Cited by 276Cardiovascular and exercise physiologyPhysical Activity and HealthCardiovascular Effects of Exercise

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Changes in cardiorespiratory fitness and coronary heart disease risk factors following 24 wk of moderate- or high-intensity exercise of equal energy cost

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O'Donovan, Gary, Owen, Andrew, Bird, Steve R., Kearney, Edward M., Nevill, Alan M., Jones, David W., Woolf-May, Kate·2005·Journal of Applied Physiology

DOI 10.1152/japplphysiol.01310.2004

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Abstract

This study was designed to investigate the effect of exercise intensity on cardiorespiratory fitness and coronary heart disease risk factors. Maximum oxygen consumption (V̇o 2 max), lipid, lipoprotein, and fibrinogen concentrations were measured in 64 previously sedentary men before random allocation to a nonexercise control group, a moderate-intensity exercise group (three 400-kcal sessions per week at 60% of V̇o 2 max), or a high-intensity exercise group (three 400-kcal sessions per week at 80% of V̇o 2 max). Subjects were instructed to maintain their normal dietary habits, and training heart rates were represcribed after monthly fitness tests. Forty-two men finished the study. After 24 wk, V̇o 2 max increased by 0.38 ± 0.14 l/min in the moderate-intensity group and by 0.55 ± 0.27 l/min in the high-intensity group. Repeated-measures analysis of variance identified a significant interaction between monthly V̇o 2 max score and exercise group ( F = 3.37, P < 0.05), indicating that V̇o 2 max responded differently to moderate- and high-intensity exercise. Trend analysis showed that total cholesterol, low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and fibrinogen concentrations changed favorably across control, moderate-intensity, and high-intensity groups. However, significant changes in total cholesterol (−0.55 ± 0.81 mmol/l), low-density lipoprotein cholesterol (−0.52 ± 0.80 mmol/l), and non-high-density lipoprotein cholesterol (−0.54 ± 0.86 mmol/l) were only observed in the high-intensity group (all P < 0.05 vs. controls). These data suggest that high-intensity training is more effective in improving cardiorespiratory fitness than moderate-intensity training of equal energy cost. These data also suggest that changes in coronary heart disease risk factors are influenced by exercise intensity.

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Authors: O'Donovan, G., Owen, A., Bird, S. R., Kearney, E. M., Nevill, A. M., Jones, D. W., & Woolf-May, K.
ORCID: Owen, Andrew
Kearney, Edward M.
Nevill, Alan M.
Jones, David W.
Venue: Journal of Applied Physiology
Publisher: American Physiological Society
Published: 2005-05
Volume: 98
Issue: 5
Pages: 1619-1625
ISSN: 0161-7567 (ISSN-L)
8750-7587
1522-1601
DOI: 10.1152/japplphysiol.01310.2004
OpenAlex: W2105188051
Cited by: 276
References: 53
Citations by year: 2026: 4 · 2025: 7 · 2024: 6 · 2023: 18 · 2022: 10 · 2021: 20 · 2020: 23 · 2019: 16 · 2018: 19 · 2017: 16 · 2016: 16 · 2015: 13 · 2014: 13 · 2013: 14 · 2012: 12
FWCI: 24.01
Type: journal article
Language: en
Open access: green
figshare.com
Licence: cc-by
Locations: Journal of Applied Physiology (publishedVersion)
PubMed (publishedVersion)
RMIT Research Repository (RMIT University Library) (submittedVersion)
Figshare (submittedVersion, cc-by)
Kent Academic Repository (University of Kent) (submittedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
Keywords: exercise intensity, cardiorespiratory fitness, VO2max, coronary risk factors, high-intensity training, moderate-intensity training, lipid profile, lipoproteins, fibrinogen, sedentary men, energy expenditure
MeSH terms: Adult, Analysis of Variance, Cholesterol, Coronary Disease, Heart Rate, Humans, Male, Middle Aged, Oxygen Consumption, Physical Fitness, Risk Factors, Exercise

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Changes in cardiorespiratory fitness and coronary heart disease risk factors following 24 wk of moderate- or high-intensity exercise of equal energy cost

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