Functional Connectivity Disruption in Neonates with Prenatal Marijuana Exposure
Open accessAbstract
Prenatal marijuana exposure (PME) is linked to neurobehavioral and cognitive impairments; however, findings in childhood and adolescence are inconsistent. Type-1 cannabinoid receptors (CB1R) modulate fetal neurodevelopment, mediating PME effects on growth of functional circuitry sub-serving behaviors critical for academic and social success. The purpose of this study was to investigate the effects of prenatal marijuana on development of early brain functional circuitry prior to prolonged postnatal environmental influences. We measured resting state functional connectivity during unsedated sleep in infants at 2-6 weeks (+MJ: 20 with PME in combination with nicotine, alcohol, opiates, and/or selective serotonin reuptake inhibitors; -MJ: 23 exposed to the same other drugs without marijuana, CTR: 20 drug-free controls). Connectivity of subcortical seed regions with high fetal CB1R expression was examined. Marijuana-specific differences were observed in insula and three striatal connections: anterior insula-cerebellum, right caudate-cerebellum, right caudate-right fusiform gyrus/inferior occipital, left caudate-cerebellum. +MJ neonates had hypo-connectivity in all clusters compared with -MJ and CTR groups. Altered striatal connectivity to areas involved in visual spatial and motor learning, attention, and in fine-tuning of motor outputs involved in movement and language production may contribute to neurobehavioral deficits reported in this at-risk group. Disrupted anterior insula connectivity may contribute to altered integration of interoceptive signals with salience estimates, motivation, decision-making, and later drug use. Compared with CTRs, both +MJ and -MJ groups demonstrated hyper-connectivity of left amygdala seed with orbital frontal cortex and hypo-connectivity of posterior thalamus seed with hippocampus, suggesting vulnerability to multiple drugs in these circuits.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Prenatal marijuana exposure is associated with altered striatal and insular functional connectivity.
“prenatal marijuana exposure is associated with altered striatal and insular functional connectivity184.”
From Imaging structural and functional brain development in early childhood (2018) · cites this paper as [184]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Desikan, R. S., Ségonne, F., Fischl, B., Quinn, B. T., Dickerson, B. C., Blacker, D., Buckner, R. L., Dale, A. M., Maguire, R. P., Hyman, B. T., et al. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.01.021 · Cited by 13,324 · see citing works
Jenkinson, M., Beckmann, C. F., Behrens, T. E. J., Woolrich, M. W., & Smith, S. M. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.09.015 · Cited by 11,314 · see citing works
AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages
Cox, R. W. (1996) · Computers and Biomedical Research · doi:10.1006/cbmr.1996.0014 · Cited by 10,913 · see citing works
Functional connectivity in the motor cortex of resting human brain using echo‐planar mri
Biswal, B., Zerrin Yetkin, F., Haughton, V. M., & Hyde, J. S. (1995) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910340409 · Cited by 9,812 · see citing works
(1982) · Trends in Neurosciences · doi:10.1016/0166-2236(82)90076-5 · Cited by 9,148 · see citing works
The organization of the human cerebellum estimated by intrinsic functional connectivity
Buckner, R. L., Krienen, F. M., Castellanos, A., Diaz, J. C., & Yeo, B. T. T. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00339.2011 · Cited by 7,304 · see citing works
Calamita, E., Schmid, M., Kunz, M., Ndebele-Murisa, M. R., Magadza, C. H. D., Nyambe, I., & Wehrli, B. (2019) · Figshare · doi:10.26181/6153922fe919c · Cited by 4,222 · see citing works
Henry, M. A. (1995) · The Journal of the American Dental Association · doi:10.14219/jada.archive.1995.0108 · Cited by 3,454 · see citing works
Forman, S. D., Cohen, J. D., Fitzgerald, M., Eddy, W. F., Mintun, M. A., & Noll, D. C. (1995) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910330508 · Cited by 3,202 · see citing works
Adverse health effects of marijuana use.
Volkow, N. D., Baler, R. D., Compton, W. M., & Weiss, S. R. B. (2014) · New England Journal of Medicine · doi:10.1056/nejmra1402309 · Cited by 2,774 · see citing works
Large-scale brain networks in cognition: emerging methods and principles
Bressler, S. L., & Menon, V. (2010) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.04.004 · Cited by 2,348 · see citing works
Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system
Tsou, K., Brown, S., Sañudo-Peña, M. C., Mackie, K., & Walker, J. M. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00436-3 · Cited by 1,586 · see citing works
Role of Endogenous Cannabinoids in Synaptic Signaling
Freund, T. F., Katona, I., & Piomelli, D. (2003) · Physiological Reviews · doi:10.1152/physrev.00004.2003 · Cited by 1,567 · see citing works
A Structural MRI Study of Human Brain Development from Birth to 2 Years
Knickmeyer, R. C., Gouttard, S., Kang, C., Evans, D., Wilber, K., Smith, J. K., Hamer, R. M., Lin, W., Gerig, G., & Gilmore, J. H. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3479-08.2008 · Cited by 1,151 · see citing works
Functional connectivity of human striatum: a resting state FMRI study
Di Martino, A., Scheres, A., Margulies, D. S., Kelly, A. M. C., Uddin, L. Q., Shehzad, Z., Biswal, B., Walters, J. R., Castellanos, F. X., & Milham, M. P. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhn041 · Cited by 1,090 · see citing works
Glass, M., Faull, R. L. M., & Dragunow, M. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00428-9 · Cited by 1,052 · see citing works
The Validation of the Edinburgh Post-natal Depression Scale on a Community Sample
Murray, L., & Carothers, A. D. (1990) · The British Journal of Psychiatry · doi:10.1192/bjp.157.2.288 · Cited by 881 · see citing works
Saad, Z. S., Gotts, S. J., Murphy, K., Chen, G., Jo, H. J., Martin, A., & Cox, R. W. (2012) · Brain Connectivity · doi:10.1089/brain.2012.0080 · Cited by 859 · see citing works
Reliability of the Timeline Followback for cocaine, cannabis, and cigarette use
Robinson, S. M., Sobell, L. C., Sobell, M. B., & Leo, G. I. (2014) · Psychology of Addictive Behaviors · doi:10.1037/a0030992 · Cited by 699 · see citing works
Gao, W., Zhu, H., Giovanello, K. S., Smith, J. K., Shen, D., Gilmore, J. H., & Lin, W. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811221106 · Cited by 601 · see citing works
Self-citationHirvonen, J., Goodwin, R. S., Li, C.-T., Terry, G. E., Zoghbi, S. S., Morse, C., Pike, V. W., Volkow, N. D., Huestis, M. A., & Innis, R. B. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.82 · Cited by 587 · see citing works
Postuma, R. B., & Dagher, A. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhj088 · Cited by 579 · see citing works
Neuronal localization of cannabinoid receptors in the basal ganglia of the rat
Herkenham, M. A., Lynn, A. B., de Costa, B. R., & Richfield, E. K. (1991) · Brain Research · doi:10.1016/0006-8993(91)90970-7 · Cited by 515 · see citing works
The cells and molecules that make a cerebellum
Goldowitz, D. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01313-7 · Cited by 493 · see citing works
Chang, C., & Glover, G. H. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.05.012 · Cited by 486 · see citing works
Mehmedic, Z., Chandra, S., Slade, D., Denham, H., Foster, S., Patel, A. S., Ross, S. A., Khan, I. A., & ElSohly, M. A. (2010) · Journal of Forensic Sciences · doi:10.1111/j.1556-4029.2010.01441.x · Cited by 475 · see citing works
Fried, P. A., Watkinson, B., & Gray, R. (2003) · Neurotoxicology and Teratology · doi:10.1016/s0892-0362(03)00029-1 · Cited by 458 · see citing works
Yan, C.-G., Craddock, R. C., Zuo, X.-N., Zang, Y.-F., & Milham, M. P. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.04.081 · Cited by 440 · see citing works
A neurocognitive approach to understanding the neurobiology of addiction
Noël, X., Brevers, D., & Bechara, A. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.01.018 · Cited by 436 · see citing works
Rubia, K., Smith, A. B., Taylor, E., & Brammer, M. (2007) · Human Brain Mapping · doi:10.1002/hbm.20347 · Cited by 417 · see citing works
Resting state functional connectivity of the striatum in Parkinson’s disease
Hacker, C. D., Perlmutter, J. S., Criswell, S. R., Ances, B. M., & Snyder, A. Z. (2012) · Brain · doi:10.1093/brain/aws281 · Cited by 408 · see citing works
Development of human brain cortical network architecture during infancy
Gao, W., Alcauter, S., Smith, J. K., Gilmore, J. H., & Lin, W. (2015) · Brain Structure and Function · doi:10.1007/s00429-014-0710-3 · Cited by 356 · see citing works
Self-citationFronto-striatal connections in the human brain: A probabilistic diffusion tractography study
Leh, S. E., Ptito, A., Chakravarty, M. M., & Strafella, A. P. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.04.049 · Cited by 352 · see citing works
Hjorthøj, C., Hjorthøj, A. R., & Nordentoft, M. (2012) · Addictive Behaviours · doi:10.1016/j.addbeh.2011.11.025 · Cited by 349 · see citing works
Addiction related alteration in resting-state brain connectivity
Ma, N., Liu, Y., Li, N., Wang, C.-X., Zhang, H., Jiang, X., Xu, H.-S., Fu, X., Hu, X. P., & Zhang, D. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.08.037 · Cited by 322 · see citing works
A literature review of the consequences of prenatal marihuana exposure
Fried, P. A., & Smith, A. (2001) · Neurotoxicology and Teratology · doi:10.1016/s0892-0362(00)00119-7 · Cited by 308 · see citing works
Meta-analytic clustering of the insular cortex
Cauda, F., Costa, T., Torta, D. M. E., Sacco, K., D’Agata, F., Duca, S., Geminiani, G. C., Fox, P. T., & Vercelli, A. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.04.012 · Cited by 289 · see citing works
Maternal Cannabis Use Alters Ventral Striatal Dopamine D2 Gene Regulation in the Offspring
DiNieri, J. A., Wang, X., Szutorisz, H., Spano, S., Kaur, J., Casaccia, P., Dow-Edwards, D. L., & Hurd, Y. L. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.06.027 · Cited by 279 · see citing works
Temporal and spatial evolution of brain network topology during the first two years of life
Gao, W., Gilmore, J. H., Giovanello, K. S., Smith, J. K., Shen, D., Zhu, H., & Lin, W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025278 · Cited by 272 · see citing works
Self-citationMarijuana craving in the brain
Filbey, F. M., Schacht, J. P., Myers, U. S., Chavez, R. S., & Hutchison, K. E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903863106 · Cited by 265 · see citing works
Tortoriello, G., Morris, C. V., Alpár, A., Fuzik, J., Shirran, S. L., Calvigioni, D., Keimpema, E., Botting, C. H., Reinecke, K., Herdegen, T., et al. (2014) · The EMBO Journal · doi:10.1002/embj.201386035 · Cited by 255 · see citing works
Chen, G., Adleman, N. E., Saad, Z. S., Leibenluft, E., & Cox, R. W. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.06.027 · Cited by 248 · see citing works
Simons, J. S., Wills, T. A., Emery, N. N., & Marks, R. M. (2015) · Addictive Behaviors · doi:10.1016/j.addbeh.2015.06.042 · Cited by 237 · see citing works
NOW vs LATER brain circuits: implications for obesity and addiction
Volkow, N. D., & Baler, R. D. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.04.002 · Cited by 237 · see citing works
Mato, S., del Olmo, E., & Pazos, Á. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02599.x · Cited by 232 · see citing works
Development of Thalamocortical Connectivity during Infancy and Its Cognitive Correlations
Alcauter, S., Lin, W., Smith, J. K., Short, S. J., Goldman, B. D., Reznick, J. S., Gilmore, J. H., & Gao, W. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0796-14.2014 · Cited by 228 · see citing works
Self-citationFunctional connectivity MR imaging reveals cortical functional connectivity in the developing brain
Lin, W., Zhu, Q., Gao, W., Chen, Y., Toh, C.-H., Styner, M., Gerig, G., Smith, J. K., Biswal, B., & Gilmore, J. H. (2008) · American Journal of Neuroradiology · doi:10.3174/ajnr.a1256 · Cited by 222 · see citing works
Self-citationFried, P. A., & Makin, J. E. (1987) · Neurotoxicology and Teratology · doi:10.1016/0892-0362(87)90062-6 · Cited by 212 · see citing works
Gao, W., Gilmore, J. H., Shen, D., Smith, J. K., Zhu, H., & Lin, W. (2013) · Cerebral Cortex · doi:10.1093/cercor/bhs043 · Cited by 194 · see citing works
Self-citationEndocannabinoid functions controlling neuronal specification during brain development
Harkany, T., Keimpema, E., Barabás, K., & Mulder, J. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.02.011 · Cited by 187 · see citing works
Fried, P. A., & O’Connell, C. M. (1987) · Neurotoxicology and Teratology · doi:10.1016/0892-0362(87)90082-1 · Cited by 180 · see citing works
Effects of prenatal marijuana on visuospatial working memory: An fMRI study in young adults
Smith, A., Fried, P. A., Hogan, M. J., & Cameron, I. G. M. (2006) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2005.12.008 · Cited by 175 · see citing works
Prenatal cannabis exposure and infant outcomes: Overview of studies
Huizink, A. C. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.09.014 · Cited by 174 · see citing works
Prenatal marijuana exposure: Effect on child depressive symptoms at ten years of age
Gray, K. A., Day, N. L., Leech, S. L., & Richardson, G. A. (2005) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2005.03.010 · Cited by 172 · see citing works
Rivkin, M. J., Davis, P. E., Lemaster, J. L., Cabral, H. J., Warfield, S. K., Mulkern, R. V., Robson, C. D., Rose-Jacobs, R., & Frank, D. A. (2008) · PEDIATRICS · doi:10.1542/peds.2007-1399 · Cited by 172 · see citing works
Reading and language in 9- to 12-year olds prenatally exposed to cigarettes and marijuana
Fried, P. A., Watkinson, B., & Siegel, L. S. (1997) · Neurotoxicology and Teratology · doi:10.1016/s0892-0362(97)00015-9 · Cited by 170 · see citing works
Effects of prenatal marijuana on response inhibition: an fMRI study of young adults
Smith, A., Fried, P. A., Hogan, M. J., & Cameron, I. G. M. (2004) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2004.04.004 · Cited by 163 · see citing works
Raichle, M. E. (2010) · Scientific American · doi:10.1038/scientificamerican0310-44 · Cited by 158 · see citing works
Spano, M. S., Ellgren, M., Wang, X., & Hurd, Y. L. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.073 · Cited by 150 · see citing works
Day, N. L., Leech, S. L., & Goldschmidt, L. (2011) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2010.07.006 · Cited by 146 · see citing works
Motor actions of cannabinoids in the basal ganglia output nuclei
Sañudo-Peña, M. C., Tsou, K., & Walker, J. M. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00293-3 · Cited by 145 · see citing works
Breast odour as the only maternal stimulus elicits crawling towards the odour source
Varendi, H., & Porter, R. (2001) · Acta Paediatrica · doi:10.1111/j.1651-2227.2001.tb00434.x · Cited by 145 · see citing works
Altering cannabinoid signaling during development disrupts neuronal activity
Bernard, C., Milh, M., Morozov, Y. M., Ben-Ari, Y., Freund, T. F., & Gozlan, H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409641102 · Cited by 144 · see citing works
Neuronal substrates and functional consequences of prenatal cannabis exposure
Calvigioni, D., Hurd, Y. L., Harkany, T., & Keimpema, E. (2014) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-014-0550-y · Cited by 138 · see citing works
Reducing proactive aggression through non-invasive brain stimulation
Dambacher, F., Schuhmann, T., Lobbestael, J., Arntz, A. R., Brugman, S., & Sack, A. T. (2015) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsv018 · Cited by 136 · see citing works
Villares, J. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.11.012 · Cited by 134 · see citing works
Campolongo, P., Trezza, V., Ratano, P., Palmery, M., & Cuomo, V. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1892-x · Cited by 133 · see citing works
GABA in the insula — a predictor of the neural response to interoceptive awareness
Wiebking, C., Duncan, N. W., Tiret, B., Hayes, D. J., Marjańska, M., Doyon, J., Bajbouj, M., & Northoff, G. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.04.042 · Cited by 131 · see citing works
Kishimoto, Y., & Kano, M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1236-06.2006 · Cited by 126 · see citing works
Wang, D., Buckner, R. L., & Liu, H. (2013) · Journal of Neurophysiology · doi:10.1152/jn.00598.2012 · Cited by 124 · see citing works
Identifying basal ganglia divisions in individuals using resting-state functional connectivity MRI
Barnes (2010) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2010.00018 · Cited by 123 · see citing works
Warner, T. D., Behnke, M., Eyler, F. D., Padgett, K. R., Leonard, C. M., Hou, W., GARVAN, C. W., Schmalfuss, I. M., & Blackband, S. J. (2006) · PEDIATRICS · doi:10.1542/peds.2006-0003 · Cited by 114 · see citing works
Dambacher, F., Sack, A. T., Lobbestael, J., Arntz, A. R., Brugman, S., & Schuhmann, T. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu077 · Cited by 113 · see citing works
Cannabinoid CB1 Receptor Calibrates Excitatory Synaptic Balance in the Mouse Hippocampus
Monory, K., Polack, M., Remus, A., Lutz, B., & Körte, M. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3167-14.2015 · Cited by 112 · see citing works
Fried, P. A., James, D., & Watkinson, B. (2001) · Neurotoxicology and Teratology · doi:10.1016/s0892-0362(01)00161-1 · Cited by 110 · see citing works
School achievement in 14-year-old youths prenatally exposed to marijuana
Goldschmidt, L., Richardson, G. A., Willford, J. A., Severtson, S. G., & Day, N. L. (2011) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2011.08.009 · Cited by 109 · see citing works
Vitalis, T., Lainé, J., Simon, A., Roland, A. B., Leterrier, C., & Lenkei, Z. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06484.x · Cited by 106 · see citing works
Lin, K., Rapalino, O., Law, M., et al. (2008) · American Journal of Neuroradiology · doi:10.3174/ajnr.a0975 · Cited by 106 · see citing works
Shen, D. G., & Davatzikos, C. A. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.12.015 · Cited by 106 · see citing works
The Consequences of Prenatal Substance Use for the Developing Fetus, Newborn, and Young Child
Behnke, M., & Eyler, F. D. (1993) · International Journal of the Addictions · doi:10.3109/10826089309062191 · Cited by 105 · see citing works
Fransson, P., Metsäranta, M., Blennow, M., Ådén, U., Lagercrantz, H., & Vanhatalo, S. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs047 · Cited by 103 · see citing works
Behan, B., Connolly, C. G., Datwani, S., Doucet, M. V., Ivanović, J., Morioka, R., Stone, A., Watts, R., Smyth, B. P., & Garavan, H. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.05.027 · Cited by 101 · see citing works
Itahashi, T., Yamada, T., Watanabe, H., Nakamura, M., Ohta, H., Kanai, C., Iwanami, A., Kato, N., & Hashimoto, R. (2015) · Molecular Autism · doi:10.1186/s13229-015-0026-z · Cited by 98 · see citing works
Type-1 Cannabinoid Receptor Signaling in Neuronal Development
Gaffuri, A.-L., Ladarré, D., & Lenkei, Z. (2012) · Pharmacology · doi:10.1159/000339075 · Cited by 98 · see citing works
Development of the human fetal insular cortex: study of the gyration from 13 to 28 gestational weeks
Afif, A., Bouvier, R., Buénerd, A., Trouillas, J., & Mertens, P. (2007) · Brain Structure and Function · doi:10.1007/s00429-007-0161-1 · Cited by 97 · see citing works
Prenatal Drug Exposure Affects Neonatal Brain Functional Connectivity
Salzwedel, A. P., Grewen, K. M., Vachet, C., Gerig, G., Lin, W., & Gao, W. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.4333-14.2015 · Cited by 93 · see citing works
Self-citationBreast odour as the only maternal stimulus elicits crawling towards the odour source
Varendi, H., & Porter, R. H. (2001) · Acta Paediatrica · doi:10.1080/080352501750126131 · Cited by 93 · see citing works
Consistent Anterior–Posterior Segregation of the Insula During the First 2 Years of Life
Alcauter, S., Lin, W., Smith, J. K., Gilmore, J. H., & Gao, W. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht312 · Cited by 89 · see citing works
Self-citationTwo-state selection of conformation-specific antibodies
Gao, J., Sidhu, S. S., & Wells, J. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812952106 · Cited by 86 · see citing works
Insel, T. R. (2010) · Scientific American · doi:10.1038/scientificamerican0410-44 · Cited by 83 · see citing works
Functional connectivity in inhibitory control networks and severity of cannabis use disorder
Filbey, F. M., & Yezhuvath, U. S. (2013) · The American Journal of Drug and Alcohol Abuse · doi:10.3109/00952990.2013.841710 · Cited by 82 · see citing works
Wang, X., Dow-Edwards, D. L., Anderson, V., MINKOFF, H. L., & Hurd, Y. L. (2006) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500375 · Cited by 79 · see citing works
Willford, J. A., Chandler, L. S., Goldschmidt, L., & Day, N. L. (2010) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2010.06.004 · Cited by 78 · see citing works
It's Not Your Mother's Marijuana
Warner, T. D., Roussos‐Ross, D., & Behnke, M. (2014) · Clinics in Perinatology · doi:10.1016/j.clp.2014.08.009 · Cited by 75 · see citing works
Integrating brain and behavior: Evaluating adolescents’ response to a cannabis intervention.
Ewing, S. W. F., McEachern, A. D., Yezhuvath, U. S., Bryan, A. D., Hutchison, K. E., & Filbey, F. M. (2012) · Psychology of Addictive Behaviors · doi:10.1037/a0029767 · Cited by 69 · see citing works
Sobell, L. C., & Sobell, M. B. (1995) · NSUWorks (Nova Southeastern University) · Cited by 67 · see citing works
Prenatal cocaine effects on brain structure in early infancy
Grewen, K., Burchinal, M., Vachet, C., Gouttard, S., Gilmore, J. H., Lin, W., Johns, J., Elam, M., & Gerig, G. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.06.070 · Cited by 65 · see citing works
Self-citationFried, P. A. (2002) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.2002.tb06009.x · Cited by 64 · see citing works
Fried, P. A. (1995) · Archives of toxicology. Supplement · doi:10.1007/978-3-642-79451-3_21 · Cited by 64 · see citing works
Cortico-striatal circuits: novel therapeutic targets for substance use disorders
Kravitz, A. V., Tomasi, D., LeBlanc, K. H., Baler, R., Volkow, N. D., Bonci, A., & Ferré, S. (2015) · Brain Research · doi:10.1016/j.brainres.2015.03.048 · Cited by 63 · see citing works
Kishimoto, Y., Nakazawa, K., Tonegawa, S., Kirino, Y., & Kano, M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4142-05.2006 · Cited by 63 · see citing works
Decreased NOS1 Expression in the Anterior Cingulate Cortex in Depression
Gao, S., Qi, X., Zhao, J., Balesar, R. A., Bao, A., & Swaab, D. F. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs285 · Cited by 59 · see citing works
Rat Models of Prenatal and Adolescent Cannabis Exposure
DiNieri, J. A., & Hurd, Y. L. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-458-2_14 · Cited by 58 · see citing works
Vakili, S., Sobell, L. C., Sobell, M. B., Simco, E. R., & Agrawal, S. (2008) · Addictive Behaviors · doi:10.1016/j.addbeh.2008.03.009 · Cited by 57 · see citing works
Gao, L., Pan, X.-M., Li, L., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020157 · Cited by 57 · see citing works
Anderson, J. J., Kask, A. M., & Chase, T. N. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(95)00661-3 · Cited by 51 · see citing works
Chang, G., Karatayev, O., & LEIBOWITZ, S. F. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5835-12.2013 · Cited by 50 · see citing works
Evolutionary appearance of von Economo’s neurons in the mammalian cerebral cortex
Cauda, F., Geminiani, G. C., & Vercelli, A. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00104 · Cited by 48 · see citing works
Cannabinoid modulation of alpha2adrenergic receptor function in rodent medial prefrontal cortex
Cathel, A. M., Reyes, B. A. S., Wang, Q., Palma, J. D., Mackie, K., Bockstaele, E. J. V., & Kirby, L. G. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12690 · Cited by 43 · see citing works
Greenemeier, L. (2010) · Scientific American · doi:10.1038/scientificamerican0610-44 · Cited by 43 · see citing works
The dynamic reorganization of the default-mode network during a visual classification task
Gao, W., Gilmore, J. H., Alcauter, S., & Lin, W. (2013) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2013.00034 · Cited by 41 · see citing works
Self-citation(2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905295106 · Cited by 40 · see citing works
Excitement Reduces Inhibition via Endocannabinoids
Freund, T. F., & Hájos, N. (2003) · Neuron · doi:10.1016/s0896-6273(03)00262-9 · Cited by 38 · see citing works
Schou, J. S., Prockop, L. D., Dahlstrøm, G., et al. (1977) · Acta Pharmacologica et Toxicologica · doi:10.1111/j.1600-0773.1977.tb02120.x · Cited by 37 · see citing works
Spano, M., Fadda, P., Fratta, W., & Fattore, L. (2010) · Current Drug Targets · doi:10.2174/138945010790980295 · Cited by 36 · see citing works
Fried, P. A. (1996) · PsycEXTRA Dataset · doi:10.1037/e495662006-011 · Cited by 34 · see citing works
Wang, S.-J., Cohen, N., Katz, D. A., Ruaño, G., Shaw, P. M., & Spear, B. (2006) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500363 · Cited by 32 · see citing works
Cannabis cue-elicited craving and the reward neurocircuitry
Filbey, F. M., & DeWitt, S. J. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.11.001 · Cited by 32 · see citing works
Diaz, M. R., Jotty, K., Locke, J. L., Jones, S. R., & Valenzuela, C. F. (2014) · Frontiers in Pediatrics · doi:10.3389/fped.2014.00046 · Cited by 32 · see citing works
Caudate asymmetry: A neurobiological marker of moderate prenatal alcohol exposure in young adults
Willford, J. A., Day, R., Aizenstein, H. J., & Day, N. L. (2010) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2010.06.012 · Cited by 27 · see citing works
Arichi, T., Gordon-Williams, R., Allievi, A., Groves, A. M., Burdet, E., & Edwards, A. D. (2013) · Acta Paediatrica · doi:10.1111/apa.12327 · Cited by 27 · see citing works
Hippocampal neuron populations are reduced in vervet monkeys with fetal alcohol exposure
Burke, M., Ptito, M., Ervin, F. R., & Palmour, R. M. (2015) · Developmental Psychobiology · doi:10.1002/dev.21311 · Cited by 25 · see citing works
Hippocampal CA1 pyramidal neurons exhibit type 1 phase-response curves and type 1 excitability
Wang, S., Musharoff, M. M., Canavier, C. C., et al. (2013) · Journal of Neurophysiology · doi:10.1152/jn.00721.2012 · Cited by 25 · see citing works
Exposure to Nicotine During Pregnancy and Altered Learning and Memory in the Rat Offspring
Li, J., Bo, L., Zhang, P., Gao, Q., Li, L., Tang, J., Wu, C., Li, D., Xiao, J., Chen, J., et al. (2014) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntu178 · Cited by 25 · see citing works
Knickmeyer, R. C., Meltzer-Brody, S. E., Woolson, S., Hamer, R. M., Smith, J. K., Lury, K. M., & Gilmore, J. H. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.114 · Cited by 20 · see citing works
The acute tobacco withdrawal syndrome among black smokers.
Robinson, C. D., Pickworth, W. B., Heishman, S. J., et al. (2013) · Psychology of Addictive Behaviors · doi:10.1037/a0031950 · Cited by 17 · see citing works
Neural Basis of Identity Information Extraction from Noisy Face Images
Hermann, P., Bankó, É. M., Gál, V., & Vidnyánszky, Z. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3572-14.2015 · Cited by 13 · see citing works
Beyond the “Pain Matrix,” inter-run synchronization during mechanical nociceptive stimulation
Cauda, F., Costa, T., Diano, M., Duca, S., & Torta, D. M. E. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00265 · Cited by 12 · see citing works
Modeling Emotion and Learning of Norms in Social Interactions
Chang, L. J., & Koban, L. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0973-13.2013 · Cited by 11 · see citing works
Perinatal Brain Development, Malformation, and Injury
Knowles, J. K., & Penn, A. A. (2011) · Colloquium Series on The Developing Brain · doi:10.4199/c00044ed1v01y201109dbr006 · Cited by 3 · see citing works
Time-varying dynamics between default-mode and attentional networks in resting state
Chang, C. E., & Glover, G. (2009) · NeuroImage · doi:10.1016/s1053-8119(09)70277-0 · Cited by 1 · see citing works
Fried, P. A., Watkinson, B., Gray, R. M., et al. (1997) · Neurotoxicology and Teratology · doi:10.1016/s0892-0362(97)82443-9 · Cited by 1 · see citing works
Fifteenth international summer school of brain research
(1987) · Neurotoxicology and Teratology · doi:10.1016/0892-0362(87)90099-7 · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Imaging structural and functional brain development in early childhood
Gilmore, J. H., Knickmeyer, R. C., & Gao, W. (2018) · Nature Reviews Neuroscience · doi:10.1038/nrn.2018.1 · Cited by 1,013 · see citing works
Self-citationFunctional Connectome of the Fetal Brain
Turk, E., van den Heuvel, M. I., Benders, M. J., de Heus, R., Franx, A., Manning, J. H., Hect, J. L., Hernandez-Andrade, E., Hassan, S. S., Romero, R., et al. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.2891-18.2019 · Cited by 176 · see citing works
Salzwedel, A. P., Grewen, K. M., Goldman, B. D., & Gao, W. (2016) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2016.05.009 · Cited by 46 · see citing works
Self-citation
- Authors
- Grewen, K., Salzwedel, A. P., & Gao, W.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Grewen, Karen
- Gao, Wei
- Venue
- Frontiers in Human Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2015-11-04
- Volume
- 9
- Pages
- 601-601
- ISSN
- 1662-5161 (ISSN-L)
- PMC
- PMC4631947
- OpenAlex
- W2172909546
- Cited by
- 72
- References
- 133
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 7 · 2023: 6 · 2022: 8 · 2021: 6 · 2020: 8 · 2019: 7 · 2018: 3 · 2017: 5 · 2016: 5
- FWCI
- 4.31
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Human Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- UNC Libraries
- Funders
- National Institute on Drug Abuse (R03DA036645, P01DA022446)
- National Institute of Neurological Disorders and Stroke (R21NS088975)
- University of North Carolina (Start Up Funds to WG)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- prenatal cannabis exposure, resting-state functional connectivity, neonates, CB1 receptor, striatal connectivity, anterior insula, caudate nucleus, cerebellum, amygdala, thalamus, fetal brain development, neurobehavioral deficits
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
