Cited by 27Neural dynamics and brain functionTraumatic Brain Injury and Neurovascular DisturbancesTraumatic Brain Injury Research

Infraslow EEG activity modulates cortical excitability in postanoxic encephalopathy

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van Putten, Michel J. A. M., Tjepkema-Cloostermans, Marleen C., Hofmeijer, Jeannette·2015·Journal of Neurophysiology

Abstract

Infraslow activity represents an important component of physiological and pathological brain function. We study infraslow activity (<0.1 Hz) in 41 patients with postanoxic coma after cardiac arrest, including the relationship between infraslow activity and EEG power in the 3–30 Hz range, using continuous full-band scalp EEG. In all patients, infraslow activity (0.015–0.06 Hz) was present, irrespective of neurological outcome or EEG activity in the conventional frequency bands. In two patients, low-amplitude (10–30 μV) infraslow activity was present while the EEG showed no rhythmic activity above 0.5 Hz. In 13/15 patients with a good outcome and 20/26 patients with a poor one, EEG power in the 3–30 Hz frequency range was correlated with the phase of infraslow activity, quantified by the modulation index. In 9/14 patients with burst-suppression with identical bursts, bursts appeared in clusters, phase-locked to the infraslow oscillations. This is substantiated by a simulation of burst-suppression in a minimal computational model. Infraslow activity is preserved in postanoxic encephalopathy and modulates cortical excitability. The strongest modulation is observed in patients with severe postanoxic encephalopathy and burst-suppression with identical bursts.

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Crossref · 10.1152/jn.00714.2014

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Authors
van Putten, M. J. A. M., Tjepkema-Cloostermans, M. C., & Hofmeijer, J.
Affiliations
  • Department of Neurology and Clinical Neurophysiology, Medisch Spectrum Twente, Enschede, the Netherlands;
  • Rijnstate Hospital (NL)
Venue
Journal of Neurophysiology
Published
2015-05
Volume
113
Issue
9
Pages
3256-3267
ISSN
  • 0022-3077 (ISSN-L)
  • 1522-1598
OpenAlex
W2095024261
Cited by
27
References
54
Citations by year
2026: 2 · 2025: 2 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 2 · 2016: 1
FWCI
1.40
Type
journal article
Language
en
Open access
Locations
  • Journal of Neurophysiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • University of Twente Research Information (publishedVersion, other-oa)
  • University of Twente Research Information (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
Keywords
postanoxic encephalopathy, postanoxic coma, cardiac arrest, cortical excitability, burst suppression, EEG spectral power, modulation index, phase locking, neurological outcome
MeSH terms
Alkaloids, Brain Diseases, Cerebral Cortex, Electroencephalography, Female, Heart Arrest, Humans, Intensive Care Units, Male, Brain Waves

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