Cognitive sequencing impairment in patients with focal or atrophic cerebellar damage
Open accessAbstract
Although cognitive impairment after cerebellar damage has been widely reported, the mechanisms of cerebro-cerebellar interactions are still a matter of debate. The cerebellum is involved in sequence detection and production in both motor and sensory domains, and sequencing has been proposed as the basic mechanism of cerebellar functioning. Furthermore, it has been suggested that knowledge of sequencing mechanisms may help to define cerebellar predictive control processes. In spite of its recognized importance, cerebellar sequencing has seldom been investigated in cognitive domains. Cognitive sequencing functions are often analysed by means of action/script elaboration. Lesion and activation studies have localized this function in frontal cortex and basal ganglia circuits. The present study is the first to report deficits in script sequencing after cerebellar damage. We employed a card-sequencing test, developed ad hoc, to evaluate the influence of the content to be sequenced. Stimuli consisted of sets of sentences that described actions with a precise logical and temporal sequence (Verbal Factor), sets of cartoon-like drawings that reproduced behavioural sequences (Behavioural Factor) or abstract figures (Spatial Factor). The influence of the lesion characteristics was analysed by grouping patients according to lesion-type (focal or atrophic) and lesion-side (right or left). The results indicated that patients with cerebellar damage present a cognitive sequencing impairment independently of lesion type or localization. A correlation was also shown between lesion side and characteristics of the material to be sequenced. Namely, patients with left lesions perform defectively only on script sequences based on pictorial material and patients with right lesions only on script sequences requiring verbal elaboration. The present data support the hypothesis that sequence processing is the cerebellar mode of operation also in the cognitive domain. In addition, the presence of right/left and pictorial/verbal differences is in agreement with the idea that cerebro-cerebellar interactions are organized in segregated cortico-cerebellar loops in which specificity is not related to the mode of functioning, but to the characteristics of the information processed.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Patients with cerebellar damage have demonstrated impairments in reconstructing a sequence of events.
“patients with cerebellar damage have demonstrated impairments in reconstructing a sequence of events (Leggio et al., 2008)”
From A double-blind, randomized, sham-controlled clinical trial of cerebellar intermittent theta burst stimulation for bipolar disorder: Safety, tolerability, mood and cognitive effects (2025) · cites this paper as Leggio et al., 2008
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
L’examen Clinique en Psychologie
Rubé, P. (1959) · American Journal of Psychotherapy · doi:10.1176/appi.psychotherapy.1959.13.4.989 · Cited by 3,299 · see citing works
Schmahmann, J. D. (2004) · Journal of Neuropsychiatry · doi:10.1176/jnp.16.3.367 · Cited by 1,442 · see citing works
Borkowski, J. G., Benton, A. L., & Spreen, O. (1967) · Neuropsychologia · doi:10.1016/0028-3932(67)90015-2 · Cited by 1,324 · see citing works
Carlesimo, G. A., Caltagirone, C., Gainotti, G., Fadda, L., Gallassi, R., Lorusso, S., Marfia, G. A., Marra, C., Nocentini, U., & Parnetti, L. (2008) · European Neurology · doi:10.1159/000117297 · Cited by 1,234 · see citing works
The Cerebellum And The Adaptive Coordination Of Movement
Thach, W. T., Goodkin, H. P., & Keating, J. G. (1992) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.15.030192.002155 · Cited by 1,058 · see citing works
Cerebellar circuitry as a neuronal machine
Ito, M. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.02.006 · Cited by 880 · see citing works
Schmahmann, J. D., & Pandya, D. N. (1997) · International Review of Neurobiology · doi:10.1016/s0074-7742(08)60346-3 · Cited by 774 · see citing works
Basal Ganglia Output and Cognition: Evidence from Anatomical, Behavioral, and Clinical Studies
Middleton, F. A., & Strick, P. L. (2000) · Brain and Cognition · doi:10.1006/brcg.1999.1099 · Cited by 662 · see citing works
MRI Atlas of the Human Cerebellum
Schmahmann, J. D., Doyon, J., Toga, A. W., Petrides, M., & Evans, A. C. (2000) · Cited by 575 · see citing works
Procedural learning in Parkinson's disease and cerebellar degeneration
Pascual‐Leone, Á., Grafman, J. H., Clark, K., Stewart, M., Massaquoi, S. G., Lou, J., & Hallett, M. (1993) · Annals of Neurology · doi:10.1002/ana.410340414 · Cited by 475 · see citing works
Cerebellum and procedural learning: evidence from focal cerebellar lesions
Molinari, M. (1997) · Brain · doi:10.1093/brain/120.10.1753 · Cited by 355 · see citing works
Self-citationIvry, R. B. (1997) · International review of neurobiology · doi:10.1016/s0074-7742(08)60370-0 · Cited by 309 · see citing works
The detection and generation of sequences as a key to cerebellar function: Experiments and theory
Braitenberg, V., Heck, D., & Sultan, F. (1997) · Behavioral and Brain Sciences · doi:10.1017/s0140525x9700143x · Cited by 298 · see citing works
Memory in patients with cerebellar degeneration
Appollonio, I. M., Grafman, J. H., Schwartz, V., Massaquoi, S. G., & Hallett, M. (1993) · Neurology · doi:10.1212/wnl.43.8.1536 · Cited by 296 · see citing works
Cerebellar contributions to cognitive functions: A progress report after two decades of research
Timmann, D., & Daum, I. (2007) · The Cerebellum · doi:10.1080/14734220701496448 · Cited by 270 · see citing works
Phonological grouping is specifically affected in cerebellar patients: a verbal fluency study
Leggio, M. G. (2000) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.69.1.102 · Cited by 229 · see citing works
Self-citationControl of Sensory Data Acquisition
Bower, J. M. (1997) · International review of neurobiology · doi:10.1016/s0074-7742(08)60367-0 · Cited by 222 · see citing works
Bases and implications of learning in the cerebellum — adaptive control and internal model mechanism
Ito, M. (2005) · Progress in brain research · doi:10.1016/s0079-6123(04)48009-1 · Cited by 218 · see citing works
Cerebellum Activation Associated with Performance Change but Not Motor Learning
Seidler, R. D., Purushotham, A., Kim, S.-G., Uǧurbil, K., Willingham, D. T., & Ashe, J. (2002) · Science · doi:10.1126/science.1068524 · Cited by 216 · see citing works
Cerebellar function: Coordination, learning or timing?
Mauk, M. D., Medina, J. F., Nores, W. L., & Ohyama, T. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00584-4 · Cited by 196 · see citing works
Doyon, J., Laforce, R. J., Bouchard, G., Gaudreau, D., Roy, J., Poirier, M., Bédard, P. J., Bédard, F., & Bouchard, J.-P. (1998) · Neuropsychologia · doi:10.1016/s0028-3932(97)00168-1 · Cited by 192 · see citing works
Anticipatory cerebellar responses during somatosensory omission in man
Tesche, C. D., & Karhu, J. (2000) · Human Brain Mapping · doi:10.1002/(sici)1097-0193(200003)9:3 · Cited by 176 · see citing works
Silveri, M. (1998) · Brain · doi:10.1093/brain/121.11.2175 · Cited by 165 · see citing works
Clustering in free recall as a function of certain methodological variations.
Cofer, C. N., Bruce, D. R., & Reicher, G. M. (1966) · Journal of Experimental Psychology · doi:10.1037/h0023217 · Cited by 162 · see citing works
Restuccia, D., Marca, G. D., Valeriani, M., Leggio, M. G., & Molinari, M. (2006) · Brain · doi:10.1093/brain/awl236 · Cited by 148 · see citing works
Self-citationEffect of focal cerebellar lesions on procedural learning in the serial reaction time task
G�mez-Beldarrain, M., Garc�a-Monc�, J. C., Rubio, B., & Pascual‐Leone, Á. (1998) · Experimental Brain Research · doi:10.1007/s002210050374 · Cited by 141 · see citing works
Spatial and Temporal Sequence Learning in Patients with Parkinson's Disease or Cerebellar Lesions
Shin, J. C., & Ivry, R. B. (2003) · Journal of Cognitive Neuroscience · doi:10.1162/089892903322598175 · Cited by 139 · see citing works
The cerebellum in the spatial problem solving: a co-star or a guest star?
Petrosini, L. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00036-7 · Cited by 133 · see citing works
Bower, J. M., & Parsons, L. M. (2003) · Scientific American · doi:10.1038/scientificamerican0803-48 · Cited by 125 · see citing works
Visuospatial abilities in cerebellar disorders.
Molinari, M., Petrosini, L., Misciagna, S., & Leggio, M. G. (2004) · PubMed Central · Cited by 125 · see citing works
Self-citationLeggio, M. G., Molinari, M., Neri, P. E., Graziano, A., Mandolesi, L., & Petrosini, L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.040554297 · Cited by 110 · see citing works
Self-citationDistinct Frontal Regions for Processing Sentence Syntax and Story Grammar
Angela Sirigu, B., Cohen, L., Zalla, T., Pradat-Diehl, P., van Eeckhout, P., Grafman, J. H., & Agid, Y. (1998) · Cortex · doi:10.1016/s0010-9452(08)70780-9 · Cited by 104 · see citing works
Ackermann, H., Mathiak, K., & Ivry, R. B. (2004) · Behavioral and Cognitive Neuroscience Reviews · doi:10.1177/1534582304263251 · Cited by 100 · see citing works
Neuronal plasticity of interrelated cerebellar and cortical networks
Molinari, M., Filippini, V., & Leggio, M. G. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00024-6 · Cited by 95 · see citing works
Self-citationCerebellar contribution to spatial event processing: characterization of procedural learning
Leggio, M. G., Neri, P. E., Graziano, A., Mandolesi, L., Molinari, M., & Petrosini, L. (1999) · Experimental Brain Research · doi:10.1007/s002210050768 · Cited by 90 · see citing works
Self-citationConstructional Apraxia in Left Brain-Damaged Patients: A Planning Disorder?
Gainotti, G., Miceli, G., & Caltagirone, C. (1977) · Cortex · doi:10.1016/s0010-9452(77)80002-6 · Cited by 86 · see citing works
Justus, T. C. (2004) · Journal of Cognitive Neuroscience · doi:10.1162/0898929041920513 · Cited by 85 · see citing works
Fronto-striatal deficit in Parkinson's disease during semantic event sequencing
Tinaz, S., Schendan, H. E., & Stern, C. E. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.10.025 · Cited by 82 · see citing works
The role of the cerebellum in preparing responses to predictable sensory events
Nixon, P. D. (2003) · The Cerebellum · doi:10.1080/14734220309410 · Cited by 80 · see citing works
Lovelace-Chandler, V. (1993) · Journal of Physical Therapy Education · doi:10.1097/00001416-199301000-00012 · Cited by 80 · see citing works
Boecker, H., Ceballos-Baumann, A., Bartenstein, P., Dagher, A., Forster, K., Haslinger, B. A., Brooks, D. J., Schwaiger, M., & Conrad, B. (2002) · NeuroImage · doi:10.1006/nimg.2002.1139 · Cited by 79 · see citing works
Distinct neural systems underlie learning visuomotor and spatial representations of motor skills
Parsons, M. W., Harrington, D. L., & Rao, S. M. (2004) · Human Brain Mapping · doi:10.1002/hbm.20084 · Cited by 66 · see citing works
Cerebellar input to the posterior parietal cortex in the rat
Giannetti, S., & Molinari, M. (2002) · Brain Research Bulletin · doi:10.1016/s0361-9230(02)00815-8 · Cited by 46 · see citing works
Self-citationSensorimotor transduction of time information is preserved in subjects with cerebellar damage
Molinari, M., Leggio, M. G., Filippini, V., Gioia, M. C., Cerasa, A., & Thaut, M. H. (2005) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2005.07.014 · Cited by 46 · see citing works
Self-citationAction Sequencing Deficit Following Frontal Lobe Lesion
Zanini, S., Rumiati, R. I., & Shallice, T. (2002) · Neurocase · doi:10.1093/neucas/8.1.88 · Cited by 46 · see citing works
Tinaz, S., Schendan, H. E., Schön, K., & Stern, C. E. (2005) · Brain Research · doi:10.1016/j.brainres.2005.10.057 · Cited by 43 · see citing works
Use of sequence information in associative learning in control subjects and cerebellar patients
Timmann, D., Drepper, J., Calabrese, S., rgerhoff, K. B. X. F., Maschke, M., Kolb, F. P., Daum, I., & Diener, H. (2004) · The Cerebellum · doi:10.1080/14734220310024890 · Cited by 41 · see citing works
Zalla, T., Angela Sirigu, B., Pillon, B., Dubois, B., Grafman, J. H., & Agid, Y. (1998) · Cortex · doi:10.1016/s0010-9452(08)70519-7 · Cited by 37 · see citing works
Villa, G., Gainotti, G., Bonis, C. D., & Marra, C. (1990) · Cortex · doi:10.1016/s0010-9452(13)80089-5 · Cited by 33 · see citing works
Gaytán-Tocavén, L. (2004) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2004.05.006 · Cited by 29 · see citing works
Action Sequencing Deficit Following Frontal Lobe Lesion
Zanini, S., Rumiati, R. I., & Shallice, T. (2002) · Neurocase · doi:10.1076/neur.8.1.88.16233 · Cited by 26 · see citing works
Graziano, A., Leggio, M. G., Mandolesi, L., Neri, P., Molinari, M., & Petrosini, L. (2002) · Behavioral Neuroscience · doi:10.1037/0735-7044.116.1.116 · Cited by 26 · see citing works
Self-citationStimulus-response versus stimulus-stimulus-response learning in cerebellar patients
Richter, S., Matthies, K. C., Ohde, T. C., Dimitrova, A., Gizewski, E. R., Beck, A., Aurich, V., & Timmann, D. (2004) · Experimental Brain Research · doi:10.1007/s00221-004-1920-3 · Cited by 23 · see citing works
Learning of Sensory Sequences in Cerebellar PatientsPreprint
Frings, M., Boenisch, R., Gerwig, M., Diener, H., & Timmann, D. (2004) · Learning & Memory · doi:10.1101/lm.66904 · Cited by 20 · see citing works
Acquisition of simple auditory and visual sequences in cerebellar patients
Frings, M., Maschke, M., Gerwig, M., Diener, H., & Timmann, D. (2006) · The Cerebellum · doi:10.1080/14734220600589251 · Cited by 11 · see citing works
Flagged first, then by citations
3 of the 58 references couldn’t be matched to a known paper.
Research works printed but not linked: 4
- Corsi PM. Human memory and the medial temporal regions of the brain. Dissertation Abstracts International, 34 (02), 891B. (University Microfilms No. AAI05-77717).
- Ivry R. Exploring the role of the cerebellum in sensory anticipation and timing: commentary on Tesche and Karhu. Hum Brain Mapp 2000; 9: 115-8.
- Lezak MD. Neuropychological assessment. New York: Oxford University Press; 1995.
- Parsons MW, Harrington DL, Rao SM. Distinct neural system underline learning visuomtor and spatial representations of motor skills. Hum Brain Mapp 2005; 24: 229-47.
Cited by
Sorted by citations
Functional topography in the human cerebellum: A meta-analysis of neuroimaging studies
STOODLEY, C., & SCHMAHMANN, J. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2008.08.039 · Cited by 2,183 · see citing works
Manto, M. U., Bower, J. M., Conforto, A. B., Delgado-Garcia, J. M., da Guarda, S. N. F., Gerwig, M., Habas, C., Hagura, N., Ivry, R. B., Mariën, P., et al. (2011) · The Cerebellum · doi:10.1007/s12311-011-0331-9 · Cited by 996 · see citing works
Self-citationThe cerebellum: adaptive prediction for movement and cognition
Sokolov, A. A., Miall, R. C., & Ivry, R. B. (2017) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2017.02.005 · Cited by 691 · see citing works
Consensus Paper: The Role of the Cerebellum in Perceptual Processes
Baumann, O., Borra, R. J., Bower, J. M., Cullen, K. E., Habas, C., Ivry, R. B., Leggio, M., Mattingley, J. B., Molinari, M., Moulton, E. A., et al. (2015) · The Cerebellum · doi:10.1007/s12311-014-0627-7 · Cited by 462 · see citing works
Self-citationConsensus Paper: Language and the Cerebellum: an Ongoing Enigma
Mariën, P., Ackermann, H., Adamaszek, M., Barwood, C. H. S., Beaton, A. A., Desmond, J. E., Witte, E. D., Fawcett, A. J., Hertrich, I., Küper, M., et al. (2013) · The Cerebellum · doi:10.1007/s12311-013-0540-5 · Cited by 505 · see citing works
Self-citationConsensus Paper: Cerebellum and Social Cognition
Overwalle, F. V., Manto, M. U., Cattaneo, Z., Clausi, S., Ferrari, C., Gabrieli, J. D. E., Guell, X., Heleven, E., Lupo, M., Ma, Q., et al. (2020) · The Cerebellum · doi:10.1007/s12311-020-01155-1 · Cited by 436 · see citing works
Self-citationD'Angelo, E., & Casali, S. (2013) · Frontiers in Neural Circuits · doi:10.3389/fncir.2012.00116 · Cited by 407 · see citing works
The human cerebellum contributes to motor, emotional and cognitive associative learning. A review
Timmann, D., Drepper, J., Frings, M., Maschke, M., Richter, S., Gerwig, M., & Kolb, F. P. (2009) · Cortex · doi:10.1016/j.cortex.2009.06.009 · Cited by 352 · see citing works
Non-invasive Cerebellar Stimulation—a Consensus Paper
Grimaldi, G., Argyropoulos, G. P. D., Boehringer, A., Celnik, P. A., Edwards, M. J., Ferrucci, R., Galea, J. M., Groiss, S., Hiraoka, K., Kassavetis, P., et al. (2013) · The Cerebellum · doi:10.1007/s12311-013-0514-7 · Cited by 290 · see citing works
Sang, L., Qin, W., Liu, Y., Han, W., Zhang, Y., Jiang, T., & Yu, C. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.04.011 · Cited by 254 · see citing works
The cerebellum: Its role in language and related cognitive and affective functions
Smet, H. J. D., Paquier, P. F., Verhoeven, J., & Mariën, P. (2013) · Brain and Language · doi:10.1016/j.bandl.2012.11.001 · Cited by 258 · see citing works
The cerebellar cognitive profile
Tedesco, A. M., Chiricozzi, F. R., Clausi, S., Lupo, M., Molinari, M., & Leggio, M. G. (2011) · Brain · doi:10.1093/brain/awr266 · Cited by 253 · see citing works
Self-citationThe Cerebellar Cognitive Affective/Schmahmann Syndrome: a Task Force Paper
Argyropoulos, G. P. D., van Dun, K., Adamaszek, M., Leggio, M. G., Manto, M. U., Masciullo, M., Molinari, M., Stoodley, C. J., Overwalle, F. V., Ivry, R. B., et al. (2019) · The Cerebellum · doi:10.1007/s12311-019-01068-8 · Cited by 246 · see citing works
Self-citationThe cerebellum and neuropsychological functioning: A critical review
O’Halloran, C., Kinsella, G., & Storey, E. (2011) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2011.614599 · Cited by 230 · see citing works
Functional Topography of the Cerebellum in Verbal Working Memory
Marvel, C. L., & Desmond, J. E. (2010) · Neuropsychology Review · doi:10.1007/s11065-010-9137-7 · Cited by 219 · see citing works
Cerebellar Sequencing: a Trick for Predicting the Future
Leggio, M. G., & Molinari, M. (2014) · The Cerebellum · doi:10.1007/s12311-014-0616-x · Cited by 200 · see citing works
Self-citationSubcortical Structures and Cognition
Koziol, L. F., & Budding, D. E. (2009) · Springer eBooks · doi:10.1007/978-0-387-84868-6 · Cited by 273 · see citing works
Cerebellum and Detection of Sequences, from Perception to Cognition
Molinari, M., Chiricozzi, F. R., Clausi, S., Tedesco, A. M., De Lisa, M., & Leggio, M. G. (2008) · The Cerebellum · doi:10.1007/s12311-008-0060-x · Cited by 173 · see citing works
Self-citationTopography of Cerebellar Deficits in Humans
Grimaldi, G., & Manto, M. U. (2011) · The Cerebellum · doi:10.1007/s12311-011-0247-4 · Cited by 172 · see citing works
Menghini, D., Finzi, A., Carlesimo, G. A., & Vicari, S. (2011) · Developmental Neuropsychology · doi:10.1080/87565641.2010.549868 · Cited by 161 · see citing works
Stoodley, C. J., & Stein, J. F. (2009) · Cortex · doi:10.1016/j.cortex.2009.10.005 · Cited by 126 · see citing works
Wang, D., Buckner, R. L., & Liu, H. (2013) · Journal of Neurophysiology · doi:10.1152/jn.00598.2012 · Cited by 124 · see citing works
Evidence for Hierarchical Cognitive Control in the Human Cerebellum
D’Mello, A. M., Gabrieli, J. D. E., & Nee, D. E. (2020) · Current Biology · doi:10.1016/j.cub.2020.03.028 · Cited by 114 · see citing works
Cerebellar contribution to feedforward control of locomotion
Pisotta, I., & Molinari, M. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00475 · Cited by 113 · see citing works
Self-citationNeural correlates underlying micrographia in Parkinson’s disease
Wu, T., Zhang, J., Hallett, M., Feng, T., Hou, Y., & Chan, P. (2015) · Brain · doi:10.1093/brain/awv319 · Cited by 106 · see citing works
N -back Working Memory Task: Meta-analysis of Normative fMRI Studies With Children
Yaple, Z. A., & Arsalidou, M. (2018) · Child Development · doi:10.1111/cdev.13080 · Cited by 99 · see citing works
The cerebellum, internal models and prediction in ‘non-motor’ aspects of language: A critical review
Argyropoulos, G. P. D. (2015) · Brain and Language · doi:10.1016/j.bandl.2015.08.003 · Cited by 103 · see citing works
The posterior Cerebellum is involved in constructing Social Action Sequences: An fMRI Study
Heleven, E., van Dun, K., & Overwalle, F. V. (2019) · Scientific Reports · doi:10.1038/s41598-019-46962-7 · Cited by 100 · see citing works
Lesion-Symptom Mapping of the Human Cerebellum
Timmann, D., Brandauer, B., Hermsdörfer, J., Ilg, W., Konczak, J., Gerwig, M., Gizewski, E. R., & Schoch, B. (2008) · The Cerebellum · doi:10.1007/s12311-008-0066-4 · Cited by 97 · see citing works
Language Prediction Is Reflected by Coupling between Frontal Gamma and Posterior Alpha Oscillations
Wang, L., Peter Hagoort, A., & Jensen, O. B. (2017) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_01190 · Cited by 94 · see citing works
The role of the cerebellum in reconstructing social action sequences: a pilot study
Overwalle, F. V., Coninck, S. D., Heleven, E., Perrotta, G., Taib, N. O. B., Manto, M. U., & Mariën, P. (2019) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsz032 · Cited by 94 · see citing works
Disruption in cerebellar and basal ganglia networks during a visuospatial task in cervical dystonia
Filip, P., Galléa, C., Lehéricy, S., Bertasi, E., Popa, T., Mareček, R., Lungu, O., Kašpárek, T., Vaníček, J., & Bareš, M. (2017) · Movement Disorders · doi:10.1002/mds.26930 · Cited by 92 · see citing works
Hautzel, H., Mottaghy, F. M., Specht, K., Müller, H., & Krause, B. J. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.06.005 · Cited by 87 · see citing works
Current advances in lesion-symptom mapping of the human cerebellum
Timmann, D., Konczak, J., Ilg, W., Donchin, O., Hermsdörfer, J., Gizewski, E. R., & Schoch, B. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.01.040 · Cited by 80 · see citing works
Overwalle, F. V., de Steen, F. V., van Dun, K., & Heleven, E. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.116326 · Cited by 75 · see citing works
Cerebellar damage impairs executive control and monitoring of movement generation
Brunamonti, E., Chiricozzi, F. R., Clausi, S., Olivito, G., Giusti, M. A., Molinari, M., Ferraina, S., & Leggio, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085997 · Cited by 70 · see citing works
Self-citationEvidence for a link among cognition, language and emotion in cerebellar malformations
Tavano, A., & Borgatti, R. (2009) · Cortex · doi:10.1016/j.cortex.2009.07.017 · Cited by 71 · see citing works
The Cerebellum, Cerebellar Disorders, and Cerebellar Research—Two Centuries of Discoveries
Manto, M. (2008) · Cerebellum · doi:10.1007/s12311-008-0063-7 · Cited by 74 · see citing works
State Estimation, Response Prediction, and Cerebellar Sensory Processing for Behavioral Control
Molinari, M., Restuccia, D., & Leggio, M. G. (2009) · The Cerebellum · doi:10.1007/s12311-009-0112-x · Cited by 67 · see citing works
Self-citationVerbal Memory Impairments in Children after Cerebellar Tumor Resection
Kirschen, M. P., Davis-Ratner, M. S., Milner, M. W., Chen, S. A., Schraedley-Desmond, P., Fisher, P. G., & Desmond, J. E. (2008) · Behavioural Neurology · doi:10.1155/2008/817253 · Cited by 67 · see citing works
Distinct critical cerebellar subregions for components of verbal working memory
Cooper, F. E., Grube, M., von Kriegstein, K., Kumar, S., English, P. T., Kelly, T. P., Chinnery, P. F., & Griffiths, T. D. (2011) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2011.11.017 · Cited by 65 · see citing works
Koziol, L. F., Budding, D. E., & Chidekel, D. (2010) · The Cerebellum · doi:10.1007/s12311-010-0192-7 · Cited by 65 · see citing works
Perciavalle, V., Apps, R., Bracha, V., Delgado-Garcia, J. M., Gibson, A. R., Leggio, M. G., Carrel, A. J., Cerminara, N. L., Coco, M., Gruart, A., et al. (2013) · The Cerebellum · doi:10.1007/s12311-013-0464-0 · Cited by 61 · see citing works
Self-citationBeuriat, P.-A., Cristofori, I., Gordon, B., & Grafman, J. H. (2022) · Behavioral and Brain Functions · doi:10.1186/s12993-022-00193-5 · Cited by 60 · see citing works
The cerebellum for jocks and nerds alike
Popa, L. S., Hewitt, A. L., & Ebner, T. J. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00113 · Cited by 58 · see citing works
Macrı̀, S., Biamonte, F., Romano, E., Marino, R., Keller, F., & Laviola, G. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.03.012 · Cited by 55 · see citing works
Bhattasali, S., Fabre, M., Luh, W., Saied, H. A., Constant, M., Pallier, C., Brennan, J., Spreng, R. N., & Hale, J. (2018) · Language Cognition and Neuroscience · doi:10.1080/23273798.2018.1518533 · Cited by 51 · see citing works
New Horizons on Non-invasive Brain Stimulation of the Social and Affective Cerebellum
Cattaneo, Z., Ferrari, C., Ciricugno, A., Heleven, E., Schutter, D. J. L. G., Manto, M. U., & Overwalle, F. V. (2021) · The Cerebellum · doi:10.1007/s12311-021-01300-4 · Cited by 54 · see citing works
Zhang, Z., Peng, P., Eickhoff, S. B., Lin, X., Zhang, D., & Wang, Y. (2021) · Developmental Science · doi:10.1111/desc.13111 · Cited by 47 · see citing works
How Consistent are Cognitive Impairments in Patients with Cerebellar Disorders?
Timmann, D., & Daum, I. (2010) · Behavioural Neurology · doi:10.1155/2010/401048 · Cited by 52 · see citing works
Mechanisms of cerebellar involvement in associative learning
Bellebaum, C., & Daum, I. (2009) · Cortex · doi:10.1016/j.cortex.2009.07.016 · Cited by 47 · see citing works
Oldrati, V., Ferrari, E., Butti, N., Cattaneo, Z., Borgatti, R., Urgesi, C., & Finisguerra, A. (2021) · Brain Structure and Function · doi:10.1007/s00429-020-02198-0 · Cited by 48 · see citing works
Addis, D. R., Moloney, E. E. J., Tippett, L. J., Roberts, R. P., & Hach, S. (2016) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2016.05.025 · Cited by 48 · see citing works
The impact of age on load-related dorsolateral prefrontal cortex activation
Toepper, M., Gebhardt, H., Bauer, E., Haberkamp, A., Beblo, T., Gallhofer, B., Drießen, M., & Sammer, G. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00009 · Cited by 46 · see citing works
Polygenic disruption of retinoid signalling in schizophrenia and a severe cognitive deficit subtype
Reay, W. R., Atkins, J. R., Quidé, Y., Carr, V. J., Green, M. J., & Cairns, M. J. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0305-0 · Cited by 46 · see citing works
TMS over the cerebellum interferes with short-term memory of visual sequences
Ferrari, C., Cattaneo, Z., Oldrati, V., Casiraghi, L., Castelli, F., D’Angelo, E., & Vecchi, T. (2018) · Scientific Reports · doi:10.1038/s41598-018-25151-y · Cited by 45 · see citing works
The posterior cerebellum supports the explicit sequence learning linked to trait attribution
Pu, M., Heleven, E., Delplanque, J., Gibert, N., Ma, Q., Funghi, G., & Overwalle, F. V. (2020) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-020-00803-7 · Cited by 45 · see citing works
Clausi, S., Bozzali, M., Leggio, M. G., Paola, M. D., Hagberg, G. E., Caltagirone, C., & Molinari, M. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.02.001 · Cited by 44 · see citing works
Self-citationPeter, B., Button, L., Stoel‐Gammon, C., Chapman, K., & Raskind, W. H. (2013) · Clinical Linguistics & Phonetics · doi:10.3109/02699206.2012.736011 · Cited by 44 · see citing works
Brain activation and functional connectivity during Chinese writing: An fMRI study
Yang, Y., Zuo, Z., Tam, F., Graham, S. J., Tao, R., Wang, N., & Bi, H.-Y. (2019) · Journal of Neurolinguistics · doi:10.1016/j.jneuroling.2019.03.002 · Cited by 44 · see citing works
Cattaneo, L., Fasanelli, M., Andreatta, O., Bonifati, D. M., Barchiesi, G., & Caruana, F. (2011) · The Cerebellum · doi:10.1007/s12311-011-0307-9 · Cited by 41 · see citing works
The Role of the Cerebellum in Social and Non-Social Action Sequences: A Preliminary LF-rTMS Study
Heleven, E., van Dun, K., Witte, S. D., Baeken, C., & Overwalle, F. V. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.593821 · Cited by 43 · see citing works
Cognitive control of movement in down syndrome
Brunamonti, E., Pani, P., Papazachariadis, O., Onorati, P., Albertini, G., & Ferraina, S. (2011) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2011.03.008 · Cited by 40 · see citing works
Cerebellar contributions to sequence prediction in verbal working memory
Peterburs, J., Blevins, L. C., Sheu, Y.-S., & Desmond, J. E. (2018) · Brain Structure and Function · doi:10.1007/s00429-018-1784-0 · Cited by 41 · see citing works
The Contribution of the Cerebellum to Cognition in Spinocerebellar Ataxia Type 6
Cooper, F. E., Grube, M., Elsegood, K. J., Welch, J. L., Kelly, T. P., Chinnery, P. F., & Griffiths, T. D. (2010) · Behavioural Neurology · doi:10.1155/2010/724861 · Cited by 41 · see citing works
Manto, M. U., & Marmolino, D. (2009) · The Cerebellum · doi:10.1007/s12311-009-0127-3 · Cited by 40 · see citing works
Cerebellar degeneration affects cortico-cortical connectivity in motor learning networks
Tzvi, E., Zimmermann, C., Bey, R., Münte, T. F., Nitschke, M. F., & Krämer, U. M. (2017) · NeuroImage Clinical · doi:10.1016/j.nicl.2017.07.012 · Cited by 39 · see citing works
Popa, L. S., Streng, M. L., & Ebner, T. J. (2017) · eneuro · doi:10.1523/eneuro.0036-17.2017 · Cited by 36 · see citing works
Zhao, G., Walsh, K., Long, J., Gui, W., & Denisova, K. (2018) · PLoS ONE · doi:10.1371/journal.pone.0196964 · Cited by 32 · see citing works
Dirnberger, G., Novak, J., Našel, C., & Zehnter, M. K. (2009) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2009.12.016 · Cited by 34 · see citing works
Haihambo, N. P., Ma, Q., Baeken, C., Deroost, N., Baetens, K., Heleven, E., & Overwalle, F. V. (2021) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsab087 · Cited by 35 · see citing works
Effect of Experimental Thyrotoxicosis on Brain Gray Matter: A Voxel-Based Morphometry Study
Göbel, A., Heldmann, M., Göttlich, M., Dirk, A.-L., Brabant, G. E., & Münte, T. F. (2015) · European Thyroid Journal · doi:10.1159/000398793 · Cited by 33 · see citing works
Brain-imaging evidence for compression of binary sound sequences in human memory
Planton, S., Roumi, F. A., Wang, L., & Dehaene, S. (2023) · eLife · doi:10.7554/elife.84376 · Cited by 30 · see citing works
Cognitive Functioning in Chiari Malformation Type I Without Posterior Fossa Surgery
García, M., Lázaro, E., Paz, J. F. L., Martínez, Ó., Pérez, M., Berrocoso, S., Al-Rashaida, M. A. H., & Amayra, I. (2018) · The Cerebellum · doi:10.1007/s12311-018-0940-7 · Cited by 31 · see citing works
Cerebellar Functional Lateralization From the Perspective of Clinical Neuropsychology
Starowicz–Filip, A., Prochwicz, K., Kłosowska, J., Chrobak, A. A., Myszka, A. M., Bętkowska-Korpała, B., & Kwinta, B. M. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.775308 · Cited by 29 · see citing works
Does the cerebellum contribute to human navigation by processing sequential information?
Tedesco, A. M., Bianchini, F., Piccardi, L., Clausi, S., Berthoz, A., Molinari, M., Guariglia, C., & Leggio, M. G. (2017) · Neuropsychology · doi:10.1037/neu0000354 · Cited by 26 · see citing works
Self-citationStarowicz–Filip, A., Chrobak, A. A., Milczarek, O., & Kwiatkowski, S. (2015) · Journal of Neuropsychology · doi:10.1111/jnp.12093 · Cited by 26 · see citing works
Siciliano, L., & Clausi, S. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.00096 · Cited by 25 · see citing works
Self-citationGeva, S., Schneider, L. M., Roberts, S. M., Green, D. W., & Price, C. J. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.664650 · Cited by 25 · see citing works
The Cerebellum and Implicit Sequencing: Evidence from Cerebellar Ataxia
Morgan, O. P., Slapik, M. B., Iannuzzelli, K. G., LaConte, S. M., Lisinski, J. M., Nopoulos, P., Cochran, A. M., Kronemer, S. I., Rosenthal, L. S., & Marvel, C. L. (2020) · The Cerebellum · doi:10.1007/s12311-020-01206-7 · Cited by 26 · see citing works
The functional neuroimaging evidence of cerebellar involvement in the simple cognitive task
Šveljo, O., Ćulić, M., Koprivšek, K., & Lučić, M. (2014) · Brain Imaging and Behavior · doi:10.1007/s11682-014-9290-3 · Cited by 23 · see citing works
Gates-Ulanet, P., Carson, C. M., Mellon, N. K., Niparko, J. K., & Ouellette, M. (2014) · Cochlear Implants International · doi:10.1179/1754762814y.0000000077 · Cited by 22 · see citing works
Chiari I malformation—neuropsychological functions and quality of life
Almotairi, F. S., Hellström, P., Skoglund, T. S., Nilsson, Å. L., & Tisell, M. (2019) · Acta Neurochirurgica · doi:10.1007/s00701-019-03897-2 · Cited by 21 · see citing works
Vecchi, T., & Gatti, D. (2020) · The MIT Press eBooks · doi:10.7551/mitpress/13543.001.0001 · Cited by 28 · see citing works
A neurocognitive model of flow states and the role of cerebellar internal models
Gold, J., & Ciorciari, J. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113244 · Cited by 19 · see citing works
Urgesi, C., Butti, N., Finisguerra, A., Biffi, E., Valente, E. M., Romaniello, R., & Borgatti, R. (2021) · Cortex · doi:10.1016/j.cortex.2021.08.008 · Cited by 21 · see citing works
Ruffieux, N., Colombo, F., Gentaz, É., Annoni, J., Chouiter, L., Hefti, S. R., Ruffieux, A., & Bihl, T. (2016) · Applied Neuropsychology Child · doi:10.1080/21622965.2015.1092087 · Cited by 20 · see citing works
Visuospatial Organization and Recall in Cerebellar Ataxia
Slapik, M. B., Kronemer, S. I., Morgan, O. P., Bloes, R., Lieberman, S., Mandel, J. A., Rosenthal, L. S., & Marvel, C. L. (2018) · The Cerebellum · doi:10.1007/s12311-018-0948-z · Cited by 19 · see citing works
Brugnaro, B. H., Oliveira, M. F. P., de Campos, A. C., Pavão, S. L., & Rocha, N. A. C. F. (2020) · Disability and Rehabilitation · doi:10.1080/09638288.2020.1830439 · Cited by 19 · see citing works
Dirnberger, G., Novak, J., & Našel, C. (2013) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00444 · Cited by 19 · see citing works
The cerebellar topography of attention sub-components in spinocerebellar ataxia type 2
Lupo, M., Olivito, G., Iacobacci, C., Clausi, S., Romano, S., Masciullo, M., Molinari, M., Cercignani, M., Bozzali, M., & Leggio, M. G. (2018) · Cortex · doi:10.1016/j.cortex.2018.07.011 · Cited by 19 · see citing works
Self-citationThe Implementation of Predictions During Sequencing
Molinari, M., & Masciullo, M. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00439 · Cited by 18 · see citing works
Self-citationThe posterior cerebellum and inconsistent trait implications when learning the sequence of actions
Pu, M., Ma, Q., Heleven, E., Haihambo, N. P., & Overwalle, F. V. (2021) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsab037 · Cited by 18 · see citing works
Affective communication deficits associated with cerebellar degeneration
Heilman, K. M., Leon, S. A., Burtis, D. B., Ashizawa, T., & Subramony, S. H. (2012) · Neurocase · doi:10.1080/13554794.2012.713496 · Cited by 18 · see citing works
Cerebellum and Emotion in Social Behavior
Clausi, S., Siciliano, L., Olivito, G., & Leggio, M. G. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-99550-8_15 · Cited by 17 · see citing works
Self-citationBehavioral disorders and cognitive impairment associated with cerebellar lesions
Grossauer, S., Koeck, K., Kau, T., Weber, J. R., & Vince, G. H. (2015) · Journal of Molecular Psychiatry · doi:10.1186/s40303-015-0009-1 · Cited by 17 · see citing works
Unconscious Effects of Action on Perception
Halász, V., & Cunnington, R. (2012) · Brain Sciences · doi:10.3390/brainsci2020130 · Cited by 17 · see citing works
Long-term sequelae after acquired pediatric hemorrhagic cerebellar lesions
Wingeier, K., Bigi, S., El‐Koussy, M., Heinks, T., Boltshauser, E., & Steinlin, M. I. (2010) · Child s Nervous System · doi:10.1007/s00381-010-1357-x · Cited by 17 · see citing works
Peter, B., Albert, A., Panagiotides, H., & Gray, S. I. (2020) · Clinical Linguistics & Phonetics · doi:10.1080/02699206.2019.1705916 · Cited by 16 · see citing works
Cognition in cerebellar disorders: What’s in the profile? A systematic review and meta-analysis
Reumers, S. F. I., Bongaerts, F. L. P., de Leeuw, F., van de Warrenburg, B. P. C., Schutter, D. J. L. G., & Kessels, R. P. C. (2025) · Journal of Neurology · doi:10.1007/s00415-025-12967-8 · Cited by 15 · see citing works
- Authors
- Leggio, M. G., Tedesco, A. M., Chiricozzi, F. R., Clausi, S., Orsini, A., & Molinari, M.
- Affiliations
- Fondazione Santa Lucia (IT)
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-03-11
- Volume
- 131
- Issue
- 5
- Pages
- 1332-1343
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W2099069737
- Cited by
- 170
- References
- 58
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 6 · 2023: 5 · 2022: 3 · 2021: 16 · 2020: 14 · 2019: 9 · 2018: 11 · 2017: 11 · 2016: 5 · 2015: 10 · 2014: 12 · 2013: 13 · 2012: 10
- FWCI
- 6.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Brain (publishedVersion)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Funders
- Ministero della Salute
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Keywords
- cerebellar lesions, cerebellar atrophy, hemispheric lateralization
- MeSH terms
- Adult, Aged, Atrophy, Cerebellar Ataxia, Cerebellar Diseases, Cerebellum, Cognition Disorders, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Psychomotor Performance, Retrospective Studies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
