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Cited by 148Exercise and Physiological ResponsesMuscle metabolism and nutritionCardiovascular and exercise physiology

Effect of vitamin supplementation on cytokine response and on muscle damage after strenuous exercise

Petersen, Emil Wolsk, Ostrowski, Kenneth, Ibfelt, Tobias, Richelle, Myriam, Offord, Elizabeth, Halkjær-Kristensen, Jens, Pedersen, Bente Klarlund·2001·American Journal of Physiology-Cell Physiology
DOI 10.1152/ajpcell.2001.280.6.c1570
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Abstract

The present double-blinded, placebo-controlled study investigated whether antioxidant vitamin supplementation was able to modulate the cytokine and lymphocyte responses after strenuous eccentric exercise. Furthermore, muscle enzyme release was examined to see whether antioxidant treatment could reduce muscle damage. Twenty male recreational runners randomly received either antioxidants (500 mg of vitamin C and 400 mg of vitamin E) or placebo for 14 days before and 7 days after a 5% downhill 90-min treadmill run at 75% V˙o 2 max. Although the supplemented group differed significantly with regard to plasma vitamin concentration before and after exercise when compared with the placebo group, the two groups showed identical exercise-induced changes in cytokine, muscle enzyme, and lymphocyte subpopulations. The plasma level of interleukin (IL)-6 and IL-1 receptor antagonist increased 20- and 3-fold after exercise. The plasma level of creatine kinase was increased sixfold the day after exercise. The concentrations of CD4+ memory T cells, CD8+ memory and naı̈ve T cells, and natural killer cells increased at the end of exercise. The total lymphocyte concentration was below prevalues in the postexercise period. In conclusion, the present study does not support the idea that exercise-induced inflammatory responses are induced by free oxygen radicals.

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Crossref · 10.1152/ajpcell.2001.280.6.c1570

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  • Several other studies have reported that dietary antioxidants do not affect the typical changes in lymphocyte function induced by acute exercise, but many of these studies have examined non-specific aspects of cell-mediated immunity.

    “Several other studies have reported that dietary antioxidants do not affect the typical changes in lymphocyte function induced by acute exercise, but many of these studies have examined non-specific aspects of cell-mediated immunity (McAnulty et al. 2011; Petersen et al. 2001).”

    From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Petersen et al. 2001

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Authors
Petersen, E. W., Ostrowski, K., Ibfelt, T., Richelle, M., Offord, E., Halkjær-Kristensen, J., & Pedersen, B. K.
Affiliations
  • Rigshospitalet (DK)
  • Nestlé (Switzerland) (CH)
ORCID
Venue
American Journal of Physiology-Cell Physiology
Publisher
American Physiological Society
Published
2001-06-01
Volume
280
Issue
6
Pages
C1570-C1575
ISSN
  • 0363-6143 (ISSN-L)
  • 1522-1563
DOI
10.1152/ajpcell.2001.280.6.c1570
OpenAlex
W2248855985
Cited by
148
References
33
Citations by year
2026: 3 · 2023: 3 · 2022: 9 · 2021: 3 · 2020: 5 · 2019: 1 · 2018: 2 · 2017: 6 · 2016: 5 · 2015: 4 · 2014: 7 · 2013: 3 · 2012: 9
FWCI
11.62
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Cell Physiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords
vitamin supplementation, antioxidant supplementation, vitamin C, vitamin E, cytokine response, exercise-induced muscle damage, eccentric exercise, interleukin-6, interleukin-1 receptor antagonist, creatine kinase, lymphocyte subsets, memory CD4+ T cells, CD8+ T cells, natural killer cells, oxygen free radicals, exercise-induced inflammation, recreational runners
MeSH terms
Adult, Antioxidants, Ascorbic Acid, Creatine Kinase, Double-Blind Method, Physical Exertion, Free Radicals, Humans, Killer Cells, Natural, Male, Oxygen Consumption, Sialoglycoproteins, Vitamin E, CD4-Positive T-Lymphocytes, Interleukin-6, CD3 Complex, Receptors, IgG, Leukocyte Common Antigens, Muscle, Skeletal, CD56 Antigen, L-Selectin, Dietary Supplements, Interleukin 1 Receptor Antagonist Protein

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