Cited by 219Thermoregulation and physiological responsesCardiovascular and exercise physiologyExercise and Physiological Responses

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Effect of heat stress on muscle energy metabolism during exercise

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Febbraio, M. A., Snow, R. J., Stathis, C. G., Hargreaves, M., Carey, M. F.·1994·Journal of Applied Physiology

DOI 10.1152/jappl.1994.77.6.2827

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Abstract

To examine the effect of heat stress on muscle energy metabolism during submaximal exercise, 12 endurance-trained men cycled on two occasions for approximately 40 min at 70% maximal O2 uptake in an environmental chamber at either 20 degrees C and 20% relative humidity (T20) or 40 degrees C and 20% relative humidity (T40). Trials were conducted > or = 1 wk apart in random order. No difference in mean O2 uptake was observed when exercise in T40 was compared with that in T20. In contrast, exercise in T40 resulted in a higher mean heart rate (P < 0.01) and respiratory exchange ratio (P < 0.05) compared with that in T20. Postexercise rectal and muscle temperatures were also higher (P < 0.01) in T40 than in T20. Lower (P < 0.01) postexercise creatine phosphate and higher creatine (P < 0.01) and ammonia (P < 0.05) were observed in muscle after exercise in T40 compared with T20. In addition, an increased (P < 0.01) muscle glycogenolysis and higher (P < 0.01) postexercise muscle lactate accumulation were observed during exercise in T40 compared with T20. In contrast, no differences were observed in postexercise concentrations of total adenine nucleotide pool (ATP+ADP+AMP), ATP/ADP ratio, or inosine 5'-monophosphate (IMP) when T40 was compared with T20. These results indicate that the rate of ATP utilization may be increased during exercise in the heat but that this increased energy demand is predominantly met by an increase in anaerobic glycolysis and creatine phosphate hydrolysis, preventing a reduction in total adenine nucleotide pool.(ABSTRACT TRUNCATED AT 250 WORDS)

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“Indeed, acute heat exposure has been shown to increase intramuscular glycogen utilization (7–9, 40) and the respiratory exchange ratio (8, 10).”
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Background
Increased air temperature during repeated‐sprint training in hypoxia amplifies changes in muscle oxygenation without decreasing cycling performance
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“…reported a greater reduction in muscle [glycogen] (Febbraio et al. 1994a, b, 1996; Starkie et al. 1999) and a greater increase in muscle [lactate] (Febbraio et al. 1994a, b, 1996; González-Alonso and Calbet 2003; Parkin et al. 1999) and other glycolytic intermediates (Edwards et al. 1972) when…”
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“Hirata et al. (1987) have found that the hyperthermia induced by immersion of the legs in warm water reduced handgrip performance.”
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Background
Heat stress increases carbohydrate oxidation rates and oxygen uptake during prolonged load carriage exercise
Rosbrook, P., Sweet, D. K., Qiao, J., Looney, D. P., Margolis, L. M., Hostler, D. P., Pryor, R. R., & Pryor, J. L. (2024) · Temperature · doi:10.1080/23328940.2024.2322920 · Cited by 8
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Effects of 2% Dehydration on Lactate Concentration During Constant-Load Cycling
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No effect of mild heat stress on the regulation of carbohydrate metabolism at the onset of exercise
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“EXERCISE IN THE HEAT INCREASES intramuscular glycogen utilization (14–16), pyruvate (24) and lactate accumulation (14, 15, 24, 27, 40), and whole body carbohydrate (CHO) oxidation in the absence of any changes in glucose oxidation (18).”
BackgroundResultInfluentialSelf-citation
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“Consequently, the simultaneous increase in carbohydrate utilisation and circulating epinephrine concentrations may represent an additional factor explaining the greater reliance on carbohydrate utilisation during prolonged exercise in the heat, as observed in previous studies [5, 17, 56, 78].”
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“…neuromuscular performance when core body temperature remains below 39.0° C (32,44), shift skeletal muscle metabolism toward carbohydrate oxidation (8), stimulate heat shock protein expression (35), alter immune responses (33), and enhance calcium kinetics (19,34) that activate protein synthesis…”
BackgroundInfluential
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Background
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Authors: Febbraio, M. A., Snow, R. J., Stathis, C. G., Hargreaves, M., & Carey, M. F.
Affiliations: Victoria University (AU)
ORCID: Febbraio, M. A.
Stathis, C. G.
Hargreaves, M.
Venue: Journal of Applied Physiology
Publisher: American Physiological Society
Published: 1994-12-01
Volume: 77
Issue: 6
Pages: 2827-2831
ISSN: 0161-7567 (ISSN-L)
8750-7587
1522-1601
DOI: 10.1152/jappl.1994.77.6.2827
OpenAlex: W2282077497
Cited by: 219
References: 0
Citations by year: 2026: 5 · 2025: 8 · 2024: 11 · 2023: 8 · 2022: 6 · 2021: 14 · 2020: 11 · 2019: 14 · 2018: 12 · 2017: 9 · 2016: 8 · 2015: 16 · 2014: 6 · 2013: 9 · 2012: 9
FWCI: 1.13
Type: journal article
Language: en
Open access: green
figshare.com
Licence: cc-by
Locations: Journal of Applied Physiology (publishedVersion)
PubMed (publishedVersion)
Deakin Research Online (Deakin University) (submittedVersion)
Figshare (submittedVersion, cc-by)
Topics: Health Sciences › Medicine › Physiology (medical) › Thermoregulation and physiological responses
Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Keywords: heat stress, muscle energy metabolism, submaximal exercise, endurance-trained men, anaerobic glycolysis, phosphocreatine, adenine nucleotide pool, ATP/ADP ratio, inosine 5'-monophosphate, muscle glycogenolysis, ammonia, respiratory exchange ratio, heart rate, muscle temperature, rectal temperature, oxygen absorption
MeSH terms: Adult, Anaerobiosis, Energy Metabolism, Physical Exertion, Glycogen, Hot Temperature, Humans, Humidity, Male, Muscles, Phosphates, Stress, Physiological, Temperature

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Effect of heat stress on muscle energy metabolism during exercise

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