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Cited by 171

The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.

Fourteen days of bed rest induces a decline in satellite cell content and robust atrophy of skeletal muscle fibers in middle-aged adults

Arentson-Lantz, Emily J., English, Kirk L., Paddon-Jones, Douglas, Fry, Christopher S.·2016·Journal of Applied Physiology
DOI 10.1152/japplphysiol.00799.2015
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Abstract

Bed rest, a ground-based spaceflight analog, induces robust atrophy of skeletal muscle, an effect that is exacerbated with increasing age. We examined the effect of 14 days of bed rest on skeletal muscle satellite cell content and fiber type atrophy in middle-aged adults, an understudied age demographic with few overt signs of muscle aging that is representative of astronauts who perform long-duration spaceflight. Muscle biopsies were obtained from the vastus lateralis of healthy middle-aged adults [ n = 7 (4 male, 3 female); age: 51 ± 1 yr] before (Pre-BR) and after (Post-BR) 14 days of bed rest. Immunohistochemical analyses were used to quantify myosin heavy chain (MyHC) isoform expression, cross-sectional area (CSA), satellite cell and myonuclear content, and capillary density. Peak oxygen consumption, knee extensor strength, and body composition were also measured Pre-BR and Post-BR. Post-BR MyHC type 2a fiber percentage was reduced, and mean CSA decreased in all fiber types (−24 ± 5%; P < 0.05). Satellite cell content was also reduced Post-BR (−39 ± 9%; P < 0.05), and the change in satellite cell content was significantly correlated with the change in mean fiber CSA ( r 2 = 0.60; P < 0.05). A decline in capillary density was observed Post-BR (−23 ± 6%; P < 0.05), and Post-BR capillary content was significantly associated with Post-BR peak aerobic capacity ( r 2 = 0.59; P < 0.05). A subtle decline in myonuclear content occurred during bed rest (−5 ± 1%; P < 0.05). The rapid maladaptation of skeletal muscle to 14 days of mechanical unloading in middle-aged adults emphasizes the need for robust countermeasures to preserve muscle function in astronauts.

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Research works printed but not linked: 56

  1. 10.1152/ajpcell.1997.273.2.C579 · DOI · Paper page
  2. 10.1152/jappl.1995.78.5.1969 · DOI
  3. 10.1042/bj2900641 · DOI
  4. 10.1152/jappl.1998.84.1.157 · DOI · Paper page
  5. 10.1111/j.1475-097X.1993.tb00334.x · DOI
  6. Bergstrom J, 1963, Scand J Clin Lab Invest, 15, 16
  7. 10.1002/mus.21780 · DOI
  8. 10.1172/JCI34022 · DOI
  9. 10.1007/s00421-006-0252-3 · DOI
  10. 10.1007/s40520-013-0132-8 · DOI
  11. 10.1152/jappl.1998.85.2.593 · DOI
  12. 10.1093/gerona/glu123 · DOI · Paper page
  13. 10.1097/00005768-199610000-00033 · DOI
  14. 10.1152/jappl.1989.67.5.1827 · DOI
  15. 10.1042/CS20140447 · DOI
  16. 10.1111/sms.12185 · DOI
  17. 10.1152/ajpendo.1996.270.4.E627 · DOI · Paper page
  18. 10.1007/s00421-006-0197-6 · DOI
  19. 10.1113/jphysiol.2014.271288 · DOI
  20. 10.1152/japplphysiol.00961.2004 · DOI
  21. 10.1042/cs0720503 · DOI
  22. 10.1002/jemt.1170 · DOI
  23. 10.1177/002215540205000501 · DOI
  24. 10.1016/0092-8674(89)90597-7 · DOI
  25. Hikida RS, 1989, Aviat Space Environ Med, 60, 664
  26. Holthofer H, 1982, Lab Invest, 47, 60
  27. 10.1016/S0002-9149(83)80063-0 · DOI
  28. Ingemann-Hansen T, 1980, Scand J Rehabil Med, 12, 27
  29. 10.1007/s004180050012 · DOI
  30. 10.1046/j.1365-201x.2000.00743.x · DOI
  31. 10.1016/j.yexmp.2004.08.007 · DOI
  32. 10.1096/fj.11-198663 · DOI
  33. Messi ML, J Gerontol A Biol Sci Med Sci
  34. 10.1152/ajpcell.00292.2004 · DOI
  35. 10.1002/ar.1091700405 · DOI · Paper page
  36. 10.1016/j.numecd.2012.02.002 · DOI
  37. 10.3945/ajcn.113.078576 · DOI
  38. 10.1113/jphysiol.2010.193243 · DOI
  39. 10.1096/fj.03-0792fje · DOI
  40. 10.1111/j.1469-7580.2008.00854.x · DOI · Paper page
  41. Saltin B, 1980, Fed Proc, 39, 1506
  42. 10.1016/0047-6374(82)90105-1 · DOI · Paper page
  43. 10.1016/j.ydbio.2006.02.022 · DOI · Paper page
  44. 10.1152/ajpcell.00495.2004 · DOI
  45. 10.1111/apha.12609 · DOI
  46. 10.1042/CS20130295 · DOI
  47. 10.1007/BF00220299 · DOI
  48. 10.1371/journal.pone.0051238 · DOI
  49. 10.1113/jphysiol.2013.257121 · DOI
  50. 10.1249/MSS.0b013e3182667c2e · DOI
  51. 10.1111/j.1532-5415.2010.03150.x · DOI
  52. 10.14814/phy2.12415 · DOI
  53. 10.1152/ajpcell.00298.2005 · DOI
  54. 10.1113/expphysiol.1984.sp002860 · DOI
  55. 10.3109/07420528.2014.979940 · DOI
  56. 10.1007/BF00580261 · DOI

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Metadata

Authors
Arentson-Lantz, E. J., English, K. L., Paddon-Jones, D., & Fry, C. S.
Venue
Journal of Applied Physiology
Publisher
American Physiological Society
Published
2016-04-15
Volume
120
Issue
8
Pages
965-975
ISSN
  • 8750-7587
  • 1522-1601
DOI
10.1152/japplphysiol.00799.2015
Cited by
171
References
20
Language
en
Funders
  • HHS | NIH | National Institute of Nursing Research (NINR) (NR012973)
  • NSBRI (NNJ08ZSA002N)
  • HHS | NIH | NICHD | National Center for Medical Rehabilitation Research (NCMRR) (HD007539)
  • HHS | NIH | National Institute on Aging (U.S. National Institute on Aging) (AG024832)
  • HHS | NIH | National Center for Research Resources (NCRR) (1UL1RR029876)
  • HHS | NIH | National Center for Advancing Translational Sciences (NCATS) (UL1TR000071)

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CoChat. (2026). Citation check: Fourteen days of bed rest induces a decline in satellite cell content and robust atrophy of skeletal muscle fibers in middle-aged adults. https://app.cochat.ai/papers/10.1152/japplphysiol.00799.2015
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Arentson-Lantz, E. J., English, K. L., Paddon-Jones, D., & Fry, C. S. (2016). Fourteen days of bed rest induces a decline in satellite cell content and robust atrophy of skeletal muscle fibers in middle-aged adults. Journal of Applied Physiology. https://doi.org/10.1152/japplphysiol.00799.2015

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