Phasic activation of locus ceruleus neurons by the central nucleus of the amygdala
Open accessAbstract
The role of the central nucleus of the amygdala (CeN) in modulating output of noradrenaline in the forebrain was evaluated by recording extracellular, single-unit activity from the noradrenergic nucleus locus ceruleus (LC) during stimulation of the CeN. Short high-frequency trains (200 Hz) delivered at 800 microA in the CeN evoked phasic responses in 90% of the neurons recorded in LC. Single pulses were also effective but less reliably. The responses were complex, multiphasic with an initial latency of 10-20 msec. This early peak was diminished or, in some cases, completely blocked by local or intracerebroventricular application of the corticotrophin releasing factor antagonist alpha helical CRF (9-41). The later excitatory peak and subsequent inhibition were not effected by the drug treatment. The results underline the reciprocal functional relationship between the amygdaloid complex and the LC and suggest that the LC might be an important "effector" of CeN activation during learning.
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The LC is activated via CRH afferent from the amygdala during stress in adults.
“Furthermore, as described above, the LC is activated via CRH afferent from the amygdala during stress in adults.”
From Early-life stress disrupts attachment learning: the role of amygdala corticosterone, locus ceruleus corticotropin releasing hormone, and olfactory bulb norepinephrine (2009) · cites this paper as Bouret et al., 2003
CRH antagonist application into the LC prevents fear conditioning.
“Indeed, CRH antagonist application into the LC prevents fear conditioning (Bouret et al., 2003) while CRH administered locally into the adult LC is able to increase the fear response (Valentino et al., 1983; Dunn and Everitt, 1987; Butler et al., 1990; Emoto et al., 1993; Borsody and Weiss, 1996; Curtis et al., 1997; Page and Abercrombie, 1999; Bouret et al., 2003; Dunn et al., 2004; Jedema and”
From Early-life stress disrupts attachment learning: the role of amygdala corticosterone, locus ceruleus corticotropin releasing hormone, and olfactory bulb norepinephrine (2009) · cites this paper as Bouret et al., 2003
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- Authors
- Bouret, S., Duvel, A., Onat, S., & Sara, S. J.
- Affiliations
- University of Illinois Urbana-Champaign (US)
- Centre National de la Recherche Scientifique (FR)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2003-04-15
- Volume
- 23
- Issue
- 8
- Pages
- 3491-3497
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6742334
- OpenAlex
- W1502932036
- Cited by
- 84
- References
- 50
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 3 · 2020: 6 · 2019: 3 · 2017: 2 · 2016: 5 · 2015: 7 · 2014: 3 · 2013: 3 · 2012: 7
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Centre National de la Recherche Scientifique
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- locus coeruleus, central amygdala, norepinephrine, corticotropin-releasing factor, alpha-helical CRF(9-41), noradrenergic neurons, single-unit activity
- MeSH terms
- Action Potentials, Amygdala, Animals, Corticotropin-Releasing Hormone, Drug Administration Routes, Electric Stimulation, Electrodes, Implanted, Evoked Potentials, Hormone Antagonists, Injections, Intraventricular, Locus Coeruleus, Male, Neurons, Peptide Fragments, Reaction Time, Rats, Sprague-Dawley, Receptors, Corticotropin-Releasing Hormone, Rats
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