Cerebellar asymmetry and its relation to cerebral asymmetry estimated by intrinsic functional connectivity
Open accessAbstract
Asymmetry of the human cerebellum was investigated using intrinsic functional connectivity. Regions of functional asymmetry within the cerebellum were identified during resting-state functional MRI ( n = 500 subjects) and replicated in an independent cohort ( n = 500 subjects). The most strongly right lateralized cerebellar regions fell within the posterior lobe, including crus I and crus II, in regions estimated to link to the cerebral association cortex. The most strongly left lateralized cerebellar regions were located in lobules VI and VIII in regions linked to distinct cerebral association networks. Comparison of cerebellar asymmetry with independently estimated cerebral asymmetry revealed that the lateralized regions of the cerebellum belong to the same networks that are strongly lateralized in the cerebrum. The degree of functional asymmetry of the cerebellum across individuals was significantly correlated with cerebral asymmetry and varied with handedness. In addition, cerebellar asymmetry estimated at rest predicted cerebral lateralization during an active language task. These results demonstrate that functional lateralization is likely a unitary feature of large-scale cerebrocerebellar networks, consistent with the hypothesis that the cerebellum possesses a roughly homotopic map of the cerebral cortex including the prominent asymmetries of the association cortex.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
There were three distinct regions (Crus I, Crus II, lobules IX/X) in the cerebellar posterior lobe that show topographical relationship with cortical association areas.
“Newly revealed were three distinct regions (Crus I, Crus II, lobules IX/X) in the cerebellar posterior lobe that show topographical relationship with cortical association areas (Buckner et al., 2011; Wang et al., 2013).”
From The Cerebro-Cerebellum as a Locus of Forward Model: A Review (2020) · cites this paper as Wang et al., 2013
The cerebro-cerebellum collects information from almost all the entire cortical areas, suggesting that the cerebellum still keeps the position of the CNS hub even in human.
“Recently, Buckner et al. (2011) and Wang et al. (2013) demonstrated base on this approach that the cerebro-cerebellum collects information from almost all the entire cortical areas, suggesting that the cerebellum still keeps the position of the CNS hub even in human.”
From The Cerebro-Cerebellum as a Locus of Forward Model: A Review (2020) · cites this paper as Wang et al. (2013)
Cites
Jenkinson, M., Bannister, P., Brady, M., & Smith, S. (2002) · NeuroImage · doi:10.1006/nimg.2002.1132 · Cited by 11,888 · see citing works
Fischl, B., Salat, D. H., Busa, E., Albert, M., Dieterich, M., Haselgrove, C., van der Kouwe, A., Killiany, R., Kennedy, D., Klaveness, S., et al. (2002) · Neuron · doi:10.1016/s0896-6273(02)00569-x · Cited by 8,610 · see citing works
Functional Network Organization of the Human Brain
Power, J. D., Cohen, A. L., Nelson, S. M., Wig, G. S., Barnes, K. A., Church, J. A., Vogel, A. C., Laumann, T. O., Miezin, F. M., Schlaggar, B. L., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.006 · Cited by 4,124 · see citing works
Coherent spontaneous activity identifies a hippocampal-parietal memory network
Vincent, J. L., Snyder, A. Z., Fox, M. D., Shannon, B. J., Andrews, J. R., Raichle, M. E., & Buckner, R. L. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00048.2006 · Cited by 959 · cited 2× · see citing works
“Resting-state fMRI data were processed using previously described procedures (Buckner et al. 2011; Van Dijk et al. 2010; Vincent et al. 2006; Yeo et al. 2011), which were adapted from Biswal et al.”
MethodSelf-citationDecreased interhemispheric functional connectivity in autism
Anderson, J. S., Druzgal, T. J., Froehlich, A., DuBray, M. B., Lange, N., Alexander, A. L., Abildskov, T., Nielsen, J. A., Cariello, A. N., Cooperrider, J. R., et al. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhq190 · Cited by 438 · see citing works
Cognitive sequencing impairment in patients with focal or atrophic cerebellar damage
Leggio, M. G., Tedesco, A. M., Chiricozzi, F. R., Clausi, S., Orsini, A., & Molinari, M. (2008) · Brain · doi:10.1093/brain/awn040 · Cited by 170 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The cerebellum and cognitive function: 25 years of insight from anatomy and neuroimaging
Buckner, R. L. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.044 · Cited by 1,173 · see citing works
Self-citationThe evolution of distributed association networks in the human brain
Buckner, R. L., & Krienen, F. M. (2013) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2013.09.017 · Cited by 836 · see citing works
Self-citationParcellating cortical functional networks in individuals
Wang, D., Buckner, R. L., Fox, M. D., Holt, D. J., Holmes, A. J., Stoecklein, S., Langs, G., Pan, R., Qian, T., Li, K., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4164 · Cited by 527 · see citing works
Self-citationKrienen, F. M., Yeo, B. T. T., & Buckner, R. L. (2014) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0526 · Cited by 372 · see citing works
Self-citationPaloyelis, Y., Doyle, O. M., Zelaya, F. O., Maltezos, S., Williams, S. C., Fotopoulou, A., & Howard, M. A. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.10.005 · Cited by 187 · see citing works
The Cerebro-Cerebellum as a Locus of Forward Model: A Review
Tanaka, H., Ishikawa, T., Lee, J., & Kakei, S. (2020) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2020.00019 · Cited by 155 · see citing works
Functional Connectivity Disruption in Neonates with Prenatal Marijuana Exposure
Grewen, K., Salzwedel, A. P., & Gao, W. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2015.00601 · Cited by 72 · see citing works
- Authors
- Wang, D., Buckner, R. L., & Liu, H.
- Affiliations
- Massachusetts General Hospital (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Liu, Hesheng
- Venue
- Journal of Neurophysiology
- Publisher
- American Physiological Society
- Published
- 2013-01-01
- Volume
- 109
- Issue
- 1
- Pages
- 46-57
- ISSN
- 0022-3077 (ISSN-L)
- 1522-1598
- PMC
- PMC3545158
- OpenAlex
- W1983834115
- Cited by
- 124
- References
- 6
- Citations by year
- 2026: 4 · 2025: 15 · 2024: 9 · 2023: 7 · 2022: 9 · 2021: 8 · 2020: 10 · 2019: 7 · 2018: 6 · 2017: 9 · 2016: 12 · 2015: 11 · 2014: 10 · 2013: 7
- FWCI
- 4.59
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Neurophysiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health
- National Institute on Aging (AG021910, R01AG021910)
- National Institute of Mental Health (U54MH091665)
- National Institute of Neurological Disorders and Stroke (K25NS069805)
- National Center for Research Resources (P41 RR14074)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hemispheric Asymmetry in Neuroscience
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
- Keywords
- hemispheric lateralization, functional asymmetry, intrinsic functional connectivity, resting-state fMRI, association cortex, handedness, language tasks
- MeSH terms
- Adolescent, Adult, Brain Mapping, Cerebellum, Female, Humans, Image Processing, Computer-Assisted, Functional Laterality, Magnetic Resonance Imaging, Male, Nerve Net
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
