The DOI matches its Crossref record.
Effect of heat stress on muscle energy metabolism during exercise
Open accessAbstract
To examine the effect of heat stress on muscle energy metabolism during submaximal exercise, 12 endurance-trained men cycled on two occasions for approximately 40 min at 70% maximal O2 uptake in an environmental chamber at either 20 degrees C and 20% relative humidity (T20) or 40 degrees C and 20% relative humidity (T40). Trials were conducted > or = 1 wk apart in random order. No difference in mean O2 uptake was observed when exercise in T40 was compared with that in T20. In contrast, exercise in T40 resulted in a higher mean heart rate (P < 0.01) and respiratory exchange ratio (P < 0.05) compared with that in T20. Postexercise rectal and muscle temperatures were also higher (P < 0.01) in T40 than in T20. Lower (P < 0.01) postexercise creatine phosphate and higher creatine (P < 0.01) and ammonia (P < 0.05) were observed in muscle after exercise in T40 compared with T20. In addition, an increased (P < 0.01) muscle glycogenolysis and higher (P < 0.01) postexercise muscle lactate accumulation were observed during exercise in T40 compared with T20. In contrast, no differences were observed in postexercise concentrations of total adenine nucleotide pool (ATP+ADP+AMP), ATP/ADP ratio, or inosine 5'-monophosphate (IMP) when T40 was compared with T20. These results indicate that the rate of ATP utilization may be increased during exercise in the heat but that this increased energy demand is predominantly met by an increase in anaerobic glycolysis and creatine phosphate hydrolysis, preventing a reduction in total adenine nucleotide pool.(ABSTRACT TRUNCATED AT 250 WORDS)
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“Other factors may impact the degradation of muscle glycogen, such as dehydration and hyperthermia [36,95,96,97].”
From Regulation of Energy Substrate Metabolism in Endurance Exercise (2021) · cites this paper as [36]
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Items 201–218 of 218
Heat acclimation for female endurance performance in hot and cool conditions
Kirby, N. V. (2018) · University of Birmingham Institutional Research Archive (University of Birmingham)
Júnior, J. F. C. R., do Prado, D. M. L., Sena, A. F. D. C., Veneroso, C. E., Cabido, C. E. T., & Sevílio, M. (2021) · The Journal of Sports Medicine and Physical Fitness · doi:10.23736/s0022-4707.21.11426-4
Heat Acclimation for Special Populations
(2020) · Frontiers research topics · doi:10.3389/978-2-88966-018-6 · Cited by 1
Sagiv, M. S. (2012) · Springer eBooks · doi:10.1007/978-1-4471-2888-5_2
Anbalagan, P., Peeling, P., Ihsan, M., et al. (2025) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000003865
The effects of glycerol ingestion on body water distribution and exercise performance
Aphamis, G. (2011) · Loughborough University Institutional Repository (Loughborough University)
Suzuki, Y., Takei, N., Tanji, F., Yamanaka, R., & Saeki, T. (2026) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.70286
Salame, A., Brown, D., Oueijan, K., & McCullough, D. (2026) · Journal of the International Society of Sports Nutrition · doi:10.1080/15502783.2026.2669307
“While Febbraio et al. (1994) described glycogen stress within 30 min at 40 °C with 20% humidity, such durations, at less extreme environmental conditions (Table 1), may not have critically elicited glycogen stress.”
Arslan, E., Soylu, Y., Silva, A. F., Yilmaz, O. C., Kilit, B., Akçay, N., Radzimiński, Ł., & Baťalík, L. (2026) · PLoS ONE · doi:10.1371/journal.pone.0351116
“Consequently, changes in the rate of energy system contribution, especially anaerobic glycolysis and creatine phosphate hydrolysis, can negatively affect exercise ability [9,10].”
Heat and Human Performance: Evidence from Marathon RunnersPreprint
Oliveira, J., & Blanco, B. (2026) · SSRN Electronic Journal · doi:10.2139/ssrn.7023169
Ice Slurry and Cold Drink Reduces Exercise Induced Physiological Strain in the Heat
Kaufman, C. E. (2012) · The Mathematics Enthusiast
Carbohydrate-electrolyte drink ingestion and skill performance in tennis
McRae, K. A. (2010) · Stirling Online Research Repository (University of Stirling)
Metadata
- Authors
- Febbraio, M. A., Snow, R. J., Stathis, C. G., Hargreaves, M., & Carey, M. F.
- Affiliations
- Victoria University (AU)
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 1994-12-01
- Volume
- 77
- Issue
- 6
- Pages
- 2827-2831
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2282077497
- Cited by
- 219
- References
- 0
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 11 · 2023: 8 · 2022: 6 · 2021: 14 · 2020: 11 · 2019: 14 · 2018: 12 · 2017: 9 · 2016: 8 · 2015: 16 · 2014: 6 · 2013: 9 · 2012: 9
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- green
- figshare.com
- Licence
- cc-by
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Deakin Research Online (Deakin University) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Thermoregulation and physiological responses
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Keywords
- heat stress, muscle energy metabolism, submaximal exercise, endurance-trained men, anaerobic glycolysis, phosphocreatine, adenine nucleotide pool, ATP/ADP ratio, inosine 5'-monophosphate, muscle glycogenolysis, ammonia, respiratory exchange ratio, heart rate, muscle temperature, rectal temperature, oxygen absorption
- MeSH terms
- Adult, Anaerobiosis, Energy Metabolism, Physical Exertion, Glycogen, Hot Temperature, Humans, Humidity, Male, Muscles, Phosphates, Stress, Physiological, Temperature
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