Medial amygdala enhances synaptic transmission and synaptic plasticity in the dentate gyrus of rats in vivo
Abstract
1. The present experiment was designed to test whether synaptic transmission and synaptic plasticity in the dentate gyrus were modulated by the medial amygdala (MeA). Field potentials in the dentate gyrus (DG) evoked by stimulations of the medial perforant path (PP) were extracellularly recorded in anesthetized rats. 2. Although single-pulse stimulation of the MeA augmented PP stimulation-evoked population spike amplitude in the DG transiently, high-frequency stimulation (100 Hz for 1 s) of the MeA induced long-lasting enhancement of synaptic transmission that was not occluded by PP tetanus-induced long-term potentiation (LTP). 3. When high-frequency stimulation of the MeA was applied concurrently with weak tetanus of the PP, which alone induced only marginal LTP, the magnitude of LTP increased considerably. 4. These results demonstrate that neuron activities in the MeA induce short- and long-lasting changes in the excitability of the PP-DG synapses and thereby enhance their synaptic plasticity.
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Electrical stimulation of the amygdala can mimic the emotion-induced enhancement of hippocampal LTP.
“Electrical stimulation of the amygdala can mimic the emotion-induced enhancement of hippocampal LTP (Ikegaya et al. [210]; Akirav and Richter-Levin [148]; Akirav and Richter-Levin [211]; Frey et al. [212]; Akirav and Richter-Levin [213])”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as Ikegaya et al. [210]
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The amygdala: vigilance and emotion
Davis, M., & Whalen, P. J. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000812 · Cited by 2,882 · see citing works
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Davidson, R. J., Pizzagalli, D., Nitschke, J. B., & Putnam, K. (2002) · Annual Review of Psychology · doi:10.1146/annurev.psych.53.100901.135148 · Cited by 1,138 · see citing works
Diamond, D. M., Campbell, A. M., Park, C. R., Halonen, J., & Zoladz, P. R. (2007) · Neural Plasticity · doi:10.1155/2007/60803 · Cited by 762 · see citing works
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BackgroundAmygdalar and Hippocampal Theta Rhythm Synchronization During Fear Memory Retrieval
Seidenbecher, T., Laxmi, T. R., Stork, O., & Pape, H.-C. (2003) · Science · doi:10.1126/science.1085818 · Cited by 728 · see citing works
Combinatorial amygdalar inputs to hippocampal domains and hypothalamic behavior systems.
Petrovich, G., Canteras, N., & Swanson, L. (2001) · Brain research. Brain research reviews · doi:10.1016/s0165-0173(01)00080-7 · Cited by 628 · see citing works
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McEwen, B. S., Eiland, L., Hunter, R. G., & Miller, M. M. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.07.014 · Cited by 596 · see citing works
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Rasia‐Filho, A. A., Fabian, C., Rigoti, K. M., & Achaval, M. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.04.009 · Cited by 164 · see citing works
Kishi, T., Tsumori, T., Yokota, S., & Yasui, Y. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.20919 · Cited by 150 · see citing works
Clayton, E. C., & Williams, C. L. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00178-9 · Cited by 115 · see citing works
Intact enhancement of declarative memory for emotional material in amnesia.
Hamann, S. B., Cahill, L., McGaugh, J. L., & Squire, L. R. (1997) · Learning & Memory · doi:10.1101/lm.4.3.301 · Cited by 105 · see citing works
Abe, K. (2001) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.86.18 · Cited by 106 · see citing works
Self-citationEmotional tagging--a simple hypothesis in a complex reality.
Bergado, J., Lucas, M., & Richter-Levin, G. (2011) · Progress in neurobiology · doi:10.1016/j.pneurobio.2011.03.004 · Cited by 85 · see citing works
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Bouret, S., Duvel, A., Onat, S., & Sara, S. J. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03491.2003 · Cited by 84 · see citing works
Moretti, D. V., Pievani, M., Fracassi, C., Binetti, G. G., Rosini, S., Geroldi, C., Zanetti, O. O., Rossini, P. M., & Frisoni, G. B. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1059 · Cited by 68 · see citing works
Moretti, D. V., Prestia, A., Fracassi, C., Binetti, G. G., Zanetti, O. O., & Frisoni, G. B. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/253153 · Cited by 57 · see citing works
Distinct Medial Temporal Lobe Network States as Neural Contexts for Motivated Memory Formation
Murty, V. P., & Adcock, R. A. (2017) · Springer eBooks · doi:10.1007/978-3-319-50406-3_15 · Cited by 51 · see citing works
Behavioral and neurotoxicological effects of subchronic manganese exposure in rats
Vezér, T., Papp, A., Hoyk, Z., Varga, C., Náray, M., & Nagymajtényi, L. (2005) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2004.12.046 · Cited by 41 · see citing works
Isolation reduces contextual but not auditory-cue fear conditioning: A role for endogenous opioids.
Rudy, J. W., Kuwagama, K., & Pugh, C. R. (1999) · Behavioral Neuroscience · doi:10.1037//0735-7044.113.2.316 · Cited by 36 · see citing works
Medial amygdala lesions differentially influence stress responsivity and sensorimotor gating in rats
Vinkers, C. H., Bijlsma, E. Y., Houtepen, L. C., Westphal, K. G. C., Veening, J. G., Groenink, L., & Olivier, B. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.12.006 · Cited by 34 · see citing works
Ézrokhi, V. L., Zosimovskiĭ, V. A., Korshunov, V. A., & Markevich, V. A. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00232-2 · Cited by 23 · see citing works
Zancan, M., da Cunha, R. S. R., Schroeder, F., Xavier, L. L., & Rasia‐Filho, A. A. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14052 · Cited by 21 · see citing works
Dickerson, K. C., & Adcock, R. A. (2018) · Wiley eBooks · doi:10.1002/9781119170174.epcn107 · Cited by 1 · see citing works
Noguchi, K., Saitō, H., & Abe, K. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00210-8 · Cited by 10 · see citing works
Self-citationSingh, A., Shim, P., Naeem, S., Rahman, S., & Lutfy, K. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1495598 · Cited by 9 · see citing works
Garrison, D. W., & Foreman, R. D. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00486-1 · Cited by 6 · see citing works
Abe, K., Noguchi, K., & Saitō, H. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00233-x · Cited by 6 · see citing works
Self-citationOberlander, J. G., Lin, A. W., Man, H., & Erskine, M. S. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06529.x · Cited by 5 · see citing works
Neural mechanisms of emotion and memory.
Ono, T., & Nishijo, H. (2001) · Shitsugoshō kenkyū/Shitsugoshou kenkyuu · doi:10.2496/apr.21.87
Cowan, E. T., & Murty, V. P. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-820480-1.00112-1
- Authors
- Ikegaya, Y., Abe, K., Saito, H., & Nishiyama, N.
- Affiliations
- The University of Tokyo (JP)
- ORCID
- Venue
- Journal of Neurophysiology
- Publisher
- American Physiological Society
- Published
- 1995-11-01
- Volume
- 74
- Issue
- 5
- Pages
- 2201-2203
- ISSN
- 0022-3077 (ISSN-L)
- 1522-1598
- OpenAlex
- W2417785691
- Cited by
- 30
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2018: 2 · 2017: 1 · 2012: 1
- FWCI
- 0.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurophysiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- medial amygdala, dentate gyrus, synaptic transmission, synaptic plasticity, long-term potentiation, perforant path, population spike, high-frequency stimulation, tetanic stimulation, excitability, hippocampus
- MeSH terms
- Amygdala, Animals, Electric Stimulation, Male, Synaptic Transmission, Neuronal Plasticity, Rats, Wistar, Long-Term Potentiation, Dentate Gyrus, Rats
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