Human cerebral activity with increasing inspiratory force: a study using positron emission tomography
Abstract
Human cerebral activity with increasing inspiratory force: a study using positron emission tomography. J. Appl. Physiol. 81(3): 1295-1305, 1996.--The major aim of this study was to use positron emission tomography (PET) to assess dose-dependent effects of inspiratory loads on relative regional cerebral blood flow as an indication of neuronal activation and recruitment. Six normal men underwent H2 15O-PET scanning during unloaded breathing and with external inspiratory loads (generating mouth pressures of -5, -10, and -15 cmH2O); positive-pressure ventilation against relaxed respiratory muscles acted as control. During unloaded breathing, the supplementary motor area was significantly activated. With the addition of the smallest load, activations also occurred in the right premotor area and bilaterally in the superolateral motor cortex (MI) in areas previously shown to be activated with deeper breathing. There was little further change in these areas with greater loads. Additional force-related activations occurred in the inferolateral sensorimotor cortex, parietal cortex, and midbrain/hypothalamus. The results suggest that volitionally induced increases in inspiratory muscle force are achieved via a complex integration of neuronal activations in cortical and subcortical regions associated with motor control.
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There is a striking overlap between areas activated during articulation of speech, vocalisation, and control of volitional breathing in the absence of vocalisation.
“There was, nevertheless, a striking overlap between the areas activated during the articulation of speech, vocalisation (Hirano et al., 1996) and the control of volitional breathing in the absence of vocalisation (Ramsay et al., 1993; Fink et al., 1996).”
From A review and synthesis of the first 20years of PET and fMRI studies of heard speech, spoken language and reading (2012) · cites this paper as Fink et al., 1996
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- Authors
- Fink, G. R., Corfield, D. R., Murphy, K., Kobayashi, I., Dettmers, C., Adams, L., Frackowiak, R. S., & Guz, A.
- Affiliations
- UCL Queen Square Institute of Neurology (GB)
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 1996-09-01
- Volume
- 81
- Issue
- 3
- Pages
- 1295-1305
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2297467792
- Cited by
- 78
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 1 · 2016: 1 · 2015: 3 · 2014: 1 · 2013: 4 · 2012: 2
- FWCI
- 0.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Funders
- Wellcome Trust
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
- Keywords
- inspiratory load, cerebral blood flow, neuronal activation, supplementary motor area, premotor cortex, motor cortex, sensorimotor cortex, parietal cortex, midbrain, hypothalamus, motor control, respiratory muscle recruitment, positive pressure ventilation
- MeSH terms
- Adult, Cerebral Cortex, Cerebrovascular Circulation, Electromyography, Humans, Male, Respiration, Tomography, Emission-Computed
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