Endothelial Cell Metabolism

Molecular distinction between arteries and veins

Torres‐Vázquez, J., Kamei, M., & Weinstein, B. M. (2003) · Cell and Tissue Research · doi:10.1007/s00441-003-0771-8 · Cited by 140

Endothelial nitric oxide synthase dysfunction in diabetic mice: importance of tetrahydrobiopterin in eNOS dimerisation

Cai, S., Khoo, J., Mussa, S., Alp, N. J., & Channon, K. M. (2005) · Diabetologia · doi:10.1007/s00125-005-1857-5 · Cited by 139

A local glucose-and oxygen concentration-based insulin secretion model for pancreatic islets

Buchwald, P. (2011) · Theoretical Biology and Medical Modelling · doi:10.1186/1742-4682-8-20 · Cited by 139

Epigenetic Changes in Diabetes and Cardiovascular Risk

Keating, S. T., Plutzky, J., & El-Osta, A. (2016) · Circulation Research · doi:10.1161/circresaha.116.306819 · Cited by 139

Nitric oxide in the pulmonary vasculature

Coggins, M. P., & Bloch, K. D. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.142943 · Cited by 138

Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1)

Liu, X., Wang, D., Zhao, Y., Tu, B., Zheng, Z., Wang, L., Wang, H., Gu, W. J., Roeder, R. G., & Zhu, W. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019619108 · Cited by 137

Isolated tumor endothelial cells maintain specific character during long-term culture

Matsuda, K., Ohga, N., Hida, Y., Muraki, C., Tsuchiya, K., Kurosu, T., Akino, T., Shih, S., Totsuka, Y., Klagsbrun, M., et al. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.03.089 · Cited by 137

Histone and DNA Methylation–Mediated Epigenetic Downregulation of Endothelial Kruppel-Like Factor 2 by Low-Density Lipoprotein Cholesterol

Kumar, A., Kumar, S., Vikram, A., Hoffman, T. A., Naqvi, A., Lewarchik, C. M., Kim, Y., & Irani, K. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.301765 · Cited by 137

Nox2 NADPH Oxidase Has a Critical Role in Insulin Resistance–Related Endothelial Cell Dysfunction

Sukumar, P., Viswambharan, H., Imrie, H., Cubbon, R. M., Yuldasheva, N. Y., Gage, M., Galloway, S. L., Skromna, A., Kandavelu, P., Santos, C. X. C., et al. (2013) · Diabetes · doi:10.2337/db12-1294 · Cited by 137

Mitochondrial damage-associated molecular patterns and vascular function

Wenceslau, C. F., McCarthy, C. G., Szasz, T., Spitler, K., Goulopoulou, S., Webb, R. C., & Working Group on DAMPs in Cardiovascular Disease (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu047 · Cited by 135

A novel mechanism of coenzyme Q10 protects against human endothelial cells from oxidative stress-induced injury by modulating NO-related pathways

Tsai, K., Huang, Y., Kao, C.-L., Yang, D., Lee, H., Chou, H., Chen, Y., Chiou, G., Chen, L.-H., Yang, Y.-P., et al. (2011) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2011.01.011 · Cited by 133

NADPH oxidase 4 protects against development of endothelial dysfunction and atherosclerosis in LDL receptor deficient mice

Langbein, H., Brunssen, C., Hofmann, A., Cimalla, P., Brux, M., Bornstein, S. R., Deussen, A., Koch, E., & Morawietz, H. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehv564 · Cited by 133

A microscopic view on the renal endothelial glycocalyx

Dane, M. J. C., van den Berg, B. M., Lee, D. H., Boels, M. G. S., Tiemeier, G. L., Avramut, M. C., van Zonneveld, A. J., van der Vlag, J., Vink, H., & Rabelink, T. J. (2015) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00532.2014 · Cited by 132

De Novo Lipogenesis Maintains Vascular Homeostasis through Endothelial Nitric-oxide Synthase (eNOS) Palmitoylation*

Wei, X., Schneider, J. G., Shenouda, S. M., Lee, A., Towler, D. A., Chakravarthy, M. V., Vita, J. A., & Semenkovich, C. F. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.193037 · Cited by 132

Coenzyme Q10 and diabetic endotheliopathy: oxidative stress and the 'recoupling hypothesis'

Chew, G., & Watts, G. F. (2004) · QJM · doi:10.1093/qjmed/hch089 · Cited by 132

Antioxidants and coronary artery disease: from pathophysiology to preventive therapy

Leopold, J. A. (2014) · Coronary Artery Disease · doi:10.1097/mca.0000000000000187 · Cited by 131

Endothelial mitochondria—less respiration, more integration

Groschner, L. N., Waldeck‐Weiermair, M., Malli, R., & Graier, W. F. (2012) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-012-1085-z · Cited by 129

Metformin and Resveratrol Inhibited High Glucose-Induced Metabolic Memory of Endothelial Senescence through SIRT1/p300/p53/p21 Pathway

Zhang, E., Guo, Q., Gao, H., Xu, R., Teng, S., & Wu, Y. (2015) · PLoS ONE · doi:10.1371/journal.pone.0143814 · Cited by 128

Arginine and nitric oxide synthase: Regulatory mechanisms and cardiovascular aspects

Lorin, J., Zeller, M., Guilland, J.-C., Cottin, Y., Vergely, C., & Rochette, L. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300033 · Cited by 126

Aberrant angiogenesis: The gateway to diabetic complications

Kota, S., Meher, L. K., Jammula, S., Kota, S., Krishna, S. V. S., & Modi, K. D. (2012) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/2230-8210.102992 · Cited by 125

LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-density lipoprotein in endothelial cells

Sugimoto, K., Ishibashi, T., Sawamura, T., Inoue, N., Kamioka, M., Uekita, H., Ohkawara, H., Sakamoto, T., Sakamoto, N., Okamoto, Y., et al. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp177 · Cited by 124

Glutamine metabolism to glucosamine is necessary for glutamine inhibition of endothelial nitric oxide synthesis

Wu, G., Haynes, T. E., Li, H. Z., Wene, Y. A. N., & Meininger, C. J. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3530245 · Cited by 122

Heterogeneity of tumor endothelial cells and drug delivery

Hida, K., Maishi, N., Sakurai, Y., Hida, Y., & Harashima, H. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.11.008 · Cited by 120

Synchronization of endothelial Dll4-Notch dynamics switch blood vessels from branching to expansion

Ubezio, B., Blanco, R., Geudens, I., Stanchi, F., Mathivet, T., Jones, M. L., Ragab, A., Bentley, K., & Gerhardt, H. (2016) · eLife · doi:10.7554/elife.12167 · Cited by 119

SIRT1, p66Shc, and Set7/9 in Vascular Hyperglycemic Memory

Paneni, F., Volpe, M., Lüscher, T. F., & Cosentino, F. (2013) · Diabetes · doi:10.2337/db12-1648 · Cited by 118

HuR keeps an angiogenic switch on by stabilising mRNA of VEGF and COX-2 in tumour endothelium

Kurosu, T., Ohga, N., Hida, Y., Maishi, N., Akiyama, K., Kakuguchi, W., Kuroshima, T., Kondo, M., Akino, T., Totsuka, Y., et al. (2011) · British Journal of Cancer · doi:10.1038/bjc.2011.20 · Cited by 118

Endothelial Uncoupling Protein 2 Regulates Mitophagy and Pulmonary Hypertension During Intermittent Hypoxia

Haslip, M., Dostanic, I., Huang, Y., Zhang, Y., Russell, K. S., Jurczak, M. J., Mannam, P., Giordano, F. J., ERZURUM, S. C., & Lee, P. J. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.304865 · Cited by 118

Role of Endothelial Nitric Oxide Synthase in Diabetic Nephropathy: Lessons from Diabetic eNOS Knockout Mice

Takahashi, T., & Harris, R. C. (2014) · Journal of Diabetes Research · doi:10.1155/2014/590541 · Cited by 117

Using the reconstructed genome-scale human metabolic network to study physiology and pathology

Bordbar, A., & Palsson, B. O. (2012) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2011.02494.x · Cited by 115

Meox2/Tcf15 Heterodimers Program the Heart Capillary Endothelium for Cardiac Fatty Acid Uptake

Coppiello, G., Collantes, M., Sirerol-Piquer, M. S., Vandenwijngaert, S., Schoors, S., Swinnen, M., Vandersmissen, I., Herijgers, P., Topal, B., Loon, J. V., et al. (2015) · Circulation · doi:10.1161/circulationaha.114.013721 · Cited by 115

Confirmation of Superoxide Generation via Xanthine Oxidase in Streptozotocin-induced Diabetic Mice

Matsumoto, S., Koshiishi, I., Inoguchi, T., Nawata, H., & Utsumi, H. (2003) · Free Radical Research · doi:10.1080/1071576031000107344 · Cited by 114

PTEN mediates Notch-dependent stalk cell arrest in angiogenesis

Serra, H., Chivite, Í., Angulo‐Urarte, A., Soler, A., Sutherland, J. D., Arruabarrena-Aristorena, A., Ragab, A., Lim, R., Malumbres, M., Fruttiger, M., et al. (2015) · Nature Communications · doi:10.1038/ncomms8935 · Cited by 114

Role of methylglyoxal adducts in the development of vascular complications in diabetes mellitus

Bourajjaj, M., Stehouwer, C. D. A., van Hinsbergh, V. W. M., & Schalkwijk, C. (2003) · Biochemical Society Transactions · doi:10.1042/bst0311400 · Cited by 112

Protein Modification by O-Linked GlcNAc Reduces Angiogenesis by Inhibiting Akt Activity in Endothelial Cells

Luo, B., Soesanto, Y., & McClain, D. A. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.159533 · Cited by 112

The Role of the Transcription Factor KLF2 in Vascular Development and Disease

Novodvorský, P., & Chico, T. (2014) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-386930-2.00007-0 · Cited by 112

Antiangiogenic Activity of 2-Deoxy-D-Glucose

Merchan, J. R., Kovács, K., Railsback, J. W., Kurtoğlu, M., Jing, Y., Piña, Y., Gao, N., Murray, T. G., Lehrman, M. A., & Lampidis, T. J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013699 · Cited by 111

Meta‐analysis of clinical metabolic profiling studies in cancer: challenges and opportunities

Goveia, J., Pircher, A., Conradi, L., Kalucka, J. M., Lagani, V., Dewerchin, M. A., Eelen, G., DeBerardinis, R. J., Wilson, I. D., & Carmeliet, P. (2016) · EMBO Molecular Medicine · doi:10.15252/emmm.201606798 · Cited by 111

Unraveling a novel transcription factor code determining the human arterial-specific endothelial cell signature

Aranguren, X. L., Agirre, X., Beerens, M., Coppiello, G., Uriz, M., Vandersmissen, I., Benkheil, M., Panadero, J., Aguado, N., Pascual-Montano, A., et al. (2013) · Blood · doi:10.1182/blood-2013-02-483255 · Cited by 110

Metabolic control of the cell cycle

Kalucka, J. M., Missiaen, R., Γεωργιάδου, Μ., Schoors, S., Lange, C. M., Bock, K. D., Dewerchin, M. A., & Carmeliet, P. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1090068 · Cited by 109

Fatty Acid Metabolism in Pulmonary Arterial Hypertension: Role in Right Ventricular Dysfunction and Hypertrophy

Talati, M. H., & Hemnes, A. R. (2015) · Pulmonary Circulation · doi:10.1086/681227 · Cited by 109

Xanthine oxidase-induced oxidative stress causes activation of NF-κB and inflammation in the liver of type I diabetic rats

Romagnoli, M., Gómez‐Cabrera, M. C., Perrelli, M.-G., Biasi, F., Pallardó, F. V., Sastre, J., Poli, G., & Viña, J. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.03.024 · Cited by 109

Premature senescence of human endothelial cells induced by inhibition of glutaminase

Unterluggauer, H., Mazurek, S., Lener, B., Hütter, E., EIGENBRODT, E., Zwerschke, W., & Jansen‐Dürr, P. (2008) · Biogerontology · doi:10.1007/s10522-008-9134-x · Cited by 109

Lipid droplets as a novel cargo of tunnelling nanotubes in endothelial cells

Astanina, K., Koch, M., Jüngst, C., Zumbusch, A., & Kiemer, A. K. (2015) · Scientific Reports · doi:10.1038/srep11453 · Cited by 109

Mechanisms of Lipid Accumulation in the Bone Morphogenetic Protein Receptor Type 2 Mutant Right Ventricle

Talati, M. H., Brittain, E. L., Fessel, J. P., Penner, N. L., Atkinson, J. R., Funke, M., Grueter, C. A., Jerome, W. G., Freeman, M. L., Newman, J. H., et al. (2016) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201507-1444oc · Cited by 109

Critical roles of glutamine as nitrogen donors in purine and pyrimidine nucleotide synthesis: asparaginase treatment in childhood acute lymphoblastic leukemia.

Cory, J. G., & Cory, A. H. (2006) · PubMed · Cited by 108

Biglycan is a specific marker and an autocrine angiogenic factor of tumour endothelial cells

Yamamoto, K., Ohga, N., Hida, Y., Maishi, N., Kawamoto, T., Kitayama, K., Akiyama, K., Osawa, T., Kondoh, M., Matsuda, K., et al. (2012) · British Journal of Cancer · doi:10.1038/bjc.2012.59 · Cited by 108

AGE-receptor-1 counteracts cellular oxidant stress induced by AGEs via negative regulation of p66shc-dependent FKHRL1 phosphorylation

Cai, W., He, C., Zhu, L., Chen, X., Striker, G. E., & Vlassara, H. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00350.2007 · Cited by 108

The regulation of ion channels and transporters by glycolytically derived ATP

Dhar-Chowdhury, P., Malester, B., Rajacic, P., & Coetzee, W. A. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7332-3 · Cited by 107

Damaging effects of hyperglycemia on cardiovascular function: spotlight on glucose metabolic pathways

Mapanga, R. F., & Essop, M. F. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00206.2015 · Cited by 107

Efficient differentiation of human embryonic stem cells to arterial and venous endothelial cells under feeder- and serum-free conditions

Sriram, G., Tan, J. Y., Islam, I., Rufaihah, A. J., & Cao, T. (2015) · Stem Cell Research & Therapy · doi:10.1186/s13287-015-0260-5 · Cited by 105

Uncoupling Lipid Metabolism from Inflammation through Fatty Acid Binding Protein-Dependent Expression of UCP2

Xu, H., Hertzel, A. V., Steen, K. A., Wang, Q., Suttles, J., & Bernlohr, D. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.01122-14 · Cited by 104

Homocysteine thiolactone and N-homocysteinylated protein induce pro-atherogenic changes in gene expression in human vascular endothelial cells

Gurda, D., Handschuh, L., Kotkowiak, W., & Jakubowski, H. (2015) · Amino Acids · doi:10.1007/s00726-015-1956-7 · Cited by 104

KLF2-induced actin shear fibers control both alignment to flow and JNK signaling in vascular endothelium

Boon, R. A., Leyen, T. A., Fontijn, R. D., Fledderus, J. O., Baggen, J. M. C., Volger, O. L., Amerongen, G. P. V. N., & Horrevoets, A. J. G. (2009) · Blood · doi:10.1182/blood-2009-06-228726 · Cited by 103

The UDP-glucuronosyltransferases of the blood-brain barrier: their role in drug metabolism and detoxication

Ouzzine, M., Gulberti, S., Ramalanjaona, N., Magdalou, J., & Fournel‐Gigleux, S. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00349 · Cited by 103

Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes

Paneni, F., Costantino, S., Castello, L., Battista, R., Capretti, G., Chiandotto, S., D’Amario, D., Scavone, G., Villano, A., Rustighi, A., et al. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu179 · Cited by 102

Role of glycocalyx in flow-induced production of nitric oxide and reactive oxygen species

Kumagai, R., Lu, X., & Kassab, G. S. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.05.034 · Cited by 101

Identification of the Major Site of O-Linked β-N-Acetylglucosamine Modification in the C Terminus of Insulin Receptor Substrate-1

Ball, L. E., Berkaw, M. N., & Buse, M. G. (2005) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m500314-mcp200 · Cited by 101

O-GlcNAcylation, an Epigenetic Mark. Focus on the Histone Code, TET Family Proteins, and Polycomb Group Proteins

Dehennaut, V., Leprince, D., & Lefebvre, T. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00155 · Cited by 101

Implication of the hypoxia response element of the Vegf promoter in mouse models of retinal and choroidal neovascularization, but not retinal vascular development

Vinores, S. A., Xiao, W., Aslam, S., Shen, J., Oshima, Y., Nambu, H., Liu, H., Carmeliet, P., & Campochiaro, P. A. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20525 · Cited by 99

Characterization of the metabolic changes underlying growth factor angiogenic activation: identification of new potential therapeutic targets

Vizán, P., Sánchez‐Tena, S., Alcarraz‐Vizán, G., Soler, M., Messeguer, R., Pujol, M. D., Lee, W.-N. P., & Cascante, M. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp083 · Cited by 99

MiR-34a regulates blood–brain barrier permeability and mitochondrial function by targeting cytochrome c

Bukeirat, M., Sarkar, S. N., Hu, H., Quintana, D. D., Simpkins, J. W., & Ren, X. S. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x15606147 · Cited by 99

Notch regulates the angiogenic response via induction of VEGFR-1

Funahashi, Y., Shawber, C. J., Vorontchikhina, M., Sharma, A., Outtz, H. H., & Kitajewski, J. (2010) · Vascular Cell · doi:10.1186/2040-2384-2-3 · Cited by 98

Foxo1 Links Hyperglycemia to LDL Oxidation and Endothelial Nitric Oxide Synthase Dysfunction in Vascular Endothelial Cells

Tanaka, J., Qiang, L., Banks, A. S., Welch, C. L., Matsumoto, M., Kitamura, T., Ido-Kitamura, Y., DePinho, R. A., & Accili, D. (2009) · Diabetes · doi:10.2337/db09-0167 · Cited by 97

Mechanosensitive PPAP2B Regulates Endothelial Responses to Atherorelevant Hemodynamic Forces

Wu, C., Huang, R., Kuo, C., Kumar, S., Kim, C. W., Lin, Y., Chen, Y., Birukova, A. A., Birukov, K. G., Dulin, N. O., et al. (2015) · Circulation Research · doi:10.1161/circresaha.117.306457 · Cited by 96

Adenoviral gene transfer of endothelial nitric-oxide synthase (eNOS) partially restores normal pulmonary arterial pressure in eNOS-deficient mice

Champion, H. C., Bivalacqua, T. J., Greenberg, S. S., Giles, T. D., Hyman, A. L., & Kadowitz, P. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182225899 · Cited by 95

Thioredoxin and glutaredoxin-mediated redox regulation of ribonucleotide reductase

Sengupta, R., & Holmgren, A. (2014) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v5.i1.68 · Cited by 95

Fatty Acid-binding Protein 4, a Point of Convergence for Angiogenic and Metabolic Signaling Pathways in Endothelial Cells

Harjes, U., Bridges, E., McIntyre, A., Fielding, B. A., & Harris, A. L. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.576512 · Cited by 95

Glucose‐6‐phosphate dehydrogenase‐deficient mice have increased renal oxidative stress and increased albuminuria

Xu, Y., Zhang, Z., Hu, J., Stillman, I. E., Leopold, J. A., Handy, D. E., Loscalzo, J., & Stanton, R. C. (2009) · The FASEB Journal · doi:10.1096/fj.09-135731 · Cited by 94

Induction of Vascular Insulin Resistance and Endothelin-1 Expression and Acceleration of Atherosclerosis by the Overexpression of Protein Kinase C-β Isoform in the Endothelium

Li, Q., Park, K., Li, C.-Z., Rask‐Madsen, C., Mima, A., Qi, W., Mizutani, K., Huang, P. L., & King, G. L. (2013) · Circulation Research · doi:10.1161/circresaha.113.301074 · Cited by 93

Endothelial development taking shape

Wacker, A., & Gerhardt, H. (2011) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2011.10.002 · Cited by 92

NRP1 function and targeting in neurovascular development and eye disease

Raimondi, C., Brash, J. T., Fantin, A., & Ruhrberg, C. (2016) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2016.02.003 · Cited by 92

Nutrient shortage triggers the hexosamine biosynthetic pathway via the GCN2-ATF4 signalling pathway

Chaveroux, C., Sarcinelli, C., Barbet, V., Belfeki, S., Barthelaix, A., Ferraro‐Peyret, C., Lebecque, S., Renno, T., Bruhat, A., Fafournoux, P., et al. (2016) · Scientific Reports · doi:10.1038/srep27278 · Cited by 92

C ‐reactive protein promotes atherosclerosis by increasing LDL transcytosis across endothelial cells

Bian, F., Yang, X., Zhou, F., Wu, P., Xing, S., Xu, G., Li, W., Chi, J., Ouyang, C., Zhang, Y., et al. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12616 · Cited by 91

Plasma α-Oxoaldehyde Levels in Diabetic and Nondiabetic Chronic Kidney Disease Patients

Nakayama, K., Nakayama, M., Iwabuchi, M., Terawaki, H., Sato, T., Kohno, M., & Ito, S. (2008) · American Journal of Nephrology · doi:10.1159/000139653 · Cited by 91

Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3

Boyd, S., Brookfield, J. L., Critchlow, S. E., Cumming, I. A., Curtis, N. J., Debreczeni, J. E., Degorce, S. L., Donald, C. S., Evans, N. J., Groombridge, S. D., et al. (2015) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b00352 · Cited by 91

Highly-accurate metabolomic detection of early-stage ovarian cancer

Gaul, D. A., Mezencev, R., Long, T. Q., Jones, C. M., Benigno, B. B., Gray, A., Fernández, F. M., & McDonald, J. F. (2015) · Scientific Reports · doi:10.1038/srep16351 · Cited by 91

The influence of high glucose on the aerobic metabolism of endothelial EA.hy926 cells

Kozieł, A., Woyda-Ploszczyca, A. M., Kicińska, A., & Jarmuszkiewicz, W. (2012) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-012-1156-1 · Cited by 90

Endoderm is required for vascular endothelial tube formation, but not for angioblast specification

Vokes, S. A., & Krieg, P. A. (2002) · Development · doi:10.1242/dev.129.3.775 · Cited by 90

Mitochondrial mechanism of microvascular endothelial cells apoptosis in hyperhomocysteinemia

Tyagi, N., Ovechkin, A. V., Lominadze, D. G., Moshal, K. S., & Tyagi, S. C. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20837 · Cited by 90

Fructose Metabolism and Relation to Atherosclerosis, Type 2 Diabetes, and Obesity

Hervik, A. K., & Svihus, B. (2015) · Journal of Nutrition and Metabolism · doi:10.1155/2015/823081 · Cited by 89

Methods for integration of transcriptomic data in genome-scale metabolic models

Kim, M. K., & Lun, D. S. (2014) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2014.08.009 · Cited by 89

O-Glycosylation Regulates Ubiquitination and Degradation of the Anti-Inflammatory Protein A20 to Accelerate Atherosclerosis in Diabetic ApoE-Null Mice

Shrikhande, G., Scali, S. T., da Silva, C. G., Damrauer, S. M., Csizmadia, E., Putheti, P., Matthey, M., Arjoon, R., Patel, R., Siracuse, J. J., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014240 · Cited by 89

Toll-like receptors 2 and 4 mediate hyperglycemia induced macrovascular aortic endothelial cell inflammation and perturbation of the endothelial glycocalyx

Pahwa, R., Nallasamy, P., & Jialal, I. (2016) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2016.01.014 · Cited by 88

Mitochondrial function in vascular endothelial cell in diabetes

Pangare, M., & Makino, A. (2012) · Journal of Smooth Muscle Research · doi:10.1540/jsmr.48.1 · Cited by 87

Lysyl oxidase secreted by tumour endothelial cells promotes angiogenesis and metastasis

Osawa, T., Ohga, N., Akiyama, K., Hida, Y., Kitayama, K., Kawamoto, T., Yamamoto, K., Maishi, N., Kondoh, M., Onodera, Y., et al. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.535 · Cited by 87

Resistance of retinal inflammatory mediators to suppress after reinstitution of good glycemic control: novel mechanism for metabolic memory

Chan, P.-S., Kanwar, M., & Kowluru, R. A. (2008) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2008.10.002 · Cited by 87

Targeting fatty acid metabolism in cancer and endothelial cells

Harjes, U., Kalucka, J. M., & Carmeliet, P. (2015) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2015.10.011 · Cited by 87

Cultured endothelial cells maintain their L-arginine level despite the continuous release of EDRF

Mitchell, J. A., Hecker, M., Änggård, E., & Vane, J. R. (1990) · European Journal of Pharmacology · doi:10.1016/0014-2999(90)90058-e · Cited by 86

Protein O-GlcNAcylation and Cardiovascular (Patho)physiology

Marsh, S. A., Collins, H. E., & Chatham, J. C. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.r114.585984 · Cited by 86

Targeting hydrogen sulfide as a promising therapeutic strategy for atherosclerosis

Xu, S., Liu, Z., & Liu, P. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.01.068 · Cited by 85

Nitric oxide and pulmonary arterial pressures in pulmonary hypertension

Machado, R. F., Nerkar, M.-V. L., Dweik, R. A., Hammel, J., Janocha, A. J., Pyle, J., Laskowski, D. M., Jennings, C. A., Arroliga, A. C., & ERZURUM, S. C. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.06.039 · Cited by 85

Hyperglycaemia promotes human brain microvascular endothelial cell apoptosis via induction of protein kinase C-βI and prooxidant enzyme NADPH oxidase

Shao, B., & Bayraktutan, U. (2014) · Redox Biology · doi:10.1016/j.redox.2014.05.005 · Cited by 85

Embelin inhibits endothelial mitochondrial respiration and impairs neoangiogenesis during tumor growth and wound healing

Coutelle, O., Hornig‐Do, H., Witt, A., Andree, M., Schiffmann, L. M., Piekarek, M., Brinkmann, K., Seeger, J. M., Liwschitz, M., Miwa, S., et al. (2014) · EMBO Molecular Medicine · doi:10.1002/emmm.201303016 · Cited by 85

Role of S-adenosylhomocysteine in cardiovascular disease and its potential epigenetic mechanism

Xiao, Y., Su, X., Huang, W. H., Zhang, J., Peng, C., Huang, H., Wu, X., Huang, H., Xia, M., & Ling, W. (2015) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2015.06.015 · Cited by 85

Evaluation of the endothelial glycocalyx damage in patients with acute coronary syndrome

Miranda, C. H., Borges, M. D. C., Schmidt, A., Marin‐Neto, J. A., & Pazin‐Filho, A. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.02.023 · Cited by 85

Metabonomics revealed xanthine oxidase-induced oxidative stress and inflammation in the pathogenesis of diabetic nephropathy

Liu, J., Wang, C., Liu, F., Lu, Y., & Cheng, J. (2015) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-015-8481-0 · Cited by 83

P53 Impairs Endothelium-Dependent Vasomotor Function Through Transcriptional Upregulation of P66shc

Kim, C., Jung, S.-B., Naqvi, A., Hoffman, T. A., DeRicco, J. S., Yamamori, T., Cole, M. P., Jeon, B. H., & Irani, K. (2008) · Circulation Research · doi:10.1161/circresaha.108.181644 · Cited by 83

Targeting nuclear thymidylate biosynthesis

Chon, J., Stover, P. J., & Field, M. S. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.11.005 · Cited by 83

Integration of tissue metabolomics, transcriptomics and immunohistochemistry reveals ERG- and gleason score-specific metabolomic alterations in prostate cancer

Meller, S., Meyer, H., Bethan, B., Dietrich, D., Maldonado, S. G., Lein, M., Montani, M., Reszka, R. C., Schatz, P., Peter, E., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.6370 · Cited by 82

Hypoxic upregulation of arginase II in human lung endothelial cells

Krotova, K. Y., Patel, J. M., Block, E. R., & Zharikov, S. I. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00068.2010 · Cited by 81

Endothelial Fatty Acid Transport: Role of Vascular Endothelial Growth Factor B

Hagberg, C. E., Mehlem, A., Falkevall, A., Muhl, L., & Eriksson, U. (2013) · Physiology · doi:10.1152/physiol.00042.2012 · Cited by 81

Exploiting tumor metabolism: challenges for clinical translation

Heiden, M. G. V. (2013) · Journal of Clinical Investigation · doi:10.1172/jci72391 · Cited by 80

Horizontal transfer of tumor DNA to endothelial cells in vivo

Ehnfors, J., Kost‐Alimova, M., Persson, N. L., Bergsmedh, A., Castro, J., Tegnebratt, T., Yang, L., Panaretakis, T., & Holmgren, L. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.7 · Cited by 80

Endothelium-Selective Activation of AMP-Activated Protein Kinase Prevents Diabetes Mellitus–Induced Impairment in Vascular Function and Reendothelialization via Induction of Heme Oxygenase-1 in Mice

Li, F. Y. L., Lam, K. S. L., Tse, H., Chen, C., Wang, Y., Vanhoutte, P. M., & Xu, A. (2012) · Circulation · doi:10.1161/circulationaha.112.108159 · Cited by 80

Sulforaphane Attenuation of Type 2 Diabetes-Induced Aortic Damage Was Associated with the Upregulation of Nrf2 Expression and Function

Wang, Y., Zhang, Z., Sun, W., Tan, Y., Liu, Y., Zheng, Y., Liu, Q., Cai, L., & Sun, J. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/123963 · Cited by 79

Mice With Targeted Inactivation of Ppap2b in Endothelial and Hematopoietic Cells Display Enhanced Vascular Inflammation and Permeability

Panchatcharam, M., Salous, A. K., Brandon, J. A., Miriyala, S., Wheeler, J., Patil, P., Sunkara, M., Morris, A. J., Escalante‐Alcalde, D., & Smyth, S. S. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.302335 · Cited by 79

PARP-1 Inhibits Glycolysis in Ischemic Kidneys

Devalaraja-Narashimha, K. B., & Padanilam, B. J. (2008) · Journal of the American Society of Nephrology · doi:10.1681/asn.2008030325 · Cited by 79

Role of Reactive Oxygen Species in Vascular Remodeling Associated with Pulmonary Hypertension

Wedgwood, S., & Black, S. M. (2003) · Antioxidants and Redox Signaling · doi:10.1089/152308603770380061 · Cited by 78

Endothelin-1 Induces a Glycolytic Switch in Pulmonary Arterial Endothelial Cells via the Mitochondrial Translocation of Endothelial Nitric Oxide Synthase

Sun, X., Kumar, S., Sharma, S., Aggarwal, S., Lü, Q., Groß, C., Rafikova, O., Lee, S. G., Dasarathi, S., Hou, Y., et al. (2014) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2013-0187oc · Cited by 78

Antiangiogenic and tumour inhibitory effects of downregulating tumour endothelial FABP4

Harjes, U., Bridges, E., Gharpure, K. M., Roxanis, I., Sheldon, H., Miranda, F., Mangala, L. S., Pradeep, S., Lopez‐Berestein, G., Ahmed, A., et al. (2016) · Oncogene · doi:10.1038/onc.2016.256 · Cited by 78

Is diabetes an acquired disorder of reactive glucose metabolites and their intermediates?

Fleming, T. H., Cuny, J., Nawroth, G., Djuric, Z., Humpert, P. M., Zeier, M. G., Bierhaus, A., & Nawroth, P. P. (2012) · Diabetologia · doi:10.1007/s00125-012-2452-1 · Cited by 77

Heterogeneity of tumor endothelial cells

Hida, K., Ohga, N., Akiyama, K., Maishi, N., & Hida, Y. (2013) · Cancer Science · doi:10.1111/cas.12251 · Cited by 76

Role of oxidative stress in endothelial insulin resistance

Paneni, F., Costantino, S., & Cosentino, F. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i2.326 · Cited by 76

Glycolytic Phenotype and AMP Kinase Modify the Pathologic Response of Tumor Xenografts to VEGF Neutralization

Nardo, G., Favaro, E., Curtarello, M., Moserle, L., Zulato, E., Persano, L., Rossi, E. M. C., Esposito, G., Crescenzi, M., Casanovas, O., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-0242 · Cited by 75

Maximum activities of some key enzymes of glycolysis, glutaminolysis, Krebs cycle and fatty acid utilization in bovine pulmonary endothelial cells

Leighton, B., Curi, R., Hussein, A., & Newsholme, E. A. (1987) · FEBS Letters · doi:10.1016/0014-5793(87)81137-7 · Cited by 74

Hyperhomocysteinemia Alters Cardiac Substrate Metabolism by Impairing Nitric Oxide Bioavailability Through Oxidative Stress

Suematsu, N., Ojaimi, C., Kinugawa, S., Wang, Z., Xu, X., Koller, Á., Recchia, F. A., & Hintze, T. H. (2007) · Circulation · doi:10.1161/circulationaha.106.652693 · Cited by 74

Control of vessel sprouting by genetic and metabolic determinants

Eelen, G., Cruys, B., Welti, J. C., Bock, K. D., & Carmeliet, P. (2013) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2013.08.006 · Cited by 73

Mast Cell Number, Phenotype, and Function in Human Pulmonary Arterial Hypertension

Farha, S., Sharp, J., Asosingh, K., Park, M. M., COMHAIR, S. A. A., Tang, W. H. W., Thomas, J., Farver, C. F., Hsieh, F. H., Loyd, J. E., et al. (2012) · Pulmonary Circulation · doi:10.4103/2045-8932.97609 · Cited by 72

The HIF1 target geneNOX2promotes angiogenesis through urotensin-II

Diebold, I., Petry, A., Sabrane, K., Djordjevic, T., Hess, J., & Görlach, A. (2012) · Journal of Cell Science · doi:10.1242/jcs.094060 · Cited by 72

Insulin-Regulated Protein Palmitoylation Impacts Endothelial Cell Function

Wei, X., Song, H., & Semenkovich, C. F. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.302848 · Cited by 72

Fructose and Uric Acid: Is There a Role in Endothelial Function?

Jia, G., Aroor, A. R., Whaley‐Connell, A. T., & Sowers, J. R. (2014) · Current Hypertension Reports · doi:10.1007/s11906-014-0434-z · Cited by 71

Hypoxia in microscopic tumors

Li, X., & O’Donoghue, J. A. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.02.037 · Cited by 70

Lipopolysaccharide (LPS)-mediated Angiopoietin-2-dependent Autocrine Angiogenesis Is Regulated by NADPH Oxidase 2 (Nox2) in Human Pulmonary Microvascular Endothelial Cells

Menden, H. L., Welak, S. R., Cossette, S. M., Ramchandran, R., & Sampath, V. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.600692 · Cited by 70

Changes in Human Endothelial Cell Energy Metabolic Capacities during in vitro Cultivation. The Role of “Aerobic Glycolysis” and Proliferation

Peters, K., Kamp, G., Berz, A., Unger, R. E., Barth, S., Salamon, A., Rychly, J., & Kirkpatrick, C. J. (2009) · Cellular Physiology and Biochemistry · doi:10.1159/000257490 · Cited by 70

Endothelium-specific insulin resistance leads to accelerated atherosclerosis in areas with disturbed flow patterns: A role for reactive oxygen species

Gage, M., Yuldasheva, N. Y., Viswambharan, H., Sukumar, P., Cubbon, R. M., Galloway, S. L., Imrie, H., Skromna, A., Smith, J., Jackson, C. L., et al. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.06.017 · Cited by 69

Insulin‐stimulated L ‐arginine transport requires SLC7A1 gene expression and is associated with human umbilical vein relaxation

González, M., Gallardo, V., Rodríguez, N., Salomón, C., Westermeier, F., Guzmán‐Gutiérrez, E., Abarzúa, F., Leiva, A., Casanello, P. C., & Sobrevía, L. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22635 · Cited by 69

Plasma arginine/ADMA ratio as a sensitive risk marker for atherosclerosis: Shimane CoHRE study

Notsu, Y., Yano, S., Shibata, H., Nagai, A., & Nabika, T. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.12.030 · Cited by 69

Human Exercise-Induced Circulating Progenitor Cell Mobilization Is Nitric Oxide-Dependent and Is Blunted in South Asian Men

Cubbon, R. M., Murgatroyd, S. R., Ferguson, C., Bowen, T. S., Rakobowchuk, M., Baliga, V., Cannon, D. T., Rajwani, A., Abbas, A., Kahn, M., et al. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.201012 · Cited by 69

Design and evaluation of novel glutaminase inhibitors

McDermott, L. A., Iyer, P. C., Vernetti, L., Rimer, S., Sun, J., Boby, M. L., Yang, T., Fioravanti, M., O’Neill, J., Wang, L., et al. (2016) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2016.03.009 · Cited by 69

Amino acids as modulators of endothelium-derived nitric oxide

Kakoki, M., Kim, H., Edgell, C. S., Maeda, N., Smithies, O., & Mattson, D. L. (2006) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00417.2005 · Cited by 68

Tumour endothelial cells acquire drug resistance in a tumour microenvironment

Hida, K., Akiyama, K., Ohga, N., Maishi, N., & Hida, Y. (2013) · Journal of Biochemistry · doi:10.1093/jb/mvs152 · Cited by 68

Crucial roles of Nox2‐derived oxidative stress in deteriorating the function of insulin receptors and endothelium in dietary obesity of middle‐aged mice

Du, J., Fan, L. M., Mai, A., & Li, J. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12336 · Cited by 67

Different Effects of Glucose Starvation on Expression and Stability of VEGF mRNA Isoforms in Murine Ovarian Cancer Cells

Zhang, L., Conejo-Garcia, J. R., Yang, N., Huang, W. C., Mohamed-Hadley, A. A., Yao, W., Benencia, F., & Coukos, G. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2002.6710 · Cited by 67

Filamentous actin and its associated binding proteins are the stimulatory site for 6-phosphofructo-1-kinase association within the membrane of human erythrocytes

Real-Hohn, A., Zancan, P., SILVA, D. N. N. D., Martins, E. R., Salgado, L. T., Mermelstein, C., Gomes, A. M. O., & Sola‐Penna, M. (2010) · Biochimie · doi:10.1016/j.biochi.2010.01.023 · Cited by 67

Binding of aldolase to actin-containing filaments. Evidence of interaction with the regulatory proteins of skeletal muscle

Walsh, T. P., Winzor, D. J., Clarke, F. M., et al. (1980) · Biochemical Journal · doi:10.1042/bj1860089 · Cited by 67

X-linked glucose-6-phosphate dehydrogenase deficiency inMus musculus

Pretsch, W., Charles, D. J., & Merkle, S. (1988) · Biochemical Genetics · doi:10.1007/bf00555491 · Cited by 65

Glutamate Dehydrogenase: Structure, Allosteric Regulation, and Role in Insulin Homeostasis

Li, M., Li, C., Allen, A., Stanley, C. A., & Smith, T. J. (2013) · Neurochemical Research · doi:10.1007/s11064-013-1173-2 · Cited by 65

Angiogenesis versus arteriogenesis: neuropilin 1 modulation of VEGF signaling

Kofler, N. M., & Simons, M. (2015) · F1000Prime Reports · doi:10.12703/p7-26 · Cited by 64

Deficiency of Lung Antioxidants in Idiopathic Pulmonary Arterial Hypertension

Masri, F. A., COMHAIR, S. A. A., Dostanic‐Larson, I., Kaneko, F. T., Dweik, R. A., Arroliga, A. C., & ERZURUM, S. C. (2008) · Clinical and Translational Science · doi:10.1111/j.1752-8062.2008.00035.x · Cited by 63

Inhibition of aldose reductase prevents angiogenesis in vitro and in vivo

Tammali, R., Reddy, A. B. M., Srivastava, S. K., & Ramana, K. V. (2011) · Angiogenesis · doi:10.1007/s10456-011-9206-4 · Cited by 63

Induction of lymphatic endothelial cell differentiation in embryoid bodies

Liersch, R., Nay, F., Lu, L., & Detmar, M. J. (2005) · Blood · doi:10.1182/blood-2005-08-3400 · Cited by 63

Asymmetric and symmetric dimethylarginine and risk of secondary cardiovascular disease events and mortality in patients with stable coronary heart disease: the KAROLA follow-up study

Siegerink, B., Maas, R., Vossen, C. Y., Schwedhelm, E., Köenig, W., Böger, R. H., Rothenbacher, D., Brenner, H., & Breitling, L. P. (2012) · Clinical Research in Cardiology · doi:10.1007/s00392-012-0515-4 · Cited by 63

Bosentan inhibits oxidative and nitrosative stress and rescues occlusive pulmonaryhypertension

Rafikova, O., Rafikov, R., Kumar, S., Sharma, S., Aggarwal, S., Schneider, F., Jonigk, D. D., Black, S. M., & Tofovic, S. P. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.09.013 · Cited by 62

G lyoxalase I reduces glycative and oxidative stress and prevents age‐related endothelial dysfunction through modulation of endothelial nitric oxide synthase phosphorylation

Jo‐Watanabe, A., Ohse, T., Nishimatsu, H., Takahashi, M., Ikeda, Y., Wada, T., Shirakawa, J., Nagai, R., Miyata, T., Nagano, T., et al. (2014) · Aging Cell · doi:10.1111/acel.12204 · Cited by 62

Glutamine and fatty acid oxidation are the main sources of energy for Kupffer and endothelial cells

Spolarics, Z., Lang, C. H., Bagby, G. J., & Spitzer, J. J. (1991) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1991.261.2.g185 · Cited by 62

Dual role of fatty acid-binding protein 5 on endothelial cell fate: a potential link between lipid metabolism and angiogenic responses

Yu, D. C. W., Liang, X., Lipsky, S., Karaaslan, Ç., Kozakewich, H. P., Hotamışlıgil, G. S., Bischoff, J. E., & Çataltepe, S. (2015) · Angiogenesis · doi:10.1007/s10456-015-9491-4 · Cited by 62

Human Aldose Reductase Expression Accelerates Atherosclerosis in Diabetic Apolipoprotein E−/− Mice

Vedantham, S., Noh, H. L., Ananthakrishnan, R., Son, N. H., Hallam, K. M., Hu, Y., Yu, S., Shen, X., Rosario, R., Lu, Y., et al. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.226902 · Cited by 61

Possible mechanisms of C-reactive protein mediated acute myocardial infarction

Asare, P. F., Wang, Y., Shi, Y., Agyemang, K., Akinyi, M., Zhang, Q., & Fan, G. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.04.010 · Cited by 61

Pulmonary Artery Endothelium Resident Endothelial Colony‐Forming Cells in Pulmonary Arterial Hypertension

Duong, H. T., COMHAIR, S. A. A., Aldred, M. A., Mavrakis, L. A., Savasky, B. M., ERZURUM, S. C., & Asosingh, K. (2011) · Pulmonary Circulation · doi:10.4103/2045-8932.93547 · Cited by 61

Diabetic angiopathy and angiogenic defects

Xu, L., Kanasaki, K., Kitada, M., & Koya, D. (2012) · Fibrogenesis & Tissue Repair · doi:10.1186/1755-1536-5-13 · Cited by 60

AMP-activated protein kinase rescues the angiogenic functions of endothelial progenitor cells via manganese superoxide dismutase induction in type 1 diabetes

Wang, X., Zhang, M., Chen, D.-D., Zhang, Y., & Chen, A. F. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00001.2011 · Cited by 59

O-GlcNAcase overexpression reverses coronary endothelial cell dysfunction in type 1 diabetic mice

Makino, A., Dai, A., Han, Y., Youssef, K. D., Wang, W., Donthamsetty, R., Scott, B. T., Wang, H., & DILLMANN, W. H. (2015) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00069.2015 · Cited by 59

Mitochondrial signaling in the vascular endothelium: beyond reactive oxygen species

Kadlec, A. O., Beyer, A., Ait‐Aissa, K., & Gutterman, D. D. (2016) · Basic Research in Cardiology · doi:10.1007/s00395-016-0546-5 · Cited by 59

Dynamics of NAD-metabolism: everything but constant

Opitz, C. A., & Heiland, I. (2015) · Biochemical Society Transactions · doi:10.1042/bst20150133 · Cited by 58

Functional Role of HSP90 Complexes with Endothelial Nitric-oxide Synthase (eNOS) and Calpain on Nitric Oxide Generation in Endothelial Cells

Averna, M., Stifanese, R., TULLIO, R. D., Passalacqua, M., Salamino, F., Pontremoli, S., & Melloni, E. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803638200 · Cited by 57

Augmentation of Vascular Remodeling by Uncoupled Endothelial Nitric Oxide Synthase in a Mouse Model of Diabetes Mellitus

Sasaki, N., Yamashita, T., Takaya, T., Shinohara, M., Shiraki, R., Takeda, M., Emoto, N., Fukatsu, A., Hayashi, T., Ikemoto, K., et al. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.160754 · Cited by 57

Control of endothelial sprouting by a Tel–CtBP complex

Roukens, M. G., Alloul‐Ramdhani, M., Baan, B., Kobayashi, K., Peterson-Maduro, J., van Dam, H., Schulte‐Merker, S., & Baker, D. A. (2010) · Nature Cell Biology · doi:10.1038/ncb2096 · Cited by 57

Presence of glutamine:fructose-6-phosphate amidotransferase for glucosamine-6-phosphate synthesis in endothelial cells: effects of hyperglycaemia and glutamine

Wu, G., Haynes, T. E., Wene, Y. A. N., & Meininger, C. J. (2001) · Diabetologia · doi:10.1007/s001250051599 · Cited by 57

Phosphorylation inactivation of endothelial nitric oxide synthesis in pulmonary arterial hypertension

Ghosh, S., Gupta, M. K., Xu, W., Mavrakis, D. A., Janocha, A. J., COMHAIR, S. A. A., Haque, M. M., Stuehr, D. J., Yu, J., POLGAR, P. R., et al. (2016) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00092.2016 · Cited by 57

Nitric Oxide Synthase in Pulmonary Hypertension: Lessons from Knockout Mice

Fagan, K. A., McMurtry, I. F., & Rodman, D. M. (2000) · Physiological Research · doi:10.33549/physiolres.930000.49.539 · Cited by 57

Shear stress modulates endothelial KLF2 through activation of P2X4

Sathanoori, R., Rosi, F., Gu, B. J., Wiley, J. S., Müller, C. E., Olde, B., & Erlinge, D. (2015) · Purinergic Signalling · doi:10.1007/s11302-014-9442-3 · Cited by 56

Hypoxia and Dark Adaptation in Diabetic Retinopathy: Interactions, Consequences, and Therapy

Ramsey, D. J., & Arden, G. B. (2015) · Current Diabetes Reports · doi:10.1007/s11892-015-0686-2 · Cited by 55

Stimulation of tetrahydrobiopterin synthesis induced by insulin: possible involvement of phosphatidylinositol 3-kinase

Ishii, M., Shimizu, S., Nagai, T., Shiota, K., Kiuchi, Y., & Yamamoto, T. (2001) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(00)00070-4 · Cited by 54

l-Leucine and NO-mediated cardiovascular function

Yang, Y., Wu, Z., Meininger, C. J., & Wu, G. (2014) · Amino Acids · doi:10.1007/s00726-014-1904-y · Cited by 53

Incomplete and transitory decrease of glycolysis

Schoors, S., Cantelmo, A. R., Γεωργιάδου, Μ., Stapor, P. C., Wang, X., Quaegebeur, A., Cauwenberghs, S., Wong, B. W., Bifari, F., Decimo, I., et al. (2013) · Cell Cycle · doi:10.4161/cc.27519 · Cited by 53

Histone Demethylases KDM4A and KDM4C Regulate Differentiation of Embryonic Stem Cells to Endothelial Cells

Wu, L., Wary, K. K., Revskoy, S., Gao, X., Tsang, K., Komarova, Y. A., Rehman, J., & Malik, A. B. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2015.05.016 · Cited by 52

Mitochondrial Coupling Factor 6 Is Present on the Surface of Human Vascular Endothelial Cells and Is Released by Shear Stress

Osanai, T., Okada, S., Sirato, K., Nakano, T., Saitoh, M., Magota, K., & Okumura, K. (2001) · Circulation · doi:10.1161/hc5001.100832 · Cited by 52

Pin1 inhibitor Juglone prevents diabetic vascular dysfunction

Costantino, S., Paneni, F., Lüscher, T. F., & Cosentino, F. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.10.221 · Cited by 51

Cross-talk between SIRT1 and p66Shc in vascular diseases

Chen, H., Wan, Y.-Z., & Liu, D. (2013) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2013.01.001 · Cited by 49

Relationship between circulating endothelial progenitor cells and endothelial dysfunction in children with type 1 diabetes: a novel paradigm of early atherosclerosis in high-risk young patients

Głowińska‐Olszewska, B., Moniuszko, M., Hryniewicz, A., Jeznach, M., Rusak, M., Dąbrowska, M., Łuczyński, W., Bodzenta‐Łukaszyk, A., & Bossowski, A. (2012) · European Journal of Endocrinology · doi:10.1530/eje-12-0857 · Cited by 48

Increased Plasma S-Adenosylhomocysteine–Accelerated Atherosclerosis Is Associated With Epigenetic Regulation of Endoplasmic Reticulum Stress in apoE−/−Mice

Xiao, Y., Huang, W. H., Zhang, J., Peng, C., Xia, M., & Ling, W. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.303817 · Cited by 47

Tip cell overtaking occurs as a side effect of sprouting in computational models of angiogenesis

Boas, S. E. M., & Merks, R. M. H. (2015) · BMC Systems Biology · doi:10.1186/s12918-015-0230-7 · Cited by 46

The RNA-binding protein quaking maintains endothelial barrier function and affects VE-cadherin and β-catenin protein expression

de Bruin, R. G., van der Veer, E. P., Prins, J., Lee, D. H., Dane, M. J. C., Zhang, H., Roeten, M. K., Bijkerk, R., de Boer, H. C., Rabelink, T. J., et al. (2016) · Scientific Reports · doi:10.1038/srep21643 · Cited by 46

Downregulation of miR-382 by propranolol inhibits the progression of infantile hemangioma via the PTEN-mediated AKT/mTOR pathway

Li, D., Li, P., Guo, Z., Wang, H., & Pan, W. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.2863 · Cited by 46

Expression and functional relevance of UGT 1 A 4 in a cohort of human drug‐resistant epileptic brains

Ghosh, C., Hossain, M., Puvenna, V., Martinez‐Gonzalez, J., Alexopolous, A., Janigro, D., & Marchi, N. (2013) · Epilepsia · doi:10.1111/epi.12318 · Cited by 44

Role of DDAH-1 in lipid peroxidation product-mediated inhibition of endothelial NO generation

Pope, A. J., Druhan, L. J., Guzman, J. E., Forbes, S. P., Murugesan, V., Lu, D., Xia, Y., Chicoine, L. G., Parinandi, N. L., & Cardounel, A. J. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00224.2007 · Cited by 44

Notable epigenetic role of hyperhomocysteinemia in atherogenesis

Zhou, S., Zhang, Z., & Xu, G. (2014) · Lipids in Health and Disease · doi:10.1186/1476-511x-13-134 · Cited by 44

Differential Roles of Protein Complexes NOX1-NOXO1 and NOX2-p47phox in Mediating Endothelial Redox Responses to Oscillatory and Unidirectional Laminar Shear Stress

Siu, K. L., Gao, L., & Cai, H. “. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.713149 · Cited by 44

Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signaling Loop

Viswambharan, H., Yuldasheva, N. Y., Sengupta, A., Imrie, H., Gage, M. C., Haywood, N., Walker, A. M. N., Skromna, A., Makova, N., Galloway, S., et al. (2017) · Circulation Research · doi:10.1161/circresaha.116.309678 · Cited by 43

Metanx Alleviates Multiple Manifestations of Peripheral Neuropathy and Increases Intraepidermal Nerve Fiber Density in Zucker Diabetic Fatty Rats

Shevalye, H., Watcho, P., Stavniichuk, R., Dyukova, E., Lupachyk, S., & Obrosova, I. G. (2012) · Diabetes · doi:10.2337/db11-1524 · Cited by 42

Symmetric dimethylarginine alters endothelial nitric oxide activity in glomerular endothelial cells

Féliers, D., Lee, D. Y., Gorin, Y. C., & Kasinath, B. S. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2014.09.024 · Cited by 41

A Possible Target of Antioxidative Therapy for Diabetic Vascular Complications-Vascular NAD(P)H Oxidase

Inoguchi, T., Tsubouchi, H., Etoh, T., Kakimoto, M., Sonta, T., Utsumi, H., Sumimoto, H., Hai, Y., Sonoda, N., Inuo, M., et al. (2003) · Current Medicinal Chemistry · doi:10.2174/0929867033457133 · Cited by 41

γ-Aminobutyric Acid Is Synthesized and Released by the Endothelium

Sen, S., Roy, S., Bandyopadhyay, G. K., Scott, B., Xiao, D., Ramadoss, S., Mahata, S. K., & Chaudhuri, G. (2016) · Circulation Research · doi:10.1161/circresaha.116.308645 · Cited by 41

Plasma concentration of coupling factor 6 and cardiovascular events in patients with end-stage renal disease

Osanai, T., Nakamura, M., Sasaki, S., Tomita, H., Saitoh, M., Osawa, H., Yamabe, H., Murakami, S., Magota, K., & Okumura, K. (2003) · Kidney International · doi:10.1046/j.1523-1755.2003.00334.x · Cited by 39

Ratio of S-adenosylmethionine to S-adenosylhomocysteine as a sensitive indicator of atherosclerosis

Zhang, H., Liu, Z., Ma, S., Zhang, H., Kong, F., He, Y., Yang, X., Wang, Y., Xu, H., Yang, A., et al. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5230 · Cited by 39

Autocrine VEGF maintains endothelial survival through regulation of metabolism and autophagy

Domigan, C. K., Warren, C. M., Antanesian, V., Happel, K., Ziyad, S., Lee, S., Krall, A. S., Duan, L., Torres‐Collado, A. X., Castellani, L. W., et al. (2015) · Development · doi:10.1242/dev.127480 · Cited by 39

p66Shc-induced redox changes drive endothelial insulin resistance

Paneni, F., Costantino, S., & Cosentino, F. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.07.027 · Cited by 38

The erbB/HER type 1 tyrosine kinase receptor family

Walker, R. A. (1998) · The Journal of Pathology · doi:10.1002/(sici)1096-9896(199807)185:3<313::aid-path93>3.0.co;2-8 · Cited by 38

The Subcellular Compartmentalization of Arginine Metabolizing Enzymes and Their Role in Endothelial Dysfunction

Chen, F., Lucas, R., & Fulton, D. J. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00184 · Cited by 38

Crosstalk between oxygen- and nitric oxide-dependent signaling pathways in angiogenesis

Fraisl, P. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.02.010 · Cited by 37

Estradiol inhibits vascular endothelial cells pro-inflammatory activation induced by C-reactive protein

Cossette, É., Cloutier, I., Tardif, K., DonPierre, G., & Tanguay, J. (2012) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-012-1482-9 · Cited by 37

Prevention of VEGF-induced growth and tube formation in human retinal endothelial cells by aldose reductase inhibition

Yadav, U. C. S., Srivastava, S. K., & Ramana, K. V. (2012) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2012.04.017 · Cited by 36

Immunochemical crossreactivity of antibodies specific for “advanced glycation endproducts” with “advanced lipoxidation endproducts”

Richter, T., Münch, G. W., Lüth, H., Arendt, T., Kientsch-Engel, R., Stahl, P., Fengler, D., & Kuhla, B. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.04.009 · Cited by 35

Circulating coupling factor 6 in human hypertension: role of reactive oxygen species

Osanai, T., Sasaki, S., Kamada, T., Fujiwara, N., Nakano, T., Tomita, H., Matsunaga, T., Magota, K., & Okumura, K. (2003) · Journal of Hypertension · doi:10.1097/00004872-200312000-00021 · Cited by 35

Insulin-Mediated Activation of the L-Arginine Nitric Oxide Pathway in Man, and Its Impairment in Diabetes

Rajapakse, N. W., Chong, A. L., Zhang, W., & Kaye, D. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061840 · Cited by 35

PFKFB3 Control of Cancer Growth by Responding to Circadian Clock Outputs

Chen, L., Zhao, J., Tang, Q., Li, H., Zhang, C., Yu, R., Zhao, Y., Huo, Y., & Wu, C. (2016) · Scientific Reports · doi:10.1038/srep24324 · Cited by 35

Methylglyoxal modulates endothelial nitric oxide synthase-associated functions in EA.hy926 endothelial cells

Su, Y., Qadri, S. M., Wu, L., & Liu, L. (2013) · Cardiovascular Diabetology · doi:10.1186/1475-2840-12-134 · Cited by 34

Liver Sinusoidal Endothelial Cells Link Hyperinsulinemia to Hepatic Insulin Resistance

Tsuchiya, K., & Accili, D. (2013) · Diabetes · doi:10.2337/db12-1296 · Cited by 34

Homocysteine reduces protein S-nitrosylation in endothelium

Chen, Y., Zhao, S., Wang, Y., Li, Y., Bai, L., Liu, R., Fan, J., & Liu, E. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1920 · Cited by 33

Vascular endothelial cell proliferation: regulation of cellular polyamines

Morrison, R. F., & Seidel, E. R. (1995) · Cardiovascular Research · doi:10.1016/s0008-6363(96)88621-4 · Cited by 33

Regulation of glycolysis by the hypoxia-inducible factor (HIF): Implications for cellular physiology

Kierans, S. J., & Taylor, C. T. (2021) · The Journal of Physiology · doi:10.1113/jp280572 · Cited by 1,015

A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling

Qian, J., Olbrecht, S., Boeckx, B., Vos, H., Laoui, D., Etlioglu, E., Wauters, E., Pomella, V., Verbandt, S., Busschaert, P., et al. (2020) · Cell Research · doi:10.1038/s41422-020-0355-0 · Cited by 817

Methylglyoxal, a Highly Reactive Dicarbonyl Compound, in Diabetes, Its Vascular Complications, and Other Age-Related Diseases

Schalkwijk, C. G., & Stehouwer, C. D. A. (2020) · Physiological Reviews · doi:10.1152/physrev.00001.2019 · Cited by 622

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Yang, J., & Liu, Z. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.816400 · Cited by 281

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Clere, N., Renault, S., & Corre, I. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00747 · Cited by 199