Astrocytes Function in Matching Blood Flow to Metabolic Activity
Abstract
The brain possesses an intrinsic regulatory mechanism to maintain an adequate supply of O(2) and nutrition despite local increases in neuronal activity. Brain astrocytes function as an intermediary cell type by responding to glutamate released from activated neurons, and they couple cerebral blood flow by producing cytochrome P-450-derived epoxyeicosatrienoic acids that induce vasodilation and increase capillary density.
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Neuroinflammation and subsequent impairment of the neuro-glial-vascular unit occur before disruption of Aβ homeostasis.
“On the other hand, it has been reported that neuroinflammation and the subsequent impairment of the neuro-glial-vascular unit, which is mainly composed of neuronal, glial, and vascular cells supporting the BBB (Harder et al., 2002), occur before the disruption of the Aβ homeostasis (Zlokovic, 2011).”
From Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes (2022) · cites this paper as Harder et al., 2002
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Self-citationFunctional Hyperemia in the Brain
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- Authors
- Harder, D. R., Zhang, C., & Gebremedhin, D.
- Affiliations
- Medical College of Wisconsin (US)
- ORCID
- Gebremedhin, Debebe
- Venue
- Physiology
- Publisher
- American Physiological Society
- Published
- 2002-02
- Volume
- 17
- Issue
- 1
- Pages
- 27-31
- ISSN
- 0886-1714 (ISSN-L)
- 1548-9213
- 1548-9221
- OpenAlex
- W2110715023
- Cited by
- 126
- References
- 16
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 7 · 2023: 7 · 2022: 13 · 2021: 11 · 2020: 5 · 2019: 3 · 2018: 5 · 2017: 5 · 2016: 5 · 2015: 7 · 2014: 5 · 2013: 4 · 2012: 4
- FWCI
- 3.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- astrocytes, cerebral blood flow, neurovascular coupling, glutamate, cytochrome P450, epoxyeicosatrienoic acids, vasodilation, capillary density, cerebral oxygenation, neuronal activity
- MeSH terms
- Animals, Astrocytes, Brain, Capillaries, Cerebrovascular Circulation, Humans, Hyperemia
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