Mitochondrial damage-associated molecular patterns and vascular function
Open accessAbstract
Immune system activation occurs not only due to foreign stimuli, but also due to endogenous molecules. As such, endogenous molecules that are released into the circulation due to cell death and/or injury alarm the immune system that something has disturbed homeostasis and a response is needed. Collectively, these molecules are known as damage-associated molecular patterns (DAMPs). Mitochondrial DAMPs (mtDAMPs) are potent immunological activators due to the bacterial ancestry of mitochondria. Mitochondrial DAMPs are recognized by specific pattern recognition receptors of the innate immune system, some of which are expressed in the cardiovascular system. Cell death leads to release of mtDAMPs that may induce vascular changes by mechanisms that are currently not well understood. This review will focus on recently published evidence linking mtDAMPs and immune system activation to vascular dysfunction and cardiovascular disease.
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mtDNA can induce a pro-inflammatory state.
“Mitochondria are a source of damage-associated molecular patterns (DAMPs), and among others, mtDNA has been shown to induce a pro-inflammatory state (Zhang et al, 2010;Oka et al, 2012;Wenceslau et al, 2014).”
From Mitochondrial DNA and TLR9 drive muscle inflammation upon Opa1 deficiency (2018) · cites this paper as Wenceslau et al, 2014
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Mitochondrial DNA and TLR9 drive muscle inflammation upon Opa1 deficiency
Rodríguez‐Nuevo, A., Díaz‐Ramos, A., Noguera, E., Díaz‐Sáez, F., Duran, X., Muñoz, J. P., Romero, M., Plana, N., Sebastián, D., Tezze, C., et al. (2018) · The EMBO Journal · doi:10.15252/embj.201796553 · Cited by 207 · see citing works
Khashchenko, E., Vysokikh, M., Uvarova, E., Krechetova, L., Vtorushina, V., Ivanets, T., Volodina, M., Tarasova, N., Sukhanova, I., & Sukhikh, G. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9051399 · Cited by 64 · see citing works
- Authors
- Wenceslau, C. F., McCarthy, C. G., Szasz, T., Spitler, K., Goulopoulou, S., Webb, R. C., & Working Group on DAMPs in Cardiovascular Disease
- Affiliations
- Augusta University (US)
- Corresponding author
- Wenceslau, C. F.
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-02-25
- Volume
- 35
- Issue
- 18
- Pages
- 1172-1177
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- PMC
- PMC4012709
- OpenAlex
- W2020415048
- Cited by
- 135
- References
- 59
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 7 · 2023: 8 · 2022: 7 · 2021: 12 · 2020: 15 · 2019: 10 · 2018: 15 · 2017: 12 · 2016: 17 · 2015: 8 · 2014: 6
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- European Heart Journal (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- mitochondrial damage-associated molecular patterns, vascular function, vascular dysfunction, cardiovascular disease, innate immunity, pattern recognition receptors, mitochondrial origin, cell death, immune activation
- MeSH terms
- Cardiovascular Diseases, DNA, Mitochondrial, Humans, Immunity, Innate, Mitochondria, Oligopeptides, Cytokines, Mitochondrial Diseases
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