Altered short-term plasticity in the prefrontal cortex after early life seizures
Open accessAbstract
Seizures during development are a relatively common occurrence and are often associated with poor cognitive outcomes. Recent studies show that early life seizures alter the function of various brain structures and have long-term consequences on seizure susceptibility and behavioral regulation. While many neocortical functions could be disrupted by epileptic seizures, we have concentrated on studying the prefrontal cortex (PFC) as disturbance of PFC functions is involved in numerous co-morbid disorders associated with epilepsy. In the present work we report an alteration of short-term plasticity in the PFC in rats that have experienced early life seizures. The most robust alteration occurs in the layer II/III to layer V network of neurons. However short-term plasticity of layer V to layer V network was also affected, indicating that the PFC function is broadly influenced by early life seizures. These data strongly suggest that repetitive seizures early in development cause substantial alteration in PFC function, which may be an important component underlying cognitive deficits in individuals with a history of seizures during development.
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FLE seizures can cause structural and functional damage of the prefrontal areas including altered short-term plasticity.
“And eventually the FLE seizures can cause structural and functional damage of the prefrontal areas including altered short-term plasticity [389, 390].”
From Development of prefrontal cortex (2022) · cites this paper as [390]
The Discussion (page unavailable) reports that early-life generalized seizures altered short-term plasticity in the prefrontal cortex of rats. The Introduction (page unavailable) also reports prefrontal architectural changes from an earlier study. This paper does not establish that frontal lobe epilepsy (FLE) seizures cause structural damage, so the claim extends beyond its evidence. (LLM, conf=0.88)
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The Burden of Epilepsy: The Contribution of Seizures (AES 2025 Presidential Symposium)
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- Authors
- Hernan, A. E., Holmes, G. L., Isaev, D., Scott, R. C., & Isaeva, E.
- Affiliations
- Dartmouth College (US)
- Corresponding author
- Hernan, A.E.
- Isaeva, E.
- Venue
- Neurobiology of Disease
- Publisher
- Elsevier BV
- Published
- 2013-02
- Volume
- 50
- Pages
- 120-126
- ISSN
- 0969-9961 (ISSN-L)
- PMC
- PMC3534893
- OpenAlex
- W2046183844
- Cited by
- 49
- References
- 84
- Citations by year
- 2026: 2 · 2025: 6 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 5 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 9 · 2015: 5 · 2014: 7 · 2013: 2
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neurobiology of Disease (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- National Institutes of Health (RO1NS056170, RO1NS041595)
- Emmory R. Shapses
- Great Ormond Street Hospital Children's Charity (RCS)
- State Foundation of Fundamental Research of Ukraine (F46.2/001)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- early-life seizures, prefrontal cortex, short-term plasticity, developmental epilepsy, cognitive impairment, recurrent seizures, epilepsy comorbidity
- MeSH terms
- Animals, Animals, Newborn, Synaptic Transmission, Neuronal Plasticity, Seizures, Rats, Sprague-Dawley, Prefrontal Cortex, Patch-Clamp Techniques, Rats
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