Perisomatic Inhibition
Open accessAbstract
Recent evidence supports the hypothesis of a functional dichotomy of perisomatic inhibition in the cerebral cortex: the parvalbumin- and cholecystokinin-containing basket cells that are specialized to control rhythm (as a clockwork) and "mood" (as a fine-tuning device), respectively, of network oscillations. Pathology extends this conclusion further, as the former is implicated in epilepsy and the latter in anxiety. The well-balanced cooperation of the two inhibitory systems is required for the normal network operations underlying the cognitive functions of the cerebral cortex.
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PV1 basket interneurons constitute the main source of perisomatic inhibition both onto excitatory and inhibitory neurons.
“PV1 basket interneurons constitute the main source of perisomatic inhibition both onto excitatory and inhibitory neurons (Freund and Katona, 2007;Pfeffer et al., 2013)”
From Perineuronal Nets Regulate the Inhibitory Perisomatic Input onto Parvalbumin Interneurons and γ Activity in the Prefrontal Cortex (2020) · cites this paper as Freund and Katona, 2007
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- Authors
- Freund, T. F., & Katona, I.
- Affiliations
- HUN-REN Institute of Experimental Medicine (HU)
- Corresponding author
- Freund, Tamás F.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2007-10
- Volume
- 56
- Issue
- 1
- Pages
- 33-42
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W4245746501
- Cited by
- 656
- References
- 15
- Citations by year
- 2026: 25 · 2025: 38 · 2024: 32 · 2023: 37 · 2022: 32 · 2021: 40 · 2020: 35 · 2019: 31 · 2018: 33 · 2017: 41 · 2016: 41 · 2015: 29 · 2014: 52 · 2013: 38 · 2012: 32
- FWCI
- 2.13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2116 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Hungarian Scientific Research Fund (F046407, T46820)
- Howard Hughes Medical Institute
- European Commission (LSHM-CT-2004-005166)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Keywords
- perisomatic inhibition, basket cells, parvalbumin, cholecystokinin, cortical oscillations, epilepsy, anxiety, inhibitory interneurons, cerebral cortex
- MeSH terms
- Animals, Anxiety, Cerebral Cortex, Cholecystokinin, Epilepsy, Humans, Models, Neurological, Nerve Net, Neural Inhibition, Neurons, Parvalbumins
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