Cited by 656Neural dynamics and brain functionNeuroscience and Neuropharmacology ResearchEpilepsy research and treatment

Perisomatic Inhibition

Open access
Freund, Tamás F., Katona, István·2007·Neuron

Abstract

Recent evidence supports the hypothesis of a functional dichotomy of perisomatic inhibition in the cerebral cortex: the parvalbumin- and cholecystokinin-containing basket cells that are specialized to control rhythm (as a clockwork) and "mood" (as a fine-tuning device), respectively, of network oscillations. Pathology extends this conclusion further, as the former is implicated in epilepsy and the latter in anxiety. The well-balanced cooperation of the two inhibitory systems is required for the normal network operations underlying the cognitive functions of the cerebral cortex.

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Crossref · 10.1016/j.neuron.2007.09.012

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15 of 15 references verified0 citation errors · 0 not checkable

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Authors
Freund, T. F., & Katona, I.
Affiliations
HUN-REN Institute of Experimental Medicine (HU)
Corresponding author
Freund, Tamás F.
Venue
Neuron
Publisher
Elsevier BV
Published
2007-10
Volume
56
Issue
1
Pages
33-42
ISSN
0896-6273 (ISSN-L)
OpenAlex
W4245746501
Cited by
656
References
15
Citations by year
2026: 25 · 2025: 38 · 2024: 32 · 2023: 37 · 2022: 32 · 2021: 40 · 2020: 35 · 2019: 31 · 2018: 33 · 2017: 41 · 2016: 41 · 2015: 29 · 2014: 52 · 2013: 38 · 2012: 32
FWCI
2.13
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Hungarian Scientific Research Fund (F046407, T46820)
  • Howard Hughes Medical Institute
  • European Commission (LSHM-CT-2004-005166)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
Keywords
perisomatic inhibition, basket cells, parvalbumin, cholecystokinin, cortical oscillations, epilepsy, anxiety, inhibitory interneurons, cerebral cortex
MeSH terms
Animals, Anxiety, Cerebral Cortex, Cholecystokinin, Epilepsy, Humans, Models, Neurological, Nerve Net, Neural Inhibition, Neurons, Parvalbumins

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