Influence of promoter region variants of insulin-like growth factor pathway genes on the strength-training response of muscle phenotypes in older adults
Open accessAbstract
To examine the influence of insulin-like growth factor (IGF) pathway gene polymorphisms on muscle mass and strength responses to strength training (ST), we studied 128 White and Black men and women before and after a 10-wk single-leg knee extension ST program. One-repetition maximum strength, muscle volume (MV) via computed tomography, and muscle quality (MQ) were assessed at baseline and after 10 wk of ST. There was a significant combined IGF1 cytosine adenine (CA) repeat gene effect, which included both the IGF1 CA repeat main effect and IGF1 CA repeat x PPP3R1 insertion-deletion (I/D) gene x gene interaction effect, on the changes in strength (P < 0.01) and MQ (P < 0.05) with ST. There was a trend for a significant gene x gene interaction between IGF1 CA repeat and PPP3R1 I/D for changes in strength (P = 0.07) and MQ (P = 0.06) with ST. The influence of the PPP3R1 A-202C gene polymorphism on change in MV with ST approached significance (P = 0.06). The IGF1 CA repeat polymorphism had a significant influence on the change in strength and MV combined with ST (P < 0.05), whereas the influence of the PPP3R1 I/D polymorphism approached significance (P = 0.08). There were no associations between the IGFBP3 A-202C gene polymorphism and the muscle phenotypic responses to ST. These data suggest that two of the three IGF pathway gene polymorphisms identified in this study influence muscle phenotypic responses to ST in both black and white older men and women.
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Variants in genes governing MPS and hypertrophy influence muscle growth response to caloric surplus.
“Variants in genes governing MPS and hypertrophy influence muscle growth response to caloric surplus.”
From Beyond Calories: Individual Metabolic and Hormonal Adaptations Driving Variability in Weight Management—A State-of-the-Art Narrative Review (2024) · cites this paper as [56]
IGF1 gene polymorphisms such as IGF1 CA-repeat variants are associated with differences in IGF-1 levels and muscle mass accretion.
“The IGF1 gene has polymorphisms such as IGF1 CA-repeat variants, associated with differences in IGF-1 levels and muscle mass accretion [56].”
From Beyond Calories: Individual Metabolic and Hormonal Adaptations Driving Variability in Weight Management—A State-of-the-Art Narrative Review (2024) · cites this paper as [56]
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Erskine, R. M., Jones, D. A., Williams, A. G., Stewart, C. E., & Degens, H. (2010) · European Journal of Applied Physiology · doi:10.1007/s00421-010-1601-9 · Cited by 124 · see citing works
Theodorakis, N., Kreouzi, M., Pappas, A., & Nikolaou, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252413438 · Cited by 43 · see citing works
- Authors
- Hand, B. D., Kostek, M. C., Ferrell, R. E., Delmonico, M. J., Douglass, L. W., Roth, S. M., Hagberg, J. M., & Hurley, B. F.
- Affiliations
- University of Maryland, College Park (US)
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2007-11
- Volume
- 103
- Issue
- 5
- Pages
- 1678-1687
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- PMC
- PMC2811278
- OpenAlex
- W1992757708
- Cited by
- 53
- References
- 60
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 3 · 2018: 4 · 2016: 1 · 2015: 2 · 2014: 4 · 2013: 2 · 2012: 3
- FWCI
- 2.15
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (AG00268, AG-4-2148, AG-021500, K01AG022791, R01AG021500, T32AG000268, L30 AG024705, AG-1620501, AG022791)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Physical Performance
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- insulin-like growth factor pathway, muscle strength, muscle volume, muscle quality, older adults, muscle phenotype
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Aging, Black or African American, Female, Gene Frequency, Genotype, Humans, Insulin-Like Growth Factor I, Male, Middle Aged, Muscle Contraction, Phenotype, Phosphoprotein Phosphatases, Polymorphism, Genetic, Promoter Regions, Genetic, Sex Factors, Time Factors, Tomography, X-Ray Computed, Exercise, Muscle, Skeletal, Dinucleotide Repeats, Insulin-Like Growth Factor Binding Proteins, Insulin-Like Growth Factor Binding Protein 3, Calcineurin, White People, Muscle Strength
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