The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
The pH of the Secretory Pathway: Measurement, Determinants, and Regulation
Abstract
The luminal pH of the secretory pathway plays a critical role in the posttranslational modification and sorting of proteins and lipids. The pH of each one of the organelles that constitute the pathway is unique, becoming more acidic as the biosynthetic cargo approaches its destination. The methods used for measurement of pH in the secretory pathway, its determinants, and its regulation are the subjects of this review.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins
Miesenböck, G., De Angelis, D. A., & Rothman, J. E. (1998) · Nature · doi:10.1038/28190 · Cited by 2,563
Molecular Structure and Physiological Function of Chloride Channels
Jentsch, T. J., Stein, V., Weinreich, F., & Zdebik, A. A. (2002) · Physiological Reviews · doi:10.1152/physrev.00029.2001 · Cited by 1,256
Llopis, J., McCaffery, J. M., Miyawaki, A., Farquhar, M. G., & Tsien, R. Y. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.6803 · Cited by 1,130
Defective acidification of intracellular organelles in cystic fibrosis
Barasch, J., Kiss, B., Prince, A., Saiman, L., Gruenert, D., & AI-Awqati, Q. (1991) · Nature · doi:10.1038/352070a0 · Cited by 490
Milieu-induced, selective aggregation of regulated secretory proteins in the trans-Golgi network.
Chanat, E., & Huttner, W. B. (1991) · The Journal of cell biology · doi:10.1083/jcb.115.6.1505 · Cited by 458
Aniento, F., Gu, F., Parton, R. G., & Gruenberg, J. (1996) · The Journal of cell biology · doi:10.1083/jcb.133.1.29 · Cited by 357
Vesicles and cisternae in the trans golgi apparatus of human fibroblasts are acidic compartments
Anderson, R. G. W., & Pathak, R. K. (1985) · Cell · doi:10.1016/0092-8674(85)90212-0 · Cited by 349
Mechanisms of pH Regulation in the Regulated Secretory Pathway
Wu, M. M., Grabe, M., Adams, S., Tsien, R. Y., Moore, H.-P. H., & Machen, T. E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103917200 · Cited by 266
Skp1 forms multiple protein complexes, including RAVE, a regulator of V-ATPase assembly
Seol, J. H., Shevchenko, A., Shevchenko, A., & Deshaies, R. J. (2001) · Nature Cell Biology · doi:10.1038/35070067 · Cited by 263
Numata, M., & Orlowski, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101319200 · Cited by 244
Cited by
Sensors and regulators of intracellular pH
Casey, J. R., Grinstein, S., & Orlowski, J. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2820 · Cited by 2,218
Self-citationNieto-Torres, J. L., Verdiá-Báguena, C., Jimenez-Guardeño, J. M., Regla-Nava, J. A., Castaño-Rodriguez, C., Fernandez-Delgado, R., Torres, J., Aguilella, V. M., & Enjuanes, L. (2015) · Virology · doi:10.1016/j.virol.2015.08.010 · Cited by 511
Trebak, M., & Kinet, J.-P. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-018-0110-7 · Cited by 508
Orij, R., Postmus, J., Ter Beek, A., Brul, S., & Smits, G. J. (2009) · Microbiology · doi:10.1099/mic.0.022038-0 · Cited by 364
Bassil, E., Coku, A., & Blumwald, E. (2012) · Journal of Experimental Botany · doi:10.1093/jxb/ers250 · Cited by 310
Metadata
- Authors
- Paroutis, P., Touret, N., & Grinstein, S.
- Venue
- Physiology
- Publisher
- American Physiological Society
- Published
- 2004-08
- Volume
- 19
- Issue
- 4
- Pages
- 207-215
- ISSN
- 0886-1714 (ISSN-L)
- 1548-9213
- 1548-9221
- OpenAlex
- W2109662957
- Cited by
- 450
- References
- 43
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The pH of the Secretory Pathway: Measurement, Determinants, and Regulation. https://app.cochat.ai/papers/10.1152/physiol.00005.2004
- The paper
- Paroutis, P., Touret, N., & Grinstein, S. (2004). The pH of the Secretory Pathway: Measurement, Determinants, and Regulation. Physiology. https://doi.org/10.1152/physiol.00005.2004
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
