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Cited by 198Exercise and Physiological ResponsesVitamin C and Antioxidants ResearchAntioxidant Activity and Oxidative Stress

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Influence of vitamin C supplementation on oxidative and immune changes after an ultramarathon

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Nieman, David C., Henson, Dru A., McAnulty, Steve R., McAnulty, Lisa, Swick, Nathaniel S., Utter, Alan C., Vinci, Debra M., Opiela, Shannon J., Morrow, Jason D.·2002·Journal of Applied Physiology
DOI 10.1152/japplphysiol.00961.2001
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Abstract

The purpose of this randomized study was to measure the influence of vitamin C ( n = 15 runners) compared with placebo ( n = 13 runners) supplementation on oxidative and immune changes in runners competing in an ultramarathon race. During the 7-day period before the race and on race day, subjects ingested in randomized, double-blind fashion 1,500 mg/day vitamin C or placebo. On race day, blood samples were collected 1 h before race, after 32 km of running, and then again immediately after race. Subjects in both groups maintained an intensity of ∼75% maximal heart rate throughout the ultramarathon race and ran a mean of 69 km (range: 48–80 km) in 9.8 h (range: 5–12 h). Plasma ascorbic acid was markedly higher in the vitamin C compared with placebo group prerace and rose more strongly in the vitamin C group during the race (postrace: 3.21 ± 0.29 and 1.28 ± 0.12 μg/100 μl, respectively, P < 0.001). No significant group or interaction effects were measured for lipid hydroperoxide, F 2-isoprostane, immune cell counts, plasma interleukin (IL)-6, IL-10, IL-1-receptor antagonist, or IL-8 concentrations, or mitogen-stimulated lymphocyte proliferation and IL-2 and IFN-γ production. These data indicate that vitamin C supplementation in carbohydrate-fed runners does not serve as a countermeasure to oxidative and immune changes during or after a competitive ultramarathon race.

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  1. Dwenger A, 1992, Eur J Clin Chem Clin Biochem, 30, 187
  2. Mylonas C, 1999, In Vivo, 13, 295

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Metadata

Authors
Nieman, D. C., Henson, D. A., McAnulty, S. R., McAnulty, L., Swick, N. S., Utter, A. C., Vinci, D. M., Opiela, S. J., & Morrow, J. D.
Affiliations
  • Appalachian State University (US)
  • Departments of Health, Leisure, and Exercise Science, and Biology, Appalachian State University, Boone, North Carolina 28608;
  • Vanderbilt University (US)
ORCID
Venue
Journal of Applied Physiology
Publisher
American Physiological Society
Published
2002-05-01
Volume
92
Issue
5
Pages
1970-1977
ISSN
  • 0161-7567 (ISSN-L)
  • 8750-7587
  • 1522-1601
DOI
10.1152/japplphysiol.00961.2001
OpenAlex
W2154060532
Cited by
198
References
39
Citations by year
2026: 2 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 6 · 2020: 7 · 2019: 1 · 2018: 13 · 2017: 11 · 2016: 6 · 2015: 7 · 2014: 6 · 2013: 8 · 2012: 8
FWCI
11.55
Type
journal article
Language
en
Open access
Locations
  • Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
  • NC Digital Online Collection of Knowledge and Scholarship (The University of North Carolina at Greensboro) (submittedVersion)
  • Figshare (submittedVersion)
  • Appalachian State University
Funders
  • National Institutes of Health (26657, GM 15431)
  • National Cancer Institute (CA77839, P01CA077839)
  • National Institute of General Medical Sciences (GM 15431)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK-26657, DK 48831, P30DK026657, R01DK048831)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
  • Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords
vitamin C supplementation, ultramarathon, exercise-induced oxidative stress, exercise immunology, lipid peroxidation, F2-isoprostanes, interleukin-6, IL-10, interleukin-1 receptor antagonist, interleukin-8, lymphocyte proliferation, plasma ascorbic acid, endurance athletes
MeSH terms
Administration, Oral, Ascorbic Acid, Blood Glucose, Energy Intake, Dietary Carbohydrates, Dietary Fats, Physical Exertion, Female, Heart Rate, Humans, Hydrocortisone, Immune System, Insulin, Leukocyte Count, Lipid Peroxides, Lymphocyte Activation, Male, Middle Aged, Oxidation-Reduction, Running, Uric Acid, Cytokines, Dietary Supplements, F2-Isoprostanes

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