The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
What makes vessels grow with exercise training?
Abstract
Exercise and muscle contractions create a powerful stimulus for structural remodeling of the vasculature. An increase in flow velocity through a vessel increases shear stress, a major stimulus for enlargement of conduit vessels. This leads to an endothelial-dependent, nitric oxide-dependent enlargement of the vessel. Increased flow within muscle, in the absence of contractions, leads to an enhanced capillarity by intussusceptive angiogenesis, a process of capillary splitting by intraluminal longitudinal divide. In contrast, sprouting angiogenesis requires extensive endothelial cell proliferation, with degradation of the extracellular matrix to permit migration and tube formation. This occurs during muscle adaptations to chronic contractions and/or muscle overload. The angiogenic growth factor VEGF appears to be an important element in angiogenesis. Recent advances in research have identified hemodynamic and mechanical stimuli that upregulate angiogenic processes, demonstrated a complexity of potent growth factors and interactions with their corresponding receptors, detected an interaction of cellular signaling events, and identified important tissue reorganization processes that must be coordinated to effect vascular remodeling. It is likely that much of this information is applicable to the vascular remodeling that occurs in response to exercise and/or muscle contractions.
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Cites
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
Shweiki, D., Itin, A., Soffer, D., & Keshet, E. (1992) · Nature · doi:10.1038/359843a0 · Cited by 4,617
Maximal perfusion of skeletal muscle in man.
Andersen, P., & Saltin, B. (1985) · The Journal of Physiology · doi:10.1113/jphysiol.1985.sp015794 · Cited by 1,250
Jiang, B. H., Semenza, G. L., Bauer, C., & Marti, H. H. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.4.c1172 · Cited by 1,213
Differential Transcriptional Regulation of the Two Vascular Endothelial Growth Factor Receptor Genes
Gerber, H.-P., Condorelli, F., Park, J., & Ferrara, N. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.38.23659 · Cited by 794
Angiogenic growth factor mRNA responses in muscle to a single bout of exercise
Breen, E. C., Johnson, E. C., Wagner, H., Tseng, H. M., Sung, L. A., & Wagner, P. D. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.81.1.355 · Cited by 302 · cited 2×
“The importance of hypoxia as an obvious candidate for the initiation of angiogenesis in active muscle during training was reinforced by data showing that hypoxia enhanced the exercise-induced upregulation of VEGF in rat muscle (10).”
BackgroundStrength and Power Training: Physiological Mechanisms of Adaptation
KRAEMER, W. J., FLECK, S. J., & EVANS, W. J. (1996) · Exercise and Sport Sciences Reviews · doi:10.1249/00003677-199600240-00014 · Cited by 298
Cited by
Chiu, J.-J., & Chien, S. (2011) · Physiological Reviews · doi:10.1152/physrev.00047.2009 · Cited by 2,280
Basso, J. C., & Suzuki, W. A. (2016) · Brain Plasticity · doi:10.3233/bpl-160040 · Cited by 911
AMPK and the biochemistry of exercise: implications for human health and disease
Richter, E. A., & Ruderman, N. B. (2009) · Biochemical Journal · doi:10.1042/bj20082055 · Cited by 481
The transcriptional coactivator PGC-1α mediates exercise-induced angiogenesis in skeletal muscle
Chinsomboon, J., Ruas, J., Gupta, R. K., Thom, R., Shoag, J., Rowe, G. C., Sawada, N., Raghuram, S., & Arany, Z. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909131106 · Cited by 379
The effects of aerobic activity on brain structure.
Thomas, A. G., Dennis, A., Bandettini, P. A., & Johansen-Berg, H. (2012) · Frontiers in Psychology · doi:10.3389/fpsyg.2012.00086 · Cited by 303
Angiogenesis during exercise and training.
Bloor, C. M. (2005) · Angiogenesis · doi:10.1007/s10456-005-9013-x · Cited by 206
Yue, Y., Ghosh, A., Long, C., Bostick, B., Smith, B. F., Kornegay, J. N., & Duan, D. (2008) · Molecular Therapy · doi:10.1038/mt.2008.207 · Cited by 173
Lactate as a myokine and exerkine: drivers and signals of physiology and metabolism
Brooks, G. A., Osmond, A. D., Arevalo, J. A., Duong, J. J., Curl, C. C., Moreno-Santillan, D. D., & Leija, R. G. (2023) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00497.2022 · Cited by 171
Clinical and Experimental Pancreatic Islet Transplantation to Striated Muscle
Christoffersson, G., Henriksnäs, J., Johansson, L., Rolny, C., Ahlström, H., Caballero-Corbalan, J., Segersvärd, R., Permert, J., Korsgren, O., Carlsson, P.-O., et al. (2010) · Diabetes · doi:10.2337/db10-0205 · Cited by 167
Jones, A. M. (2014) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2014-0036 · Cited by 144
Kiuchi, T., Lee, H., & Mikami, T. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.01.023 · Cited by 116
Martins, A. S., Crescenzi, A., Stern, J. E., Bordin, S., & Michelini, L. C. (2005) · Hypertension · doi:10.1161/01.hyp.0000175812.03322.59 · Cited by 115
Exercise induces interleukin‐8 receptor (CXCR2) expression in human skeletal muscle
Frydelund‐Larsen, L., Penkowa, M., Akerstrom, T., Zankari, A., Nielsen, S., & Pedersen, B. K. (2007) · Experimental Physiology · doi:10.1113/expphysiol.2006.034769 · Cited by 106
Blood Vessels and the Satellite Cell Niche
Mounier, R., Chrétien, F., & Chazaud, B. (2011) · Current Topics in Developmental Biology · doi:10.1016/b978-0-12-385940-2.00005-x · Cited by 89
Role of diet and exercise in aging, Alzheimer’s disease, and other chronic diseases
Khemka, S., Reddy, A., Garcia, R. I., Jacobs, M., Reddy, R. P., Roghani, A. K., Pattoor, V., Basu, T., Sehar, U., & Reddy, P. H. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102091 · Cited by 88
Cudmore, R. H., Dougherty, S. E., & Linden, D. J. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16682508 · Cited by 54
Blanchard, T. S., Whitehead, A., Dong, Y. W., & Wright, P. A. (2018) · Journal of Experimental Biology · doi:10.1242/jeb.186486 · Cited by 25
Rissanen, A.-P. E., Tikkanen, H. O., Koponen, A. S., Aho, J. M., Hägglund, H., Lindholm, H., & Peltonen, J. E. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00265 · Cited by 25
Medical Treatment of Peripheral Artery Disease
Gornik, H. L., & Creager, M. A. (2013) · Vascular Medicine: A Companion to Braunwald's Heart Disease · doi:10.1016/b978-1-4377-2930-6.00019-7 · Cited by 12
Metadata
- Authors
- Prior, B. M., Yang, H. T., & Terjung, R. L.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2004-09
- Volume
- 97
- Issue
- 3
- Pages
- 1119-1128
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2099216922
- Cited by
- 511
- References
- 6
- FWCI
- 39.24
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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