Endothelial Cell Metabolism

Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton

Hu, H., Juvekar, A., Lyssiotis, C. A., Lien, E. C., Albeck, J. G., Oh, D., Varma, G., Hung, Y. P., Ullas, S., Lauring, J., et al. (2016) · Cell · doi:10.1016/j.cell.2015.12.042 · Cited by 380

Hyperproliferative apoptosis-resistant endothelial cells in idiopathic pulmonary arterial hypertension

Masri, F. A., Xu, W., Comhair, S. A. A., Asosingh, K., Koo, M., Vasanji, A., Drazba, J., Anand-Apte, B., & Erzurum, S. C. (2007) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00428.2006 · Cited by 376

Prevention of Incipient Diabetic Nephropathy by High-Dose Thiamine and Benfotiamine

Babaei-Jadidi, R., Karachalias, N., Ahmed, N., Battah, S., & Thornalley, P. J. (2003) · Diabetes · doi:10.2337/diabetes.52.8.2110 · Cited by 373

Insulin-Dependent Activation of Endothelial Nitric Oxide Synthase Is Impaired by O-Linked Glycosylation Modification of Signaling Proteins in Human Coronary Endothelial Cells

Federici, M., Menghini, R., Mauriello, A., Hribal, M. L., Ferrelli, F., Lauro, D., Sbraccia, P., Spagnoli, L. G., Sesti, G., & Lauro, R. (2002) · Circulation · doi:10.1161/01.cir.0000023043.02648.51 · Cited by 373

Liver glucose metabolism in humans

Adeva-Andany, M. M., Pérez-Felpete, N., Fernández-Fernández, C., Donapetry-García, C., & Pazos-García, C. (2016) · Bioscience Reports · doi:10.1042/bsr20160385 · Cited by 372

Increased arginase II and decreased NO synthesis in endothelial cells of patients with pulmonary arterial hypertension

Xu, W., Kaneko, F. T., Zheng, S., Comhair, S. A. A., Janocha, A. J., Goggans, T., Thunnissen, F. B. J. M., Farver, C., Hazen, S. L., Jennings, C., et al. (2004) · The FASEB Journal · doi:10.1096/fj.04-2317fje · Cited by 369

II. Glutamine and glutamate

Tapiero, H., Mathé, G., Couvreur, P., & Tew, K. D. (2002) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(02)00285-8 · Cited by 369

Impaired Amino Acid Transport at the Blood Brain Barrier Is a Cause of Autism Spectrum Disorder

Tărlungeanu, D. C., Deliu, E., Dotter, C. P., Kara, M., Janiesch, P. C., Scalise, M., Galluccio, M., Tesulov, M., Morelli, E., Sonmez, F. M., et al. (2016) · Cell · doi:10.1016/j.cell.2016.11.013 · Cited by 367

Oxidative Stress in Severe Pulmonary Hypertension

Bowers, R., Cool, C., Murphy, R. C., Tuder, R. M., Hopken, M. W., Flores, S. C., & Voelkel, N. F. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200301-147oc · Cited by 366

Differential Regulation of Glucose Transport and Transporters by Glucose in Vascular Endothelial and Smooth Muscle Cells

Kaiser, N., Sasson, S., Feener, E. P., Boukobza-Vardi, N., Higashi, S., Moller, D. E., Davidheiser, S., Przybylski, R. J., & King, G. L. (1993) · Diabetes · doi:10.2337/diab.42.1.80 · Cited by 359

The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance

Vicent, D., Ilany, J., Kondo, T., Naruse, K., Fisher, S. J., Kisanuki, Y. Y., Bursell, S., Yanagisawa, M., King, G. L., & Kahn, C. R. (2003) · Journal of Clinical Investigation · doi:10.1172/jci15211 · Cited by 356

Molecular Insights and Therapeutic Targets for Diabetic Endothelial Dysfunction

Xu, J., & Zou, M.-H. (2009) · Circulation · doi:10.1161/circulationaha.108.835223 · Cited by 353

Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation

McDonnell, E., Crown, S. B., Fox, D. B., Kitir, B., Ilkayeva, O. R., Olsen, C. A., Grimsrud, P. A., & Hirschey, M. D. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.10.012 · Cited by 351

Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice

Zhang, Q.-J., Wang, Z., Chen, H.-Z., Zhou, S., Zheng, W., Liu, G., Wei, Y.-S., Cai, H., Liu, D.-P., & Liang, C.-C. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn224 · Cited by 349

Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation

Du, X., Edelstein, D., Obici, S., Higham, N., Zou, & Brownlee, M. (2006) · Journal of Clinical Investigation · doi:10.1172/jci23354 · Cited by 347

O-GlcNAc signaling: a metabolic link between diabetes and cancer?

Slawson, C., Copeland, R. J., & Hart, G. W. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.04.005 · Cited by 346

Mitochondria, endothelial cell function, and vascular diseases

Tang, X., Luo, Y.-X., Chen, H.-Z., & Liu, D.-P. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00175 · Cited by 345

GPIHBP1 Is Responsible for the Entry of Lipoprotein Lipase into Capillaries

Davies, B. S. J., Beigneux, A. P., Barnes, R. H., Tu, Y., Gin, P., Weinstein, M. M., Nobumori, C., Nyrén, R., Goldberg, I., Olivecrona, G., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.04.016 · Cited by 342

The role of fatty acid β-oxidation in lymphangiogenesis

Wong, B. W., Wang, X., Zecchin, A., Thienpont, B., Cornelissen, I., Kalucka, J., García-Caballero, M., Missiaen, R., Huang, H., Brüning, U., et al. (2017) · Nature · doi:10.1038/nature21028 · Cited by 336

Pulsatile Versus Oscillatory Shear Stress Regulates NADPH Oxidase Subunit Expression: Implication for Native LDL Oxidation

Hwang, J., Ing, M. H., Salazar, A., Lassègue, B., Griendling, K., Navab, M., Sevanian, A., & Hsiai, T. K. (2003) · Circulation Research · doi:10.1161/01.res.0000104087.29395.66 · Cited by 334

Metabolomics in cancer biomarker discovery: Current trends and future perspectives

Armitage, E. G., & Barbas, C. (2014) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2013.08.041 · Cited by 331

Inhibition of Phosphatidylinositol 3-Kinase Enhances Mitogenic Actions of Insulin in Endothelial Cells

Montagnani, M., Golovchenko, I., Kim, I., Koh, G. Y., Goalstone, M. L., Mundhekar, A. N., Johansen, M., Kucik, D. F., Quon, M. J., & Draznin, B. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m103728200 · Cited by 330

Abnormal biopterin metabolism is a major cause of impaired endothelium-dependent relaxation through nitric oxide/O2- imbalance in insulin-resistant rat aorta.

Shinozaki, K., Kashiwagi, A., Nishio, Y., Okamura, T., Yoshida, Y., Masada, M., Toda, N., & Kikkawa, R. (1999) · Diabetes · doi:10.2337/diabetes.48.12.2437 · Cited by 329

Mitochondrial reserve capacity in endothelial cells: The impact of nitric oxide and reactive oxygen species

Dranka, B. P., Hill, B. G., & Darley-Usmar, V. M. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.01.015 · Cited by 329

Fatty acid binding protein 4 is a target of VEGF and a regulator of cell proliferation in endothelial cells

Elmasri, H., Karaaslan, C., Teper, Y., Ghelfi, E., Weng, M., Ince, T. A., Kozakewich, H., Bischoff, J., & Cataltepe, S. (2009) · The FASEB Journal · doi:10.1096/fj.09-134882 · Cited by 328

Pathways and Subcellular Compartmentation of NAD Biosynthesis in Human Cells

Nikiforov, A., Dölle, C., Niere, M., & Ziegler, M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.213298 · Cited by 326

Role of glutamine and interlinked asparagine metabolism in vessel formation

Huang, H., Vandekeere, S., Kalucka, J., Bierhansl, L., Zecchin, A., Brüning, U., Visnagri, A., Yuldasheva, N., Goveia, J., Cruys, B., et al. (2017) · The EMBO Journal · doi:10.15252/embj.201695518 · Cited by 320

The Wnt/β-Catenin Pathway Modulates Vascular Remodeling and Specification by Upregulating Dll4/Notch Signaling

Corada, M., Nyqvist, D., Orsenigo, F., Caprini, A., Giampietro, C., Taketo, M. M., Iruela-Arispe, M. L., Adams, R. H., & Dejana, E. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.05.006 · Cited by 318

Endothelial NADPH oxidases: which NOX to target in vascular disease?

Drummond, G. R., & Sobey, C. G. (2014) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2014.06.012 · Cited by 315

The Metabolic Theory of Pulmonary Arterial Hypertension

Paulin, R., & Michelakis, E. D. (2014) · Circulation Research · doi:10.1161/circresaha.115.301130 · Cited by 314

Atherosclerosis: Successes, Surprises, and Future Challenges

Libby, P., Bornfeldt, K. E., & Tall, A. R. (2016) · Circulation Research · doi:10.1161/circresaha.116.308334 · Cited by 314

Pericytes promote endothelial cell survival through induction of autocrine VEGF-A signaling and Bcl-w expression

Franco, M., Roswall, P., Cortez, E., Hanahan, D., & Pietras, K. (2011) · Blood · doi:10.1182/blood-2011-01-331694 · Cited by 310

Regulation of Endothelial Cell Differentiation and Specification

Marcelo, K. L., Goldie, L. C., & Hirschi, K. K. (2013) · Circulation Research · doi:10.1161/circresaha.113.300506 · Cited by 307

Free Fatty Acid Impairment of Nitric Oxide Production in Endothelial Cells Is Mediated by IKKβ

Kim, F., Tysseling, K. A., Rice, J., Pham, M., Haji, L., Gallis, B. M., Baas, A. S., Paramsothy, P., Giachelli, C. M., Corson, M. A., et al. (2005) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000160549.60980.a8 · Cited by 307

Characterization of the receptors for vascular endothelial growth factor.

Vaisman, N., Gospodarowicz, D., & Neufeld, G. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)45395-6 · Cited by 303

Loss of Insulin Signaling in Vascular Endothelial Cells Accelerates Atherosclerosis in Apolipoprotein E Null Mice

Rask-Madsen, C., Li, Q., Freund, B., Feather, D., Abramov, R., Wu, I.-H., Chen, K., Yamamoto-Hiraoka, J., Goldenbogen, J., Sotiropoulos, K. B., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.03.013 · Cited by 303

Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation

Xue, M., Rabbani, N., Momiji, H., Imbasi, P., Anwar, M. M., Kitteringham, N., Park, B. K., Souma, T., Moriguchi, T., Yamamoto, M., et al. (2012) · Biochemical Journal · doi:10.1042/bj20111648 · Cited by 302

Initial apoptosis is followed by increased proliferation of apoptosis‐resistant endothelial cells

Sakao, S., Taraseviciene‐Stewart, L., Lee, J. D., Wood, K., Cool, C. D., & Voelkel, N. F. (2005) · The FASEB Journal · doi:10.1096/fj.04-3261fje · Cited by 301

Direct evidence of a role for Nox2 in superoxide production, reduced nitric oxide bioavailability, and early atherosclerotic plaque formation in ApoE−/−mice

Judkins, C. P., Diep, H., Broughton, B. R. S., Mast, A. E., Hooker, E. U., Miller, A. A., Selemidis, S., Dusting, G. J., Sobey, C. G., & Drummond, G. R. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00799.2009 · Cited by 299

Laminar Shear Stress Inhibits Endothelial Cell Metabolism via KLF2-Mediated Repression of PFKFB3

Doddaballapur, A., Michalik, K. M., Manavski, Y., Lucas, T., Houtkooper, R. H., You, X., Chen, W., Zeiher, A. M., Potente, M., Dimmeler, S., et al. (2015) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.114.304277 · Cited by 297

Altered angiogenesis and survival in human tumor‐derived endothelial cells

Bussolati, B., Deambrosis, I., Russo, S., Deregibus, M. C., & Camussi, G. (2003) · The FASEB Journal · doi:10.1096/fj.02-0557fje · Cited by 288

Nitric oxide and the proliferation of vascular smooth muscle cells

Jeremy, J. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(99)00171-6 · Cited by 285

Increase in Three α,β-Dicarbonyl Compound Levels in Human Uremic Plasma: Specificin VivoDetermination of Intermediates in Advanced Maillard Reaction

Odani, H., Shinzato, T., Matsumoto, Y., Usami, J., & Maeda, K. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0221 · Cited by 284

Microarray analysis of retinal endothelial tip cells identifies CXCR4 as a mediator of tip cell morphology and branching

Strasser, G. A., Kaminker, J. S., & Tessier-Lavigne, M. (2010) · Blood · doi:10.1182/blood-2009-07-230284 · Cited by 283

Endothelin 1 transcription is controlled by nuclear factor-kappaB in AGE-stimulated cultured endothelial cells.

Quehenberger, P., Bierhaus, A., Fasching, P., Muellner, C., Klevesath, M., Hong, M., Stier, G., Sattler, M., Schleicher, E., Speiser, W., et al. (2000) · Diabetes · doi:10.2337/diabetes.49.9.1561 · Cited by 283

Sirtuin 1-Mediated Cellular Metabolic Memory of High Glucose via the LKB1/AMPK/ROS Pathway and Therapeutic Effects of Metformin

Zheng, Z., Chen, H., Li, J., Li, T., Zheng, B., Zheng, Y., Jin, H., He, Y., Gu, Q., & Xu, X. (2012) · Diabetes · doi:10.2337/db11-0416 · Cited by 282

Current trends and future requirements for the mass spectrometric investigation of microbial, mammalian and plant metabolomes

Dunn, W. B. (2008) · Physical Biology · doi:10.1088/1478-3975/5/1/011001 · Cited by 278

Lactate Activates HIF-1 in Oxidative but Not in Warburg-Phenotype Human Tumor Cells

De Saedeleer, C. J., Copetti, T., Porporato, P. E., Verrax, J., Feron, O., & Sonveaux, P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046571 · Cited by 277

Repression of P66Shc Expression by SIRT1 Contributes to the Prevention of Hyperglycemia-Induced Endothelial Dysfunction

Zhou, S., Chen, H.-Z., Wan, Y.-Z., Zhang, Q.-J., Wei, Y.-S., Huang, S., Liu, J.-J., Lu, Y.-B., Zhang, Z.-Q., Yang, R.-F., et al. (2011) · Circulation Research · doi:10.1161/circresaha.111.243592 · Cited by 273

MicroRNA‐320 EXPRESSION IN MYOCARDIAL MICROVASCULAR ENDOTHELIAL CELLS AND ITS RELATIONSHIP WITH INSULIN‐LIKE GROWTH FACTOR‐1 IN TYPE 2 DIABETIC RATS

Wang, X., Qian, R., Zhang, W., Chen, S., Jin, H., & Hu, R. (2009) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2008.05057.x · Cited by 271

The Metabolic Basis of Pulmonary Arterial Hypertension

Sutendra, G., & Michelakis, E. D. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.01.004 · Cited by 268

Hypoxia Inducible-Factor1α Regulates the Metabolic Shift of Pulmonary Hypertensive Endothelial Cells

Fijalkowska, I., Xu, W., Comhair, S. A. A., Janocha, A. J., Mavrakis, L. A., Krishnamachary, B., Zhen, L., Mao, T., Richter, A., Erzurum, S. C., et al. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.090832 · Cited by 263

Aerobically Derived Lactate Stimulates Revascularization and Tissue Repair via Redox Mechanisms

Hunt, T. K., Aslam, R. S., Beckert, S., Wagner, S., Ghani, Q. P., Hussain, M. Z., Roy, S., & Sen, C. K. (2007) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1674 · Cited by 261

The Golgi Association of Endothelial Nitric Oxide Synthase Is Necessary for the Efficient Synthesis of Nitric Oxide

Sessa, W. C., Garca-Cardea, G., Liu, J., Keh, A., Pollock, J. S., Bradley, J., Thiru, S., Braverman, I. M., & Desai, K. M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.30.17641 · Cited by 258

Modulation of Endothelial Glycocalyx Structure under Inflammatory Conditions

Kolářová, H., Ambrůzová, B., Švihálková Šindlerová, L., Klinke, A., & Kubala, L. (2014) · Mediators of Inflammation · doi:10.1155/2014/694312 · Cited by 257

Further Pharmacological and Genetic Evidence for the Efficacy of PlGF Inhibition in Cancer and Eye Disease

Van de Veire, S., Stalmans, I., Heindryckx, F., Oura, H., Tijeras-Raballand, A., Schmidt, T., Loges, S., Albrecht, I., Jonckx, B., Vinckier, S., et al. (2010) · Cell · doi:10.1016/j.cell.2010.02.039 · Cited by 256

Lactate promotes glioma migration by TGF-β2–dependent regulation of matrix metalloproteinase-2

Baumann, F., Leukel, P., Doerfelt, A., Beier, C. P., Dettmer, K., Oefner, P. J., Kastenberger, M., Kreutz, M., Nickl-Jockschat, T., Bogdahn, U., et al. (2009) · Neuro-Oncology · doi:10.1215/15228517-2008-106 · Cited by 256

Gene Silencing of the Mitochondrial Adaptor p66 Shc Suppresses Vascular Hyperglycemic Memory in Diabetes

Paneni, F., Mocharla, P., Akhmedov, A., Costantino, S., Osto, E., Volpe, M., Lüscher, T. F., & Cosentino, F. (2012) · Circulation Research · doi:10.1161/circresaha.112.266593 · Cited by 256

Endothelial Dysfunction: The Link Between Homocysteine and Hydrogen Sulfide

Pushpakumar, S., Kundu, S., & Sen, U. (2014) · Current Medicinal Chemistry · doi:10.2174/0929867321666140706142335 · Cited by 256

Diabetes impairs progenitor cell mobilisation after hindlimb ischaemia–reperfusion injury in rats

Fadini, G. P., Sartore, S., Schiavon, M., Albiero, M., Baesso, I., Cabrelle, A., Agostini, C., & Avogaro, A. (2006) · Diabetologia · doi:10.1007/s00125-006-0401-6 · Cited by 255

Interleukin (IL) 1β Induction of IL-6 Is Mediated by a Novel Phosphatidylinositol 3-Kinase-dependent AKT/IκB Kinase α Pathway Targeting Activator Protein-1

Cahill, C. M., & Rogers, J. T. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m707692200 · Cited by 252

Fatty Acid Metabolic Defects and Right Ventricular Lipotoxicity in Human Pulmonary Arterial Hypertension

Brittain, E. L., Talati, M., Fessel, J. P., Zhu, H., Penner, N., Calcutt, M. W., West, J. D., Funke, M., Lewis, G. D., Gerszten, R. E., et al. (2016) · Circulation · doi:10.1161/circulationaha.115.019351 · Cited by 252

Genetic deletion of p66 Shc adaptor protein prevents hyperglycemia-induced endothelial dysfunction and oxidative stress

Camici, G. G., Schiavoni, M., Francia, P., Bachschmid, M., Martin-Padura, I., Hersberger, M., Tanner, F. C., Pelicci, P., Volpe, M., Anversa, P., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609656104 · Cited by 249

I. Arginine

Tapiero, H., Mathé, G., Couvreur, P., & Tew, K. D. (2002) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(02)00284-6 · Cited by 249

Endothelial PFKFB3 Plays a Critical Role in Angiogenesis

Xu, Y., An, X., Guo, X., Habtetsion, T. G., Wang, Y., Xu, X., Kandala, S., Li, Q., Li, H., Zhang, C., et al. (2014) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.113.303041 · Cited by 248

Lactate in Solid Malignant Tumors: Potential Basis of a Metabolic Classification in Clinical Oncology

Walenta, S., Schroeder, T., & Mueller-Klieser, W. (2004) · Current Medicinal Chemistry · doi:10.2174/0929867043364711 · Cited by 248

Mitofusin 2 maintains haematopoietic stem cells with extensive lymphoid potential

Luchsinger, L. L., de Almeida, M. J., Corrigan, D. J., Mumau, M., & Snoeck, H.-W. (2016) · Nature · doi:10.1038/nature16500 · Cited by 247

Physiology and pathophysiology of oxLDL uptake by vascular wall cells in atherosclerosis

Di Pietro, N., Formoso, G., & Pandolfi, A. (2016) · Vascular Pharmacology · doi:10.1016/j.vph.2016.05.013 · Cited by 247

Nonvenous Origin of Dermal Lymphatic Vasculature

Martinez-Corral, I., Ulvmar, M. H., Stanczuk, L., Tatin, F., Kizhatil, K., John, S. W. M., Alitalo, K., Ortega, S., & Makinen, T. (2015) · Circulation Research · doi:10.1161/circresaha.116.306170 · Cited by 246

Gene expression of tumor angiogenesis dissected: specific targeting of colon cancer angiogenic vasculature

van Beijnum, J. R., Dings, R. P., van der Linden, E., Zwaans, B. M. M., Ramaekers, F. C. S., Mayo, K. H., & Griffioen, A. W. (2006) · Blood · doi:10.1182/blood-2006-02-004291 · Cited by 244

Intussusceptive angiogenesis and its role in vascular morphogenesis, patterning, and remodeling

Makanya, A. N., Hlushchuk, R., & Djonov, V. G. (2009) · Angiogenesis · doi:10.1007/s10456-009-9129-5 · Cited by 243

Angiopoietin signaling in the vasculature

Eklund, L., & Saharinen, P. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.03.011 · Cited by 242

Nuclear Targeting of 6-Phosphofructo-2-kinase (PFKFB3) Increases Proliferation via Cyclin-dependent Kinases

Yalcin, A., Clem, B. F., Simmons, A., Lane, A., Nelson, K., Clem, A. L., Brock, E., Siow, D., Wattenberg, B., Telang, S., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.016816 · Cited by 242

l -Arginine Supplementation in Peripheral Arterial Disease: No Benefit and Possible Harm

Wilson, A. M., Harada, R., Nair, N., Balasubramanian, N., & Cooke, J. P. (2007) · Circulation · doi:10.1161/circulationaha.106.683656 · Cited by 241

cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels

Stanczuk, L., Martinez-Corral, I., Ulvmar, M. H., Zhang, Y., Laviña, B., Fruttiger, M., Adams, R. H., Saur, D., Betsholtz, C., Ortega, S., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.02.026 · Cited by 238

Metabolism in physiological cell proliferation and differentiation

Agathocleous, M., & Harris, W. A. (2013) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.05.004 · Cited by 238

The Relationship Between Pluripotency and Mitochondrial DNA Proliferation During Early Embryo Development and Embryonic Stem Cell Differentiation

Facucho-Oliveira, J. M., & St. John, J. C. (2009) · Stem Cell Reviews and Reports · doi:10.1007/s12015-009-9058-0 · Cited by 235

Activation of NF-E2–Related Factor-2 Reverses Biochemical Dysfunction of Endothelial Cells Induced by Hyperglycemia Linked to Vascular Disease

Xue, M., Qian, Q., Adaikalakoteswari, A., Rabbani, N., Babaei-Jadidi, R., & Thornalley, P. J. (2008) · Diabetes · doi:10.2337/db06-1003 · Cited by 235

Leucine metabolism in regulation of insulin secretion from pancreatic beta cells: Nutrition Reviews©, Vol. 68, No. 5

Yang, J., Chi, Y., Burkhardt, B. R., Guan, Y., & Wolf, B. A. (2010) · Nutrition Reviews · doi:10.1111/j.1753-4887.2010.00282.x · Cited by 235

Vascular NADPH oxidases as drug targets for novel antioxidant strategies

Guzik, T. J., & Harrison, D. G. (2006) · Drug Discovery Today · doi:10.1016/j.drudis.2006.04.003 · Cited by 235

eNOS activation and NO function: Structural motifs responsible for the posttranslational control of endothelial nitric oxide synthase activity

Rafikov, R., Fonseca, F. V., Kumar, S., Pardo, D., Darragh, C., Elms, S., Fulton, D., & Black, S. M. (2011) · Journal of Endocrinology · doi:10.1530/joe-11-0083 · Cited by 235

Requirement of argininosuccinate lyase for systemic nitric oxide production

Erez, A., Nagamani, S. C. S., Shchelochkov, O. A., Premkumar, M. H., Campeau, P. M., Chen, Y., Garg, H. K., Li, L., Mian, A., Bertin, T. K., et al. (2011) · Nature Medicine · doi:10.1038/nm.2544 · Cited by 233

Lactate promotes glutamine uptake and metabolism in oxidative cancer cells

Pérez-Escuredo, J., Dadhich, R. K., Dhup, S., Cacace, A., Van Hée, V. F., De Saedeleer, C. J., Sboarina, M., Rodriguez, F., Fontenille, M.-J., Brisson, L., et al. (2016) · Cell Cycle · doi:10.1080/15384101.2015.1120930 · Cited by 231

Tetrahydrobiopterin in Cardiovascular Health and Disease

Bendall, J. K., Douglas, G., McNeill, E., Channon, K. M., & Crabtree, M. J. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5566 · Cited by 231

Fibrates down-regulate IL-1–stimulated C-reactive protein gene expression in hepatocytes by reducing nuclear p50-NFκB–C/EBP-β complex formation

Kleemann, R., Gervois, P. P., Verschuren, L., Staels, B., Princen, H. M. G., & Kooistra, T. (2003) · Blood · doi:10.1182/blood-2002-06-1762 · Cited by 229

Rosiglitazone Reduces Glucose-Induced Oxidative Stress Mediated by NAD(P)H Oxidase via AMPK-Dependent Mechanism

Ceolotto, G., Gallo, A., Papparella, I., Franco, L., Murphy, E., Iori, E., Pagnin, E., Fadini, G. P., Albiero, M., Semplicini, A., et al. (2007) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.107.155762 · Cited by 229

Glucose Starvation in Cardiomyocytes Enhances Exosome Secretion and Promotes Angiogenesis in Endothelial Cells

Garcia, N. A., Ontoria-Oviedo, I., González-King, H., Diez-Juan, A., & Sepúlveda, P. (2015) · PLOS ONE · doi:10.1371/journal.pone.0138849 · Cited by 229

Signal transduction in vasculogenesis and developmental angiogenesis

Patel-Hett, S., & DAmore, P. A. (2011) · The International Journal of Developmental Biology · doi:10.1387/ijdb.103213sp · Cited by 228

Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization

Kondo, T., Vicent, D., Suzuma, K., Yanagisawa, M., King, G. L., Holzenberger, M., & Kahn, C. R. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17455 · Cited by 228

Development of the mammalian lymphatic vasculature

Yang, Y., & Oliver, G. (2014) · Journal of Clinical Investigation · doi:10.1172/jci71609 · Cited by 226

Reactive oxygen species mediate a cellular ‘memory’ of high glucose stress signalling

Ihnat, M. A., Thorpe, J. E., Kamat, C. D., Szabó, C., Green, D. E., Warnke, L. A., Lacza, Z., Cselenyák, A., Ross, K., Shakir, S., et al. (2007) · Diabetologia · doi:10.1007/s00125-007-0684-2 · Cited by 224

Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells

Pirola, L., Balcerczyk, A., Tothill, R. W., Haviv, I., Kaspi, A., Lunke, S., Ziemann, M., Karagiannis, T., Tonna, S., Kowalczyk, A., et al. (2011) · Genome Research · doi:10.1101/gr.116095.110 · Cited by 223

Oncogenes and Angiogenesis: Signaling Three-Dimensional Tumor Growth

Rak, J., Yu, J. L., Klement, G., & Kerbel, R. S. (2000) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1046/j.1087-0024.2000.00012.x · Cited by 222

Regulation of Nitric Oxide Synthesis and Apoptosis by Arginase and Arginine Recycling

Mori, M. (2007) · The Journal of Nutrition · doi:10.1093/jn/137.6.1616s · Cited by 222

High Glucose Inhibits Glucose-6-phosphate Dehydrogenase via cAMP in Aortic Endothelial Cells

Zhang, Z., Apse, K., Pang, J., & Stanton, R. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m007505200 · Cited by 220

Tumor Endothelial Cells Express Epidermal Growth Factor Receptor (EGFR) but not ErbB3 and Are Responsive to EGF and to EGFR Kinase Inhibitors

Amin, D. N., Hida, K., Bielenberg, D. R., & Klagsbrun, M. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3387 · Cited by 220

Energy turnover of vascular endothelial cells

Culic, O., Gruwel, M. L., & Schrader, J. (1997) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1997.273.1.c205 · Cited by 219

Glucose-6-Phosphate Dehydrogenase Overexpression Decreases Endothelial Cell Oxidant Stress and Increases Bioavailable Nitric Oxide

Leopold, J. A., Zhang, Y.-Y., Scribner, A. W., Stanton, R. C., & Loscalzo, J. (2003) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000056744.26901.ba · Cited by 218

Shear-induced endothelial NOS activation and remodeling via heparan sulfate, glypican-1, and syndecan-1

Ebong, E. E., Lopez-Quintero, S. V., Rizzo, V., Spray, D. C., & Tarbell, J. M. (2014) · Integr. Biol. · doi:10.1039/c3ib40199e · Cited by 217

Human type II arginase: sequence analysis and tissue-specific expression

Morris, S. M., Bhamidipati, D., & Kepka-Lenhart, D. (1997) · Gene · doi:10.1016/s0378-1119(97)00099-1 · Cited by 216

Cell behaviors and dynamics during angiogenesis

Betz, C., Lenard, A., Belting, H.-G., & Affolter, M. (2016) · Development · doi:10.1242/dev.135616 · Cited by 215

Lymphatic vessels arise from specialized angioblasts within a venous niche

Nicenboim, J., Malkinson, G., Lupo, T., Asaf, L., Sela, Y., Mayseless, O., Gibbs-Bar, L., Senderovich, N., Hashimshony, T., Shin, M., et al. (2015) · Nature · doi:10.1038/nature14425 · Cited by 214

Methylglyoxal promotes oxidative stress and endothelial dysfunction

Sena, C. M., Matafome, P., Crisóstomo, J., Rodrigues, L., Fernandes, R., Pereira, P., & Seiça, R. M. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.03.004 · Cited by 212

The coordination of S-sulfhydration, S-nitrosylation, and phosphorylation of endothelial nitric oxide synthase by hydrogen sulfide

Altaany, Z., Ju, Y., Yang, G., & Wang, R. (2014) · Science Signaling · doi:10.1126/scisignal.2005478 · Cited by 210

Acute Regulation of Fatty Acid Oxidation and AMP-Activated Protein Kinase in Human Umbilical Vein Endothelial Cells

Dagher, Z., Ruderman, N., Tornheim, K., & Ido, Y. (2001) · Circulation Research · doi:10.1161/hh1201.092998 · Cited by 209

Updates on Aldose Reductase Inhibitors for Management of Diabetic Complications and Non-diabetic Diseases

Singh Grewal, A., Bhardwaj, S., Pandita, D., Lather, V., & Singh Sekhon, B. (2015) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557515666150909143737 · Cited by 208

Increased Pericyte Coverage Mediated by Endothelial-Derived Fibroblast Growth Factor-2 and Interleukin-6 Is a Source of Smooth Muscle–Like Cells in Pulmonary Hypertension

Ricard, N., Tu, L., Le Hiress, M., Huertas, A., Phan, C., Thuillet, R., Sattler, C., Fadel, E., Seferian, A., Montani, D., et al. (2014) · Circulation · doi:10.1161/circulationaha.113.007469 · Cited by 208

Therapeutic Potential of Endothelial Progenitor Cells in Cardiovascular Diseases

Dzau, V. J., Gnecchi, M., Pachori, A. S., Morello, F., & Melo, L. G. (2005) · Hypertension · doi:10.1161/01.hyp.0000168923.92885.f7 · Cited by 208

Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia

Herranz, D., Ambesi-Impiombato, A., Sudderth, J., Sánchez-Martín, M., Belver, L., Tosello, V., Xu, L., Wendorff, A. A., Castillo, M., Haydu, J. E., et al. (2015) · Nature Medicine · doi:10.1038/nm.3955 · Cited by 208

Mitochondrial division and fusion in metabolism

Roy, M., Reddy, P. H., Iijima, M., & Sesaki, H. (2015) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2015.02.001 · Cited by 207

Aldose Reductase Deficiency Prevents Diabetes-Induced Blood-Retinal Barrier Breakdown, Apoptosis, and Glial Reactivation in the Retina of db/db Mice

Cheung, A. K. H., Fung, M. K. L., Lo, A. C. Y., Lam, T. T. L., So, K. F., Chung, S. S. M., & Chung, S. K. (2005) · Diabetes · doi:10.2337/diabetes.54.11.3119 · Cited by 207

Resveratrol regulates mitochondrial reactive oxygen species homeostasis through Sirt3 signaling pathway in human vascular endothelial cells

Zhou, X., Chen, M., Zeng, X., Yang, J., Deng, H., Yi, L., & Mi, M.-T. (2014) · Cell Death & Disease · doi:10.1038/cddis.2014.530 · Cited by 206

Ubiad1 Is an Antioxidant Enzyme that Regulates eNOS Activity by CoQ10 Synthesis

Mugoni, V., Postel, R., Catanzaro, V., De Luca, E., Turco, E., Digilio, G., Silengo, L., Murphy, M. P., Medana, C., Stainier, D. Y. R., et al. (2013) · Cell · doi:10.1016/j.cell.2013.01.013 · Cited by 206

Insulin stimulates endothelin-1 secretion from human endothelial cells and modulates its circulating levels in vivo

Ferri, C. (1995) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.80.3.829 · Cited by 205

Immune-suppressive properties of the tumor microenvironment

Becker, J. C., Andersen, M. H., Schrama, D., & thor Straten, P. (2013) · Cancer Immunology, Immunotherapy · doi:10.1007/s00262-013-1434-6 · Cited by 204

Mitochondrial crisis in cerebrovascular endothelial cells opens the blood-brain barrier

Doll, D. N., Hu, H., Sun, J., Lewis, S. E., Simpkins, J. W., & Ren, X. (2015) · Stroke · doi:10.1161/strokeaha.115.009099 · Cited by 202

Aldose Reductase Inhibitor Fidarestat Prevents Retinal Oxidative Stress and Vascular Endothelial Growth Factor Overexpression in Streptozotocin-Diabetic Rats

Obrosova, I. G., Minchenko, A. G., Vasupuram, R., White, L., Abatan, O. I., Kumagai, A. K., Frank, R. N., & Stevens, M. J. (2003) · Diabetes · doi:10.2337/diabetes.52.3.864 · Cited by 201

Resveratrol treatment rescues neurovascular coupling in aged mice: role of improved cerebromicrovascular endothelial function and downregulation of NADPH oxidase

Toth, P., Tarantini, S., Tucsek, Z., Ashpole, N. M., Sosnowska, D., Gautam, T., Ballabh, P., Koller, A., Sonntag, W. E., Csiszar, A., et al. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00744.2013 · Cited by 200

6-Phosphofructo-2-kinase (PFKFB3) promotes cell cycle progression and suppresses apoptosis via Cdk1-mediated phosphorylation of p27

Yalcin, A., Clem, B. F., Imbert-Fernandez, Y., Ozcan, S. C., Peker, S., O'Neal, J., Klarer, A. C., Clem, A. L., Telang, S., & Chesney, J. (2014) · Cell Death & Disease · doi:10.1038/cddis.2014.292 · Cited by 199

MOLECULAR MECHANISMS REGULATING iNOS EXPRESSION IN VARIOUS CELL TYPES

Rao, K. M. K. (2000) · Journal of Toxicology and Environmental Health, Part B · doi:10.1080/109374000281131 · Cited by 199

Epigenetic mechanisms in diabetic vascular complications

Reddy, M. A., & Natarajan, R. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvr024 · Cited by 199

Hematopoietic induction and respecification of A-P identity by visceral endoderm signaling in the mouse embryo

Belaoussoff, M., Farrington, S. M., & Baron, M. H. (1998) · Development · doi:10.1242/dev.125.24.5009 · Cited by 198

Quantitative H2S-mediated protein sulfhydration reveals metabolic reprogramming during the integrated stress response

Gao, X.-H., Krokowski, D., Guan, B.-J., Bederman, I., Majumder, M., Parisien, M., Diatchenko, L., Kabil, O., Willard, B., Banerjee, R., et al. (2015) · eLife · doi:10.7554/elife.10067 · Cited by 196

Blood flow drives lumen formation by inverse membrane blebbing during angiogenesis in vivo

Gebala, V., Collins, R., Geudens, I., Phng, L.-K., & Gerhardt, H. (2016) · Nature Cell Biology · doi:10.1038/ncb3320 · Cited by 195

Control of angiogenesis by AIBP-mediated cholesterol efflux

Fang, L., Choi, S.-H., Baek, J. S., Liu, C., Almazan, F., Ulrich, F., Wiesner, P., Taleb, A., Deer, E., Pattison, J., et al. (2013) · Nature · doi:10.1038/nature12166 · Cited by 192

Nitric oxide and AMPK cooperatively regulate PGC-1α in skeletal muscle cells: NO/AMPK-dependent regulation of PGC-1α

Lira, V. A., Brown, D. L., Lira, A. K., Kavazis, A. N., Soltow, Q. A., Zeanah, E. H., & Criswell, D. S. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.194035 · Cited by 191

MicroRNA profiling unveils hyperglycaemic memory in the diabetic heart

Costantino, S., Paneni, F., Lüscher, T. F., & Cosentino, F. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehv599 · Cited by 190

Insulin's effect on protein kinase C and diacylglycerol induced by diabetes and glucose in vascular tissues

Inoguchi, T., Xia, P., Kunisaki, M., Higashi, S., Feener, E. P., & King, G. L. (1994) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1994.267.3.e369 · Cited by 190

Reactive Oxygen Species Can Provide Atheroprotection via NOX4-Dependent Inhibition of Inflammation and Vascular Remodeling

Gray, S. P., Di Marco, E., Kennedy, K., Chew, P., Okabe, J., El-Osta, A., Calkin, A. C., Biessen, E. A. L., Touyz, R. M., Cooper, M. E., et al. (2016) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.115.307012 · Cited by 189

Sulforaphane prevents the development of cardiomyopathy in type 2 diabetic mice probably by reversing oxidative stress-induced inhibition of LKB1/AMPK pathway

Zhang, Z., Wang, S., Zhou, S., Yan, X., Wang, Y., Chen, J., Mellen, N., Kong, M., Gu, J., Tan, Y., et al. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.09.022 · Cited by 188

Metabolic control of hyaluronan synthases

Vigetti, D., Viola, M., Karousou, E., De Luca, G., & Passi, A. (2014) · Matrix Biology · doi:10.1016/j.matbio.2013.10.002 · Cited by 188

Wnt signaling in the vasculature

Reis, M., & Liebner, S. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2012.12.023 · Cited by 187

Angiogenic morphogenesis driven by dynamic and heterogeneous collective endothelial cell movement

Arima, S., Nishiyama, K., Ko, T., Arima, Y., Hakozaki, Y., Sugihara, K., Koseki, H., Uchijima, Y., Kurihara, Y., & Kurihara, H. (2011) · Development · doi:10.1242/dev.068023 · Cited by 187

Glycolysis is the primary bioenergetic pathway for cell motility and cytoskeletal remodeling in human prostate and breast cancer cells

Shiraishi, T., Verdone, J. E., Huang, J., Kahlert, U. D., Hernandez, J. R., Torga, G., Zarif, J. C., Epstein, T., Gatenby, R., McCartney, A., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.2766 · Cited by 186

Cardiomyocyte exosomes regulate glycolytic flux in endothelium by direct transfer of GLUT transporters and glycolytic enzymes

Garcia, N. A., Moncayo-Arlandi, J., Sepulveda, P., & Diez-Juan, A. (2016) · Cardiovascular Research · doi:10.1093/cvr/cvv260 · Cited by 185

Modeling cancer metabolism on a genome scale

Yizhak, K., Chaneton, B., Gottlieb, E., & Ruppin, E. (2015) · Molecular Systems Biology · doi:10.15252/msb.20145307 · Cited by 183

Cytogenetic Abnormalities of Tumor-Associated Endothelial Cells in Human Malignant Tumors

Akino, T., Hida, K., Hida, Y., Tsuchiya, K., Freedman, D., Muraki, C., Ohga, N., Matsuda, K., Akiyama, K., Harabayashi, T., et al. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.090202 · Cited by 183

Oxygen-induced retinopathy: a model for vascular pathology in the retina

Scott, A., & Fruttiger, M. (2010) · Eye · doi:10.1038/eye.2009.306 · Cited by 182

Lactate Engages Receptor Tyrosine Kinases Axl, Tie2, and Vascular Endothelial Growth Factor Receptor 2 to Activate Phosphoinositide 3-Kinase/Akt and Promote Angiogenesis

Ruan, G.-X., & Kazlauskas, A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.474619 · Cited by 181

Role of Nox4 and Nox2 in Hyperoxia-Induced Reactive Oxygen Species Generation and Migration of Human Lung Endothelial Cells

Pendyala, S., Gorshkova, I. A., Usatyuk, P. V., He, D., Pennathur, A., Lambeth, J. D., Thannickal, V. J., & Natarajan, V. (2009) · Antioxidants & Redox Signaling · doi:10.1089/ars.2008.2203 · Cited by 181

Distinguishing Hyperglycemic Changes by Set7 in Vascular Endothelial Cells

Okabe, J., Orlowski, C., Balcerczyk, A., Tikellis, C., Thomas, M. C., Cooper, M. E., & El-Osta, A. (2012) · Circulation Research · doi:10.1161/circresaha.112.266171 · Cited by 180

Xanthine oxidoreductase in atherosclerosis pathogenesis: Not only oxidative stress

Battelli, M. G., Polito, L., & Bolognesi, A. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.10.006 · Cited by 179

FoxOs Integrate Pleiotropic Actions of Insulin in Vascular Endothelium to Protect Mice from Atherosclerosis

Tsuchiya, K., Tanaka, J., Shuiqing, Y., Welch, C. L., DePinho, R. A., Tabas, I., Tall, A. R., Goldberg, I. J., & Accili, D. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.018 · Cited by 179

Endothelial Progenitor Thrombospondin-1 Mediates Diabetes-Induced Delay in Reendothelialization Following Arterial Injury

Ii, M., Takenaka, H., Asai, J., Ibusuki, K., Mizukami, Y., Maruyama, K., Yoon, Y.-S., Wecker, A., Luedemann, C., Eaton, E., et al. (2006) · Circulation Research · doi:10.1161/01.res.0000209948.50943.ea · Cited by 179

Metabolism of exogenous substrates by coronary endothelial cells in culture

Krützfeldt, A. (1990) · Journal of Molecular and Cellular Cardiology · doi:10.1016/0022-2828(90)90984-a · Cited by 178

Effect of Endothelium-Specific Insulin Resistance on Endothelial Function In Vivo

Duncan, E. R., Crossey, P. A., Walker, S., Anilkumar, N., Poston, L., Douglas, G., Ezzat, V. A., Wheatcroft, S. B., Shah, A. M., & Kearney, M. I. (2008) · Diabetes · doi:10.2337/db07-1111 · Cited by 178

Co-option of Liver Vessels and Not Sprouting Angiogenesis Drives Acquired Sorafenib Resistance in Hepatocellular Carcinoma

Kuczynski, E. A., Yin, M., Bar-Zion, A., Lee, C. R., Butz, H., Man, S., Daley, F., Vermeulen, P. B., Yousef, G. M., Foster, F. S., et al. (2016) · Journal of the National Cancer Institute · doi:10.1093/jnci/djw030 · Cited by 174

Atherosclerosis Is Attenuated by Limiting Superoxide Generation in Both Macrophages and Vessel Wall Cells

Vendrov, A. E., Hakim, Z. S., Madamanchi, N. R., Rojas, M., Madamanchi, C., & Runge, M. S. (2007) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.107.152629 · Cited by 173

Autocrine VEGF maintains endothelial survival through regulation of metabolism and autophagy

Domigan, C. K., Warren, C. M., Antanesian, V., Happel, K., Ziyad, S., Lee, S., Krall, A., Duan, L., Torres-Collado, A. X., Castellani, L. W., et al. (2015) · Journal of Cell Science · doi:10.1242/jcs.163774 · Cited by 172

Role of Mitochondrial DNA Damage in the Development of Diabetic Retinopathy, and the Metabolic Memory Phenomenon Associated with Its Progression

Madsen–Bouterse, S. A., Mohammad, G., Kanwar, M., & Kowluru, R. A. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2932 · Cited by 170

Inhibition of Rat Liver Arginase by an Intermediate in NO Biosynthesis, NG-Hydroxy-L-arginine: Implications for the Regulation of Nitric Oxide Biosynthesis by Arginase

Daghigh, F., Fukuto, J. M., & Ash, D. E. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.1909 · Cited by 170

Nω-Hydroxy-L-Arginine, an Intermediate in the L-Arginine to Nitric Oxide Pathway, Is a Strong Inhibitor of Liver and Macrophage Arginase

Boucher, J. L., Custot, J., Vadon, S., Delaforge, M., Lepoivre, M., Tenu, J. P., Yapo, A., & Mansuy, D. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.2371 · Cited by 170

VEGF ‐B‐induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart

Kivelä, R., Bry, M., Robciuc, M. R., Räsänen, M., Taavitsainen, M., Silvola, J. M., Saraste, A., Hulmi, J. J., Anisimov, A., Mäyränpää, M. I., et al. (2014) · EMBO Molecular Medicine · doi:10.1002/emmm.201303147 · Cited by 170

Blockade of the Nuclear Factor-κB Pathway in the Endothelium Prevents Insulin Resistance and Prolongs Life Spans

Hasegawa, Y., Saito, T., Ogihara, T., Ishigaki, Y., Yamada, T., Imai, J., Uno, K., Gao, J., Kaneko, K., Shimosawa, T., et al. (2012) · Circulation · doi:10.1161/circulationaha.111.054346 · Cited by 169

Interactions between glycolytic enzymes and components of the cytomatrix.

Masters, C. (1984) · The Journal of cell biology · doi:10.1083/jcb.99.1.222s · Cited by 168

Uncoupling of Acetylation from Phosphorylation Regulates FoxO1 Function Independent of Its Subcellular Localization

Qiang, L., Banks, A. S., & Accili, D. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.140228 · Cited by 168

Final Common Molecular Pathways of Aging and Cardiovascular Disease: Role of the p66 Shc Protein

Cosentino, F., Francia, P., Camici, G. G., Pelicci, P. G., Volpe, M., & Lüscher, T. F. (2008) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.107.156059 · Cited by 168

Endothelial cell-fatty acid binding protein 4 promotes angiogenesis: role of stem cell factor/c-kit pathway

Elmasri, H., Ghelfi, E., Yu, C.-W., Traphagen, S., Cernadas, M., Cao, H., Shi, G.-P., Plutzky, J., Sahin, M., Hotamisligil, G., et al. (2012) · Angiogenesis · doi:10.1007/s10456-012-9274-0 · Cited by 167

Enhancement of Glucose Transporter Expression of Brain Endothelial Cells by Vascular Endothelial Growth Factor Derived from Glioma Exposed to Hypoxia

Yeh, W.-L., Lin, C.-J., & Fu, W.-M. (2008) · Molecular Pharmacology · doi:10.1124/mol.107.038851 · Cited by 167

Hypothesis: the ‘metabolic memory’, the new challenge of diabetes

Ihnat, M. A., Thorpe, J. E., & Ceriello, A. (2007) · Diabetic Medicine · doi:10.1111/j.1464-5491.2007.02138.x · Cited by 167

Glycolytic regulation of cell rearrangement in angiogenesis

Cruys, B., Wong, B. W., Kuchnio, A., Verdegem, D., Cantelmo, A. R., Conradi, L.-C., Vandekeere, S., Bouché, A., Cornelissen, I., Vinckier, S., et al. (2016) · Nature Communications · doi:10.1038/ncomms12240 · Cited by 167

Systemic and Vascular Oxidation Limits the Efficacy of Oral Tetrahydrobiopterin Treatment in Patients With Coronary Artery Disease

Cunnington, C., Van Assche, T., Shirodaria, C., Kylintireas, I., Lindsay, A. C., Lee, J. M., Antoniades, C., Margaritis, M., Lee, R., Cerrato, R., et al. (2012) · Circulation · doi:10.1161/circulationaha.111.038919 · Cited by 166

Heterogeneity of Tumor Endothelial Cells

Ohga, N., Ishikawa, S., Maishi, N., Akiyama, K., Hida, Y., Kawamoto, T., Sadamoto, Y., Osawa, T., Yamamoto, K., Kondoh, M., et al. (2012) · The American Journal of Pathology · doi:10.1016/j.ajpath.2011.11.035 · Cited by 166

Anticancer Agents That Counteract Tumor Glycolysis

Granchi, C., & Minutolo, F. (2012) · ChemMedChem · doi:10.1002/cmdc.201200176 · Cited by 166

Arginase and vascular aging

Santhanam, L., Christianson, D. W., Nyhan, D., & Berkowitz, D. E. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90627.2008 · Cited by 165

Roles of O-GlcNAc in chronic diseases of aging

Banerjee, P. S., Lagerlöf, O., & Hart, G. W. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.05.005 · Cited by 165

Therapeutic potential of nadph oxidase 1/4 inhibitors

Teixeira, G., Szyndralewiez, C., Molango, S., Carnesecchi, S., Heitz, F., Wiesel, P., & Wood, J. M. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13532 · Cited by 163

Glucose-6-phosphate Dehydrogenase Modulates Vascular Endothelial Growth Factor-mediated Angiogenesis

Leopold, J. A., Walker, J., Scribner, A. W., Voetsch, B., Zhang, Y.-Y., Loscalzo, A. J., Stanton, R. C., & Loscalzo, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301293200 · Cited by 163

Reactive Oxygen Species Modulate the Barrier Function of the Human Glomerular Endothelial Glycocalyx

Singh, A., Ramnath, R. D., Foster, R. R., Wylie, E. C., Fridén, V., Dasgupta, I., Haraldsson, B., Welsh, G. I., Mathieson, P. W., & Satchell, S. C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055852 · Cited by 163

Differential Toxic Mechanisms of 2-Deoxy-D-Glucose versus 2-Fluorodeoxy-D -Glucose in Hypoxic and Normoxic Tumor Cells

Kurtoglu, M., Maher, J. C., & Lampidis, T. J. (2007) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1714 · Cited by 163

Endothelial PGC-1α Mediates Vascular Dysfunction in Diabetes

Sawada, N., Jiang, A., Takizawa, F., Safdar, A., Manika, A., Tesmenitsky, Y., Kang, K.-T., Bischoff, J., Kalwa, H., Sartoretto, J. L., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.014 · Cited by 163

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Chen, Z. B., Wen, L., Martin, M., Hsu, C., Fang, L., Lin, F.-M., Lin, T.-Y., Geary, M. J., Geary, G. G., Zhao, Y., et al. (2014) · Circulation · doi:10.1161/circulationaha.114.013675 · Cited by 162

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Matafome, P., Sena, C., & Seiça, R. (2013) · Endocrine · doi:10.1007/s12020-012-9795-8 · Cited by 162

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Parra-Bonilla, G., Alvarez, D. F., Al-Mehdi, A.-B., Alexeyev, M., & Stevens, T. (2010) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00274.2009 · Cited by 162

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Roe, N. D., & Ren, J. T. (2012) · Vascular Pharmacology · doi:10.1016/j.vph.2012.02.004 · Cited by 161

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Wang, R., Szabo, C., Ichinose, F., Ahmed, A., Whiteman, M., & Papapetropoulos, A. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.05.007 · Cited by 160

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Hida, K., & Klagsbrun, M. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0002 · Cited by 160

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Cellular fatty acid uptake: the contribution of metabolism

Mashek, D. G., & Coleman, R. (2006) · Current Opinion in Lipidology · doi:10.1097/01.mol.0000226119.20307.2b · Cited by 156

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Akiyama, K., Ohga, N., Hida, Y., Kawamoto, T., Sadamoto, Y., Ishikawa, S., Maishi, N., Akino, T., Kondoh, M., Matsuda, A., et al. (2012) · The American Journal of Pathology · doi:10.1016/j.ajpath.2011.11.029 · Cited by 154

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Murphy, C., Kanaganayagam, G. S., Jiang, B., Chowienczyk, P., Zbinden, R., Saha, M., Rahman, S., Shah, A. M., Marber, M. S., & Kearney, M. T. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000258788.11372.d0 · Cited by 154

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Rosso, A., Balsamo, A., Gambino, R., Dentelli, P., Falcioni, R., Cassader, M., Pegoraro, L., Pagano, G., & Brizzi, M. F. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509293200 · Cited by 153

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Leopold, J. A., Cap, A., Scribner, A. W., Stanton, R. C., & Loscalzo, J. (2001) · The FASEB Journal · doi:10.1096/fj.00-0893fje · Cited by 153

Nitric oxide regulates mitochondrial oxidative stress protection via the transcriptional coactivator PGC‐1α

Borniquel, S., Valle, I., Cadenas, S., Lamas, S., & Monsalve, M. (2006) · The FASEB Journal · doi:10.1096/fj.05-5189fje · Cited by 151

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Yeo, H., Lyssiotis, C. A., Zhang, Y., Ying, H., Asara, J. M., Cantley, L. C., & Paik, J.-H. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.186 · Cited by 149

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Girgis, R. E., Champion, H. C., Diette, G. B., Johns, R. A., Permutt, S., & SYLVESTER, J. T. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200412-1684oc · Cited by 148

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Iso, T., Maeda, K., Hanaoka, H., Suga, T., Goto, K., Syamsunarno, M. R. A. A., Hishiki, T., Nagahata, Y., Matsui, H., Arai, M., et al. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.301588 · Cited by 148

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Sahoo, S., Meijles, D. N., & Pagano, P. J. (2016) · Clinical Science · doi:10.1042/cs20150087 · Cited by 147

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Al-Delaimy, W. K., Merchant, A. T., Rimm, E. B., Willett, W. C., Stampfer, M. J., & Hu, F. B. (2004) · The American Journal of Medicine · doi:10.1016/j.amjmed.2003.09.038 · Cited by 143

Solubility of long-chain fatty acids in phosphate buffer at pH 7.4

Vorum, H., Brodersen, R., Kragh‐Hansen, U., & Pedersen, A. O. (1992) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(92)90283-2 · Cited by 143

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Ferguson, J. E., Kelley, R. W., & Patterson, C. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000183609.55154.44 · Cited by 143

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Yamanishi, S., Katsumura, K., Kobayashi, T., & Puro, D. G. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01012.2005 · Cited by 142

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Lilly, B. (2014) · Physiology · doi:10.1152/physiol.00047.2013 · Cited by 142

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Maishi, N., Ohba, Y., Akiyama, K., Ohga, N., Hamada, J., Nagao‐Kitamoto, H., Alam, M. T., Yamamoto, K., Kawamoto, T., Inoue, N., et al. (2016) · Scientific Reports · doi:10.1038/srep28039 · Cited by 142

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Fessel, J. P., Hamid, R., Wittmann, B. M., Robinson, L. J., Blackwell, T., Tada, Y., Tanabe, N., Tatsumi, K., Hemnes, A. R., & West, J. D. (2012) · Pulmonary Circulation · doi:10.4103/2045-8932.97606 · Cited by 141

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Miele, C., Riboulet, A., Maitan, M. A., Oriente, F., Romano, C., Formisano, P., Giudicelli, J., Bèguinot, F., & OBBERGHEN, E. V. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301088200 · Cited by 141

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Srinivas, S. R., Gopal, E., Zhuang, L., Itagaki, S., Martin, P. M., Fei, Y.-J., Ganapathy, V., & Prasad, P. D. (2005) · Biochemical Journal · doi:10.1042/bj20050927 · Cited by 141

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Mani, S., Untereiner, A. A., Wu, L., & Wang, R. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5324 · Cited by 141

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Qian, J., Olbrecht, S., Boeckx, B., Vos, H., Laoui, D., Etlioglu, E., Wauters, E., Pomella, V., Verbandt, S., Busschaert, P., et al. (2020) · Cell Research · doi:10.1038/s41422-020-0355-0 · Cited by 817

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