F., Leeolou, M. C., Henn, D., Steele, S. R., Huskins, S. L., Trotsyuk, A. A., Kussie, H. C., Greco, A. H., et al. (2022) · Wound Repair and Regeneration · doi:10.1111/wrr.13012 · Cited by 80 · see citing works
Horejs, C., Serio, A., Purvis, A., Gormley, A. J., Bertazzo, S., Poliniewicz, A., Wang, A. J., DiMaggio, P. A., Hohenester, E., & Stevens, M. M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1403139111 · Cited by 79 · see citing works
Machine Learning in Tissue Engineering
Guo, J. L., Januszyk, M., & Longaker, M. T. (2022) · Tissue Engineering Part A · doi:10.1089/ten.tea.2022.0128 · Cited by 79 · see citing works
Trujillo, J., Molina‐Jijón, E., Medina‐Campos, O. N., Rodríguez‐Muñoz, R., Reyes, J. L., Loredo, M. L., Barrera‐Oviedo, D., Pinzón, E., Rodríguez‐Rangel, D. S., & Pedraza‐Chaverrí, J. (2015) · Food & Function · doi:10.1039/c5fo00624d · Cited by 76 · see citing works
Spatiotemporal control of growth factors in three-dimensional printed scaffolds
Bittner, S. M., Guo, J. L., & Mikos, A. G. (2018) · Bioprinting · doi:10.1016/j.bprint.2018.e00032 · Cited by 76 · see citing works
Hussein, K. H., Park, K.-M., Yu, L., Kwak, H.-H., & Woo, H.-M. (2020) · Materials Science and Engineering: C · doi:10.1016/j.msec.2020.111160 · Cited by 75 · see citing works
Shear stress-induced alteration of epithelial organization in human renal tubular cells
Maggiorani, D., Dissard, R., Belloy, M., Saulnier-Blache, J.-S., Casemayou, A., Ducasse, L., Grès, S., Bellière, J., Caubet, C., Bascands, J.-L., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0131416 · Cited by 74 · see citing works
Pittet, P., Lee, K., Kulik, A., Meister, J.-J., & Hinz, B. (2008) · Journal of Cell Science · doi:10.1242/jcs.024877 · Cited by 72 · see citing works
Microfluidic Organ-on-a-Chip Devices for Liver Disease Modeling In Vitro
Kanabekova, P., Kadyrova, A., & Kulsharova, G. (2022) · Micromachines · doi:10.3390/mi13030428 · Cited by 72 · see citing works
Narayanan, V., Schappell, L. E., Mayer, C. R., Duke, A. A., Armiger, T. J., Arsenovic, P. T., Mohan, A., Dahl, K. N., Gleghorn, J. P., & Conway, D. E. (2020) · Current Biology · doi:10.1016/j.cub.2019.12.025 · Cited by 70 · see citing works
Ibañez, R. I. R., do Amaral, R. J. F. C., Reis, R. L., Marques, A. P., Murphy, C. M., & O’Brien, F. J. (2021) · Polymers · doi:10.3390/polym13152510 · Cited by 69 · see citing works
Wu, M., Pedroza, M., Lafyatis, R., George, A., Mayes, M. D., Assassi, S., Tan, F. K., Brenner, M. B., & Agarwal, S. K. (2013) · Arthritis & Rheumatology · doi:10.1002/art.38275 · Cited by 68 · see citing works
Ultrafine Carbon Black Particles Inhibit Human Lung Fibroblast-Mediated Collagen Gel Contraction
Kim, H., Liu, X., Kobayashi, T., Kohyama, T., Wen, F., Romberger, D. J., Conner, H., Gilmour, P. S., Donaldson, K., MacNee, W., et al. (2003) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.4796 · Cited by 67 · see citing works
HDAC8 inhibition ameliorates pulmonary fibrosis
Saito, S., Zhuang, Y., Suzuki, T., Ota, Y., Bateman, M. E., Alkhatib, A. L., Morris, G. F., & Lasky, J. A. (2018) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00551.2017 · Cited by 65 · see citing works
Lumacaftor-ivacaftor in the treatment of cystic fibrosis: design, development and place in therapy
Connett, G. J. (2019) · Drug Design Development and Therapy · doi:10.2147/dddt.s153719 · Cited by 59 · see citing works
Mechanoregulation of cytoskeletal dynamics by TRP channels
Kuipers, A. J., Middelbeek, J., & van Leeuwen, F. N. (2012) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2012.05.006 · Cited by 58 · see citing works
Suppression of SUN2 by DNA methylation is associated with HSCs activation and hepatic fibrosis
Chen, X., Li, W., Chen, Y., Li, X., Li, H.-D., Huang, H., Bu, F., Pan, X., Yang, Y., Huang, C., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-1032-9 · Cited by 58 · see citing works
Park, K. C., Park, J. H., Jeon, J. Y., Kim, S. Y., Kim, J. M., Lim, C. Y., Lee, T. H., Kim, H. K., Lee, H. G., Kim, S. M., et al. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12590 · Cited by 57 · see citing works
Selective inhibition of class IIa histone deacetylases alleviates renal fibrosis
Xiong, C., Guan, Y. A., Zhou, X., Liu, L., Zhuang, M. A., Zhang, W., Zhang, Y., Masucci, M. V., Bayliss, G. P., Zhao, T. C., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201801067rr · Cited by 57 · see citing works
Mechanotransduction in Liver Diseases
Kang, N. (2020) · Seminars in Liver Disease · doi:10.1055/s-0039-3399502 · Cited by 57 · see citing works
Novel Therapies for the Treatment of Cardiac Fibrosis Following Myocardial Infarction
Raziyeva, K., Kim, Y., Zharkinbekov, Z., Temirkhanova, K., & Saparov, A. (2022) · Biomedicines · doi:10.3390/biomedicines10092178 · Cited by 56 · see citing works
Chen, L., Li, Z., Zheng, Y., Zhou, F., Zhao, J., Zhai, Q., Zhang, Z., Liu, T., Chen, Y., & Qi, S. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.09.008 · Cited by 54 · see citing works
Li, W., Li, P., Li, N., Du, Y. M., Lü, S., Elad, D., & Long, M. (2020) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00379.2019 · Cited by 53 · see citing works
Spatially Resolved Deconvolution of the Fibrotic Niche in Lung Fibrosis
Eyres, M., Bell, J. A., Davies, E. R., Fabre, A., Alzetani, A., Jogai, S., Marshall, B. G., Johnston, D. A., Xu, Z., Fletcher, S., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111230 · Cited by 53 · see citing works
Baddam, S. R., Arsenovic, P. T., Narayanan, V., Duggan, N. R., Mayer, C. R., Newman, S. T., Abutaleb, D. A., Mohan, A., Kowalczyk, A. P., & Conway, D. E. (2018) · Cells · doi:10.3390/cells7070066 · Cited by 53 · see citing works
Horejs, C., St‐Pierre, J., Ojala, J. R. M., Steele, J. A. M., da Silva, P. B., Rynne‐Vidal, Á., Maynard, S. A., Hansel, C. S., Rodríguez-Fernández, C., Mazo, M. M., et al. (2017) · Nature Communications · doi:10.1038/ncomms15509 · Cited by 51 · see citing works
Bioengineered in Vitro Tissue Model of Fibroblast Activation for Modeling Pulmonary Fibrosis
Sundarakrishnan, A., Zukas, H., Coburn, J. M., Bertini, B. T., Liu, Z., Georgakoudi, I., Baugh, L. M., Dasgupta, Q., Black, L. D., & Kaplan, D. L. (2019) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.8b01262 · Cited by 51 · see citing works
Fan, G., Wang, W., Zhao, H., Cai, L., Zhang, P., Yang, Z., Zhang, J., & Wang, X. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000430373 · Cited by 51 · see citing works
High-throughput 3D imaging of single cells with light-sheet fluorescence microscopy on chip
Sala, F., Castriotta, M., Paiè, P., Farina, A., D’Annunzio, S., Zippo, A., Osellame, R., Bragheri, F., & Bassi, A. L. (2020) · Biomedical Optics Express · doi:10.1364/boe.393892 · Cited by 51 · see citing works
Anno, T., Sakamoto, N., & Sato, M. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.06.073 · Cited by 50 · see citing works
The Effect of Gold Nanorods on Cell-Mediated Collagen Remodeling
Sisco, P. N., Wilson, C. G. M., Mironova, E. S., Baxter, S. C., Murphy, C. J., & Goldsmith, E. C. (2008) · Nano Letters · doi:10.1021/nl802142h · Cited by 49 · see citing works
A blueprint for translational regenerative medicine
Armstrong, J. P. K., Keane, T. J., Roques, A. C., Patrick, P. S., Mooney, C. M., Kuan, W., Pisupati, V., Oreffo, R. O. C., Stuckey, D. J., Watt, F. M., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aaz2253 · Cited by 48 · see citing works
Pothapragada, S. P., Gupta, P., Mukherjee, S., & Das, T. (2022) · Nature Communications · doi:10.1038/s41467-021-27896-z · Cited by 48 · see citing works
A History of Regulatory Animal Testing: What Can We Learn?
Swaters, D., van Veen, A., van Meurs, W. P., Turner, J. E., & Ritskes-Hoitinga, M. J. (2022) · Alternatives to Laboratory Animals · doi:10.1177/02611929221118001 · Cited by 47 · see citing works
Seccia, T. M., Maniero, C., Belloni, A. S., Guidolin, D., Pothen, P., Pessina, A. C., & Rossi, G. P. (2008) · Journal of Hypertension · doi:10.1097/hjh.0b013e328309f00a · Cited by 45 · see citing works
Engineering rotating apical-out airway organoid for assessing respiratory cilia motility
Wijesekara, P., Yadav, P., Perkins, L. A., Stolz, D. B., Franks, J. M., Watkins, S. C., Jacome, E. R., Brody, S. L., Horani, A., Xu, J., et al. (2022) · iScience · doi:10.1016/j.isci.2022.104730 · Cited by 44 · see citing works
Zhang, J., Corciulo, C., Liu, H., Wilder, T., Ito, M., & Cronstein, B. N. (2017) · American Journal Of Pathology · doi:10.1016/j.ajpath.2017.05.005 · Cited by 42 · see citing works
Zeng, Y., Sun, H.-R., Yu, C., Lai, Y., Liu, X., Wu, J., Chen, H., & Liu, X. (2010) · Cytokine · doi:10.1016/j.cyto.2010.09.007 · Cited by 41 · see citing works
Ollech, D., Pflästerer, T., Shellard, A., Zambarda, C., Spatz, J. P., Marcq, P., Mayor, R., Wombacher, R., & Cavalcanti‐Adam, E. A. (2020) · Nature Communications · doi:10.1038/s41467-020-14390-1 · Cited by 40 · see citing works
Liu, Y., Bai, F., Tang, Z., Liu, N., & Liu, Q. (2021) · BMC Cardiovascular Disorders · doi:10.1186/s12872-020-01819-0 · Cited by 38 · see citing works
Barbosa, D. M., Fahlbusch, P., de Wiza, D. H., Jacob, S., Kettel, U., Al‐Hasani, H., Krüger, M., Ouwens, D. M., Hartwig, S., Lehr, S., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-61886-3 · Cited by 35 · see citing works
Huang, K. Y., & Petretto, E. G. (2021) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00594.2020 · Cited by 35 · see citing works
Saleh, K. S., Hewawasam, R. S., Šerbedžija, P., Blomberg, R., Noreldeen, S. E., Edelman, B., Smith, B. J., Riches, D. W. H., & Magin, C. M. (2022) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-022-00726-y · Cited by 34 · see citing works
Ablation of SUN2-containing LINC complexes drives cardiac hypertrophy without interstitial fibrosis
Stewart, R. M., Rodriguez, E. C., & King, M. C. (2019) · Molecular Biology of the Cell · doi:10.1091/mbc.e18-07-0438 · Cited by 33 · see citing works
Urushima, H., Yuasa, H., Matsubara, T., Kuroda, N., Hara, Y., Inoue, K., Wake, K., Sato, T., Friedman, S. L., & Ikeda, K. (2020) · American Journal Of Pathology · doi:10.1016/j.ajpath.2020.12.007 · Cited by 33 · see citing works
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Mascharak, S., desJardins-Park, H. E., Davitt, M. F., Guardino, N. J., Gurtner, G. C., Wan, D. C., & Longaker, M. T. (2021) · Advances in Wound Care · doi:10.1089/wound.2021.0040 · Cited by 33 · see citing works
Self-citationPhysical confinement alters sarcoma cell cycle progression and division
Moriarty, R. A., & Stroka, K. M. (2018) · Cell Cycle · doi:10.1080/15384101.2018.1533776 · Cited by 33 · see citing works
Guan, G., Huo, D., Li, Y., Zhao, X., Li, Y., Qin, Z., Sun, D., Yang, G., Yang, M., Tan, J., et al. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.04.010 · Cited by 32 · see citing works
Kumari, J., Wagener, F. A. D. T. G., & Kouwer, P. H. J. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c02549 · Cited by 32 · see citing works
Nifedipine Prevents Renal Injury in Rats With Chronic Nitric Oxide Inhibition
Ribeiro, M. O., Antunes, E., Muscará, M. N., Nucci, G. D., & Zatz, R. (1995) · Hypertension · doi:10.1161/01.hyp.26.1.150 · Cited by 32 · see citing works
Constructing Nanoscale Topology on the Surface of Microfibers Inhibits Fibroblast Fibrosis
Jiao, Y., Li, X., Chen, J., Li, C., Liu, L., Liu, X., Wang, F., Chen, G., & Wang, L. (2022) · Advanced Fiber Materials · doi:10.1007/s42765-022-00165-4 · Cited by 32 · see citing works
Ma, H., Caldwell, A. S., Azagarsamy, M. A., Rodriguez, A. G., & Anseth, K. S. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120205 · Cited by 31 · see citing works
Hayward, K. L., Kouthouridis, S., & Zhang, B. (2020) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.0c01089 · Cited by 31 · see citing works
Cell-Based Mechanosensation, Epigenetics, and Non-Coding RNAs in Progression of Cardiac Fibrosis
Ferrari, S., & Pesce, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms21010028 · Cited by 30 · see citing works
Pirfenidone in idiopathic pulmonary fibrosis: the CAPACITY program
Richeldi, L., & du Bois, R. M. (2011) · Expert Review of Respiratory Medicine · doi:10.1586/ers.11.52 · Cited by 29 · see citing works
Involvement of Smad3 pathway in atrial fibrosis induced by elevated hydrostatic pressure
Wei, W., Rao, F., Liu, F., Xue, Y., Deng, C., Wang, Z., Zhu, J.-N., Yang, H., Li, X., Zhang, M., et al. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26337 · Cited by 29 · see citing works
Myofibroblast specific targeting approaches to improve fibrosis treatment
Beaven, E., Kumar, R., Bhatt, H. N., Esquivel, S. V., & Nurunnabi, M. (2022) · Chemical Communications · doi:10.1039/d2cc04825f · Cited by 29 · see citing works
Miyano, T., Suzuki, A., & Sakamoto, N. (2021) · PLoS ONE · doi:10.1371/journal.pone.0261345 · Cited by 29 · see citing works
Wang, Y., Chen, P., Wang, L., Zhao, J., Zhong, Z., Wang, Y., & Xu, J. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000493672 · Cited by 26 · see citing works
Watanabe, Y., Tamura, M., Osajima, A., Anai, H., Kabashima, N., Serino, R., & Nakashima, Y. (2003) · Kidney International · doi:10.1046/j.1523-1755.2003.00122.x · Cited by 25 · see citing works
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de la Lastra, J. M. P., Wardell, S. J. T., Pal, T., de la Fuente‐Núñez, C., & Pletzer, D. (2024) · Journal of Medical Systems · doi:10.1007/s10916-024-02089-5 · Cited by 92 · see citing works
The mechanobiology of fibroblast activation in disease
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Mechanical Signaling: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets
Long, Y., Wang, P., Lei, J., Su, B., Wei, Q., & Liu, X. (2025) · MedComm · doi:10.1002/mco2.70523 · Cited by 25 · see citing works
Advanced 3D scaffolds for corneal stroma regeneration: a preclinical progress
Salehi, A. O. M., Soleimani, M., Rios, K. S. C., Ortega-Lara, W. D. L., & Mamidi, N. (2025) · Journal of Materials Chemistry B · doi:10.1039/d5tb00090d · Cited by 22 · see citing works
How to Keep Myofibroblasts under Control: Culture of Mouse Skin Fibroblasts on Soft Substrates
Son, D. O., Benítez, R., Diao, L., & Hinz, B. (2024) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2024.05.033 · Cited by 18 · see citing works
Mucosa‐Interfacing Capsule for In Situ Sensing the Elasticity of Biological Tissues
Kim, K., Edwards, S., Fuxa, K., Lin, H., Shrestha, S., Fan, H., Diaz, N., Berinstein, J., Naik, R. D., Zhou, Y., et al. (2024) · Advanced Materials Technologies · doi:10.1002/admt.202401487 · Cited by 15 · see citing works
Protein prenylation in mechanotransduction: implications for disease and therapy
Chen, H., Yang, J., Yang, Q., Jia, Y., & Guo, X. (2025) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2024.12.008 · Cited by 13 · see citing works
Mechanotherapy: Modulating immune cell function in tissue regeneration and fibrosis
Ward, N. A., Prendeville, H., Wallace, E. J., Shokrani, P., Trask, L., Dillon, R., Beatty, R., Roche, E. T., Duffy, G. P., & Dolan, E. B. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.08.048 · Cited by 10 · see citing works
Mechanical memory primes cells for confined migration
Lee, J. W. N., Chang, Y., Chitnis, M. S., Li, Y., Gao, X., Sun, A. R., Zhu, J., Young, J. L., & Holle, A. W. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117267 · Cited by 9 · see citing works
The importance of mechanical forces in chronic respiratory diseases
Burgess, J. K., Nawroth, J. C., Ibáñez‐Fonseca, A., & Gavara, N. (2026) · European Respiratory Review · doi:10.1183/16000617.0155-2025 · Cited by 9 · see citing works
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Link, P. A., & Tschumperlin, D. J. (2025) · Annual Review of Physiology · doi:10.1146/annurev-physiol-031725-021041 · Cited by 9 · see citing works
Estrogen attenuates stiffness-driven fibrotic signaling via transcriptional regulation
Zhu, H., Wang, J., Liu, Y., Wang, X., Lu, T. J., Feng, X., & Lin, M. (2025) · Biophysical Journal · doi:10.1016/j.bpj.2025.05.007 · Cited by 6 · see citing works
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Hyppolito, J. O. P., Hesham, A., Sunavala‐Dossabhoy, G., & Kim, D. D. (2025) · Oral Diseases · doi:10.1111/odi.70113 · Cited by 5 · see citing works
TFAP4 exacerbates pathological cardiac fibrosis by modulating mechanotransduction
Liu, J., Feng, J., Zhao, J., Kong, X., Yu, Z., Huang, Y., He, Z., Liu, M., Liu, Z., Lu, Z., et al. (2025) · Cell Insight · doi:10.1016/j.cellin.2025.100256 · Cited by 5 · see citing works
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Wilczak, W., Schleinhege, R., Loescher, C. M., Schwab, A., & Pethő, Z. (2025) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00564.2025 · Cited by 4 · see citing works
Jia, Q., Ding, Y., Su, Z., Chen, H., Ye, J., Xie, D., Wu, Y., He, H., Peng, Y., & Ni, Y. (2024) · Biofabrication · doi:10.1088/1758-5090/ad9cc4 · Cited by 4 · see citing works
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Li, K., Wei, P., Li, Z., Kuang, W., Zhang, M., Luo, C., Cui, K., Lin, D., & Chen, Z. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-07855-2 · Cited by 3 · see citing works
Wang, J., & Xu, A. (2025) · Pharmaceuticals · doi:10.3390/ph18101487 · Cited by 2 · see citing works
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Zhou, Y., Wu, Y., Ren, D., Shao, Q., Wang, X., Zhang, C., & Bao, M. (2026) · Acta Biomaterialia · doi:10.1016/j.actbio.2026.04.040 · Cited by 2 · see citing works
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Zhou, Z., Li, T., Cai, W. M., Zhu, X., Zhang, Z., & Huang, G. (2024) · Lab on a Chip · doi:10.1039/d4lc00753k · Cited by 2 · see citing works
Chen, C., Gan, A., Huang, C., Weng, Y., & Wang, T. (2026) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2026.1792350 · Cited by 1 · see citing works
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Xue, Y., Dai, R., Reddy, S., & Garza, L. A. (2026) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2026.02.008 · Cited by 1 · see citing works
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Luo, R., Lai, Y., Zhang, S., Yao, R., He, P., Liu, S., Li, H., Chen, X., Shi, H., Huang, J.-M., et al. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158496 · Cited by 1 · see citing works
Li, Y., Wang, Y., Tong, C., Fu, X., Ma, N., Hao, Y., Feng, Z., Ling, S., Yin, Z., Li, H., et al. (2026) · Journal of Clinical Investigation · doi:10.1172/jci203412 · Cited by 1 · see citing works
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Chen, L., Li, Z., Su, Z., Luo, Y., Hu, X., & Zhang, Y. (2025) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5c00802
Varshiny, G., Patel, N., Chitteti, R., Balakrishnan, N., Selvam, M. K. P., Patel, H. H., Lal, R., Muthuvijayan, V., & Rajasekaran, M. R. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5420394
Yu, H., & Pathak, A. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2423875122
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Ezzo, M., & Hinz, B. (2025) · Nature Biomedical Engineering · doi:10.1038/s41551-025-01482-w
Biointerface interaction regulation based on organic semiconducting polymers
Liu, X., Li, B., Qiu, L., Gao, D. M., Zhang, R., Qi, J., Lv, H., & Xing, C. (2025) · Fundamental Research · doi:10.1016/j.fmre.2025.09.015
Gadare, N. T., & Rode, S. V. (2025) · International Conference on Future Technologies (ICFT) · doi:10.1109/icft66708.2025.11336782
Gopinath, V., Patel, N., Chitteti, R., Balakrishnan, N., Selvam, M. K. P., Patel, H. H., Lal, R., Muthuvijayan, V., & Rajasekaran, M. (2026) · Materials Today Bio · doi:10.1016/j.mtbio.2026.103033
Wu, H., Wang, T., Jiang, C., Wen, T., Meng, J., Liu, J., Yang, A., Wang, J., & Xu, H. (2026) · Nano Letters · doi:10.1021/acs.nanolett.6c01231
Ma, Q.-Q., Wang, L. X., Zhou, S.-Y., Zhang, B., & Hou, L. (2026) · Nanotechnology · doi:10.1088/1361-6528/ae6788
Hypertension associated with systemic therapy for hepatocellular carcinoma and management strategies
Li, Y., Wang, B., Zhang, D., Xin, Y., & Wang, X. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1780200
Ciliary-Mediated Mechanotransduction in Skeletal Development and Diseases
Faisal, M., Tran, L., Gutierrez, Y. V., Bi, J., Yamaguchi, H., & Komatsu, Y. (2026) · Results and problems in cell differentiation · doi:10.1007/978-3-032-19509-8_12
Shared mechanisms of organ fibrosis
Humphreys, B. D. (2026) · JCI Insight · doi:10.1172/jci.insight.200952
Bogdan, R. G., Blidișel, A., Ciobota, I., Cîmpean, A. M., Helgiu, A., Helgiu, C., Bodea, I. C., Orbulescu, D. I., Heredea, R., & Crăiniceanu, Z. P. (2026) · Methods and Protocols · doi:10.3390/mps9030094
Onishi, A., Onodera, T., Sugaya, S., Matsushita, T., Komorisono, M., Shin, J., Nishitani, S., Fukuhara, A., & Shimomura, I. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158522
Engineered models of skin fibrosis: from biomaterial-free to biomaterial-based in vitro systems
Amaral, S., Presa, R., & Pereira, R. F. (2026) · Biomaterials Science · doi:10.1039/d6bm00232c
Li, W., & Chen, L. (2026) · Progress in Materials Science · doi:10.1016/j.pmatsci.2026.101784
Mesothelial plasticity regulates lung mechanical homeostasis in regeneration and fibrosis
Yang, G., Mou, J., Li, Z., Li, C., Yang, J., Zhang, J., Lin, X., He, H., Sun, S., Rinkevich, Y., et al. (2026) · Developmental Cell · doi:10.1016/j.devcel.2026.09.014
Pan, Q., Zhao, Y., Zhang, E., Gao, Y., Ye, L., He, B., & Pu, Y. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.153664
Tricou, L., Hwang, C., Talbot, S. G., Hibler, B. P., Leaker, B. D., Tam, J., & Freedman, B. R. (2026) · Nature Reviews Bioengineering · doi:10.1038/s44222-026-00489-5
Mechanobiology of orofacial tissues: principles, mechanisms, and therapeutic applications
Qi, J., Wang, Y., Xie, Y., Ma, W., Yi, L., Tang, X., Sun, H., & Chang, B. (2026) · International Journal of Oral Science · doi:10.1038/s41368-026-00458-z
Jin, Z., Chen, H., & Zhang, Y. (2026) · Journal of Tissue Engineering · doi:10.1177/20417314261486144
Zhou, J., Zhang, Y., Yu, J., Fu, Y., Zhang, J., & Gu, Z. (2026) · Journal of Materials Chemistry B · doi:10.1039/d6tb01472k
Cutaneous endothelial cells and their roles in wound healing
Li, H., Sormani, L., Sim, S.-L., Shafiee, A., & Khosrotehrani, K. (2026) · JID Innovations · doi:10.1016/j.xjidi.2026.100539
- Authors
- Mascharak, S., L. Guo, J., Griffin, M., E. Berry, C., C. Wan, D., & T. Longaker, M.
- Affiliations
- Stanford Medicine (US)
- Venue
- Nature Reviews Bioengineering
- Published
- 2024-01-18
- Volume
- 2
- Issue
- 4
- Pages
- 305-323
- ISSN
- 2731-6092 (ISSN-L)
- PMC
- PMC11567675
- OpenAlex
- W4390964997
- Cited by
- 59
- References
- 226
- Citations by year
- 2026: 33 · 2025: 21 · 2024: 5
- FWCI
- 3.12
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Nature Reviews Bioengineering (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (F32HL167318)
- National Institute of General Medical Sciences (R01GM136659)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR081343)
- National Institute of Dental and Craniofacial Research (R01DE027346, U24DE029463, R01DE032677)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Keywords
- organ fibrosis, mechanotransduction, mechanical forces, cell-matrix interactions, cell-cell contact, fluid flow, pulmonary fibrosis, liver cirrhosis, scar tissue
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