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Cited by 276Cardiovascular and exercise physiologyPhysical Activity and HealthCardiovascular Effects of Exercise

The DOI matches its Crossref record; 50 of the 53 references it cites were found in a registry or an index.

Changes in cardiorespiratory fitness and coronary heart disease risk factors following 24 wk of moderate- or high-intensity exercise of equal energy cost

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O'Donovan, Gary, Owen, Andrew, Bird, Steve R., Kearney, Edward M., Nevill, Alan M., Jones, David W., Woolf-May, Kate·2005·Journal of Applied Physiology
DOI 10.1152/japplphysiol.01310.2004
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Abstract

This study was designed to investigate the effect of exercise intensity on cardiorespiratory fitness and coronary heart disease risk factors. Maximum oxygen consumption (V̇o 2 max), lipid, lipoprotein, and fibrinogen concentrations were measured in 64 previously sedentary men before random allocation to a nonexercise control group, a moderate-intensity exercise group (three 400-kcal sessions per week at 60% of V̇o 2 max), or a high-intensity exercise group (three 400-kcal sessions per week at 80% of V̇o 2 max). Subjects were instructed to maintain their normal dietary habits, and training heart rates were represcribed after monthly fitness tests. Forty-two men finished the study. After 24 wk, V̇o 2 max increased by 0.38 ± 0.14 l/min in the moderate-intensity group and by 0.55 ± 0.27 l/min in the high-intensity group. Repeated-measures analysis of variance identified a significant interaction between monthly V̇o 2 max score and exercise group ( F = 3.37, P < 0.05), indicating that V̇o 2 max responded differently to moderate- and high-intensity exercise. Trend analysis showed that total cholesterol, low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and fibrinogen concentrations changed favorably across control, moderate-intensity, and high-intensity groups. However, significant changes in total cholesterol (−0.55 ± 0.81 mmol/l), low-density lipoprotein cholesterol (−0.52 ± 0.80 mmol/l), and non-high-density lipoprotein cholesterol (−0.54 ± 0.86 mmol/l) were only observed in the high-intensity group (all P < 0.05 vs. controls). These data suggest that high-intensity training is more effective in improving cardiorespiratory fitness than moderate-intensity training of equal energy cost. These data also suggest that changes in coronary heart disease risk factors are influenced by exercise intensity.

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Crossref · 10.1152/japplphysiol.01310.2004

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  1. 10.1001/jama.1985.03360070057023 · DOI

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Metadata

Authors
O'Donovan, G., Owen, A., Bird, S. R., Kearney, E. M., Nevill, A. M., Jones, D. W., & Woolf-May, K.
ORCID
Venue
Journal of Applied Physiology
Publisher
American Physiological Society
Published
2005-05
Volume
98
Issue
5
Pages
1619-1625
ISSN
  • 0161-7567 (ISSN-L)
  • 8750-7587
  • 1522-1601
DOI
10.1152/japplphysiol.01310.2004
OpenAlex
W2105188051
Cited by
276
References
53
Citations by year
2026: 4 · 2025: 7 · 2024: 6 · 2023: 18 · 2022: 10 · 2021: 20 · 2020: 23 · 2019: 16 · 2018: 19 · 2017: 16 · 2016: 16 · 2015: 13 · 2014: 13 · 2013: 14 · 2012: 12
FWCI
24.01
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
  • RMIT Research Repository (RMIT University Library) (submittedVersion)
  • Figshare (submittedVersion, cc-by)
  • Kent Academic Repository (University of Kent) (submittedVersion)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
Keywords
exercise intensity, cardiorespiratory fitness, VO2max, coronary risk factors, high-intensity training, moderate-intensity training, lipid profile, lipoproteins, fibrinogen, sedentary men, energy expenditure
MeSH terms
Adult, Analysis of Variance, Cholesterol, Coronary Disease, Heart Rate, Humans, Male, Middle Aged, Oxygen Consumption, Physical Fitness, Risk Factors, Exercise

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