Somatosensory spatial attention modulates amplitudes, latencies, and latency jitter of laser-evoked brain potentials
Open accessAbstract
Several studies provided evidence that the amplitudes of laser-evoked potentials (LEPs) are modulated by attention. However, previous reports were based on across-trial averaging of LEP responses at the expense of losing information about intertrial variability related to attentional modulation. The aim of this study was to investigate the effects of somatosensory spatial attention on single-trial parameters (i.e., amplitudes, latencies, and latency jitter) of LEP components (N2 and P2). Twelve subjects participated in a sustained spatial attention paradigm while noxious laser stimuli (left hand) and noxious electrical stimuli (right hand) were sequentially delivered to the dorsum of the respective hand with nonnoxious air puffs randomly interspersed within the sequence of noxious stimuli. Participants were instructed to mentally count all stimuli (i.e., noxious and nonnoxious) applied to the attended location. Laser stimuli, presented to the attended hand (ALS), elicited larger single-trial amplitudes of the N2 component compared with unattended laser stimuli (ULS). In contrast, single-trial amplitudes of the P2 component were not significantly affected by spatial attention. Single-trial latencies of the N2 and P2 were significantly smaller for ALS vs. ULS. Additionally, the across-trial latency jitter of the N2 component was reduced for ALS. Conversely, the latency jitter of the P2 component was smaller for ULS compared with ALS. With the use of single-trial analysis, the study provided new insights into brain dynamics of LEPs related to spatial attention. Our results indicate that single-trial parameters of LEP components are differentially modulated by spatial attention.
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The P2 component has been shown to be modulated specifically by factors reflecting the salience of noxious stimuli and to reflect multimodal (rather than somatosensory-specific) processes.
“The P2 component has been shown to be modulated specifically by factors reflecting the salience of noxious stimuli (e.g. stimulus probability) 33, 59, 69 and to reflect multimodal (rather than somatosensory‐specific) processes 61.”
From The Analgesic Effect of Oxytocin in Humans: A Double‐Blind, Placebo‐Controlled Cross‐Over Study Using Laser‐Evoked Potentials (2016) · cites this paper as [69]
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- Authors
- Franz, M., Nickel, M. M., Ritter, A., Miltner, W. H. R., & Weiss, T.
- Affiliations
- Friedrich Schiller University Jena (DE)
- Technical University of Munich (DE)
- Corresponding author
- Weiss, Thomas
- Venue
- Journal of Neurophysiology
- Publisher
- American Physiological Society
- Published
- 2015-04
- Volume
- 113
- Issue
- 7
- Pages
- 2760-2768
- ISSN
- 0022-3077 (ISSN-L)
- 1522-1598
- PMC
- PMC4416583
- OpenAlex
- W1980045424
- Cited by
- 28
- References
- 49
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 3 · 2021: 5 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 2
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Neurophysiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- German Federal Ministry of Education and Research (01EC1003B)
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- laser-evoked potentials, N2 component, P2 component, single-trial analysis, latency jitter, trial-to-trial variability
- MeSH terms
- Adaptation, Physiological, Adult, Attention, Cues, Evoked Potentials, Somatosensory, Female, Humans, Lasers, Male, Reaction Time, Sensitivity and Specificity, Reproducibility of Results, Young Adult, Pain Perception, Spatial Processing
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