Substrate utilization during exercise with glucose and glucose plus fructose ingestion in boys ages 10–14 yr

Abstract

We measured substrate utilization during exercise performed with water (W), exogenous glucose (G), and exogenous fructose plus glucose (FG) ingestion in boys age 10–14 yr. Subjects ( n = 12) cycled for 90 min at 55% maximal O 2 uptake while ingesting either W (25 ml/kg), 6% G (1.5 g/kg), or 3% F plus 3% G (1.5 g/kg). Fat oxidation increased during exercise in all trials but was higher in the W (0.28 ± 0.023 g/min) than in the G (0.24 ± 0.023 g/min) and FG (0.25 ± 0.029 g/min) trials ( P = 0.04). Conversely, total carbohydrate (CHO) oxidation decreased in all trials and was lower in the W (0.63 ± 0.05 g/min) than in the G (0.78 ± 0.051 g/min) and FG (0.74 ± 0.056 g/min) trials ( P = 0.009). Exogenous CHO oxidation, as determined by expired 13 CO 2, reached a maximum of 0.36 ± 0.032 and 0.31 ± 0.030 g/min at 90 min in G and FG, respectively ( P = 0.04). Plasma insulin levels decrease during exercise in all trials but were twofold higher in G than in W and FG ( P < 0.001). Plasma glucose levels decreased transiently after the onset of exercise in all trials and then returned to preexercise values in the W and FG (∼4.5 mmol/l) trials but were elevated by ∼1.0 mmol/l in the G trial ( P < 0.001). Plasma lactate concentrations decreased after the onset of exercise in all trials but were lower by ∼0.5 mmol/l in W than in G and FG ( P = 0.02). Thus, in boys exercising at a moderate intensity, the oxidation rate of G plus F is slightly less than G alone, but both spare endogenous CHO and fat to a similar extent. In addition, compared with flavored W, the ingestion of G alone and of G plus F delays exhaustion at 90% peak power by ∼25 and 40%, respectively, after 90 min of moderate-intensity exercise.