Amygdalar and Hippocampal Theta Rhythm Synchronization During Fear Memory Retrieval
Abstract
The amygdalohippocampal circuit plays a pivotal role in Pavlovian fear memory. We simultaneously recorded electrical activity in the lateral amygdala (LA) and the CA1 area of the hippocampus in freely behaving fear-conditioned mice. Patterns of activity were related to fear behavior evoked by conditioned and indifferent sensory stimuli and contexts. Rhythmically synchronized activity at theta frequencies increased between the LA and the CA1 after fear conditioning and became significant during confrontation with conditioned fear stimuli and expression of freezing behavior. Synchronization of theta activities in the amygdalohippocampal network represents a neuronal correlate of conditioned fear, apt to improve neuronal communication during memory retrieval.
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Cross-correlation of activity in the theta frequency in lateral amygdala and CA1 increases in response to the conditioned stimulus following fear conditioning.
“cross-correlation of activity in the theta frequency in lateral amygdala and CA1 increase in response to the CS following fear conditioning133.”
From Resolving the neural circuits of anxiety (2015) · cites this paper as [133]
Theta rhythm synchrony between hippocampus and amygdala may underlie anxiety behaviors.
“Theta rhythm synchrony between hippocampus and amygdala may underlie anxiety behaviors as well”
From Resolving the neural circuits of anxiety (2015) · cites this paper as [133]
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- Authors
- Seidenbecher, T., Laxmi, T. R., Stork, O., & Pape, H.-C.
- Affiliations
- Otto-von-Guericke-Universität Magdeburg (DE)
- Corresponding author
- Seidenbecher, Thomas
- Laxmi, T. Rao
- Pape, Hans-Christian
- Venue
- Science
- Published
- 2003-08-08
- Volume
- 301
- Issue
- 5634
- Pages
- 846-850
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1997679949
- Cited by
- 728
- References
- 28
- Citations by year
- 2026: 6 · 2025: 26 · 2024: 31 · 2023: 22 · 2022: 32 · 2021: 39 · 2020: 32 · 2019: 46 · 2018: 30 · 2017: 43 · 2016: 48 · 2015: 44 · 2014: 30 · 2013: 40 · 2012: 34
- FWCI
- 11.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- lateral amygdala, CA1, theta oscillations, neuronal synchronization, fear memory retrieval, fear conditioning, freezing behavior, hippocampal CA1, mice
- MeSH terms
- Amygdala, Animals, Behavior, Animal, Conditioning, Psychological, Cues, Electrophysiology, Electroshock, Fear, Hippocampus, Male, Memory, Mice, Inbred C57BL, Motor Activity, Theta Rhythm, Mice
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