Cited by 298Pain Mechanisms and TreatmentsPain Management and TreatmentPain Management and Placebo Effect

Association and dissociation between laser-evoked potentials and pain perception

Garcí-Larrea, Luis, Peyron, Roland, Laurent, Bernard, Mauguière, François·1997·NeuroReport

Abstract

We investigated the relation between the subjective sensation of pain and two different components of the laser evoked potential, namely the vertex response (N220-P350) and an earlier lateralized response (middle-latency NP160). Brain responses to laser stimuli were obtained in 15 subjects under attentive and distractive conditions. Although stimulus intensity was kept constant, it was perceived as significantly higher when subjects attended the stimulation. There was a positive correlation between subjective intensity perception and the amplitude of the vertex potential, but no correlation existed with the middle-latency component. While laser vertex potentials may reflect attentional/perceptual mechanisms that determine subjective experience, the NP160 behaves as a pre-perceptual sensory response that should be advantageous in the assessment of early cortical pain processing.

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Crossref · 10.1097/00001756-199712010-00026

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11 of 11 references verified0 citation errors · 0 not checkable

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  • The early N1 component reflects activity of cortical generators in the contralateral operculoinsular and primary somatosensory cortices and is largely driven by the magnitude of ascending nociceptive input, representing an early stage of sensory processing before the perceptual outcome is determined.

    “The early N1 component, reflecting the activity of cortical generators in the contralateral operculoinsular and primary somatosensory cortices 30, 63, is largely driven by the magnitude of the ascending nociceptive input, representing an early stage of sensory processing before the perceptual outcome of the nociceptive input is determined 48, 64, 65.”

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Research works printed but not linked: 1

  1. 1991, Rev Neurol, 147, 625

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Authors
Garcí-Larrea, L., Peyron, R., Laurent, B., & Mauguière, F.
Affiliations
Centre d'Exploration et de Recherche Médicale par Emission de Positons (FR)
Venue
NeuroReport
Published
1997-12
Volume
8
Issue
17
Pages
3785-3789
ISSN
0959-4965 (ISSN-L)
OpenAlex
W2048109090
Cited by
298
References
11
Citations by year
2026: 7 · 2025: 6 · 2024: 5 · 2023: 7 · 2022: 8 · 2021: 11 · 2020: 8 · 2019: 6 · 2018: 6 · 2017: 7 · 2016: 8 · 2015: 17 · 2014: 11 · 2013: 17 · 2012: 16
FWCI
3.66
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroreport (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
Keywords
laser-evoked potentials, pain perception, pain intensity, middle latency response, attention, cortical pain processing, subjective pain
MeSH terms
Adult, Attention, Brain, Brain Mapping, Evoked Potentials, Humans, Lasers, Pain, Pain Measurement, Regression Analysis

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