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Cited by 478

The DOI matches its Crossref record; 220 of the 220 references it cites were found in a registry or an index.

Tropomyosin-Based Regulation of the Actin Cytoskeleton in Time and Space

Gunning, Peter, O’neill, Geraldine, Hardeman, Edna·2008·Physiological Reviews
DOI 10.1152/physrev.00001.2007
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Abstract

Tropomyosins are rodlike coiled coil dimers that form continuous polymers along the major groove of most actin filaments. In striated muscle, tropomyosin regulates the actin-myosin interaction and, hence, contraction of muscle. Tropomyosin also contributes to most, if not all, functions of the actin cytoskeleton, and its role is essential for the viability of a wide range of organisms. The ability of tropomyosin to contribute to the many functions of the actin cytoskeleton is related to the temporal and spatial regulation of expression of tropomyosin isoforms. Qualitative and quantitative changes in tropomyosin isoform expression accompany morphogenesis in a range of cell types. The isoforms are segregated to different intracellular pools of actin filaments and confer different properties to these filaments. Mutations in tropomyosins are directly involved in cardiac and skeletal muscle diseases. Alterations in tropomyosin expression directly contribute to the growth and spread of cancer. The functional specificity of tropomyosins is related to the collaborative interactions of the isoforms with different actin binding proteins such as cofilin, gelsolin, Arp 2/3, myosin, caldesmon, and tropomodulin. It is proposed that local changes in signaling activity may be sufficient to drive the assembly of isoform-specific complexes at different intracellular sites.

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Metadata

Authors
Gunning, P., O’neill, G., & Hardeman, E.
Venue
Physiological Reviews
Publisher
American Physiological Society
Published
2008-01
Volume
88
Issue
1
Pages
1-35
ISSN
  • 0031-9333 (ISSN-L)
  • 1522-1210
DOI
10.1152/physrev.00001.2007
OpenAlex
W2162225623
Cited by
478
References
220
FWCI
2.04
Type
journal article
Language
en
Open access
closed

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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