The neurovascular unit - concept review

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Pericytes regulate the blood–brain barrier

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The blood–brain barrier: an overview

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Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.

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On the Regulation of the Blood‐supply of the Brain

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Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation

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Astrocyte Control of Synaptic Transmission and Neurovascular Coupling

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Bidirectional control of CNS capillary diameter by pericytes

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Astrocyte-mediated control of cerebral blood flow

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New insights into neuron-glia communication.

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Astroglial networks: a step further in neuroglial and gliovascular interactions

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Brain metabolism dictates the polarity of astrocyte control over arterioles

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Glial Cells Dilate and Constrict Blood Vessels: A Mechanism of Neurovascular Coupling

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Signaling at the Gliovascular Interface

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Engaging neuroscience to advance translational research in brain barrier biology

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Win-Stay-Lose-Learn Promotes Cooperation in the Spatial Prisoner's Dilemma Game

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Blood vessels and nerves: common signals, pathways and diseases

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Pericyte-mediated regulation of capillary diameter: a component of neurovascular coupling in health and disease

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VEGF165 mediates formation of complexes containing VEGFR‐2 and neuropilin‐1 that enhance VEGF165‐receptor binding

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Characteristics of CA1 neurons recorded intracellularly in the hippocampalin vitro slice preparation

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Role of Astrocytes in Neurovascular Coupling

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Pericytes in capillaries are contractile in vivo, but arterioles mediate functional hyperemia in the mouse brain

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Suppressed Neuronal Activity and Concurrent Arteriolar Vasoconstriction May Explain Negative Blood Oxygenation Level-Dependent Signal

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Overview and introduction: The blood–brain barrier in health and disease

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Astrocyte control of the cerebrovasculature

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Role of astrocytes in cerebrovascular regulation

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Neurovascular Unit: a Focus on Pericytes

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The neurovascular unit in brain function and disease: The neurovascular unit function

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The Hemo-Neural Hypothesis: On The Role of Blood Flow in Information Processing

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The role(s) of astrocytes and astrocyte activity in neurometabolism, neurovascular coupling, and the production of functional neuroimaging signals

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Semaphorin 3A–Vascular Endothelial Growth Factor-165 Balance Mediates Migration and Apoptosis of Neural Progenitor Cells by the Recruitment of Shared Receptor

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Gliotransmission and the Tripartite Synapse

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Neuron-Glial Interactions in Blood-Brain Barrier Formation

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Nitric oxide: Orchestrator of endothelium-dependent responses

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Modulation of Cerebral Arteriolar Diameter by Intraluminal Flow and Pressure

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Neurovascular congruence results from a shared patterning mechanism that utilizes Semaphorin3A and Neuropilin-1

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ATP: a vasoactive signal in the pericyte-containing microvasculature of the rat retina

Kawamura, H., Sugiyama, T., Wu, D. M., Kobayashi, M., Yamanishi, S., Katsumura, K., & Puro, D. G. (2003) · The Journal of Physiology · doi:10.1111/j.1469-7793.2003.00787.x · Cited by 156 · see citing works

A Novel Brain Neurovascular Unit Model with Neurons, Astrocytes and Microvascular Endothelial Cells of Rat

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Neuronal messengers in the human cerebral circulation

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Astrocytes Function in Matching Blood Flow to Metabolic Activity

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The neurovascular unit and its growth factors: coordinated response in the vascular and nervous systems

Ward, N. L., & Lamanna, J. C. (2004) · Neurological Research · doi:10.1179/016164104x3798 · Cited by 122 · see citing works

The neurovascular unit, matrix proteases, and innate inflammation

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Biphasic Mechanisms of Neurovascular Unit Injury and Protection in CNS Diseases

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Mechanisms underlying blood–brain barrier dysfunction in brain pathology and epileptogenesis: Role of astroglia

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Neurovascular relationships in hippocampal slices: physiological and anatomical studies of mechanisms underlying flow-metabolism coupling in intraparenchymal microvessels

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Vascular developmental biology: getting nervous

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Neurovascular development and links to disease

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Estrogen and Visceral Nociception at the Level of Primary Sensory Neurons

Chaban, V. V. (2011) · Pain Research and Treatment · doi:10.1155/2012/960780 · Cited by 92 · see citing works

Injury and repair in the neurovascular unit

Xing, C., Hayakawa, K., Lok, J. M., Arai, K., & Lo, E. H. (2012) · Neurological Research · doi:10.1179/1743132812y.0000000019 · Cited by 91 · see citing works

The molecular basis of the blood brain barrier differentiation and maintenance. Is it still a mystery?

Paolinelli, R., Corada, M., Orsenigo, F., & Dejana, E. (2010) · Pharmacological Research · doi:10.1016/j.phrs.2010.11.012 · Cited by 83 · see citing works

The complex contribution of NOS interneurons in the physiology of cerebrovascular regulation

Duchemin, S., Boily, M., Sadekova, N., & Girouard, H. (2012) · Frontiers in Neural Circuits · doi:10.3389/fncir.2012.00051 · Cited by 82 · see citing works

Neurogenic control of the cerebral microcirculation: is dopamine minding the store?

Iadecola, C. (1998) · Nature Neuroscience · doi:10.1038/1074 · Cited by 79 · see citing works

Role of nitric oxide synthase-containing vascular nerves in cerebrovasodilation elicited from cerebellum

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Targeting the neurovascular unit for treatment of neurological disorders

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Purinergic mechanisms in gliovascular coupling

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Oxygen-Glucose Deprivation Induced Glial Scar-Like Change in Astrocytes

Wang, R., Zhang, X., Zhang, J., Fan, Y., Shen, Y., Hu, W., & Chen, Z. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037574 · Cited by 67 · see citing works

Basic Fibroblast Growth Factor Modulates Density of Blood Vessels and Preserves Tight Junctions in Organotypic Cortical Cultures of Mice: A NewIn VitroModel of the Blood–Brain Barrier

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Paracrine control of vascularization and neurogenesis by neurotrophins

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Nitric oxide contributes to functional hyperemia in cerebellar cortex

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Neurobarrier coupling in the brain: Adjusting glucose entry with demand

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Advanced in vitro approach to study neurovascular coupling mechanisms in the brain microcirculation

Kim, K., & Filosa, J. A. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2011.222778 · Cited by 57 · see citing works

Influence of the glia limitans on pial arteriolar relaxation in the rat

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Glial glutamate transporters: New actors in brain signaling

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Neuronal and non-neuronal modulation of sympathetic neurovascular transmission

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Electrotonic Transmission Within Pericyte‐Containing Retinal Microvessels

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Local oestrogenic/androgenic balance in the cerebral vasculature

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The Energy Demand of Fast Neuronal Network Oscillations: Insights from Brain Slice Preparations

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Brain pericyte plasticity as a potential drug target in CNS repair

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The astrocytic contribution to neurovascular coupling – Still more questions than answers?

Kowiański, P., Lietzau, G., Steliga, A., Waśkow, M., & Moryś, J. (2013) · Neuroscience Research · doi:10.1016/j.neures.2013.01.014 · Cited by 50 · see citing works

Subarachnoid Hemorrhage, Spreading Depolarizations and Impaired Neurovascular Coupling

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Vascular tone and neurovascular coupling: considerations toward an improved in vitro model

Filosa (2010) · Frontiers in Neuroenergetics · doi:10.3389/fnene.2010.00016 · Cited by 42 · see citing works

Impact of acute hypobaric hypoxia on blood flow distribution in brain

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Neurovascular Unit and the Effects of Dosage in VEGF Toxicity: Role for Oxidative Stress and Thrombin

Sanchez, A. C., Tripathy, D., Luo, J., Yin, X., Martinez, J. M., & Grammas, P. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-121636 · Cited by 39 · see citing works

Endothelin and the neurovascular unit in pediatric traumatic brain injury

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Neuronal activity‐related coupling in cortical arterioles: involvement of astrocyte‐derived factors

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Astroglial Integrins in the Development and Regulation of Neurovascular Units

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Slice Cultures as a Model to Study Neurovascular Coupling and Blood Brain Barrier In Vitro

Kovács, R., Papageorgiou, I. E., & Heinemann, U. (2011) · Cardiovascular Psychiatry and Neurology · doi:10.1155/2011/646958 · Cited by 34 · see citing works

Neurotrophins novel mediators of angiogenesis

Hempstead, B. L. (2003) · Frontiers in bioscience · doi:10.2741/1169 · Cited by 34 · see citing works

Neurovascular Protection by Targeting Early Blood–Brain Barrier Disruption with Neurotrophic Factors after Ischemia–Reperfusion in Rats

Pillai, D. R., Shanbhag, N. C., Dittmar, M. S., Bogdahn, U., & Schlachetzki, F. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.201 · Cited by 30 · see citing works

Neurogliovascular unit after cerebral ischemia: Is the vascular wall a pharmacological target

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Axo-axonal interaction in autonomic regulation of the cerebral circulation

Lee, T. J. F., Chang, H., Lee, H. C., Chen, P. Y., Lee, Y.-U., Kuo, J. S., & Chen, M.-S. (2010) · Acta Physiologica · doi:10.1111/j.1748-1716.2010.02231.x · Cited by 23 · see citing works

The angiogenic gene profile of circulating endothelial progenitor cells from ischemic stroke patients

Navarro-Sobrino, M., Hernández‐Guillamón, M., Fernández‐Cadenas, I., Ribó, M., Romero, I. A., Couraud, P., Weksler, B. B., Montaner, J., & Rosell, A. (2013) · Vascular Cell · doi:10.1186/2045-824x-5-3 · Cited by 21 · see citing works

Carbon monoxide exposure during exercise performance: muscle and cerebral oxygenation

Keramidas, M. E., Kounalakis, S. N., Eiken, O., & Mekjavić, I. B. (2011) · Acta Physiologica · doi:10.1111/j.1748-1716.2011.02363.x · Cited by 19 · see citing works

Alzheimers Disease and Retinal Neurodegeneration Share a Consistent Stress Response of the Neurovascular Unit

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Acute CO2-independent vasodilatation of penetrating and pre-capillary arterioles in mouse cerebral parenchyma upon hypoxia revealed by a thinned-skull window method

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Preservation of transendothelial glucose transporter 1 and P-glycoprotein transporters in a cortical slice culture model of the blood–brain barrier

Camenzind, R. S., Chip, S., Gutmann, H., Kapfhammer, J. P., Nitsch, C., & Bendfeldt, K. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.06.073 · Cited by 17 · see citing works

THE USE OF STEREOTACTIC DISSECTION FOLLOWED BY FLUORIMETRIC ASSAY, TO DETERMINE THE DISTRIBUTION OF NORADRENALINE, DOPAMINE AND 5‐HYDROXYTRYPTAMINE IN THE PREOPTIC HYPOTHALAMIC AREA OF RABBIT BRAIN: AN ALTERNATIVE APPROACH TO HISTOCHEMISTRY

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Modulation of in vivo GABA-evoked responses by nitric oxide-active compounds in the globus pallidus of rat

Carletti, F., Ferraro, G., Rizzo, V., Friscia, S., & Sardo, P. (2012) · Journal of Neural Transmission · doi:10.1007/s00702-011-0760-0 · Cited by 9 · see citing works

Disturbance in neurovascular unit plays a pivotal role in pathophysiology of small vessel disease in the brain

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Nitric oxide-active compounds modulate the intensity of glutamate-evoked responses in the globus pallidus of the rat

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Superoxide generation in different brain regions of rats during normoxia and hypoxia-reoxygenation

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Untitled work

(1998) · doi:10.1002/(sici)1098-1136(199805)23:1

Physiology of Astroglia

Verkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678 · see citing works

Interaction of Microglia and Astrocytes in the Neurovascular Unit

Liu, L., Liu, J., Bao, J.-S., Bai, Q.-Q., & Wang, G. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01024 · Cited by 591 · see citing works

Claudin-5: gatekeeper of neurological function

Greene, C., Hanley, N., & Campbell, M. (2019) · Fluids and Barriers of the CNS · doi:10.1186/s12987-019-0123-z · Cited by 583 · see citing works

The epidemiology of multiple sclerosis

Goodin, D. S. (2016) · Handbook of clinical neurology · doi:10.1016/b978-0-12-802973-2.00011-2 · Cited by 517 · see citing works

Targeting and Crossing the Blood-Brain Barrier with Extracellular Vesicles

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The neuropathology and cerebrovascular mechanisms of dementia

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