The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Electron spin resonance spectroscopy, exercise, and oxidative stress: an ascorbic acid intervention study
Abstract
Oxygen free radicals are highly reactive species that are produced in increased quantities during strenuous exercise and can damage critical biological targets such as membrane phospholipids. The present study examined the effect of acute ascorbic acid supplementation on exercise-induced free radical production in healthy subjects. Results demonstrate increases in the intensity of the α-phenyl- tert-butylnitrone adduct (0.05 ± 0.02 preexercise vs. 0.19 ± 0.03 postexercise, P = 0.002, arbitrary units) together with increased lipid hydroperoxides (1.14 ± 0.06 μmol/l preexercise vs. 1.62 ± 0.19 μmol/l postexercise, P = 0.005) and malondialdehyde (0.70 ± 0.04 μmol/l preexercise vs. 0.80 ± 0.04 μmol/l postexercise, P = 0.0152) in the control phase. After supplementation with ascorbic acid, there was no significant increase in the electron spin resonance signal intensity (0.02 ± 0.01 preexercise vs. 0.04 ± 0.02 postexercise, arbitrary units), lipid hydroperoxides (1.12 ± 0.21 μmol/l preexercise vs. 1.12 ± 0.08 μmol/l postexercise), or malondialdehyde (0.63 ± 0.07 μmol/l preexercise vs. 0.68 ± 0.05 μmol/l postexercise). The results indicate that acute ascorbic acid supplementation prevented exercise-induced oxidative stress in these subjects.
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“Athletes with low circulating levels of ascorbic acid may show more significant responses to supplementation: several studies have shown that a 500 mg intake over a few days can lead to a 40–50% increase in vitamin C concentrations [37].”
From Use of Nutritional Strategies, Bioactive Compounds, and Dietary Supplements in Young Athletes: From Evidence to Potential Risks—A Narrative Review (2025) · cites this paper as [37]
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Cites
Ascorbate is an outstanding antioxidant in human blood plasma
Frei, B., England, L., & Ames, B. N. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.16.6377 · Cited by 1,870
Free radicals and tissue damage produced by exercise
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Vitamin C exhibits pro-oxidant properties
Podmore, I. D., Griffiths, H. R., Herbert, K. E., Mistry, N., Mistry, P., & Lunec, J. (1998) · Nature · doi:10.1038/33308 · Cited by 800
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Cited by
Oxidative Stress: Relationship with Exercise and Training
Finaud, J., Lac, G., & Filaire, E. (2006) · Sports Medicine · doi:10.2165/00007256-200636040-00004 · Cited by 771
Hemilä, H. (2017) · Nutrients · doi:10.3390/nu9040339 · Cited by 461
Antioxidant Supplementation during Exercise Training: Beneficial or Detrimental?
Peternelj, T.-T., & Coombes, J. S. (2011) · Sports Medicine · doi:10.2165/11594400-000000000-00000 · Cited by 314
Mastaloudis, A., Morrow, J. D., Hopkins, D. W., Devaraj, S., & Traber, M. G. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.02.069 · Cited by 244
Influence of vitamin C supplementation on oxidative and immune changes after an ultramarathon
Nieman, D. C., Henson, D. A., McAnulty, S. R., McAnulty, L., Swick, N. S., Utter, A. C., Vinci, D. M., Opiela, S. J., & Morrow, J. D. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00961.2001 · Cited by 198
Selenium supplementation and exercise: Effect on oxidant stress in overweight adults
Savory, L. A., Kerr, C. J., Whiting, P., Finer, N., McEneny, J., & Ashton, T. (2012) · Obesity · doi:10.1038/oby.2011.83 · Cited by 37
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Metadata
- Authors
- Ashton, T., Young, I. S., Peters, J. R., Jones, E., Jackson, S. K., Davies, B., & Rowlands, C. C.
- Affiliations
- School of Applied Sciences, University of Glamorgan, Pontypridd, Wales, CF37 1DL;
- Department of Clinical Biochemistry, Institute of Clinical Science, Queens University, Belfast, Northern Ireland, BT12 6BL;
- Department of Medicine, University Hospital of Wales, Cardiff, Wales, CF4 4XW;
- University of Wales Institute Cardiff, Cardiff, Wales, CF3 7XR;
- Department of Medical Microbiology, Section of Immunology, University of Wales College of Medicine, Cardiff, Wales, CF4 4XN; and
- Department of Chemistry, National EPSRC ENDOR Centre, Cardiff University, Cardiff, Wales, CF1 3TB, United Kingdom
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 1999-12-01
- Volume
- 87
- Issue
- 6
- Pages
- 2032-2036
- ISSN
- 8750-7587
- 1522-1601
- Cited by
- 104
- References
- 3
- Language
- en
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
